Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's disease.

abstract：:Ventral root avulsion (VRA) triggers a strong glial reaction which contributes to neuronal loss, as well as to synaptic detachment. To overcome the degenerative effects of VRA, treatments with neurotrophic factors and stem cells have been proposed. Thus, we investigated neuroprotection elicited by human embryonic stem...

journal_title：Experimental neurology

authors： Araújo MR,Kyrylenko S,Spejo AB,Castro MV,Ferreira Junior RS,Barraviera B,Oliveira ALR

更新日期：2017-08-01 00:00:00

abstract：:We examined the response of neuronal nitric oxide synthase (nNOS)-containing CNS neurons in rats exposed to a unilateral hypoxic-ischemic insult at 7 days of age. Animals were sacrificed at several time points after the injury, up to and including 7 days (Postnatal Day 14). Brain regions ipsilateral to the injury (inc...

journal_title：Experimental neurology

authors： Ishida A,Ishiwa S,Trescher WH,Nakajima W,Lange MS,Blue ME,Johnston MV

更新日期：2001-04-01 00:00:00

abstract：:Granule cell (GC) neurogenesis increases following seizures, and some newborn GCs develop in abnormal locations within the hilus. These ectopic GCs (EGCs) display robust spontaneous and evoked excitatory activity. However, the pattern of afferent input they receive has not been fully defined. This study used electron ...

journal_title：Experimental neurology

authors： Pierce JP,Melton J,Punsoni M,McCloskey DP,Scharfman HE

更新日期：2005-12-01 00:00:00

abstract：:A graded contusion spinal cord injury (SCI) was created in the adult rat spinal cord using the Infinite Horizons (IH) impactor to study the correlation between injury severity and anatomical, behavioral, and electrophysiological outcomes. Adult Fisher rats were equally divided into five groups and received contusion i...

journal_title：Experimental neurology

authors： Cao Q,Zhang YP,Iannotti C,DeVries WH,Xu XM,Shields CB,Whittemore SR

更新日期：2005-02-01 00:00:00

abstract：:The behavioral effects of augmenting dopamine D1 receptor expression in the brain were investigated in mice incorporating additional copies of the mouse D1 receptor gene. Two transgenic lines showed increases in brain D1 receptor binding sites, which were greatest in extrastriatal regions. The full D1 agonist SKF 8129...

journal_title：Experimental neurology

authors： Dracheva S,Xu M,Kelley KA,Haroutunian V,Holstein GR,Haun S,Silverstein JH,Sealfon SC

更新日期：1999-05-01 00:00:00

abstract：:The present study evaluated the growth potential and differentiation of human fetal spinal cord (FSC) tissue in the injured adult rat spinal cord under different lesion and grafting conditions. Donor tissue at 6-9 weeks of gestational age was obtained through elective abortions and transplanted either immediately into...

journal_title：Experimental neurology

authors： Giovanini MA,Reier PJ,Eskin TA,Wirth E,Anderson DK

更新日期：1997-12-01 00:00:00

abstract：:l-DOPA therapy in Parkinson's disease often results in side effects such as l-DOPA-induced dyskinesia (LID). Our previous studies demonstrated that defective desensitization of dopamine receptors caused by decreased expression of G protein-coupled receptor kinases (GRKs) plays a role. Overexpression of GRK6, the isofo...

journal_title：Experimental neurology

authors： Ahmed MR,Bychkov E,Kook S,Zurkovsky L,Dalby KN,Gurevich EV

更新日期：2015-04-01 00:00:00

abstract：:It is not yet clear how L-dopa, that is the most effective drug for the treatment of Parkinson's disease, enters into the dopaminergic neurons to be transformed into dopamine. It is suggested that L-dopa is mainly transported into cells by a group of L-amino acid carriers named "System L". Since these carriers are sel...

journal_title：Experimental neurology

authors： Sebastianelli L,Ledonne A,Marrone MC,Bernardi G,Mercuri NB

更新日期：2008-07-01 00:00:00

abstract：:A central role for noradrenergic dysregulation in the pathophysiology of post-traumatic stress disorder (PTSD) is increasingly suggested by both clinical and basic neuroscience research. Here, we integrate recent findings from clinical and animal research with the earlier literature. We first review the evidence for n...

journal_title：Experimental neurology

authors： Hendrickson RC,Raskind MA

更新日期：2016-10-01 00:00:00

abstract：:Astrocytes are relatively resistant to injury compared to neurons and oligodendrocytes. Here, we report transient region-specific loss of astrocytes in mice early after pilocarpine-induced status epilepticus (SE). In the dentate hilus, immunoreactivity for glial acidic fibrillary protein (GFAP) was decreased, and the ...

