Abstract:
:Electrical stimulation of the midbrain tegmentum can produce differential modulation of quiet biting attack and affective defense behavior elicited from the hypothalamus of the cat. Stimulation of the lateral half of the tegmentum facilitated quiet biting attack and suppressed affective defense. Conversely, stimulation of the medial tegmentum suppressed quiet biting attack and facilitated affective defense. These results clearly indicate a topographic organization of modulatory sites controlling hypothalamic aggression within the midbrain tegmentum.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Shaikh MB,Brutus M,Siegel HE,Siegel Adoi
10.1016/S0014-4886(84)90112-2subject
Has Abstractpub_date
1984-02-01 00:00:00pages
436-42issue
2eissn
0014-4886issn
1090-2430pii
S0014-4886(84)90112-2journal_volume
83pub_type
杂志文章abstract::Functional relations between hippocampal lamellae, the modular units arranged in parallel in the hippocampal formation, were studied in the guinea pig in experiments of evoked field potential analysis. Perforant path volleys, synaptically elicited by stimulation of the dorsal hippocampal commissure, were used to activ...
journal_title:Experimental neurology
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abstract::Ubiquitin (Ub) C-terminal hydrolase L1 (UCHL1) is a multifunctional protein that is expressed in neurons throughout brain at high levels. UCHL1 deletion is associated with axonal degeneration, progressive sensory motor ataxia, and premature death in mice. UCHL1 has been hypothesized to play a role in the pathogenesis ...
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abstract::Human immunodeficiency virus (HIV) patients treated with nucleoside reverse transcriptase inhibitors (NRTIs), have been known to develop neuropathic pain. While there has been a major shift away from some neurotoxic NRTIs in current antiretroviral therapy, a large number of HIV patients alive today have previously rec...
journal_title:Experimental neurology
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abstract::Exogenous myelin- or axolemma-enriched fractions were assessed for the ability to inhibit biochemical and morphological expressions of reactive gliosis in rat optic nerve. Elvax pellets containing exogenous myelin, axolemma, whole-brain homogenate, liver, or red cell extracts or no homogenate were inserted into a dura...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(88)90108-2
更新日期:1988-05-01 00:00:00
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(86)90241-4
更新日期:1986-12-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章,评审
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journal_title:Experimental neurology
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doi:10.1006/exnr.2000.7466
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abstract::Adult neurogenesis is modulated by growth factors, physical conditions, and other alterations in the physical microenvironment. We studied the effects of focal ischemia on neurogenesis in the subventricular zone (SVZ), olfactory bulb (OB), and hippocampal dentate gyrus (DG) (known to be persistent neurogenic regions) ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2006.03.012
更新日期:2006-05-01 00:00:00
abstract::The kindling phenomenon, i.e., the progressive development of focal and secondarily generalized seizures upon repeated electrical stimulation of a limbic brain region, occurs in various species, but with marked differences in kindling rate between species and also within the same species. In rats, differences in kindl...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1998.6948
更新日期:1998-12-01 00:00:00
abstract::The contribution of chondroitin sulfate proteoglycan (CSPG) in the suppression of axonal growth in rat spinal cord has been examined by means of an in vitro bioassay in which regenerating neurons are grown on tissue section substrata. Dissociated embryonic chick dorsal root ganglionic neurons were grown on normal and ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1998.6951
更新日期:1998-12-01 00:00:00
abstract::Roles of protein kinases in mediating adaptive neuronal responses to activation of signal transduction pathways are well known. Recent findings suggest that kinases may also be involved in pathological processes in the nervous system. The present study employed cultured human cerebral cortical neurons to test the hypo...
journal_title:Experimental neurology
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更新日期:1991-04-01 00:00:00
abstract::Electrical stimulation of the trigeminal ganglion has been widely used as a model of nociception, characterizing migraine. This treatment is known to evoke release of neuropeptides and neurotransmitters from nerve fibers of the dura mater. On the basis of immunocytochemical investigations, we found that under normal c...
