当前位置： SCI文献检索 > EXPERIMENTAL NEUROLOGY期刊下所有文献 > Evidence of axon connectivity across a spinal cord transection in rats treated with epidural stimulation and motor training combined with olfactory ensheathing cell transplantation.

Evidence of axon connectivity across a spinal cord transection in rats treated with epidural stimulation and motor training combined with olfactory ensheathing cell transplantation.

Abstract：

:Olfactory ensheathing cells (OECs) are unique glia that support axon outgrowth in the olfactory system, and when used as cellular therapy after spinal cord injury, improve recovery and axon regeneration. Here we assessed the effects of combining OEC transplantation with another promising therapy, epidural electrical stimulation during a rehabilitative motor task. Sprague-Dawley rats received a mid-thoracic transection and transplantation of OECs or fibroblasts (FBs) followed by lumbar stimulation while climbing an inclined grid. We injected pseudorabies virus (PRV) into hindlimb muscles 7 months post-injury to assess connectivity across the transection. Analyses showed that the number of serotonergic (5-HT) axons that crossed the rostral scar border and the area of neurofilament-positive axons in the injury site were both greater in OEC- than FB-treated rats. We detected PRV-labeled cells rostral to the transection and remarkable evidence of 5-HT and PRV axons crossing the injury site in 1 OEC- and 1 FB-treated rat. The axons that crossed suggested either axon regeneration (OEC) or small areas of probable tissue sparing (FB). Most PRV-labeled thoracic neurons were detected in laminae VII or X, and ~25% expressed Chx10, a marker for V2a interneurons. These findings suggest potential regeneration or sparing of circuits that connect thoracic interneurons to lumbar somatic motor neurons. Despite evidence of axonal connectivity, no behavioral changes were detected in this small-scale study. Together these data suggest that when supplemented with epidural stimulation and climbing, OEC transplantation can increase axonal growth across the injury site and may promote recovery of propriospinal circuitry.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Thornton MA,Mehta MD,Morad TT,Ingraham KL,Khankan RR,Griffis KG,Yeung AK,Zhong H,Roy RR,Edgerton VR,Phelps PE

doi

10.1016/j.expneurol.2018.07.015

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

119-133

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(18)30263-2

journal_volume

309

pub_type

杂志文章

相关文献

EXPERIMENTAL NEUROLOGY文献大全
  • Cyclic AMP elevates tubulin expression without increasing intrinsic axon growth capacity.

    abstract：:Exposing rat dorsal root ganglion (DRG) neurons to dibutyryl cAMP (db-cAMP) enables central branches to regenerate in the spinal cord by nullifying the ability of CNS myelin to inhibit elongation. A conditioning lesion (CL) promotes similar regeneration of central branches in the spinal cord by increasing neuronal cAM...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2004.03.010

    authors： Han PJ,Shukla S,Subramanian PS,Hoffman PN

    更新日期：2004-10-01 00:00:00

  • Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound.

    abstract：:Noninvasive, targeted drug delivery to the brain can be achieved using transcranial focused ultrasound (FUS), which transiently increases the permeability of the blood-brain barrier (BBB) for localized delivery of therapeutics from the blood to the brain. Previously, we have demonstrated that FUS can deliver intraveno...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2013.05.008

    authors： Jordão JF,Thévenot E,Markham-Coultes K,Scarcelli T,Weng YQ,Xhima K,O'Reilly M,Huang Y,McLaurin J,Hynynen K,Aubert I

    更新日期：2013-10-01 00:00:00

  • Allosteric modulation of NMDA receptors alters neurotransmission in the striatum of a mouse model of Parkinson's disease.

    abstract：:The GluN2 subunits that compose N-methyl-d-aspartate receptors (NMDARs) are attractive drug targets for therapeutic intervention in several diseases, in particular Parkinson's disease (PD). The precise roles and possible dysfunctions of NMDARs attributed to specific GluN2 subunits are however unresolved. Through the u...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2014.03.001

    authors： Feng ZJ,Zhang X,Chergui K

    更新日期：2014-05-01 00:00:00

  • Okadaic acid induces epileptic seizures and hyperphosphorylation of the NR2B subunit of the NMDA receptor in rat hippocampus in vivo.

    abstract：:Overactivation of N-methyl-D-aspartate (NMDA) glutamate receptors is closely related to epilepsy and excitotoxicity, and the phosphorylation of these receptors may facilitate glutamate-mediated synaptic transmission. Here we show that in awake rats the microinjection into the hippocampus of okadaic acid, a potent inhi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2002.7988

    authors： Arias C,Montiel T,Peña F,Ferrera P,Tapia R

    更新日期：2002-09-01 00:00:00

  • Enhancing KCC2 activity decreases hyperreflexia and spasticity after chronic spinal cord injury.

