In vivo microdialysis studies on somatodendritic dopamine release in the rat substantia nigra: effects of unilateral 6-OHDA lesions and GDNF.

abstract：:The study investigates if alpha-lipoic acid is neuroprotective against chemotherapy induced neurotoxicity, if mitochondrial damage plays a critical role in toxic neurodegenerative cascade, and if neuroprotective effects of alpha-lipoic acid depend on mitochondria protection. We used an in vitro model of chemotherapy i...

journal_title：Experimental neurology

authors： Melli G,Taiana M,Camozzi F,Triolo D,Podini P,Quattrini A,Taroni F,Lauria G

更新日期：2008-12-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) is produced by the choroid plexus and moved by multi-ciliated ependymal cells through the ventricular system of the vertebrate brain. Defects in the ependymal layer functionality are a common cause of hydrocephalus. N-WASP (Neural-Wiskott Aldrich Syndrome Protein) is a brain-enriched regulato...

journal_title：Experimental neurology

authors： Jain N,Lim LW,Tan WT,George B,Makeyev E,Thanabalu T

更新日期：2014-04-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a rare neurodegenerative disease of undetermined cause manifesting with progressive autonomic failure (AF), cerebellar ataxia and parkinsonism due to neuronal loss in multiple brain areas associated with (oligodendro)glial cytoplasmic alpha-synuclein (alpha SYN) inclusions (GCIs). Usin...

journal_title：Experimental neurology

authors： Stemberger S,Poewe W,Wenning GK,Stefanova N

更新日期：2010-08-01 00:00:00

abstract：:Neurons from cerebral neocortex and hippocampus exhibit a striking difference in vulnerability to transient global ischemia. In order to study the contribution of neuronal connections and neuron-glia interactions to this variation in neuronal vulnerability, we used hippocampal and neocortical cultures submitted to var...

journal_title：Experimental neurology

authors： Bernaudin M,Nouvelot A,MacKenzie ET,Petit E

更新日期：1998-03-01 00:00:00

abstract：:The regional cerebral blood flow of 27 young (mean age 24 years) schizophrenic patients was measured using the intravenous 133Xe method. The results were compared with those obtained from a group of age- and sex-matched control subjects. The main findings of the study were as follows: (a) the gray matter mean values o...

journal_title：Experimental neurology

authors： Dousse M,Mamo H,Ponsin JC,Tran Dinh Y

更新日期：1988-04-01 00:00:00

abstract：:In the neocortex, the effectiveness of potential transplantation therapy for diseases involving neuronal loss may depend upon whether donor neurons can reestablish the precise long-distance projections that form the basis of sensory, motor, and cognitive function. During corticogenesis, the formation of these connecti...

journal_title：Experimental neurology

authors： Hernit-Grant CS,Macklis JD

更新日期：1996-05-01 00:00:00

abstract：:Children who are born preterm are at risk for encephalopathy of prematurity, a leading cause of cerebral palsy, cognitive delay and behavioral disorders. Current interventions are limited and none have been shown to reverse cognitive and behavioral impairments, a primary determinant of poor quality of life for these c...

journal_title：Experimental neurology

authors： Robinson S,Corbett CJ,Winer JL,Chan LAS,Maxwell JR,Anstine CV,Yellowhair TR,Andrews NA,Yang Y,Sillerud LO,Jantzie LL

更新日期：2018-04-01 00:00:00

abstract：:Impaired olfaction is an early symptom of Alzheimer disease (AD). This likely to reflect neurodegenerative processes taking place in basal telencephalic structures that mediate olfactory processing, including the anterior olfactory nucleus. Betaeta-amyloid (Abeta) accumulation in AD brain may relate to decline in soma...

journal_title：Experimental neurology

authors： Saiz-Sanchez D,Ubeda-Bañon I,de la Rosa-Prieto C,Argandoña-Palacios L,Garcia-Muñozguren S,Insausti R,Martinez-Marcos A

更新日期：2010-06-01 00:00:00

abstract：:The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which produces Parkinsonism, is mediated by its metabolite 1-methyl-4-phenylpyridinium ion (MPP+). When injected into the striatum MPP+ is accumulated by dopaminergic nerve terminals and is then retrogradely transported to the substantia nigra compacta...

journal_title：Experimental neurology

authors： Fallon J,Matthews RT,Hyman BT,Beal MF

更新日期：1997-03-01 00:00:00

abstract：:Activation of GABA(A) receptors by GABA causes phasic and tonic conductances in different brain areas. In the ventrobasal (VB) thalamus, tonic inhibition originates from GABA acting on extrasynaptic receptors. Here we show that dopamine (DA), the D2-like agonist quinpirole and the selective D4R agonist PD-168,077 decr...