journal_title：Experimental neurology

authors： Borges K,McDermott D,Irier H,Smith Y,Dingledine R

更新日期：2006-10-01 00:00:00

abstract：:Respiratory motor output after cervical spinal cord injury (cSCI) is profoundly influenced by spinal serotonin. We hypothesized that intraspinal transplantation of embryonic midline brainstem (MB) cells rich in serotonergic raphé neurons would improve respiratory outcomes after cSCI. One week after hemisection of the ...

journal_title：Experimental neurology

authors： Dougherty BJ,Gonzalez-Rothi EJ,Lee KZ,Ross HH,Reier PJ,Fuller DD

更新日期：2016-04-01 00:00:00

abstract：:Grafting fetal striatal cells into the brain of Huntington's disease (HD) patients has raised certain expectations in the past decade as an effective cell-based-therapy for this devastating condition. We argue that the first requirement for successful transplantation is defining the window of plasticity for the striat...

journal_title：Experimental neurology

authors： Sarchielli E,Marini M,Ambrosini S,Peri A,Mazzanti B,Pinzani P,Barletta E,Ballerini L,Paternostro F,Paganini M,Porfirio B,Morelli A,Gallina P,Vannelli GB

更新日期：2014-07-01 00:00:00

abstract：:This work investigated the extent to which constituent proportions of fast- and slow-twitch muscle units determine whole muscle contractile properties. We employed several self- and cross-reinnervation models using synergistic homogeneous and heterogeneous muscles. By comparing the present data with previously publish...

journal_title：Experimental neurology

authors： Foehring RC,Sypert GW,Munson JB

更新日期：1988-09-01 00:00:00

abstract：:Spinal lamina II, where nociceptive C-fibers terminate, expresses high amounts of the polysialylated form of neural cell adhesion molecule (PSA-NCAM). While enzymatic removal of the PSA moiety from NCAM did not affect normal sensitivity to thermal stimuli, it exacerbated nerve injury-induced neuropathic hyperalgesia. ...

journal_title：Experimental neurology

authors： El Maarouf A,Kolesnikov Y,Pasternak G,Rutishauser U

更新日期：2012-02-01 00:00:00

abstract：:Mutations in the human NOTCH3 gene cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), but the pathogenesis of CADASIL has remained unclear. Recently, endocytosis of the Notch ectodermal domain into ligand-expressing cells, called transendocytosis, has come to be...

journal_title：Experimental neurology

authors： Watanabe-Hosomi A,Watanabe Y,Tanaka M,Nakagawa M,Mizuno T

更新日期：2012-01-01 00:00:00

abstract：:Copyright ...

journal_title：Experimental neurology

authors：

更新日期：1998-06-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal peptide (VIP), and their receptors have been localized within the hippocampus but their physiological function on synaptic transmission is still unclear. We investigated the effects of PACAP and VIP on evoked excitatory postsynaptic curr...

journal_title：Experimental neurology

authors： Ciranna L,Cavallaro S

更新日期：2003-12-01 00:00:00

abstract：:Convection-enhanced delivery (CED) distributes macromolecules in the brain in a homogeneous, targeted fashion in clinically useful volumes. However, the binding of growth factors to heparin-binding sites in the extracellular matrix may limit the volume of distribution (V(d)). To overcome this limitation, we examined t...

journal_title：Experimental neurology

authors： Hamilton JF,Morrison PF,Chen MY,Harvey-White J,Pernaute RS,Phillips H,Oldfield E,Bankiewicz KS

更新日期：2001-03-01 00:00:00

abstract：:Although axons lose some of their intrinsic capacity for growth after their developmental period, some axons retain the potential for regrowth after injury. When provided with a growth-promoting substrate such as a peripheral nerve graft (PNG), severed axons regenerate into and through the graft; however, they stop wh...

journal_title：Experimental neurology

authors： Tom VJ,Sandrow-Feinberg HR,Miller K,Domitrovich C,Bouyer J,Zhukareva V,Klaw MC,Lemay MA,Houlé JD

更新日期：2013-01-01 00:00:00

abstract：:Sulforaphane (SFN) is an organosulfur compound present in vegetables and has potent anti-oxidant and anti-inflammatory activities. This study was aimed at investigating the effect of treatment with SFN on inflammation and oxidative stress, and the potential mechanisms underlying the action of SFN in experimental autoi...