    abstract：:After spinal cord injury (SCI), the majority of individuals develop spasticity, a debilitating condition involving involuntary movements, co-contraction of antagonistic muscles, and hyperreflexia. By acting on GABAergic and Ca2+-dependent signaling, current anti-spastic medications lead to serious side effects, includ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2021.113605

    authors： Bilchak JN,Yeakle K,Caron G,Malloy D,Côté MP

    更新日期：2021-01-13 00:00:00

  • Localization and developmental expression patterns of CSPG-cs56 (aggrecan) in normal and dystrophic retinas in two rat strains.

    abstract：:Proteoglycans have a number of important functions in the central nervous system. Aggrecan (hyaluronan-binding proteoglycan, CSPG-cs56) is found in the extracellular matrix of cartilage as well as in the developing brain. We compared the postnatal distribution of CSPG-cs56 in Long Evans (LE) and Royal College of Surge...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2012.01.023

    authors： Chen LF,FitzGibbon T,He JR,Yin ZQ

    更新日期：2012-04-01 00:00:00

  • Inspiratory muscle conditioning exercise and diaphragm gene therapy in Pompe disease: Clinical evidence of respiratory plasticity.

    abstract：:Pompe disease is an inherited disorder due to a mutation in the gene that encodes acid α-glucosidase (GAA). Children with infantile-onset Pompe disease develop progressive hypotonic weakness and cardiopulmonary insufficiency that may eventually require mechanical ventilation (MV). Our team conducted a first in human t...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2016.07.013

    authors： Smith BK,Martin AD,Lawson LA,Vernot V,Marcus J,Islam S,Shafi N,Corti M,Collins SW,Byrne BJ

    更新日期：2017-01-01 00:00:00

  • Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats.

    abstract：:Patients with neuropathic pain frequently experience hypersensitivity to cold stimulation. However, the underlying mechanisms of this enhanced sensitivity to cold are not well understood. After partial nerve injury, the transient receptor potential ion channel TRPV1 increases in the intact small dorsal root ganglion (...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.01.031

    authors： Katsura H,Obata K,Mizushima T,Yamanaka H,Kobayashi K,Dai Y,Fukuoka T,Tokunaga A,Sakagami M,Noguchi K

    更新日期：2006-07-01 00:00:00

  • Fluoxetine inhibits cortical spreading depression in weaned and adult rats suckled under favorable and unfavorable lactation conditions.

    abstract：:Wistar rats (n = 58) were injected subcutaneously during the lactation period with fluoxetine (5, 10, 20 or 40 mg/kg/day) and cortical spreading depression (SD) was recorded immediately after weaning (25-30 days of life). An additional group (10 mg/kg; n = 8) was SD-recorded at 60-70 days. As compared to the saline-in...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.02.014

    authors： dos Santos AA,Pinheiro PC,de Lima DS,Ozias MG,de Oliveira MB,Guimarães NX,Guedes RC

    更新日期：2006-08-01 00:00:00

  • Noninvasive detection of sleep/wake changes and cataplexy-like behaviors in orexin/ataxin-3 transgenic narcoleptic mice across the disease onset.

    abstract：:Sleep and behavioral monitoring of young mice is necessary for understating the progress of symptoms in congenital and acquired diseases associated with sleep and movement disorders. In the current study, we have developed a non-invasive sleep monitoring system that identifies wake and sleep patterns of newborn mice u...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2014.08.004

    authors： Sato M,Sagawa Y,Hirai N,Sato S,Okuro M,Kumar S,Kanbayashi T,Shimizu T,Sakai N,Nishino S

    更新日期：2014-11-01 00:00:00

  • Synaptic evoked potentials from regenerating dorsal root axons within fetal spinal cord tissue transplants.

    abstract：:Previously injured dorsal roots were electrically stimulated to determine if regenerating sensory axons can form physiologically active synaptic contacts with neurons within fetal spinal cord tissue transplants. Dorsal rootlets, sectioned at their spinal cord entry zone, were apposed to intraspinal transplants of feta...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1996.0101

    authors： Houle JD,Skinner RD,Garcia-Rill E,Turner KL

    更新日期：1996-06-01 00:00:00

  • Effect of 192 IgG-saporin on circadian activity rhythms, expression of P75 neurotrophin receptors, calbindin-D28K, and light-induced Fos in the suprachiasmatic nucleus in rats.

    abstract：:Photic entrainment of circadian rhythms in mammals is mediated through a direct retinal projection to the core region of the suprachiasmatic nucleus (SCN), the circadian clock. A proportion of this projection contains the low-affinity p75 neurotrophic receptor (p75NTR). Neonatal monosodium glutamate (MSG) treatment, w...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2002.7969

    authors： Beaulé C,Amir S

    更新日期：2002-08-01 00:00:00

  • Desmoplakin is involved in organization of an adhesion complex in peripheral nerve regeneration after injury.

