Dysfunction of the ubiquitin-proteasome system in the cerebellum of aging Ts65Dn mice.

abstract：:Alzheimer's disease (AD) is characterized by cognitive decline and deposition of beta-amyloid (Abeta) plaques in cortex and hippocampus. A transgenic mouse AD model (Tg2576) that overexpresses a mutant form of human Abeta precursor protein exhibits age-related cognitive deficits, Abeta plaque deposition, and oxidative...

journal_title：Experimental neurology

authors： Stackman RW,Eckenstein F,Frei B,Kulhanek D,Nowlin J,Quinn JF

更新日期：2003-11-01 00:00:00

abstract：:Most neurons in the dorsal neostriatum die 1 day after 30 min of cerebral ischemia. Dopamine may play a role in the pathogenesis of neuronal injury in neostriatum following ischemia. It has been shown that the number of surviving neurons in the right neostriatum dramatically increased following ischemia after lesions ...

journal_title：Experimental neurology

authors： Xu ZC,Chwang W,Li X,Chen X,He P

更新日期：1999-07-01 00:00:00

abstract：:The dendritic organization of the phrenic nucleus as a whole was studied after injections of the B-subunit of cholera toxin conjugated to horseradish peroxidase were made into the diaphragm of adult rats. Transverse, sagittal, and horizontal sections through the phrenic nucleus (C3-C5) were incubated according to a mo...

journal_title：Experimental neurology

authors： Furicchia JV,Goshgarian HG

更新日期：1987-06-01 00:00:00

abstract：:The kindling phenomenon, i.e., the progressive development of focal and secondarily generalized seizures upon repeated electrical stimulation of a limbic brain region, occurs in various species, but with marked differences in kindling rate between species and also within the same species. In rats, differences in kindl...

journal_title：Experimental neurology

authors： Löscher W,Cramer S,Ebert U

更新日期：1998-12-01 00:00:00

abstract：:Intracerebral transplants of ventral mesencephalic (VM) tissue have been well characterized. VM grafts contain numerous tyrosine hydroxylase immunoreactive neurons which send axons into the host brain. Transplanted neurons in VM grafts develop normally in that they contain tyrosine hydroxylase and GAP43. An overlooked...

journal_title：Experimental neurology

authors： Mahalik TJ,Hahn WE,Clayton GH,Owens GP

更新日期：1994-09-01 00:00:00

abstract：:Bax, a member of the Bcl-2 gene family, is known to promote apoptosis in many cases but to block cell death under certain conditions. To investigate the potential role of Bax in 6-hydroxydopamine (6-OHDA)-induced cell death, we first established and characterized a dopaminergic neuronal cell line (MN9D) stably overexp...

journal_title：Experimental neurology

authors： Oh JH,Choi WS,Kim JE,Seo JW,O'Malley KL,Oh YJ

更新日期：1998-11-01 00:00:00

abstract：:Ibuprofen is commonly used as an anti-inflammatory analgesic drug, although it is not amongst the first-line treatments for neuropathic pain. Its main effects are mediated by non-specific inhibition of COX enzymes, but it also exerts some COX-independent effects, such as the inhibition of RhoA signaling and the modula...

journal_title：Experimental neurology

authors： Redondo-Castro E,Navarro X

更新日期：2014-02-01 00:00:00

abstract：:Impaired olfaction is an early symptom of Alzheimer disease (AD). This likely to reflect neurodegenerative processes taking place in basal telencephalic structures that mediate olfactory processing, including the anterior olfactory nucleus. Betaeta-amyloid (Abeta) accumulation in AD brain may relate to decline in soma...

journal_title：Experimental neurology

authors： Saiz-Sanchez D,Ubeda-Bañon I,de la Rosa-Prieto C,Argandoña-Palacios L,Garcia-Muñozguren S,Insausti R,Martinez-Marcos A

更新日期：2010-06-01 00:00:00

abstract：:Although ciliary neurotrophic factor (CNTF) has been shown to promote the survival of magnocellular neurons when applied exogenously to explants of the paraventricular and supraoptic nuclei (SON) in vitro, little is known regarding its expression or regulation in the adult magnocellular neurosecretory system (MNS) fol...

journal_title：Experimental neurology

authors： Watt JA,Bone S,Pressler M,Cranston HJ,Paden CM

更新日期：2006-01-01 00:00:00

abstract：:c-Fos protein-like immunoreactivity (IR) was investigated in the rat brain following an application of weak anodal direct current to the surface of the unilateral sensorimotor cortex in an attempt to elucidate the cellular and molecular bases of central plasticity. Anodal polarization resulted in a massive increase in...

