Differential change in mRNA expression of p75 and Trk neurotrophin receptors in nucleus gracilis after spinal nerve ligation in the rat.

abstract：:Axons of the CNS do normally not regenerate after injury, in contrast to axons of the PNS. This is due to a different microenvironment at the site of the lesion as well as a particular intrinsic program of axonal regrowth. Although transplantation of peripheral nerve tissue bridges is perhaps the most successful appro...

journal_title：Experimental neurology

authors： Blits B,Dijkhuizen PA,Carlstedt TP,Poldervaart H,Schiemanck S,Boer GJ,Verhaagen J

更新日期：1999-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is the leading cause of dementia and the most common neurodegenerative disorder. AD is mostly a sporadic disorder and its main risk factor is age, but mutations in three genes that promote the accumulation of the amyloid-β (Aβ42) peptide revealed the critical role of amyloid precursor protein ...

journal_title：Experimental neurology

authors： Fernandez-Funez P,de Mena L,Rincon-Limas DE

更新日期：2015-12-01 00:00:00

abstract：:Posttraumatic inflammation has been implicated in secondary tissue damage after spinal cord injury (SCI). Tumor necrosis factor-alpha (TNF-alpha) is a key inflammatory mediator that is increasingly expressed after SCI. The effect of TNF-alpha is mediated through its receptors TNFR1 (p55) and TNFR2 (p75). However, whet...

journal_title：Experimental neurology

authors： Yan P,Liu N,Kim GM,Xu J,Xu J,Li Q,Hsu CY,Xu XM

更新日期：2003-10-01 00:00:00

abstract：:Parkinson's disease (PD) is an aging-associated neurodegenerative disorder with progressive pathology involving the loss of midbrain dopaminergic neurons. Neurotrophic factors are promising for PD gene therapy; they are integrally involved in the development of the nigrostriatal system. Cerebral dopamine neurotrophic ...

journal_title：Experimental neurology

authors： Ren X,Zhang T,Gong X,Hu G,Ding W,Wang X

更新日期：2013-10-01 00:00:00

abstract：:Ubiquitin (Ub) C-terminal hydrolase L1 (UCHL1) is a multifunctional protein that is expressed in neurons throughout brain at high levels. UCHL1 deletion is associated with axonal degeneration, progressive sensory motor ataxia, and premature death in mice. UCHL1 has been hypothesized to play a role in the pathogenesis ...

journal_title：Experimental neurology

authors： Mi Z,Liu H,Rose ME,Ma X,Reay DP,Ma J,Henchir J,Dixon CE,Graham SH

更新日期：2021-02-01 00:00:00

abstract：:In 3-, 9-, 24-, and 30-month-old male rats (Fischer 344), the nuclear perimeter and the density and diameter of nuclear pore complexes in the granule cells of the dentate fascia were studied. Whereas the nuclear perimeter and the diameter of nuclear pore complexes did not change as a function of age, there was a signi...

journal_title：Experimental neurology

authors： Fifková E,Tonks M,Cullen-Dockstader K

更新日期：1987-03-01 00:00:00

abstract：:Osteopontin (OPN) is a glycosylated phosphoprotein that regulates both oxidative stress and inflammatory processes. OPN is present in the rat substantia nigra (SN) and both protein and mRNA levels are up-regulated following a pro-inflammatory insult produced by lipopolysaccharide. We now report on the effects of lesio...

journal_title：Experimental neurology

authors： Iczkiewicz J,Rose S,Jenner P

更新日期：2007-09-01 00:00:00

abstract：:Fibroblast and epidermal growth factors (FGF-2 and EGF) are powerful mitogens for neural precursor cells isolated from the developing striatum and grown as neurospheres. However, questions remain as to the exact role of each of these molecules, and how the proteoglycan heparin may modify their behavior. Here, we show ...

journal_title：Experimental neurology

authors： Caldwell MA,Garcion E,terBorg MG,He X,Svendsen CN

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:N,N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. Our aim was to demonstrate the in vivo neuroprotective effect of DMT following ischemia-reperfusion injury in the rat brain. METHODS:Transient...

journal_title：Experimental neurology

authors： Nardai S,László M,Szabó A,Alpár A,Hanics J,Zahola P,Merkely B,Frecska E,Nagy Z

更新日期：2020-05-01 00:00:00

abstract：:The dependence of movement on visual information was compared for healthy individuals and Stage II-III patients with Parkinson's disease (PD). A time delay (0-1400 ms) was introduced into a visually guided motor tracking task which required the subject to maintain constant index finger position relative to a stationar...

