Astrocyte-derived fatty acid-binding protein 7 protects blood-brain barrier integrity through a caveolin-1/MMP signaling pathway following traumatic brain injury.

abstract：:The effects of neonatal 6-hydroxydopamine (6-OHDA) treatment on the projection of locus coeruleus (LC) neurons to the dorsal part of the lateral geniculate nucleus (dLGN) were examined using histofluorescence and electrophysiological methods. Histofluorescence studies confirmed the previous results of Gustafson and Mo...

journal_title：Experimental neurology

authors： Aoki F,Nakamura S

更新日期：1991-06-01 00:00:00

abstract：:A single fourth lumbar dorsal rootlet was transected at the entry point into the spinal cord. The nerve fibres were labelled with biotin dextran injected into the rootlet. An endogenous matrix containing olfactory-ensheathing cells (OECs) labelled with green fluorescent protein was applied to the opposing cut surfaces...

journal_title：Experimental neurology

authors： Li Y,Carlstedt T,Berthold CH,Raisman G

更新日期：2004-08-01 00:00:00

abstract：:AMPAkines are positive modulators of AMPA receptors, and previous work has shown that these compounds can facilitate synaptic plasticity and improve learning and memory in both animals and humans; thus, their role in the treatment of cognitive impairment is worthy of investigation. In this study, we have utilized an o...

journal_title：Experimental neurology

authors： Kanju PM,Parameshwaran K,Sims C,Bahr BA,Shonesy BC,Suppiramaniam V

更新日期：2008-11-01 00:00:00

abstract：:Following a traumatic brain injury (TBI), the excessive release of interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) is a major cause of cerebral edema, which, in turn, can cause permanent neuronal loss and cognitive deficits in laboratory rats. This study examined the changes in expression of t...

journal_title：Experimental neurology

authors： He J,Evans CO,Hoffman SW,Oyesiku NM,Stein DG

更新日期：2004-10-01 00:00:00

abstract：:Genetic and protein studies have indicated abnormalities in alpha-synuclein in neurodegenerative diseases. However, the developmental localization and cellular role of synuclein isoforms is contentious. We investigated the cellular localization of alpha-, beta-, and gamma-synuclein in developing cultured rat neurons a...

journal_title：Experimental neurology

authors： Quilty MC,Gai WP,Pountney DL,West AK,Vickers JC

更新日期：2003-07-01 00:00:00

abstract：:Dopaminergic projections to the caudate putamen (CPu) involve fibers in the nigrostriatal pathway from the ipsilateral substantia nigra-pars compacta. Post-synaptic receptor populations on cells receiving this information are composed of both D1 and D2 dopamine receptor subtypes. In the present study, unilateral lesio...

journal_title：Experimental neurology

authors： Narang N,Hunt ME,Pundt LL,Alburges ME,Wamsley JK

更新日期：1993-05-01 00:00:00

abstract：:c-Fos protein-like immunoreactivity (IR) was investigated in the rat brain following an application of weak anodal direct current to the surface of the unilateral sensorimotor cortex in an attempt to elucidate the cellular and molecular bases of central plasticity. Anodal polarization resulted in a massive increase in...

journal_title：Experimental neurology

authors： Islam N,Moriwaki A,Hattori Y,Hayashi Y,Lu YF,Hori Y

更新日期：1995-05-01 00:00:00

abstract：:In a model of Parkinson's disease (PD), amphetamine, a dopamine (DA)-releasing drug, fails to induce ipsilateral drug rotations in a proportion of rats with complete unilateral 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle and DA neurons of the substantia nigra. To investigate this phenomenon, indi...

journal_title：Experimental neurology

authors： Moore AE,Cicchetti F,Hennen J,Isacson O

更新日期：2001-12-01 00:00:00

abstract：:There is evidence to suggest that the reticular activating system may have an influence on the neurons of the preoptic area (POA). We studied the responses of POA neurons and their relation to the cortical EEG, on stimulation of the midbrain reticular formation (MRF) at various frequencies, in unanesthetized, encéphal...

journal_title：Experimental neurology

authors： Mohan Kumar V,Mallick BN,Chhina GS,Singh B

更新日期：1984-10-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the polymerization of wild-type (WT) or mutant alpha-synuclein (AS) into aggregates and fibrils, which are observed as Lewy bodies (LBs) and Lewy neurites (LNs) in PD patients. However, inability to demonstrate aggregation in many cell culture systems is a major drawback fo...