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doi:10.1016/j.expneurol.2003.12.001
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:The pathogenesis of pain in irritable bowel syndrome (IBS) is poorly understood and treatment remains difficult. We have previously reported that TTX-resistant (TTX-R) sodium channels in colon-specific dorsal root ganglion (DRG) neurons were sensitized and the expression of the endogenous hydrogen sulfide pr...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2013.06.027
更新日期:2013-10-01 00:00:00
abstract::Forebrain-bisected cats underwent kindling at primary and secondary amygdala sites. The behavioral effect of amygdala kindling was then examined according to the extent of the surgical lesion in the forebrain commissures. Bisection of the corpus callosum with or without lesion of the hippocampal commissure modified bo...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90083-5
更新日期:1987-10-01 00:00:00
abstract::Opening of the mitochondrial permeability transition pore has increasingly been implicated in excitotoxic, ischemic, and apoptotic cell death, as well as in several neurodegenerative disease processes. However, much of the work directly characterizing properties of the transition pore has been performed in isolated li...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2000.7438
更新日期:2000-08-01 00:00:00
abstract::Huntingtin is a cytoplasmic protein that is found in neurons and somatic cells. In patients with Huntington's disease (HD), the NH2-terminal region of huntingtin has an expanded polyglutamine tract. An abnormal protein interaction by mutant huntingtin has been proposed as a mechanism for HD pathogenesis. Huntingtin as...
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2014-10-01 00:00:00
abstract::The roles of activated NF-kappaB subunits in the CNS remain to be discerned. Members of this family of transcription factors are essential to diverse physiological processes and can be activated by pathogens, stress, pharmacological agents, and trauma. We are particularly interested in long-term NF-kappaB activation a...
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abstract::Disease-modifying treatments remain an unmet medical need in Parkinson's disease (PD). Such treatments can be operationally defined as interventions that slow down the clinical evolution to advanced disease milestones. A treatment may achieve this outcome by either inhibiting primary neurodegenerative events ("neuropr...
journal_title:Experimental neurology
pub_type: 杂志文章,评审
doi:10.1016/j.expneurol.2017.10.001
更新日期:2017-12-01 00:00:00
abstract::Kindling is traditionally viewed as a chronic, focal epilepsy model which consistently induces complex partial seizures from limbic structures in animals. This study revealed that primary or exceedingly rapid secondary generalized seizures could also be kindled when stimulation was applied to the lateral geniculate nu...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(84)90063-3
更新日期:1984-10-01 00:00:00
abstract::Paclitaxel is an effective chemotherapeutic agent that, despite its common use, often causes peripheral sensory neuropathy. In neurons, paclitaxel binds to and stabilizes microtubules, and through unknown mechanisms, bundles microtubules and disrupts their organization. Because microtubules serve as tracks on which a ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2015.06.023
更新日期:2015-09-01 00:00:00
abstract::We have previously shown that lesions of the sensorimotor cortex induced by either thermocoagulation or aspiration produce different effects on axonal plasticity. We have now investigated whether these methods of lesion also influence the behavioral outcome. The behavioral effects of unilateral and bilateral lesions o...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1998.6893
更新日期:1998-11-01 00:00:00
abstract::As in Alzheimer's disease, brains of Guam Chamorros with amyotrophic lateral sclerosis (ALS) and Parkinsonism-dementia complex (PDC) contain intraneuronal-paired helical filaments composed of accumulated phosphorylated tau protein. Tau mRNA expression in rat neuronal cultures-normally modulated by glutamate-increases ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1998.6962
更新日期:1999-01-01 00:00:00
abstract::Cortical spreading depression (CSD) is associated with various short- and long-term physiological and neurochemical changes and has been shown to confer an increased susceptibility to accompanying ischemic injury or provide protection against a subsequent experimental ischemia. Nitric oxide is involved in the processe...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7218
更新日期:1999-12-01 00:00:00
abstract::Penile (cavernous) nerves are readily damaged during radical prostatectomy, invariably causing impotence. Erectile function can return, however this may take months or years and capacity often remains poor. Many studies have attempted to improve penile nerve regeneration but have not explored mechanisms underlying the...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2007.05.011
更新日期:2007-09-01 00:00:00
abstract::Neonatal hypoxia ischemia (HI) is the main cause of newborn mortality and morbidity. Preclinical studies have shown that the immature rat brain is more resilient to HI injury, suggesting innate mechanisms of neuroprotection. During neonatal period brain metabolism experience changes that might greatly affect the outco...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2020.113317
更新日期:2020-08-01 00:00:00