journal_title：Experimental neurology

authors： Li B,Cui W,Liu J,Li R,Liu Q,Xie XH,Ge XL,Zhang J,Song XJ,Wang Y,Guo L

更新日期：2013-12-01 00:00:00

abstract：:We compared the magnetic cerebral activity of 10 fetal subjects at two different gestational ages. Spontaneous cerebral activity was recorded with a large array magnetometer specially designed to conform to the maternal gravid abdomen during the third trimester of pregnancy. We recorded each fetal subject at least twi...

journal_title：Experimental neurology

authors： Rose DF,Eswaran H

更新日期：2004-11-01 00:00:00

abstract：:Penile (cavernous) nerves are readily damaged during radical prostatectomy, invariably causing impotence. Erectile function can return, however this may take months or years and capacity often remains poor. Many studies have attempted to improve penile nerve regeneration but have not explored mechanisms underlying the...

journal_title：Experimental neurology

authors： Nangle MR,Keast JR

更新日期：2007-09-01 00:00:00

abstract：:Alpha-synuclein (alphaSN) is implicated in Parkinson's disease (PD) and is the major component of Lewy bodies (LBs). Although alphaSN is mainly expressed in neuronal cells and exists as a cytoplasmic protein, it has been found in body fluids including cerebrospinal fluid and blood. This study explored plasma alphaSN a...

journal_title：Experimental neurology

authors： Li QX,Mok SS,Laughton KM,McLean CA,Cappai R,Masters CL,Culvenor JG,Horne MK

更新日期：2007-04-01 00:00:00

abstract：:Inherited neurological diseases in animals are of interest to a wide range of scientific disciplines, particularly because such animals may be suited as genetic animal models for respective human disorders. Because the pig has a number of anatomic and physiologic features similar to those of human beings, this species...

journal_title：Experimental neurology

authors： Richter A,Wissel J,Harlizius B,Simon D,Schelosky L,Scholz U,Poewe W,Löscher W

更新日期：1995-08-01 00:00:00

abstract：:Neurosphere-forming cells (NSFCs) derived from primary cultures of adult human olfactory epithelium were established in minimum essential medium (MEM) with Hanks balanced salts and 10% heat-inactivated fetal bovine serum (FBS). A totally defined medium (DM) was employed to examine their proliferation, lineage restrict...

journal_title：Experimental neurology

authors： Zhang X,Klueber KM,Guo Z,Lu C,Roisen FJ

更新日期：2004-04-01 00:00:00

abstract：:We examined the myelin repair potential of transplanted neural precursor cells derived from the adult human brain from tissue removed during surgery. Sections of removed brain indicated that nestin-positive cells were found predominantly in the subventricular zone around the anterior horns of the lateral ventricle and...

journal_title：Experimental neurology

authors： Akiyama Y,Honmou O,Kato T,Uede T,Hashi K,Kocsis JD

更新日期：2001-01-01 00:00:00

abstract：:The aim of this study was to characterize the microglial and astroglial reactions to degeneration of (a) hippocampal CA1 pyramidal cells and dentate hilar neurons induced by cerebral ischemia and (b) CA3 pyramidal cells and dentate hilar neurons induced by intraventricular injections of kainic acid (KA). The microglia...

journal_title：Experimental neurology

authors： Jørgensen MB,Finsen BR,Jensen MB,Castellano B,Diemer NH,Zimmer J

更新日期：1993-03-01 00:00:00

abstract：:Ghrelin, a 28-amino acid peptide, is an endogenous ligand for the growth hormone secretagogue (GHS) receptor. Our previous data showed that ghrelin could inhibit apoptosis in Parkinson's disease (PD) models both in vitro and in vivo. There is now growing evidence that oxidative stress has a critical role in the etiolo...

journal_title：Experimental neurology

authors： Liu L,Xu H,Jiang H,Wang J,Song N,Xie J

更新日期：2010-03-01 00:00:00

abstract：:One of the sexual dimorphic differences in adult rodents is neural proliferation. Here we demonstrate that physiological hormone stages can modulate this proliferation in the adult forebrain. Female mice, both pregnant and synchronized in oestrus, exhibited higher proliferating cell percentages than males in both the ...

journal_title：Experimental neurology

authors： Díaz D,Valero J,Airado C,Baltanás FC,Weruaga E,Alonso JR

更新日期：2009-04-01 00:00:00

abstract：:In the present study homonymous and heteronymous projections of muscle spindle afferent fibers in the human jaw-closing system were investigated. Stretch reflex responses were elicited with percutaneous displacement stimuli applied to the belly of the anterior superficial divisions of temporalis and masseter muscles. ...

journal_title：Experimental neurology

authors： Smith A,Moore CA,Pratt CA

更新日期：1985-06-01 00:00:00