Abstract：
:The contribution of chondroitin sulfate proteoglycan (CSPG) in the suppression of axonal growth in rat spinal cord has been examined by means of an in vitro bioassay in which regenerating neurons are grown on tissue section substrata. Dissociated embryonic chick dorsal root ganglionic neurons were grown on normal and injured adult spinal cord tissue sections treated with chondroitinases. Neuritic growth on normal spinal cord tissue was meager. However, both the percentage of neurons with neurites and the average neurite length were substantially greater on sections treated with chondroitinase ABC. Enzymes that specifically degraded dermatan sulfate or hyaluronan were ineffective. Neuritic growth was significantly greater on injured (compared to normal) spinal cord and a further dramatic increase resulted from chondroitinase ABC treatment. Neurites grew equally within white and gray matter regions after chondroitinase treatment. Observed increases in neurite outgrowth on chondroitinase-treated tissues were largely inhibited in the presence of function-blocking laminin antibodies. These findings indicate that inhibitory CSPG is widely distributed and predominant in both normal and injured spinal cord tissues. Additionally, inhibitory CSPG is implicated in negating the potential stimulatory effects of laminin that might otherwise support spinal cord regeneration.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Zuo J,Neubauer D,Dyess K,Ferguson TA,Muir Ddoi
10.1006/exnr.1998.6951subject
Has Abstractpub_date
1998-12-01 00:00:00pages
654-62issue
2eissn
0014-4886issn
1090-2430pii
S0014-4886(98)96951-5journal_volume
154pub_type
杂志文章abstract：:Contusion of the spinal cord causes an immediate local loss of neurons and disruption of vasculature; additional loss continues thereafter. To explore the possibility of a causal link between delayed endothelial cell (EC) death and secondary neural cell loss, we evaluated neural and endothelial cell survival, and meas...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.05.028
更新日期：2006-11-01 00:00:00
abstract：:In a model of Parkinson's disease (PD), amphetamine, a dopamine (DA)-releasing drug, fails to induce ipsilateral drug rotations in a proportion of rats with complete unilateral 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle and DA neurons of the substantia nigra. To investigate this phenomenon, indi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7823
更新日期：2001-12-01 00:00:00
abstract：:A 168-nucleotide exon, found in alternatively spliced amyloid precursor protein (APP) mRNAs, encodes a Kunitz protease inhibitor (KPI) domain. Kainic acid (ip) caused a selective increase of KPI mRNA in rat hippocampus. By in situ hybridization, KPI mRNA was induced in the neuronal layers of the hippocampus 11-12 h af...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(92)90191-r
更新日期：1992-12-01 00:00:00
abstract：:The role of capsaicin-sensitive afferents in neurogenic voiding dysfunction was studied in chronic spinal cord injured rats (SCI). Cystometry and external urethral sphincter (EUS) electromyography were performed on 2 consecutive days after induction of urethane anesthesia in SCI rats 6-8 weeks after spinal cord injury...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.02.014
更新日期：2004-06-01 00:00:00
abstract：:Neglect is a clinical syndrome characterized by an inability to orient, report, or respond to novel or meaningful stimuli presented to one side of the body or in one hemispace. Neglect in humans and monkeys most often results from damage to one of several interconnected cortical areas, including limbic cortex. In rats...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90132-5
更新日期：1989-09-01 00:00:00
abstract：:CNS damage often results in demyelination of spared axons due to oligodendroglial cell death and dysfunction near the injury site. Although new oligodendroglia are generated following CNS injury and disease, the process of remyelination is typically incomplete resulting in long-term functional deficits. Chondroitin su...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2013.04.003
更新日期：2013-09-01 00:00:00
abstract：:Previous studies have suggested that defective high-affinity glutamate uptake, due mainly to a major loss of the astroglial-specific GLT-1 glutamate transporter, underlies the selective motoneuron degeneration observed in sporadic ALS (24, 28). If a defect in glutamate transport underlies the pathogenesis of sporadic ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.0198
更新日期：1996-12-01 00:00:00
