Role of the corpus callosum and hippocampal commissure on transfer phenomenon in amygdala-kindled cats.

abstract：:Aberrant accumulation of neurofilaments is a feature of human motor neuron diseases. Experimentally motor neuron disease can be induced in transgenic mice by overexpressing the mouse neurofilament light subunit (NF-L), the human heavy subunit (NF-H), or mouse peripherin. Here we describe that mice harboring a bacteria...

journal_title：Experimental neurology

authors： Gama Sosa MA,Friedrich VL Jr,DeGasperi R,Kelley K,Wen PH,Senturk E,Lazzarini RA,Elder GA

更新日期：2003-11-01 00:00:00

abstract：:A complex propriospinal network is synaptically coupled to phrenic and intercostal motoneurons, and this makes it difficult to predict how gray matter intraspinal microstimulation (ISMS) will recruit respiratory motor units. We therefore mapped the cervical and high thoracic gray matter at locations which ISMS activat...

journal_title：Experimental neurology

authors： Sunshine MD,Ganji CN,Reier PJ,Fuller DD,Moritz CT

更新日期：2018-04-01 00:00:00

abstract：:Paired corticospinal-motoneuronal stimulation (PCMS) elicits spinal synaptic plasticity in humans with chronic incomplete cervical spinal cord injury (SCI). Here, we examined whether PCMS-induced plasticity could be potentiated by acute intermittent hypoxia (AIH), a treatment also known to induce spinal synaptic plast...

journal_title：Experimental neurology

authors： Christiansen L,Chen B,Lei Y,Urbin MA,Richardson MSA,Oudega M,Sandhu M,Rymer WZ,Trumbower RD,Mitchell GS,Perez MA

更新日期：2021-01-01 00:00:00

abstract：:Periodic changes in ovarian steroid levels during fertility cycles affect learning both in humans and in rats in parallel with electrophysiological and morphological fluctuations in selective neuronal populations. In particular, during the estrous cycle of the female rat, hippocampal CA1 region undergoes cyclic modifi...

journal_title：Experimental neurology

authors： Crispino M,Stone DJ,Wei M,Anderson CP,Tocco G,Finch CE,Baudry M

更新日期：1999-10-01 00:00:00

abstract：:Diffuse noxious inhibitory controls (DNIC) are very powerful long-lasting descending inhibitory controls which are pivotal in modulating the activity of spinal and trigeminal nociceptive neurons. DNIC are subserved by a loop involving supraspinal structures such as the lateral parabrachial nucleus and the subnucleus r...

journal_title：Experimental neurology

authors： Chebbi R,Boyer N,Monconduit L,Artola A,Luccarini P,Dallel R

更新日期：2014-06-01 00:00:00

abstract：:Embryonic substantia nigra grafts partially reinnervate the dopamine-denervated corpus striatum when implanted adjacent to that structure. This reinnervation is generally limited to a small portion of the denervated striatum and does not completely compensate for the behavioral effects of a 6-hydroxydopamine lesion of...

journal_title：Experimental neurology

authors： de Beaurepaire R,Freed WJ

更新日期：1987-02-01 00:00:00

abstract：:In this study we investigated whether the link between mitochondrial dysfunction and deregulation of Ca(2+) homeostasis preceding excitotoxic cell death is mediated by cellular deenergization. Glycolytic and/or mitochondrial ATP synthesis was inhibited with 2-deoxy-D-glucose (2DG) and oligomycin, respectively. Changes...

journal_title：Experimental neurology

authors： Vergun O,Han YY,Reynolds IJ

更新日期：2003-10-01 00:00:00

abstract：:Tamoxifen-induced mutagenesis via the so-called CreER(T2) fusion enzyme is a key technology for the inducible gene knockout in the adult murine brain. However, it requires a subchronic transient treatment with high doses of the non-selective estrogen receptor antagonist tamoxifen. It has been shown earlier that acute ...

journal_title：Experimental neurology

authors： Vogt MA,Chourbaji S,Brandwein C,Dormann C,Sprengel R,Gass P

更新日期：2008-05-01 00:00:00

abstract：:Human spinal cord injury (SCI) can result in progressive degeneration that may continue for many years and lead to the formation of highly septated cystic cavities. This hallmark feature has been reproduced in experimental models, but neither its pathogenesis nor clinically relevant features have been fully elucidated...

journal_title：Experimental neurology

authors： Radojicic M,Reier PJ,Steward O,Keirstead HS

更新日期：2005-12-01 00:00:00

abstract：:Dopamine (DA) release and metabolism within the substantia nigra (SN) were studied in normal rats, rats with unilateral 6-hydroxydopamine (6-OHDA) lesions, and 6-OHDA-lesioned rats treated with glial cells line-derived neurotrophic factor (GDNF). Animals with > 99% DA depletions, as determined by apomorphine-induced c...

