Ampakine CX516 ameliorates functional deficits in AMPA receptors in a hippocampal slice model of protein accumulation.

abstract：:Potassium and caffeine contractures of isolated small bundles (100 to 200 micron diameter) of muscle fibers isolated from the diaphragm of normal and dystrophic (C57BL/6J dy2J/dy2J) mice were compared. In diaphragms of pathologic mice (3 to 5 months old) the resting potential, the characteristics of the twitch, and so...

journal_title：Experimental neurology

authors： Noireaud J,Léoty C

更新日期：1984-03-01 00:00:00

abstract：:Clinical studies have provided evidence that the progression of HIV-1-associated neurocognitive disorders (HAND) involves alterations in dopamine (DA) systems. Drugs of abuse that act on the brain DA system, such as cocaine (Coc), may exacerbate HIV-1 infection and consequent behavioral and neurological manifestations...

journal_title：Experimental neurology

authors： Moran LM,Booze RM,Webb KM,Mactutus CF

更新日期：2013-01-01 00:00:00

abstract：:Mice lacking the gene encoding for substance P and neurokinin A, or the NK-1 receptor, exhibit alterations in behavior to various acute nociceptive stimuli. However, behavioral responses of NK-1 mutant animals have not been well characterized in models of chronic pain. We studied the behavioral responses of NK-1 knock...

journal_title：Experimental neurology

authors： Mansikka H,Sheth RN,DeVries C,Lee H,Winchurch R,Raja SN

更新日期：2000-04-01 00:00:00

abstract：:With the consideration of the multifactorial etiology of diabetic peripheral neuropathy, an ideal drug or drug combination should target at least several key pathogenetic mechanisms. The flavonoid baicalein (5,6,7-trihydroxyflavone) has been reported to counteract sorbitol accumulation, activation of 12/15-lipoxygenas...

journal_title：Experimental neurology

authors： Stavniichuk R,Drel VR,Shevalye H,Maksimchyk Y,Kuchmerovska TM,Nadler JL,Obrosova IG

更新日期：2011-07-01 00:00:00

abstract：:Previous studies have shown that traumatic brain injury (TBI) produces progressive degradation of cytoskeletal proteins including neurofilaments (e.g., neurofilament 68 [NF68] and neurofilament 200 [NF200]) within the first 24 h after injury. Thus, we employed immunofluorescence (light and confocal microscopy) to stud...

journal_title：Experimental neurology

authors： Posmantur RM,Newcomb JK,Kampfl A,Hayes RL

更新日期：2000-01-01 00:00:00

abstract：:Parkinson's Disease (PD) and Extrapyramidal Syndrome (EPS) are movement disorders that result from degeneration of the dopaminergic input to the striatum and chronic inhibition of striatal dopamine D(2) receptors by antipsychotics, respectively. Adenosine A(2A) receptors are selectively localized in the basal ganglia,...

journal_title：Experimental neurology

authors： Hodgson RA,Bedard PJ,Varty GB,Kazdoba TM,Di Paolo T,Grzelak ME,Pond AJ,Hadjtahar A,Belanger N,Gregoire L,Dare A,Neustadt BR,Stamford AW,Hunter JC

更新日期：2010-10-01 00:00:00

abstract：:As early as 1928, Cajal suggested that plaques contain a trophic substance which attracts neurites. Recently, basic fibroblast growth factor (bFGF) levels were shown to be elevated in Alzheimer's disease (AD) and localized to plaques and neurofibrillary tangles. We sought to clarify the subtype of plaques which contai...

journal_title：Experimental neurology

authors： Cummings BJ,Su JH,Cotman CW

更新日期：1993-12-01 00:00:00

abstract：:The aim of this study was to compare the physiological properties of single neurons in the glabrous (G) and heterogeneous (H) subdivisions of primary somatosensory digit 3 cortex of adult raccoons. Extracellular recordings were obtained from 50 G neurons whose receptive fields (RFs) were confined to the glabrous skin ...

journal_title：Experimental neurology

authors： Doetsch GS,Stoney SD Jr,Hauge DH

更新日期：1992-02-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is often accompanied by granule cell dispersion (GCD), a migration defect of granule cells in the dentate gyrus. We have previously shown that a decrease in the expression of reelin, an extracellular matrix protein important for neuronal positioning, is associated with the development of G...

journal_title：Experimental neurology

authors： Müller MC,Osswald M,Tinnes S,Häussler U,Jacobi A,Förster E,Frotscher M,Haas CA