journal_title：Experimental neurology

authors： Yagüe JG,Cavaccini A,Errington AC,Crunelli V,Di Giovanni G

更新日期：2013-09-01 00:00:00

abstract：:Cinnamophilin (CINN, (8R, 8'S)-4, 4'-dihydroxy-3, 3'-dimethoxy-7-oxo-8, 8'-neolignan) protects against ischemic stroke in mice. While some anti-oxidative effects of CINN have been characterized, its therapeutic window and molecular basis for neuroprotection remain unclear. We evaluated antioxidant and anti-inflammator...

journal_title：Experimental neurology

authors： Lee EJ,Chen HY,Hung YC,Chen TY,Lee MY,Yu SC,Chen YH,Chuang IC,Wu TS

更新日期：2009-05-01 00:00:00

abstract：:GABAergic dysfunction is implicated in hippocampal deficits of the Ts65Dn mouse model of Down syndrome (DS). Since Ts65Dn mice overexpress G-protein coupled inward-rectifying potassium (GIRK2) containing channels, we sought to evaluate whether increased GABAergic function disrupts the functioning of hippocampal circui...

journal_title：Experimental neurology

authors： Best TK,Cramer NP,Chakrabarti L,Haydar TF,Galdzicki Z

更新日期：2012-02-01 00:00:00

abstract：:Rats with precollicular transections leaving the brain stem intact were subjected to electroshock or pentylenetetrazol-induced convulsions. Animals with transections failed to display the face and forelimb clonus (with or without rearing) typically seen in sham-operated rats subjected to pentylenetetrazol- or minimal ...

journal_title：Experimental neurology

authors： Browning RA,Nelson DK

更新日期：1986-09-01 00:00:00

abstract：:Contusive spinal cord injury (SCI) results in the formation of a chronic lesion cavity surrounded by a rim of spared fibers. Tissue bridges containing axons extend from the spared rim into the cavity dividing it into chambers. Whether descending axons can grow into these trabeculae or whether fibers within the trabecu...

journal_title：Experimental neurology

authors： Hill CE,Beattie MS,Bresnahan JC

更新日期：2001-09-01 00:00:00

abstract：:Parkinson's Disease (PD) is the most common neurodegenerative movement disorder. Autosomal-recessive mutations in the mitochondrial protein kinase PINK1 (PTEN-induced kinase 1) account for 1-2% of the hereditary early-onset cases. To study the mechanisms underlying disease development, we generated Pink1-deficient mic...

journal_title：Experimental neurology

authors： Glasl L,Kloos K,Giesert F,Roethig A,Di Benedetto B,Kühn R,Zhang J,Hafen U,Zerle J,Hofmann A,de Angelis MH,Winklhofer KF,Hölter SM,Vogt Weisenhorn DM,Wurst W

更新日期：2012-05-01 00:00:00

abstract：:Electrophysiological studies on preganglionic neurons (PGNs) in the dorsal motor nucleus (DMN) of the vagus nerve has been hampered by technical limitations. Conventional electrical stimulation of the vagus nerve with cathodal square-wave pulses activates both preganglionic and afferent fibers. Thus, some PGNs cannot ...

journal_title：Experimental neurology

authors： Nosaka S

更新日期：1986-02-01 00:00:00

abstract：:Peripheral nerve grafts (PNG) into the rat spinal cord support axon regeneration after acute or chronic injury, with synaptic reconnection across the lesion site and some level of behavioral recovery. Here, we grafted a peripheral nerve into the injured spinal cord of cats as a preclinical treatment approach to promot...

journal_title：Experimental neurology

authors： Côté MP,Hanna A,Lemay MA,Ollivier-Lanvin K,Santi L,Miller K,Monaghan R,Houlé JD

更新日期：2010-09-01 00:00:00

abstract：:Ghrelin has been shown to regulate neurogenesis in the hippocampus. The aim of this study was to investigate the possible influence of ghrelin on cell proliferation and neuroblast formation in the subventricular zone (SVZ) and rostral migratory system (RMS) and generation of interneurons in the olfactory bulb (OB). We...

journal_title：Experimental neurology

authors： Li E,Kim Y,Kim S,Sato T,Kojima M,Park S

更新日期：2014-02-01 00:00:00

abstract：:The tendency of a rat to approach the wall of an open-field and to travel along the perimeter of the field (termed as "peritaxis" or "wall-facing") is affected by unilateral removal of the vibrissae. Peritaxis is lateralized by hemivibrissotomy. The finding that the dopamine agonist apomorphine reversed the direction ...

journal_title：Experimental neurology

authors： Steiner H,Bonatz AE,Huston JP,Schwarting R

更新日期：1988-03-01 00:00:00

abstract：:Adeno-associated virus (AAV) vectors are derived from a nonpathogenic and defective human parvovirus. Although currently unable to display the integration specificity featured by its wild-type parent, the recombinant AAV (rAAV) system has continued to attract enormous interest primarily due to its unique features such...