journal_title：Experimental neurology

authors： Hoffman AF,van Horne CG,Eken S,Hoffer BJ,Gerhardt GA

更新日期：1997-09-01 00:00:00

abstract：:Huntington's disease is an autosomal dominant neurogenetic disorder leading to striatal atrophy, characterized by involuntary movements. Voluntary movements also deteriorate, but the neurophysiological mechanisms are less understood. We investigated voluntary movement execution and its neural correlates by means of mo...

journal_title：Experimental neurology

authors： Beste C,Konrad C,Saft C,Ukas T,Andrich J,Pfleiderer B,Hausmann M,Falkenstein M

更新日期：2009-03-01 00:00:00

abstract：:The success of peripheral nerve regeneration depends on intrinsic properties of neurons and a favorable environment, although the mechanisms underlying the molecular events during degeneration and regeneration are still not elucidated. Schwann cells are considered one of the best candidates to be closely involved in t...

journal_title：Experimental neurology

authors： Narciso MS,Mietto Bde S,Marques SA,Soares CP,Mermelstein Cdos S,El-Cheikh MC,Martinez AM

更新日期：2009-05-01 00:00:00

abstract：:Mirror-image pain is a phenomenon in which unprovoked pain is detected on the uninjured contralateral side after unilateral nerve injury. Although it has been implicated that enhanced production of nerve growth factor (NGF) in the contralateral dorsal root ganglion is important in the development of mirror-image pain,...

journal_title：Experimental neurology

authors： Kambiz S,Brakkee EM,Duraku LS,Hovius SE,Ruigrok TJ,Walbeehm ET

更新日期：2015-05-01 00:00:00

abstract：:Hypernatremic dehydration was induced in rabbits during a 3- to 5-day period resulting in mean plasma sodium concentrations of 187 meq/liter. The animals were then rehydrated during a 4-h period by intravenous administration of a 2.5% glucose or fructose solution. The water content of four regions of brain sample show...

journal_title：Experimental neurology

authors： Hogan GR,Pickering LK,Dodge PR,Shepard JB,Master S

更新日期：1985-02-01 00:00:00

abstract：:Seizures were induced in immature 18-day-old rats by i.p. administration of homocysteine (11 mmol/kg) and the effects of selected antagonists of NMDA receptors [MK-801 (0.5 mg/kg), AP7 (0.33 mmol/kg), CGP 40116 (10 mg/kg)] and non-NMDA receptors [GDEE (4 mmol/kg), NBQX (two doses, 30 mg/kg each)] were studied. The eff...

journal_title：Experimental neurology

authors： Folbergrová J

更新日期：1997-06-01 00:00:00

abstract：:Alpha-synuclein (alphaSN) is implicated in Parkinson's disease (PD) and is the major component of Lewy bodies (LBs). Although alphaSN is mainly expressed in neuronal cells and exists as a cytoplasmic protein, it has been found in body fluids including cerebrospinal fluid and blood. This study explored plasma alphaSN a...

journal_title：Experimental neurology

authors： Li QX,Mok SS,Laughton KM,McLean CA,Cappai R,Masters CL,Culvenor JG,Horne MK

更新日期：2007-04-01 00:00:00

abstract：:Although prior studies have implicated maladaptive remodeling of dendritic spines on wide-dynamic range dorsal horn neurons as a contributor to pain after spinal cord injury, there have been no studies on dendritic spines after peripheral nerve injury. To determine whether dendritic spine remodeling contributes to neu...

journal_title：Experimental neurology

authors： Tan AM,Chang YW,Zhao P,Hains BC,Waxman SG

更新日期：2011-12-01 00:00:00

abstract：:Experimental autoimmune neuritis (EAN) is an animal model of the human disease Guillain-Barré syndrome. In this autoimmune inflammatory disease, CD4(+) T cells mediate demyelination in the peripheral nervous system (PNS). Infiltrating macrophages and T cells as well as cytokines like interferon (IFN)-gamma are intimat...

journal_title：Experimental neurology

authors： Zhu Y,Ljunggren HG,Mix E,Li HL,van der Meide P,Elhassan AM,Winblad B,Zhu J

更新日期：2001-06-01 00:00:00

abstract：:Sarcoplasmic reticulum (SR) of high purity and functional integrity was isolated from skeletal muscle of normal and ethanol-tolerant rats. Ethanol at low concentrations (0.1 to 0.2 M), added in vitro to isolated SR, resulted in slight inhibition of both calcium loading and calcium-stimulated ATPase rates. Higher conce...

journal_title：Experimental neurology

authors： Mrak RE

更新日期：1983-06-01 00:00:00

abstract：:In the present study homonymous and heteronymous projections of muscle spindle afferent fibers in the human jaw-closing system were investigated. Stretch reflex responses were elicited with percutaneous displacement stimuli applied to the belly of the anterior superficial divisions of temporalis and masseter muscles. ...