更新日期：2009-04-01 00:00:00

abstract：:Previously, our lab reported the isolation of patient-specific neurosphere-forming progenitor lines from human adult olfactory epithelium from cadavers as well as patients undergoing nasal sinus surgery. RT-PCR and ELISA demonstrated that the neurosphere-forming cells (NSFCs) produced BDNF. Since rubrospinal tract (RS...

journal_title：Experimental neurology

authors： Xiao M,Klueber KM,Lu C,Guo Z,Marshall CT,Wang H,Roisen FJ

更新日期：2005-07-01 00:00:00

abstract：:In this review we focus on Charcot-Marie-Tooth (CMT) neuropathies and hereditary spastic paraplegias (HSPs). Although these diseases differ in whether they primarily affect the peripheral or central nervous system, both are genetically determined, progressive, long axonopathies that affect motor and sensory pathways. ...

journal_title：Experimental neurology

authors： Timmerman V,Clowes VE,Reid E

更新日期：2013-08-01 00:00:00

abstract：:In previous studies of our group, we have reported differential alterations in opioidergic receptor subtypes densities in infarcted and periinfarcted brain tissue following middle cerebral artery occlusion (MCAO) in mice. Other studies have also described subcortical alterations consecutive to focal cortical ischemia....

journal_title：Experimental neurology

authors： Boutin H,Dauphin F,Jauzac P,MacKenzie ET

更新日期：2000-08-01 00:00:00

abstract：:Dementia and parkinsonism are late-onset symptoms associated with repetitive head injury, as documented in multiple contact-sport athletes. Clinical symptomatology is the likely phenotype of chronic degeneration and circuit disruption in the substantia nigra (SN). To investigate the initiating neuropathology, we hypot...

journal_title：Experimental neurology

authors： van Bregt DR,Thomas TC,Hinzman JM,Cao T,Liu M,Bing G,Gerhardt GA,Pauly JR,Lifshitz J

更新日期：2012-03-01 00:00:00

abstract：:Increasing evidence indicates that the cytokines, tumor necrosis factor (TNF), interleukin-1, and/or interferon-gamma, may play a crucial role in the pathogenesis of multiple sclerosis. Several reports demonstrated that inhibition of TNF is highly protective in experimental allergic encephalomyelitis (EAE) when sensit...

journal_title：Experimental neurology

authors： Martin D,Near SL,Bendele A,Russell DA

更新日期：1995-02-01 00:00:00

abstract：:With the use of four independent cell markers and Brd-U birthdating we have charted the earliest stages of neuronal differentiation and migration in the developing rat central nervous system, including the cortex, spinal cord, and retina. One of the markers, the monoclonal antibody 2G12, labeled a large subpopulation ...

journal_title：Experimental neurology

authors： Brittis PA,Meiri K,Dent E,Silver J

更新日期：1995-07-01 00:00:00

abstract：:Lead induces peripheral nerve segmental demyelination in rats. Arsenic and thallium produce a peripheral neuropathy characterized by axonal degeneration in humans. Mercury and thallium appear to damage both the peripheral and the central nervous system. It is not known whether this difference in effect is due to diffe...

journal_title：Experimental neurology

authors： Windebank AJ

更新日期：1986-10-01 00:00:00

abstract：:Traumatic brain injuries (TBI) sustained during peri-adolescent development produce lasting neuro-behavioral changes that render individuals at an increased risk for developing substance abuse disorders. Experimental and clinical evidence of a prolonged period of hypodopaminergia after TBI have been well documented, b...

journal_title：Experimental neurology

authors： Karelina K,Gaier KR,Weil ZM

更新日期：2017-11-01 00:00:00

abstract：:Studies of the effects of lesions of the parietal cortex suggest that this region plays a critical role in visuomotor guidance, whereas experiments on the effects of disconnecting this region from visual input have been inconsistent in supporting this hypothesis. In the present experiment, monkeys with a unilateral oc...

journal_title：Experimental neurology

authors： Jason GW

更新日期：1983-07-01 00:00:00

abstract：:RNA interference appears to have a great potential not only as an in vitro target validation, but also as a novel therapeutic strategy based on the highly specific and efficient silencing of a target gene. We hypothesize that MMP-9 siRNA can be effective as an MMP-9 protein inhibitor in a rat focal ischemia model. Mal...

journal_title：Experimental neurology

authors： Hu Q,Chen C,Yan J,Yang X,Shi X,Zhao J,Lei J,Yang L,Wang K,Chen L,Huang H,Han J,Zhang JH,Zhou C

更新日期：2009-03-01 00:00:00

abstract：:The role of 5-HT2 and opioid receptors in pudendal inhibition of bladder activity induced by intravesical infusion of saline or 0.25% acetic acid (AA) was investigated in anesthetized cats using methysergide (a 5-HT2 receptor antagonist) and naloxone (an opioid receptor antagonist). AA irritated the bladder and signif...

