Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's disease.


:A transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins. We examined whether excitotoxin resistance characterizes mice with mutant huntingtin transgenes. In a new transgenic mouse with 3 kb of mutant human huntingtin cDNA with 18, 46, or 100 CAG repeats, we found no change in susceptibility to intrastriatal injections of the excitotoxin quinolinic acid, compared to wild-type littermates. The new transgenic mice were injected with the same dose of quinolinic acid (30 nmol) as had been the R6 mice. Our findings highlight the importance of studying pathogenetic mechanisms in different transgenic models of a disease.


Exp Neurol


Experimental neurology


Petersén A,Chase K,Puschban Z,DiFiglia M,Brundin P,Aronin N





Has Abstract


2002-05-01 00:00:00














  • Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson's disease.

    abstract::Excessive synchronization of neuronal activity at around 20 Hz is a common finding in the basal ganglia of patients with untreated Parkinson's disease (PD). Correlative evidence suggests, but does not prove, that this spontaneous activity may contribute to slowness of movement in this condition. Here we investigate wh...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Chen CC,Litvak V,Gilbertson T,Kühn A,Lu CS,Lee ST,Tsai CH,Tisch S,Limousin P,Hariz M,Brown P

    更新日期:2007-05-01 00:00:00

  • Neuronal activity and axonal sprouting differentially regulate CNTF and CNTF receptor complex in the rat supraoptic nucleus.

    abstract::We demonstrated previously that the hypothalamic supraoptic nucleus (SON) undergoes a robust axonal sprouting response following unilateral transection of the hypothalamo-neurohypophysial tract. Concomitant with this response is an increase in ciliary neurotrophic factor (CNTF) and CNTF receptor alpha (CNTFRα) express...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Askvig JM,Leiphon LJ,Watt JA

    更新日期:2012-01-01 00:00:00

  • Interaction of olfactory ensheathing cells with other cell types in vitro and after transplantation: glial scars and inflammation.

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    journal_title:Experimental neurology

    pub_type: 杂志文章,评审


    authors: Chuah MI,Hale DM,West AK

    更新日期:2011-05-01 00:00:00

  • Tooth pulp-evoked jaw-opening reflex in the cat: evidence for central facilitation induced by noxious discharge in the intradental nerve fibers.

    abstract::The tooth pulp-evoked jaw-opening reflex was studied in the barbiturate-anesthetized cat. At liminal intensity of the stimulus, a stable short-latency response was obtained in the digastricus and in the tongue. At a higher stimulus intensity, there occasionally appeared to be a prolonged discharge of variable duration...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Pertovaara A,Huopaniemi T,Aukee K

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  • Minocycline delays disease onset and mortality in reovirus encephalitis.

    abstract::Minocycline is neuroprotective in many experimental models of neurodegenerative diseases and central nervous system (CNS) injury but has not previously been tested in a model of viral encephalitis. Experimental infection of neonatal mice with neurotropic reoviruses is a classic model for studying the pathogenesis of v...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Richardson-Burns SM,Tyler KL

    更新日期:2005-04-01 00:00:00

  • Epigenetic mechanisms of neuroplasticity and the implications for stroke recovery.

    abstract::Ischemic stroke is a devastating brain injury and an important cause of neurologic disability worldwide and across the lifespan. Despite the physical, social, and economic burdens of this disease there is only a single approved medicine for the treatment of acute stroke, and its use is unfortunately limited to the sma...

    journal_title:Experimental neurology

    pub_type: 杂志文章,评审


    authors: Felling RJ,Song H

    更新日期:2015-06-01 00:00:00

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Szczurowska E,Ergang P,Kubová H,Druga R,Salaj M,Mareš P

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  • Targeted overexpression of human alpha-synuclein in oligodendroglia induces lesions linked to MSA-like progressive autonomic failure.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Stemberger S,Poewe W,Wenning GK,Stefanova N

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  • Nerve injury-induced mechanical but not thermal hyperalgesia is attenuated in neurokinin-1 receptor knockout mice.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Mansikka H,Sheth RN,DeVries C,Lee H,Winchurch R,Raja SN

    更新日期:2000-04-01 00:00:00

  • Perturbation of a hippocampal zinc-binding pool after postnatal lead exposure in rats.

    abstract::Morphologic alterations of the hippocampal mossy fiber pathway after postnatal lead exposure have been observed in rats. It is hypothesized that lead might perturb zinc pools found in this pathway. To test this hypothesis, rat pups were exposed to lead indirectly by administering 0.2% lead acetate to dams via the drin...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Sato SM,Frazier JM,Goldberg AM

    更新日期:1984-09-01 00:00:00

  • Herpes simplex virus vector-mediated expression of Bcl-2 protects spinal motor neurons from degeneration following root avulsion.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Yamada M,Natsume A,Mata M,Oligino T,Goss J,Glorioso J,Fink DJ

    更新日期:2001-04-01 00:00:00

  • Autosomal dominant spinocerebellar ataxia (SCA) in a Siberian founder population: assignment to the SCA1 locus.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Lunkes A,Goldfarb LG,Platonov FA,Alexeev VP,Duenas-Barajas E,Gajdusek DC,Auburger G

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Dallimore EJ,Park KK,Pollett MA,Taylor JS,Harvey AR

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Kamber D,Erez H,Spira ME

    更新日期:2009-09-01 00:00:00

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    pub_type: 杂志文章,评审


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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Little S,Pogosyan A,Kuhn AA,Brown P

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  • Ca2+ capacity and uptake rate in skinned fibers of myodystrophic muscle.