journal_title：Experimental neurology

authors： Pandey N,Schmidt RE,Galvin JE

更新日期：2006-02-01 00:00:00

abstract：:Axonal lesions to the optic nerve (ON) induce c-Jun expression in retinal ganglion cells (RGCs) of the rat in vivo. Detailed investigations using retrograde tracers, and double labeling studies for c-Jun and regeneration-associated factors, such as the growth-associated protein GAP-43, have suggested that this upregul...

journal_title：Experimental neurology

authors： Isenmann S,Bähr M

更新日期：1997-09-01 00:00:00

abstract：:The cascade of events leading to post-traumatic epilepsy (PTE) after traumatic brain injury (TBI) remains unclear. Altered inhibition in the hippocampal formation and dentate gyrus is a hallmark of several neurological disorders, including TBI and PTE. Inhibitory synaptic signaling in the hippocampus is predominately ...

journal_title：Experimental neurology

authors： Butler CR,Boychuk JA,Smith BN

更新日期：2016-06-01 00:00:00

abstract：:Cordotomy-denervation interactions were studied on contractile and myofibrillar properties of slow (soleus) and fast (extensor digitorum longus) muscles of the rat. The spinal cord was transected midthoracically in neonatal (2-day-old) animals. Two months after birth, a unilateral transection of the sciatic nerve was ...

journal_title：Experimental neurology

authors： Midrio M,Danieli Betto D,Betto R,Noventa D,Antico F

更新日期：1988-04-01 00:00:00

abstract：:The effects of delta-9-tetrahydrocannabinol on sensory activity in the thalamic intralaminar nuclei, centralis lateralis and the mesencephalic reticular formation were compared with the effects on cortical association or heterosensory systems in alpha-chloralose-anesthetized cats. The drug depressed the anterior margi...

journal_title：Experimental neurology

authors： Pontzer NJ,Wilkison DM

更新日期：1987-09-01 00:00:00

abstract：:Triggering receptor expressed on myeloid cells-2 (TREM2) was a newly identified receptor expressed on microglia. Several observations support the hypothesis that TREM2 variation may confer susceptibility to Parkinson's disease (PD). Therefore, in this paper, we explored the role of TREM2 in the 1-methyl-4-phenyl-1,2,3...

journal_title：Experimental neurology

authors： Ren M,Guo Y,Wei X,Yan S,Qin Y,Zhang X,Jiang F,Lou H

更新日期：2018-04-01 00:00:00

abstract：:AMPA receptors (AMPARs) are responsible for fast excitatory neurotransmission, and their prolonged activation can result in the generation and spread of epileptic seizures. At early stages of postnatal development, the majority of AMPARs are permeable to both Na(+) and Ca(2+) ions. This permeability, which increases n...

journal_title：Experimental neurology

authors： Szczurowska E,Ergang P,Kubová H,Druga R,Salaj M,Mareš P

更新日期：2016-09-01 00:00:00

abstract：:Embryonic spinal cord motor neurons (MNs) can be maintained in vitro for weeks with a cocktail of trophic factors and muscle-derived factors under serum-containing conditions. Here we investigated the beneficial effects of muscle-derived factors in the form of muscle-conditioned medium (MCM) on the survival and neurit...

journal_title：Experimental neurology

authors： Montoya G JV,Sutachan JJ,Chan WS,Sideris A,Blanck TJ,Recio-Pinto E

更新日期：2009-12-01 00:00:00

abstract：:We recently described an experimental model of spinal cord contusive injury in the rat in which a modified weight-drop apparatus is used to generate reproducible mild, moderate, or severe final functional deficit. We now report several inexpensive alternatives for portions of the original apparatus which allow the pro...

journal_title：Experimental neurology

authors： Noble LJ,Wrathall JR

更新日期：1987-02-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease characterized by motor neuron death. Since most ALS patients succumb to ventilatory failure from loss of respiratory motor neurons, any effective ALS treatment must preserve and/or restore breathing capacity. In rats over-expressi...

journal_title：Experimental neurology

authors： Nichols NL,Satriotomo I,Harrigan DJ,Mitchell GS

更新日期：2015-11-01 00:00:00

abstract：:The distribution and relative intrafascicular contribution of myelin fibers derived from spinal segments L-4 to L-6 were analyzed in adult rat sciatic nerve and its main branches, using 200-kDa neurofilament subunit immunodetection in previously injured nerve sections in the L-4 or L-5 spinal branch or both. These bra...

journal_title：Experimental neurology

authors： Montoya G JV,Ariza J,Sutachán JJ,Hurtado H

更新日期：2002-02-01 00:00:00

abstract：:Injury of a peripheral nerve not only leads to target denervation, but also induces massive stripping of spinal synapses on axotomized motoneurons, with disruption of spinal circuits. Even when regeneration is successful, unspecific reinnervation and the limited reconnection of the spinal circuits impair functional re...