journal_title：Experimental neurology

authors： Matsuta Y,Schwen Z,Mally AD,Shen B,Wang J,Roppolo JR,de Groat WC,Tai C

更新日期：2013-09-01 00:00:00

abstract：:Fibroblast and epidermal growth factors (FGF-2 and EGF) are powerful mitogens for neural precursor cells isolated from the developing striatum and grown as neurospheres. However, questions remain as to the exact role of each of these molecules, and how the proteoglycan heparin may modify their behavior. Here, we show ...

journal_title：Experimental neurology

authors： Caldwell MA,Garcion E,terBorg MG,He X,Svendsen CN

更新日期：2004-08-01 00:00:00

abstract：:The vanilloid receptor TRPV(1) is a key nociceptive molecule located in primary afferent nociceptive neurons in dorsal root ganglia (DRG) for initiating neurogenic inflammation and pain. Our recent study demonstrates that up-regulation of TRPV(1) receptors by intradermal injection of capsaicin is modulated by activati...

journal_title：Experimental neurology

authors： Xu X,Wang P,Zou X,Li D,Fang L,Gong K,Lin Q

更新日期：2010-03-01 00:00:00

abstract：:Children who are born preterm are at risk for encephalopathy of prematurity, a leading cause of cerebral palsy, cognitive delay and behavioral disorders. Current interventions are limited and none have been shown to reverse cognitive and behavioral impairments, a primary determinant of poor quality of life for these c...

journal_title：Experimental neurology

authors： Robinson S,Corbett CJ,Winer JL,Chan LAS,Maxwell JR,Anstine CV,Yellowhair TR,Andrews NA,Yang Y,Sillerud LO,Jantzie LL

更新日期：2018-04-01 00:00:00

abstract：:A transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins. We examined whether excitotoxin resistance characterizes mice with mutant huntingtin transgenes. In a n...

journal_title：Experimental neurology

authors： Petersén A,Chase K,Puschban Z,DiFiglia M,Brundin P,Aronin N

更新日期：2002-05-01 00:00:00

abstract：:Epidermal growth factor responsive (EGFr) neural progenitor (NP) cells have been shown to be a potential alternative tissue source for neural transplantation and for developmental study. We have shown that nonpassaged EGFr NP cells can self-renew for 2 years in neurospheres and can robustly differentiate into glia and...

journal_title：Experimental neurology

authors： Zhou FC,Kelley MR,Chiang YH,Young P

更新日期：2000-07-01 00:00:00

abstract：:The role of capsaicin-sensitive afferents in neurogenic voiding dysfunction was studied in chronic spinal cord injured rats (SCI). Cystometry and external urethral sphincter (EUS) electromyography were performed on 2 consecutive days after induction of urethane anesthesia in SCI rats 6-8 weeks after spinal cord injury...

journal_title：Experimental neurology

authors： Cheng CL,de Groat WC

更新日期：2004-06-01 00:00:00

abstract：:The effect of olfactory deprivation in the postnatal development of the anterior olfactory nucleus (AON) was studied in 60-day-old rats which underwent unilateral naris closure after birth (postnatal day 1). Volumetric and morphometric analyses of the AON ipsilateral and contralateral to the closed naris were performe...

journal_title：Experimental neurology

authors： Barbado MV,Briñón JG,Weruaga E,Porteros A,Arévalo R,Aijón J,Alonso JR

更新日期：2001-10-01 00:00:00

abstract：:The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyram...

journal_title：Experimental neurology

authors： Immonen T,Alakuijala A,Hytönen M,Sainio K,Poteryaev D,Saarma M,Pasternack M,Sariola H

更新日期：2008-04-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a rare neurodegenerative disease of undetermined cause manifesting with progressive autonomic failure (AF), cerebellar ataxia and parkinsonism due to neuronal loss in multiple brain areas associated with (oligodendro)glial cytoplasmic alpha-synuclein (alpha SYN) inclusions (GCIs). Usin...

journal_title：Experimental neurology

authors： Stemberger S,Poewe W,Wenning GK,Stefanova N

更新日期：2010-08-01 00:00:00

abstract：:Many reports indicate that GM1 ganglioside is effective in reducing CNS ischemic injury in animal models. These models employ invasive surgery to induce ischemic damage in otherwise healthy animals. The purpose of this study was to determine if the beneficial effects of GM1 could be generalized to Spontaneously Hypert...

journal_title：Experimental neurology

authors： Hernandez NE,MacDonall JS,Stier CT Jr,Belmonte A,Fernandez R,Karpiak SE

更新日期：1994-03-01 00:00:00