    abstract：:Peripheral nerves have the unique capability to regenerate after injury. Insights into regeneration of peripheral nerves after injury may have implications for neurodegenerative diseases of the nervous system. In this study, we analyzed the expression and function of desmoplakin in peripheral nerve regeneration. Desmo...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2014.12.005

    authors： Gess B,Röhr D,Lange E,Halfter H,Young P

    更新日期：2015-02-01 00:00:00

  • Aripiprazole and environmental enrichment independently improve functional outcome after cortical impact injury in adult male rats, but their combination does not yield additional benefits.

    abstract：:Typical antipsychotic drugs (APDs) with D2antagonistic properties impede functional outcome after experimental traumatic brain injury (TBI) and reduce the effectiveness of environmental enrichment (EE). Here we test the hypothesis that aripiprazole (ARIP), an atypical APD with partial D2and 5-HT1Areceptor agonist acti...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2019.01.010

    authors： Besagar S,Radabaugh HL,Bleimeister IH,Meyer EA,Niesman PJ,Cheng JP,Bondi CO,Kline AE

    更新日期：2019-04-01 00:00:00

  • Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat.

    abstract：:Reactive synaptogenesis and terminal proliferation are known to occur in the dentate gyrus of the rat hippocampus following removal of specific afferents. In the present study we have examined the relation of synaptophysin immunoreactivity to the immunohistochemical staining pattern of GAP-43, a putative marker of neu...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(91)90169-d

    authors： Masliah E,Fagan AM,Terry RD,DeTeresa R,Mallory M,Gage FH

    更新日期：1991-08-01 00:00:00

  • Quisqualate injection into the nucleus basalis magnocellularis produces seizure-related brain damage that is prevented by MK-801.

    abstract：:Quisqualate (Quis) and other excitotoxins such as ibotenate and N-methyl aspartate, have been used to destroy neurons in the area of the nucleus basalis magnocellularis (NBM) in order to study the relationship between loss of cholinergic neurons in the basal forebrain and various behavioral deficits, including learnin...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1994.1046

    authors： Wozniak DF,Huss J,Olney JW

    更新日期：1994-03-01 00:00:00

  • S-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity.

    abstract：:Nitric oxide may be a key mediator of excitotoxic neuronal injury in the central nervous system. In the present experiments we found that S-methylthiocitrulline, a relatively selective neuronal nitric oxide synthase (NOS) inhibitor, produced significant neuroprotection against striatal lesions produced by malonate, an...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1996.6406

    authors： Matthews RT,Yang L,Beal MF

    更新日期：1997-02-01 00:00:00

  • Participation of par-4 in the degeneration of striatal neurons induced by metabolic compromise with 3-nitropropionic acid.

    abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by chorea, psychiatric disturbances, and dementia. It is caused by a polyglutamine repeat expansion in the huntingtin protein. The striatum is a major site of neuronal loss in HD, but the mechanisms underlying the neurodegenerative pro...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2000.7434

    authors： Duan W,Guo Z,Mattson MP

    更新日期：2000-09-01 00:00:00

  • One hour electrical stimulation accelerates functional recovery after femoral nerve repair.

    abstract：:The clinical outcome of peripheral nerve injuries requiring surgical repair is usually poor and efficient therapies do not exist. Recent work has suggested that low-frequency electrical stimulation of the severed nerve which produces repeated discharges of the parent motoneuron perikarya positively influences axonal r...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2007.08.005

    authors： Ahlborn P,Schachner M,Irintchev A

    更新日期：2007-11-01 00:00:00

  • Increased epileptogenicity in a mouse model of neurofibromatosis type 1.

    abstract：RATIONALE:Neurofibromatosis type 1 (NF1) is associated with higher rates of epilepsy compared to the general population. Some NF1 patients with epilepsy do not have intracranial lesions, suggesting the genetic mutation itself may contribute to higher rates of epilepsy in these patients. We have recently demonstrated in...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2020.113373

    authors： Sabetghadam A,Wu C,Liu J,Zhang L,Reid AY

    更新日期：2020-09-01 00:00:00

  • Effect of diabetes on motor conduction velocity in different branches of the rat sciatic nerve.

    abstract：:Motor nerve conduction velocity was measured in six branches of the sciatic nerve in streptozotocin-diabetic rats. It was markedly reduced in nerves to the gastrocnemius, soleus, tibialis anterior, and extensor digitorum longus muscles. The branch to the plantaris muscle remained unaffected. In control rats none of th...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(86)90315-8

    authors： Cameron NE,Cotter MA,Harrison J

    更新日期：1986-06-01 00:00:00

  • Development and maturation of postural reflexes in normal kittens.