abstract：:Dementia and parkinsonism are late-onset symptoms associated with repetitive head injury, as documented in multiple contact-sport athletes. Clinical symptomatology is the likely phenotype of chronic degeneration and circuit disruption in the substantia nigra (SN). To investigate the initiating neuropathology, we hypot...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.12.003
更新日期：2012-03-01 00:00:00
abstract：:The electromyographic (EMG) activity of the gastrocnemius and tibialis anterior muscles was recorded from normal geriatric subjects and from hemiplegic patients subjected to a continuous back-and-forth movement of the platform on which they stood. The platform oscillated at a fixed frequency of 0.5 Hz. Movement amplit...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90156-2
更新日期：1988-02-01 00:00:00
abstract：:As early as 1928, Cajal suggested that plaques contain a trophic substance which attracts neurites. Recently, basic fibroblast growth factor (bFGF) levels were shown to be elevated in Alzheimer's disease (AD) and localized to plaques and neurofibrillary tangles. We sought to clarify the subtype of plaques which contai...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1993.1202
更新日期：1993-12-01 00:00:00
abstract：:Spinal motor neurons of Sprague-Dawley rats were examined to determine which of the neuronal isoforms of actin (beta or gamma) upregulate following axon injury. In situ hybridization studies showed greater beta-actin mRNA levels but no change in gamma-actin mRNA levels-suggesting that axon regrowth utilizes beta-actin...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2002.8034
更新日期：2002-12-01 00:00:00
abstract：:Green tea polyphenol is known to act as a buffer, reducing biological responses to oxidative stress. Several effects of polyphenol have been reported, such as protection of tissue from ischemia, antineoplasmic and anti-inflammatory effects, and suppression of arteriosclerosis. In this study, we investigated whether pe...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/S0014-4886(03)00344-3
更新日期：2003-12-01 00:00:00
abstract：:The sub-thalamic nucleus (STN) is relevant to the preparation of movement ignition but its role in movement termination is uncertain. Fourteen patients with Parkinson's disease (PD) received local field potentials (LFPs) recording at the left STN on the fourth day after deep brain stimulation surgery. They performed p...
journal_title：Experimental neurology
pub_type： 临床试验,杂志文章
doi：10.1016/j.expneurol.2011.10.013
更新日期：2012-01-01 00:00:00
abstract：:A new mutant, peroneal muscular atrophy (pma) mouse in CF#1 strain has an autosomal recessively inherited equinovarus (club foot deformity) of the hind legs because of the absence of the common peroneal nerve branch of the sciatic nerve. We found the peroneal muscles were hypoplastic with histochemical and electron mi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(86)90053-1
更新日期：1986-03-01 00:00:00
abstract：:The astrocyte-endothelial cell interaction is crucial for normal brain homeostasis and blood-brain barrier (BBB) disruption in pathological conditions. However, the mechanism by which astrocytes control BBB integrity, especially after traumatic brain injury (TBI), remains unclear. Here, we present evidence that astroc...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2019.113044
更新日期：2019-12-01 00:00:00
abstract：:Electroconvulsive therapy (ECT) is one of the most effective treatments in cases of severe and treatment resistant major depression. 60-80% of patients respond to ECT, but the procedure is demanding and robust prediction of ECT responses would be of great clinical value. Predictions based on neuroimaging data have rec...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113505
更新日期：2021-01-01 00:00:00
abstract：:Olfactory ensheathing cells (OECs) have been investigated extensively as a therapy to promote repair in the injured CNS, with variable efficacy in numerous studies over the previous decade. In many studies that report anatomical and functional recovery, the beneficial effects have been attributed to the ability of OEC...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2010.08.012
更新日期：2011-05-01 00:00:00
abstract：:The blood-brain barrier (BBB) constitutes a neurovascular unit formed by microvascular endothelial cells, pericytes, and astrocytes. Brain pericytes are important regulators of BBB integrity, permeability, and blood flow. Pericyte loss has been implicated in injury; however, how the crosstalk among pericytes, endothel...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2019.03.014
更新日期：2019-07-01 00:00:00
abstract：:It has been reported that the severe cerebral edema produced in experimental animals by Clostridium perfringens (Cl p) type D epsilon toxin can be prevented by prior treatment with its precursor prototoxin due to competitive binding to endothelial cells (ECs) at the blood-brain barrier (BBB). In this study we investig...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7652
