Abstract:
:Exogenous myelin- or axolemma-enriched fractions were assessed for the ability to inhibit biochemical and morphological expressions of reactive gliosis in rat optic nerve. Elvax pellets containing exogenous myelin, axolemma, whole-brain homogenate, liver, or red cell extracts or no homogenate were inserted into a dural slit in distal regions of crushed optic nerve. Biochemical and morphological expressions of reactive gliosis were assessed at 7 or 14 days postoperatively. Post-traumatic elevations in lactic dehydrogenase activity normally seen at 7 days postoperatively were prevented by placement of Elvax pellets containing myelin or axolemmal fractions into the optic nerve. Morphological analyses indicated an inhibition of post-traumatic elevations in glial cell numbers, surface area, and nuclear size at the 14-day time point. Exposure of the axolemmal fraction to heat or trypsin inactivated its ability to modulate reactive gliotic changes. Myelin fractions were trypsin-sensitive, but not heat-sensitive. In contrast, Elvax pellets containing whole-brain tissue homogenates or liver and red cell membranes had no significant effects on post-traumatic glial changes relative to preparations in which homogenate-free pellets were used.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Politis MJdoi
10.1016/0014-4886(88)90108-2subject
Has Abstractpub_date
1988-05-01 00:00:00pages
288-96issue
2eissn
0014-4886issn
1090-2430pii
0014-4886(88)90108-2journal_volume
100pub_type
杂志文章abstract::Multiple cellular and molecular interactions are required for the differentiation and development of central neurons. For example, neural activity may modulate trophic function. In the developing cerebellum, establishment of functional excitatory synaptic connections coincides with the expression of NGF and its recept...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1993.1018
更新日期:1993-02-01 00:00:00
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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doi:10.1006/exnr.1999.7028
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0161
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章,评审
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7163
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abstract::Anatomic and electrophysiologic evidence suggests there is a vestibular input to eye movement-related pause neurons in the midline of the pontine reticular formation of the cat. The present investigation sought to explore the functional significance of this vestibular drive by examining pause neuron response to horizo...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90300-1
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(83)90017-1
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(85)90179-7
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journal_title:Experimental neurology
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pub_type: 杂志文章
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(88)90117-3
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