journal_title：Experimental neurology

authors： Arbat-Plana A,Torres-Espín A,Navarro X,Udina E

更新日期：2015-01-01 00:00:00

abstract：:Huntingtin is a cytoplasmic protein that is found in neurons and somatic cells. In patients with Huntington's disease (HD), the NH2-terminal region of huntingtin has an expanded polyglutamine tract. An abnormal protein interaction by mutant huntingtin has been proposed as a mechanism for HD pathogenesis. Huntingtin as...

journal_title：Experimental neurology

authors： Velier J,Kim M,Schwarz C,Kim TW,Sapp E,Chase K,Aronin N,DiFiglia M

更新日期：1998-07-01 00:00:00

abstract：:Activation of the visual system with a moving black and white geometric pattern resulted in dense patches or columns of 2-deoxyglucose label in primate extrastriate visual cortex. The three-dimensional reconstruction of these metabolic columns showed that they were arranged in irregularly shaped slabs which extended i...

journal_title：Experimental neurology

authors： Herdman SJ,Hand CL,Hand PJ

更新日期：1984-08-01 00:00:00

abstract：:Neuronal apoptosis is a central pathological process in subarachnoid hemorrhage (SAH)-induced early brain injury. Previous studies indicated that ErbB4 (EGFR family member v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) is essential for normal development and maintenance of the nervous system. In this...

journal_title：Experimental neurology

authors： Yan F,Tan X,Wan W,Dixon BJ,Fan R,Enkhjargal B,Li Q,Zhang J,Chen G,Zhang JH

更新日期：2017-11-01 00:00:00

abstract：:Overt behavioral symptoms of Parkinson's disease (PD) do not occur until over 80% of the striatal dopamine content has been lost. Diagnosis of the disorder relies on identifying clinical symptoms including akinesia, resting tremor, and rigidity. In retrospect, behavioral deficits are observed several years prior to di...

journal_title：Experimental neurology

authors： Tillerson JL,Caudle WM,Reverón ME,Miller GW

更新日期：2002-11-01 00:00:00

abstract：:RNA interference appears to have a great potential not only as an in vitro target validation, but also as a novel therapeutic strategy based on the highly specific and efficient silencing of a target gene. We hypothesize that MMP-9 siRNA can be effective as an MMP-9 protein inhibitor in a rat focal ischemia model. Mal...

journal_title：Experimental neurology

authors： Hu Q,Chen C,Yan J,Yang X,Shi X,Zhao J,Lei J,Yang L,Wang K,Chen L,Huang H,Han J,Zhang JH,Zhou C

更新日期：2009-03-01 00:00:00

abstract：:Urethane-induced cortical slow wave activity (SWA) spreads into the basal ganglia in dopamine (DA)-depleted rat models of Parkinson's disease (PD). During physiological sleep, SWA is powerfully expressed at the beginning of night and progressively reduced during sleep-time reflecting the sleep need. However, its under...

journal_title：Experimental neurology

authors： Galati S,Song W,Orban G,Luft AR,Kaelin-Lang A

更新日期：2018-03-01 00:00:00

abstract：:Traumatic brain injury (TBI) in animals and man generates widespread axonal injury characterized by focal axolemmal permeability changes, induction of calpain-mediated proteolysis, and neurofilament side-arm modification associated with neurofilament compaction (NFC) evolving to axonal disconnection. Recent observatio...

journal_title：Experimental neurology

authors： Büki A,Koizumi H,Povlishock JT

更新日期：1999-09-01 00:00:00

abstract：:Kindling is traditionally viewed as a chronic, focal epilepsy model which consistently induces complex partial seizures from limbic structures in animals. This study revealed that primary or exceedingly rapid secondary generalized seizures could also be kindled when stimulation was applied to the lateral geniculate nu...

journal_title：Experimental neurology

authors： Shouse MN,Ryan W

更新日期：1984-10-01 00:00:00

abstract：:The precise mechanisms underlying the efficacy of intravenous immunoglobulin (IVIg) in autoimmune neurological disorders including Guillain-Barré syndrome (GBS) are not known. Anti-ganglioside antibodies have been reported to be pathogenic in some variants of GBS, and we have developed passive transfer animal models t...

journal_title：Experimental neurology

authors： Zhang G,Massaad CA,Gao T,Pillai L,Bogdanova N,Ghauri S,Sheikh KA

更新日期：2016-08-01 00:00:00