更新日期：2001-05-01 00:00:00
abstract：:Peripheral nerve grafts (PNG) into the rat spinal cord support axon regeneration after acute or chronic injury, with synaptic reconnection across the lesion site and some level of behavioral recovery. Here, we grafted a peripheral nerve into the injured spinal cord of cats as a preclinical treatment approach to promot...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2010.06.011
更新日期：2010-09-01 00:00:00
abstract：:A prospective, multicenter, randomized trial did not demonstrate improved outcomes in severe traumatic brain injured patients treated with mild hypothermia [Clifton, G.L., Miller, E.R., Choi, S.C., Levin, H.S., McCauley, S., Smith, K.R., Jr., Muizelaar, J.P., Wagner, F.C., Jr., Marion, D.W., Luerssen, T.G., Chesnut, R...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.09.024
更新日期：2009-01-01 00:00:00
abstract：:Intracellular proteinaceous inclusions are well-documented hallmarks of the fatal motor neuron disorder amyotrophic lateral sclerosis (ALS). The pathological significance of these inclusions remains unknown. Peripherin, a type III intermediate filament protein, is upregulated in ALS and identified as a component withi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2014.05.024
更新日期：2014-11-01 00:00:00
abstract：:Intercostal muscle tendon organs have an inhibitory effect on the medullary neurons driving all inspiratory muscles, and on a subpopulation of medullary bulbospinal expiratory neurons. Results from this study showed that the activity of expiratory related neurons in the region of the retrofacial nucleus (Botzinger com...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90129-4
更新日期：1987-09-01 00:00:00
abstract：:This work investigated the extent to which constituent proportions of fast- and slow-twitch muscle units determine whole muscle contractile properties. We employed several self- and cross-reinnervation models using synergistic homogeneous and heterogeneous muscles. By comparing the present data with previously publish...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90048-9
更新日期：1988-09-01 00:00:00
abstract：:Sympathetic axons have been shown to invade the rat hippocampal formation after lesions of the septohippocampal (cholinergic) projection. To test the generality of this type of transmitter-specific sprouting within the central nervous system, lesions were placed within the horizontal limb of the diagonal band in order...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90235-8
更新日期：1984-05-01 00:00:00
abstract：:Neurogenesis continues in various regions of the central nervous system (CNS) throughout life. As the mitogen basic fibroblast growth factor (bFGF) can proliferate neuronal precursors of CNS neurons in culture, and is also upregulated within adult dorsal root ganglia following axotomy, it is possible that the postnata...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7761
更新日期：2001-11-01 00:00:00
abstract：:Neuronal migration was investigated in rodent cerebellum in vitro and in vivo. Time-lapse video recording showed that cultured neurons migrated on laminin by first extending neurites that formed contacts with other neurons. This was followed by movement of the cell nucleus inside the preformed process. No guidance cue...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(92)90119-b
更新日期：1992-08-01 00:00:00
abstract：:Levodopa or short-acting dopamine (DA) agonist treatment of advanced parkinsonian patients exposes striatal DA receptors to non-physiologic intermittent stimulation that contributes to the development of dyskinesias and other motor complications. To determine whether continuous dopaminergic stimulation can delay or pr...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.11.013
更新日期：2005-03-01 00:00:00
abstract：:Axons of retinal ganglion cells (RGCs) of adult cats were transected and regenerated by the transplantation of peripheral nerves. Two months after transplantation dendritic arbors of RGCs with regenerated axons (r-RGCs) were visualized with intracellular injections of horseradish peroxidase (HRP). The HRP-filled r-RGC...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.6345
更新日期：1997-01-01 00:00:00
abstract：:One approach to repair of transected nerves is to attempt extrinsic guidance of axons across the gaps. We inserted the proximal and distal stumps of severed mouse sciatic nerves into opposite ends of biodegradable polyester tubes. The nerves and ensheathing tubes were examined after postoperative survival times of as ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90162-1
更新日期：1985-12-01 00:00:00