journal_title：Experimental neurology

authors： Smith A,Moore CA,Pratt CA

更新日期：1985-06-01 00:00:00

abstract：:The beta-amyloid precursor protein (betaAPP) is found in skeletal muscle localized to the base of the postsynaptic folds of the neuromuscular junction; yet here, as well as in neurons, its function remains enigmatic. Here we report that the motor nerve-derived trophic factor neuregulin-1 (NRG1) regulates both steady-s...

journal_title：Experimental neurology

authors： Rosen KM,Ford BD,Querfurth HW

更新日期：2003-06-01 00:00:00

abstract：RATIONALE:Neurofibromatosis type 1 (NF1) is associated with higher rates of epilepsy compared to the general population. Some NF1 patients with epilepsy do not have intracranial lesions, suggesting the genetic mutation itself may contribute to higher rates of epilepsy in these patients. We have recently demonstrated in...

journal_title：Experimental neurology

authors： Sabetghadam A,Wu C,Liu J,Zhang L,Reid AY

更新日期：2020-09-01 00:00:00

abstract：:Transplantation of genetically engineered cells can provide sustained focal delivery of naturally occurring molecules, including neurotransmitters and growth factors. We have engineered immortalized mouse cortical neurons and glia to deliver GABA by driving GAD(65) expression. Engineered cell lines showed GAD(65) mRNA...

journal_title：Experimental neurology

authors： Thompson K,Anantharam V,Behrstock S,Bongarzone E,Campagnoni A,Tobin AJ

更新日期：2000-02-01 00:00:00

abstract：:Regeneration of axons in the peripheral nervous system is enhanced by the removal of glycosaminoglycan side chains (GAGs) of chondroitin sulfate proteoglycans. However, some axons regenerate poorly despite such treatment, suggesting the existence of additional inhibitors. We compared the effects of enzymatic removal o...

journal_title：Experimental neurology

authors： Groves ML,McKeon R,Werner E,Nagarsheth M,Meador W,English AW

更新日期：2005-10-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) are unique glia that support axon outgrowth in the olfactory system, and when used as cellular therapy after spinal cord injury, improve recovery and axon regeneration. Here we assessed the effects of combining OEC transplantation with another promising therapy, epidural electrical s...

journal_title：Experimental neurology

authors： Thornton MA,Mehta MD,Morad TT,Ingraham KL,Khankan RR,Griffis KG,Yeung AK,Zhong H,Roy RR,Edgerton VR,Phelps PE

更新日期：2018-11-01 00:00:00

abstract：:Anti-CD40 ligand monoclonal antibody prevents the interaction between CD40 and its T-cell-based ligand, thereby resulting in selective inhibition of T cell costimulation without pan-T-cell suppression. This antibody has found application in several animal models of solid organ transplantation. This study investigated ...

journal_title：Experimental neurology

authors： Brenner MJ,Tung TH,Mackinnon SE,Myckatyn TM,Hunter DA,Mohanakumar T

更新日期：2004-03-01 00:00:00

abstract：:Chondroitin sulfate proteoglycans (CSPGs), extracellular matrix molecules that increase dramatically following a variety of CNS injuries or diseases, have long been known for their potent capacity to curtail cell migrations as well as axon regeneration and sprouting. The inhibition can be conferred through binding to ...

journal_title：Experimental neurology

authors： Tran AP,Warren PM,Silver J

更新日期：2020-06-01 00:00:00

abstract：:In the cerebellum of adult-aging Ts65Dn mice, a murine model of Down syndrome, Purkinje cells undergo degeneration. Searching for the cause of Purkinje cell degeneration, we have studied the ubiquitin-proteasome system (UPS) in the cerebellum of aging Ts65Dn mice. Inhibition of UPS is sufficient to induce neuron degen...

journal_title：Experimental neurology

authors： Necchi D,Lomoio S,Scherini E

更新日期：2011-12-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) is produced by the choroid plexus and moved by multi-ciliated ependymal cells through the ventricular system of the vertebrate brain. Defects in the ependymal layer functionality are a common cause of hydrocephalus. N-WASP (Neural-Wiskott Aldrich Syndrome Protein) is a brain-enriched regulato...

journal_title：Experimental neurology

authors： Jain N,Lim LW,Tan WT,George B,Makeyev E,Thanabalu T

更新日期：2014-04-01 00:00:00

abstract：:A novel model of status epilepticus based on the kindling model of epilepsy is described. The model involves the administration of a small dose of pilocarpine (20 mg/kg) to rats that have been previously kindled. Stimulation of these pretreated rats produces seizures which continue uninterrupted for approximately 4 h ...

journal_title：Experimental neurology

authors： Buterbaugh GG,Michelson HB,Keyser DO

更新日期：1986-10-01 00:00:00