journal_title：Experimental neurology

authors： Beuter A,Milton JG,Labrie C,Glass L,Gauthier S

更新日期：1990-11-01 00:00:00

abstract：:The importance of mitochondria in spinal cord injury has mainly been attributed to their participation in apoptosis at the site of injury. But another aspect of mitochondrial function is the generation of more than 90% of cellular energy in the form of ATP, mediated by the oxidative phosphorylation (OxPhos) process. C...

journal_title：Experimental neurology

authors： Hüttemann M,Nantwi KD,Lee I,Liu J,Mohiuddin S,Petrov T

更新日期：2010-06-01 00:00:00

abstract：:Monosialoganglioside GM1 prevents excitatory amino acid (EAA)-related neuronal death in cultured central nervous system (CNS) neurons and reduces the severity of acute brain damage in different experimental models of cerebral ischemia. Using a model of brain damage induced by intracerebroventricular administration of ...

journal_title：Experimental neurology

authors： Lipartiti M,Lazzaro A,Zanoni R,Mazzari S,Toffano G,Leon A

更新日期：1991-09-01 00:00:00

abstract：:Neuron loss in layer III of the entorhinal cortex (EC) occurs in patients with temporal lobe epilepsy and in several animal models of the disease and may play a role in the development of spontaneously recurring seizures. This damage can be reproduced in rats by a focal microinjection of the indirect excitotoxin amino...

journal_title：Experimental neurology

authors： Wu HQ,Schwarcz R

更新日期：1998-10-01 00:00:00

abstract：:Green tea polyphenol is known to act as a buffer, reducing biological responses to oxidative stress. Several effects of polyphenol have been reported, such as protection of tissue from ischemia, antineoplasmic and anti-inflammatory effects, and suppression of arteriosclerosis. In this study, we investigated whether pe...

journal_title：Experimental neurology

authors： Ikeguchi R,Kakinoki R,Okamoto T,Matsumoto T,Hyon SH,Nakamura T

更新日期：2003-12-01 00:00:00

abstract：:Cross-species transplantation of dopamine-releasing cell lines protected against immune rejection by a semi-permeable synthetic membrane may provide a source of neurotransmitters for the treatment of Parkinson's disease. Experiments were carried out to assess whether polymer-encapsulated PC12 cells, a catecholaminergi...

journal_title：Experimental neurology

authors： Aebischer P,Tresco PA,Winn SR,Greene LA,Jaeger CB

更新日期：1991-03-01 00:00:00

abstract：:Massive increases in extracellular dopamine have been reported in the ischemic rodent striatum, implicating this neurotransmitter in toxic events. We have examined whether dopamine receptor antagonists are protective against hypoxic insult, using brain slices containing the rostral striatum obtained from adult male C5...

journal_title：Experimental neurology

authors： Davis S,Brotchie J,Davies I

更新日期：2002-07-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) have been shown both in vitro and in vivo to support the survival and differentiation of developing chick or rat motoneurons. To explore the potential use of these and other neurotrophic factors as therapeutic agents in human motoneuron di...

journal_title：Experimental neurology

authors： Kato AC,Lindsay RM

更新日期：1994-12-01 00:00:00

abstract：:Intractable pain is the single most common cause of disability, affecting more than 20% of the population world-wide. There is accordingly a global effort to decipher how changes in nociceptive processing in the peripheral and central nervous systems contribute to the onset and maintenance of chronic pain. The past se...

journal_title：Experimental neurology

authors： Xie YF,Wang J,Bonin RP

更新日期：2018-08-01 00:00:00

abstract：:Immune rejection of transplanted material is a potential complication of organ donation. In response to tissue transplantation, immune rejection has two components: a host defense directed against the grafted tissue and an immune response from the grafted tissue against the host (graft vs host disease). To treat immun...

journal_title：Experimental neurology

authors： Weiss ML,Mitchell KE,Hix JE,Medicetty S,El-Zarkouny SZ,Grieger D,Troyer DL

更新日期：2003-08-01 00:00:00

abstract：:Focal infarction (stroke) of the lateral cerebral cortex of rats (including the sensorimotor cortex) produces deficits in sensorimotor function of the contralateral limbs that recover partially over time. In previous studies, we found that the intracisternal injection of basic fibroblast growth factor (bFGF), a potent...

journal_title：Experimental neurology

authors： Kawamata T,Ren J,Cha JH,Finklestein SP

更新日期：1999-07-01 00:00:00

abstract：:In mammals, free d-aspartate (D-Asp) is abundant in the embryonic brain, while levels remain very low during adulthood as a result of the postnatal expression and activity of the catabolizing enzyme d-aspartate oxidase (DDO). Previous studies have shown that long-lasting exposure to nonphysiological, higher D-Asp conc...