journal_title：Experimental neurology

authors： Islam N,Moriwaki A,Hattori Y,Hayashi Y,Lu YF,Hori Y

更新日期：1995-05-01 00:00:00

abstract：:The influence that the amygdala may exert on the development of hippocampal kindling was investigated using three different approaches: (i) after uni- or bilateral amygdalectomy by thermocoagulation, (ii) after prestimulation of the amygdala until the appearance of masticatory movements, and (iii) after increasing the...

journal_title：Experimental neurology

authors： Le Gal La Salle G,Feldblum S

更新日期：1983-11-01 00:00:00

abstract：:The amount of myelination in vivo and in vitro depends on the number of oligodendrocyte progenitors, their differentiation, and on the neuron function. It has been shown that continuous administration of FGF2, a mitotic and neuroprotective factor, allows oligodendrocyte progenitors to proliferate, but prevents them fr...

journal_title：Experimental neurology

authors： Magy L,Keita M,Richard L,Piaser M,Vallat JM

更新日期：2003-05-01 00:00:00

abstract：:The blood-brain barrier function and the vasomotor response in rat microcirculation was studied using a closed cranial window technique and an intravital fluorescence microscope with an attempt to reduce both the light intensity and the amount of 2% Na(+)-fluorescein to as little as possible. The light intensities in ...

journal_title：Experimental neurology

authors： Kawamura S,Yasui N

更新日期：1992-09-01 00:00:00

abstract：:Sulforaphane (SFN) is an organosulfur compound present in vegetables and has potent anti-oxidant and anti-inflammatory activities. This study was aimed at investigating the effect of treatment with SFN on inflammation and oxidative stress, and the potential mechanisms underlying the action of SFN in experimental autoi...

journal_title：Experimental neurology

authors： Li B,Cui W,Liu J,Li R,Liu Q,Xie XH,Ge XL,Zhang J,Song XJ,Wang Y,Guo L

更新日期：2013-12-01 00:00:00

abstract：:To compare the evolution of cell body responses to two different types of axonal injuries--sciatic nerve crush (axotomy) and chronic 2,5-hexanedione-induced neuropathy--we studied rat lumbar dorsal root ganglion neurons with light microscopy and morphometry. Compared with control neurons, axotomized cells showed early...

journal_title：Experimental neurology

authors： Sterman AB,Delannoy MR

更新日期：1985-08-01 00:00:00

abstract：:Chemotherapy-related cognitive deficits are a major neurological problem, but the underlying mechanisms are unclear. The death of neural stem/precursor cell (NSC) by cisplatin has been reported as a potential cause, but this requires high doses of chemotherapeutic agents. Cisplatin is frequently used in modern oncolog...

journal_title：Experimental neurology

authors： Andres AL,Gong X,Di K,Bota DA

更新日期：2014-05-01 00:00:00

abstract：:Cervical injuries are the most common form of SCI. In this study, we used a neuromodulatory approach to promote skilled movement recovery and repair of the corticospinal tract (CST) after a moderately severe C4 midline contusion in adult rats. We used bilateral epidural intermittent theta burst (iTBS) electrical stimu...

journal_title：Experimental neurology

authors： Zareen N,Shinozaki M,Ryan D,Alexander H,Amer A,Truong DQ,Khadka N,Sarkar A,Naeem S,Bikson M,Martin JH

更新日期：2017-11-01 00:00:00

abstract：:Astrocytes are relatively resistant to injury compared to neurons and oligodendrocytes. Here, we report transient region-specific loss of astrocytes in mice early after pilocarpine-induced status epilepticus (SE). In the dentate hilus, immunoreactivity for glial acidic fibrillary protein (GFAP) was decreased, and the ...

journal_title：Experimental neurology

authors： Borges K,McDermott D,Irier H,Smith Y,Dingledine R

更新日期：2006-10-01 00:00:00

abstract：:Infant rats were subjected to pentylenetetrazol-induced convulsions on alternate days from 5 to 13 days of age. At 17 days of age, their susceptibility to the convulsant effects of hyperthermia was examined. It was found that previous pentylenetetrazol-induced convulsions caused a significant facilitation in the devel...

journal_title：Experimental neurology

authors： McCaughran JA Jr,Manetto C

更新日期：1983-01-01 00:00:00

abstract：:This work investigated the extent to which constituent proportions of fast- and slow-twitch muscle units determine whole muscle contractile properties. We employed several self- and cross-reinnervation models using synergistic homogeneous and heterogeneous muscles. By comparing the present data with previously publish...