    abstract：:In order to evaluate neurologic development, postural reflexes were tested in normal kittens from birth through 7 weeks of age until stable adult patterns of performance were attained. These reflex tests included: body and air righting, visual placing, chin placing, tactile placing, hopping, and locomotion. A protocol...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(84)90084-0

    authors： Sechzer JA,Folstein SE,Geiger EH,Mervis RF,Meehan SM

    更新日期：1984-12-01 00:00:00

  • Traumatic brain injury and trichloroethylene exposure interact and produce functional, histological, and mitochondrial deficits.

    abstract：:Mitochondria play a pivotal role in the development of pathology associated with Parkinson's disease (PD), traumatic brain injury (TBI), and following exposure to the environmental toxin trichloroethylene (TCE). Evidence from humans indicates that both TBI and TCE can play a role in the development of PD and that each...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2011.12.012

    authors： Sauerbeck A,Hunter R,Bing G,Sullivan PG

    更新日期：2012-03-01 00:00:00

  • Neural precursor-derived astrocytes of wobbler mice induce apoptotic death of motor neurons through reduced glutamate uptake.

    abstract：:In the present study, we investigated whether cultured astrocytes derived from adult neural precursor cells (NPCs) obtained from the subventricular zone (SVZ) of wobbler mice display metabolic traits of the wobbler astrocytes in situ and in primary culture. We also utilized NPC-derived astrocytes as a tool to investig...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2010.06.008

    authors： Diana V,Ottolina A,Botti F,Fumagalli E,Calcagno E,De Paola M,Cagnotto A,Invernici G,Parati E,Curti D,Mennini T

    更新日期：2010-09-01 00:00:00

  • Myelination of axons emerging from neural progenitor grafts after spinal cord injury.

    abstract：:Neural progenitor cells (NPCs) grafted to sites of spinal cord injury (SCI) extend numerous axons over long distances and form new synaptic connections with host neurons. In the present study we examined the myelination of axons emerging from NPC grafts. Rat embryonic day 14 (E14) multipotent NPCs constitutively expre...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2017.07.005

    authors： Hunt M,Lu P,Tuszynski MH

    更新日期：2017-10-01 00:00:00

  • Nerve growth factor influences the distribution of sympathetic sprouting into the hippocampal formation by implanted superior cervical ganglia.

    abstract：:Following cholinergic denervation of the hippocampal formation, peripheral sympathetic fibers from the superior cervical ganglion (SCG) sprout into hippocampal tissue. The molecular mechanism controlling this process is unknown, although a role by trophic factors seems likely. In the present study, neonatal SCG were u...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1994.1180

    authors： Conner JM,Varon S

    更新日期：1994-11-01 00:00:00

  • Lack of NF-kappaB p50 exacerbates degeneration of hippocampal neurons after chemical exposure and impairs learning.

    abstract：:The roles of activated NF-kappaB subunits in the CNS remain to be discerned. Members of this family of transcription factors are essential to diverse physiological processes and can be activated by pathogens, stress, pharmacological agents, and trauma. We are particularly interested in long-term NF-kappaB activation a...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2002.7967

    authors： Kassed CA,Willing AE,Garbuzova-Davis S,Sanberg PR,Pennypacker KR

    更新日期：2002-08-01 00:00:00

  • Electrophysiology and morphometry of the Aalpha- and Abeta-fiber populations in the normal and regenerating rat sciatic nerve.

    abstract：:We studied electrophysiological and morphological properties of the Aalpha- and Abeta-fibers in the regenerating sciatic nerve to establish whether these fiber types regenerate in numerical proportion and whether and how the electrophysiological properties of these fiber types are adjusted during regeneration. Compoun...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2004.01.019

    authors： Vleggeert-Lankamp CL,van den Berg RJ,Feirabend HK,Lakke EA,Malessy MJ,Thomeer RT

    更新日期：2004-06-01 00:00:00

  • Effects of pathway and neuronal aging on the specificity of motor axon regeneration.

    abstract：:Youth is a strong predictor of functional recovery after peripheral nerve repair, while adulthood is commonly associated with poor outcome. Identification of the factors responsible for this difference could form the basis for strategies to improve regeneration in adults. Preferential reinnervation of motor pathways b...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2000.7538

    authors： Le TB,Aszmann O,Chen YG,Royall RM,Brushart TM

    更新日期：2001-01-01 00:00:00

  • Is electrical stimulation of the rat incisor an appropriate experimental nociceptive stimulus?

    abstract：:The purpose of this study was to determine whether or not tooth pulp stimulation in the rat can selectively activate the pulp nerve fibers without excitation of the periodontium and to decide if the nerve fibers situated in the pulp of the rat's incisor are involved in the nociceptive reactions caused by an intrapulpa...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(86)90190-1

    authors： Rajaona J,Dallel R,Woda A

    更新日期：1986-08-01 00:00:00