journal_title：Experimental neurology

authors： Nuzzo T,Feligioni M,Cristino L,Pagano I,Marcelli S,Iannuzzi F,Imperatore R,D'Angelo L,Petrella C,Carella M,Pollegioni L,Sacchi S,Punzo D,De Girolamo P,Errico F,Canu N,Usiello A

更新日期：2019-07-01 00:00:00

abstract：:The functional and morphologic consequences of treatment of peripheral nerve lesions with exogenous 3,3',5-triiodo-L-thyronine (T3) are unclear. In this study adult Wistar rats with sciatic nerve crush lesions were treated with 20 micrograms/kg/day of T3. The treated animals gained weight though more slowly than vehic...

journal_title：Experimental neurology

authors： Allpress SJ,Pollock M

更新日期：1986-02-01 00:00:00

abstract：:The precise role of hypothalamic norepinephrine (NE) in the control of vasopressin (AVP) release has remained unclear, due to reports of both inhibitory and excitatory effects of NE and only a few studies with direct hypothalamic manipulations. The present study utilized a chronically implanted swivel brain cannula to...

journal_title：Experimental neurology

authors： Leibowitz SF,Eidelman D,Suh JS,Diaz S,Sladek CD

更新日期：1990-12-01 00:00:00

abstract：:The present study demonstrates that the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes significantly greater reductions in striatal dopamine levels in C57/bl mice than in CD-1 mice, thus confirming a greater sensitivity of the C57/bl mice to MPTP. To determine the possible reasons for this diffe...

journal_title：Experimental neurology

authors： Muthane U,Ramsay KA,Jiang H,Jackson-Lewis V,Donaldson D,Fernando S,Ferreira M,Przedborski S

更新日期：1994-04-01 00:00:00

abstract：:Neuronal migration was investigated in rodent cerebellum in vitro and in vivo. Time-lapse video recording showed that cultured neurons migrated on laminin by first extending neurites that formed contacts with other neurons. This was followed by movement of the cell nucleus inside the preformed process. No guidance cue...

journal_title：Experimental neurology

authors： Liesi P

更新日期：1992-08-01 00:00:00

abstract：:Osteogenic protein-1 (OP-1), a member of the transforming growth factor-beta (TGF-beta) superfamily, has been demonstrated to stimulate dendrite growth from sympathetic neurons in culture. However, it is not known whether OP-1 affects dendrite growth from central nervous system neurons. Therefore we quantified axon an...

journal_title：Experimental neurology

authors： Le Roux P,Behar S,Higgins D,Charette M

更新日期：1999-11-01 00:00:00

abstract：:Dopaminergic projections to the caudate putamen (CPu) involve fibers in the nigrostriatal pathway from the ipsilateral substantia nigra-pars compacta. Post-synaptic receptor populations on cells receiving this information are composed of both D1 and D2 dopamine receptor subtypes. In the present study, unilateral lesio...

journal_title：Experimental neurology

authors： Narang N,Hunt ME,Pundt LL,Alburges ME,Wamsley JK

更新日期：1993-05-01 00:00:00

abstract：:This paper reports that endolymphatic hydrops causes a significant reduction of retrogradely labeled cell bodies of the ipsilateral trigeminal ganglion following application of horseradish peroxidase in the cochlea. We previously showed that the trigeminal ganglion is a source of primary sensory innervation to the coc...

journal_title：Experimental neurology

authors： Vass Z,Shore SE,Nuttall AL,Miller JM

更新日期：1998-06-01 00:00:00

abstract：:Chemotherapy-related cognitive deficits are a major neurological problem, but the underlying mechanisms are unclear. The death of neural stem/precursor cell (NSC) by cisplatin has been reported as a potential cause, but this requires high doses of chemotherapeutic agents. Cisplatin is frequently used in modern oncolog...

journal_title：Experimental neurology

authors： Andres AL,Gong X,Di K,Bota DA

更新日期：2014-05-01 00:00:00

abstract：:An in vivo assay was developed for long-term analyses of Schwann cells at the single cell level. Schwann cells were isolated from sciatic nerves and labeled with the fluorescent gold label Fluoro-Gold. Cells were then transplanted into severed sciatic nerves of young adult rats. Gold-labeled Schwann cells, identified ...

journal_title：Experimental neurology

authors： Daniloff JK

更新日期：1991-10-01 00:00:00