journal_title：Experimental neurology

authors： Foehring RC,Sypert GW,Munson JB

更新日期：1988-09-01 00:00:00

abstract：:Recently it has been shown that there is impaired cerebral endothelial function in many chronic neurodegenerative disorders including Alzheimer's and Huntington's disease. Such problems have also been reported in Parkinson's disease, in which α-synuclein aggregation is the pathological hallmark. However, little is kno...

journal_title：Experimental neurology

authors： Kuan WL,Bennett N,He X,Skepper JN,Martynyuk N,Wijeyekoon R,Moghe PV,Williams-Gray CH,Barker RA

更新日期：2016-11-01 00:00:00

abstract：:Periodic changes in ovarian steroid levels during fertility cycles affect learning both in humans and in rats in parallel with electrophysiological and morphological fluctuations in selective neuronal populations. In particular, during the estrous cycle of the female rat, hippocampal CA1 region undergoes cyclic modifi...

journal_title：Experimental neurology

authors： Crispino M,Stone DJ,Wei M,Anderson CP,Tocco G,Finch CE,Baudry M

更新日期：1999-10-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for nigrostriatal dopaminergic, central cholinergic, and motoneurons. GDNF also prevents the neuronal loss in experimental animal models for Parkinson's disease (PD). We have now investigated the GDNF gene for possible mutations in a group ...

journal_title：Experimental neurology

authors： Wartiovaara K,Hytönen M,Vuori M,Paulin L,Rinne J,Sariola H

更新日期：1998-08-01 00:00:00

abstract：:In previous studies on sensory axons we reported that the effect of a conditioning lesion on increasing regeneration rate was enhanced if the two lesions were superimposed, rather than made at separate sites on the nerve, and proposed that this was due to the growth of axons through nerve predegenerated by the conditi...

journal_title：Experimental neurology

authors： Bisby MA

更新日期：1985-11-01 00:00:00

abstract：:Microfilaments (MFs) play an important role in wound healing and other regenerative events. The purpose of this study was to characterize changes in the distribution of MFs in traumatized auditory epithelia and compare these changes between avian (regenerating) and mammalian (nonregenerating) ears. Chicks and guinea p...

journal_title：Experimental neurology

authors： Raphael Y,Altschuler RA

更新日期：1992-01-01 00:00:00

abstract：:Theoretical and experimental analyses of deep brain stimulation (DBS) in the subthalamic nucleus (STN) show both excitatory and inhibitory effects on the neural elements surrounding the electrode. Given these observations, the mechanism underlying the therapeutic effect of STN DBS on parkinsonian motor signs remains u...

journal_title：Experimental neurology

authors： Hahn PJ,Russo GS,Hashimoto T,Miocinovic S,Xu W,McIntyre CC,Vitek JL

更新日期：2008-05-01 00:00:00

abstract：:Increased intercellular coupling has been implicated in contributing to the synchronization of discharges characteristic of epileptic foci. Using RNA blot analysis, the level of mRNA for the heart-type gap junction protein, connexin43, is shown to be elevated in samples of temporal lobe neocortex obtained at the time ...

journal_title：Experimental neurology

authors： Naus CC,Bechberger JF,Paul DL

更新日期：1991-02-01 00:00:00

abstract：:The ventrolateral orbital cortex (VLO) is part of an endogenous analgesic system consisting of an ascending pathway from the spinal cord to VLO via the thalamic nucleus submedius (Sm) and a descending pathway to the spinal cord relaying in the periaqueductal gray (PAG). This study examines whether activation of D(1)-l...

journal_title：Experimental neurology

authors： Sheng HY,Qu CL,Huo FQ,Du JQ,Tang JS

更新日期：2009-01-01 00:00:00

abstract：:Cells dissociated from 6-day rat cerebellum were seeded on glass coverslips coated with polylysine on one half and hyaluronectin on the other. Cell attachment and neurite extension were drastically reduced on hyaluronectin-coated surfaces. ...

journal_title：Experimental neurology

authors： Bignami A,Dahl D,Gilad VH,Gilad GM

更新日期：1988-04-01 00:00:00

abstract：:Neonatal hypoxia ischemia (HI) is the main cause of newborn mortality and morbidity. Preclinical studies have shown that the immature rat brain is more resilient to HI injury, suggesting innate mechanisms of neuroprotection. During neonatal period brain metabolism experience changes that might greatly affect the outco...

journal_title：Experimental neurology

authors： Odorcyk FK,Duran-Carabali LE,Rocha DS,Sanches EF,Martini AP,Venturin GT,Greggio S,da Costa JC,Kucharski LC,Zimmer ER,Netto CA

更新日期：2020-08-01 00:00:00