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    pub_type: 杂志文章


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    abstract::Functional regeneration of brainstem-spinal pathways occurs in the developing chick when the spinal cord is severed prior to embryonic day (E) 13. Functional spinal cord regeneration is not observed in animals injured after E13. This developmental transition from a permissive to a restrictive repair period may be due ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Borisoff JF,Pataky DM,McBride CB,Steeves JD

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  • Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Harris ME,Hensley K,Butterfield DA,Leedle RA,Carney JM

    更新日期:1995-02-01 00:00:00

  • Discharge from total populations of Ia and II afferent fibers in the cat's deefferented medial gastrocnemius muscle during static stretch.

    abstract::Estimates were made of the changing volumes of discharge arising from the total populations of Ia and II spindle afferent fibers in the cat's deefferented medial gastrocnemius as the muscle was extended stepwise over its excursion range. The estimates were based on values reported elsewhere for (i) the incidence of ac...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Botterman BR,Eldred E

    更新日期:1983-04-01 00:00:00

  • Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice.

    abstract::Olfactomedin 1 (Olfm1) is a secreted glycoprotein that is preferentially expressed in neuronal tissues. Here we show that deletion of exons 4 and 5 from the Olfm1 gene, which encodes a 52 amino acid long region in the N-terminal part of the protein, increased neonatal death and reduced body weight of surviving homozyg...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Nakaya N,Sultana A,Munasinghe J,Cheng A,Mattson MP,Tomarev SI

    更新日期:2013-12-01 00:00:00

  • Immortalized neural stem cells differ from nonimmortalized cortical neurospheres and cerebellar granule cell progenitors.

    abstract::Pluripotent neural stem cells (NSCs) have been used as replacement cells in a variety of neurological disease models. Among the many different NSCs that have been used to date, most robust results have been obtained with the immortalized neural stem cell line (C17.2) isolated from postnatal cerebellum. However, it is ...

    journal_title:Experimental neurology

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    authors: Mi R,Luo Y,Cai J,Limke TL,Rao MS,Höke A

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  • Nuclear magnetic resonance response of protons in normal and pathological human muscles.

    abstract::An in vitro study of the nuclear magnetic resonance (NMR) response of protons in normal and pathological human skeletal muscle is presented. Muscle biopsies from 34 patients with various neuromuscular diseases and five normal subjects were studied by proton NMR techniques and the results were compared with those of li...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Borghi L,Savoldi F,Scelsi R,Villa M

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  • Spatial diversity of blood-brain barrier alteration and macrophage invasion in experimental autoimmune encephalomyelitis: a comparative MRI study.

    abstract::Inflammation plays a central role in the development of numerous disorders of the central nervous system (CNS) such as multiple sclerosis (MS). For a long time it was assumed that recruitment of macrophages into the CNS and breakdown of the blood-brain barrier (BBB) are closely linked. In the present study we challeng...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Ladewig G,Jestaedt L,Misselwitz B,Solymosi L,Toyka K,Bendszus M,Stoll G

    更新日期:2009-11-01 00:00:00

  • Behavioral specializations of SI and SII cortex: a comparative examination of the neural logic of touch in rats, cats, and other mammals.

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    journal_title:Experimental neurology

    pub_type: 杂志文章,评审


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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Sugimoto T,Hara T,Shirai H,Abe T,Ichikawa H,Sato T

    更新日期:1994-10-01 00:00:00

  • Moderate posttraumatic hypothermia decreases early calpain-mediated proteolysis and concomitant cytoskeletal compromise in traumatic axonal injury.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Büki A,Koizumi H,Povlishock JT

    更新日期:1999-09-01 00:00:00

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Nosaka S

    更新日期:1986-02-01 00:00:00

  • Identification of novel genes regulated in the developing human ventral mesencephalon.

    abstract::In the human embryo, from approximately 6 weeks gestational age (GA), dopaminergic (DA) neurons can be found in the ventral mesencephalon (VM). More specifically, the post-mitotic neurons are located in the ventral part of the tegmentum (VT), whereas no mature DA neurons are found in the neighboring dorsal part. We us...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Jørgensen JR,Juliusson B,Henriksen KF,Hansen C,Knudsen S,Petersen TN,Blom N,Seiger A,Wahlberg LU

    更新日期:2006-04-01 00:00:00

  • Striatal AMPA receptor binding is unaltered in the MPTP-lesioned macaque model of Parkinson's disease and dyskinesia.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Silverdale MA,Crossman AR,Brotchie JM

    更新日期:2002-03-01 00:00:00