Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's disease.

Abstract:

:A transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins. We examined whether excitotoxin resistance characterizes mice with mutant huntingtin transgenes. In a new transgenic mouse with 3 kb of mutant human huntingtin cDNA with 18, 46, or 100 CAG repeats, we found no change in susceptibility to intrastriatal injections of the excitotoxin quinolinic acid, compared to wild-type littermates. The new transgenic mice were injected with the same dose of quinolinic acid (30 nmol) as had been the R6 mice. Our findings highlight the importance of studying pathogenetic mechanisms in different transgenic models of a disease.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Petersén A,Chase K,Puschban Z,DiFiglia M,Brundin P,Aronin N

doi

10.1006/exnr.2002.7885

keywords:

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

297-300

issue

1

eissn

0014-4886

issn

1090-2430

pii

S0014488602978854

journal_volume

175

pub_type

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