journal_title：Experimental neurology

authors： Xiao X,Li J,McCown TJ,Samulski RJ

更新日期：1997-03-01 00:00:00

abstract：:Chronic dopamine depletion produces neurochemical changes within the striatum as well as enhanced behavioral and metabolic responses to dopamine agonists. Changes in striatal neuropeptides have been consistently described, including increased expression of preproenkephalin mRNA and decreased expression of preprotachyk...

journal_title：Experimental neurology

authors： Harrison MB,Kumar S,Hubbard CA,Trugman JM

更新日期：2001-02-01 00:00:00

abstract：:Administration of endogenous corticosterone to intact animals induces calbindin-D28k protein in the hippocampal CA1-CA2 subfields. The fact that this effect on calbindin-D28k was shown to be specific for the hippocampus argues for a receptor-mediated effect on gene expression. In addition, chronic pretreatment with co...

journal_title：Experimental neurology

authors： Rami A,Rabié A,Winckler J

更新日期：1998-02-01 00:00:00

abstract：:As in Alzheimer's disease, brains of Guam Chamorros with amyotrophic lateral sclerosis (ALS) and Parkinsonism-dementia complex (PDC) contain intraneuronal-paired helical filaments composed of accumulated phosphorylated tau protein. Tau mRNA expression in rat neuronal cultures-normally modulated by glutamate-increases ...

journal_title：Experimental neurology

authors： Esclaire F,Kisby G,Spencer P,Milne J,Lesort M,Hugon J

更新日期：1999-01-01 00:00:00

abstract：:Local field potential recordings made from the basal ganglia of patients undergoing deep brain stimulation have suggested that frequency specific activity is involved in determining the rate of force development and the peak force at the outset of a movement. However, the extent to which the basal ganglia might be inv...

journal_title：Experimental neurology

authors： Tan H,Pogosyan A,Anzak A,Foltynie T,Limousin P,Zrinzo L,Ashkan K,Bogdanovic M,Green AL,Aziz T,Brown P

更新日期：2013-02-01 00:00:00

abstract：:Local application of exogenous agents with neurotrophic properties enhances the regenerative capacity of injured neurons, especially following reconstructions of long nerve gaps and delayed nerve repairs. Recent advances in biomaterials and biomedical engineering have provided options for the sustained and controlled ...

journal_title：Experimental neurology

authors： Tajdaran K,Chan K,Gordon T,Borschel GH

更新日期：2019-09-01 00:00:00

abstract：:CNS damage often results in demyelination of spared axons due to oligodendroglial cell death and dysfunction near the injury site. Although new oligodendroglia are generated following CNS injury and disease, the process of remyelination is typically incomplete resulting in long-term functional deficits. Chondroitin su...

journal_title：Experimental neurology

authors： Pendleton JC,Shamblott MJ,Gary DS,Belegu V,Hurtado A,Malone ML,McDonald JW

更新日期：2013-09-01 00:00:00

abstract：:MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, was tested for anticonvulsant effects in rats using two seizure models, coadministration of lithium and pilocarpine and administration of a high dose of pilocarpine alone. Three major results are reported. First, pretreatment with MK-801 produce...

journal_title：Experimental neurology

authors： Ormandy GC,Jope RS,Snead OC 3rd

更新日期：1989-11-01 00:00:00

abstract：:We have investigated the formation of DNA adducts and oxidative base damage produced by copper sulfate activation of dopamine and 6-hydroxydopamine. In the presence of 10 microM copper sulfate both 100 microM dopamine and 100 microM 6-hydroxydopamine formed three similar DNA adducts with relative adduct levels of 8.36...

journal_title：Experimental neurology

authors： Lévay G,Ye Q,Bodell WJ

更新日期：1997-08-01 00:00:00

abstract：:Myelin accelerates action potential conduction velocity and provides essential energy support for axons. Unfortunately, myelin and myelinating cells are often vulnerable to injury or disease, resulting in myelin damage, which in turn can lead to axon dysfunction, overt pathology and neurological impairment. Inflammati...

journal_title：Experimental neurology

authors： Goldstein EZ,Church JS,Hesp ZC,Popovich PG,McTigue DM

更新日期：2016-09-01 00:00:00

abstract：:It is not yet clear how L-dopa, that is the most effective drug for the treatment of Parkinson's disease, enters into the dopaminergic neurons to be transformed into dopamine. It is suggested that L-dopa is mainly transported into cells by a group of L-amino acid carriers named "System L". Since these carriers are sel...

journal_title：Experimental neurology

authors： Sebastianelli L,Ledonne A,Marrone MC,Bernardi G,Mercuri NB

更新日期：2008-07-01 00:00:00