Abstract:
:Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for nigrostriatal dopaminergic, central cholinergic, and motoneurons. GDNF also prevents the neuronal loss in experimental animal models for Parkinson's disease (PD). We have now investigated the GDNF gene for possible mutations in a group of nonfamilial PD and other patients. By cleavase fragment length polymorphism (CFLP) analysis and direct sequencing of the full coding region of GDNF gene we found a novel GDNF sequence variant in 1 of 30 PD patients. The alteration does not change the predicted amino acid sequence and it was also found in 1 of 20 patients without PD, suggesting that it represents a polymorphism in the gene. No other sequence variations were found. We conclude therefore that mutations in the GDNF coding region are not commonly contributing to the pathogenesis of PD.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Wartiovaara K,Hytönen M,Vuori M,Paulin L,Rinne J,Sariola Hdoi
10.1006/exnr.1998.6857subject
Has Abstractpub_date
1998-08-01 00:00:00pages
307-9issue
2eissn
0014-4886issn
1090-2430pii
S0014-4886(98)96857-1journal_volume
152pub_type
杂志文章abstract::We have investigated the long-term effects of 15-16 min or 19-20 min of perinatal asphyxia on D1, D2, and D3 receptors (analyzed by quantitative autoradiography) in the mesotelencephalic dopamine systems of the 4-week-old rat. Perinatal asphyxia reduced D1 antagonist binding ([3H]SCH 23390 in the presence of ketanseri...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1997.6497
更新日期:1997-07-01 00:00:00
abstract::We have recently shown that tanycytes present in the median eminence (ME) constitute a preferential support for the regeneration of lesioned neurohypophysial oxytocinergic and vasopressinergic axons. However, although tanycytes are particularly abundant in the ME, they are also present along the third ventricle wall. ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1998.6784
更新日期:1998-05-01 00:00:00
abstract::We demonstrated previously that the hypothalamic supraoptic nucleus (SON) undergoes a robust axonal sprouting response following unilateral transection of the hypothalamo-neurohypophysial tract. Concomitant with this response is an increase in ciliary neurotrophic factor (CNTF) and CNTF receptor alpha (CNTFRα) express...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2011.10.009
更新日期:2012-01-01 00:00:00
abstract::The presence of the alpha2macroglobulin receptor/low density lipoprotein receptor-related protein (alpha2Mr/LRP) and its ligands alpha2macroglobulin (alpha2M), apoliprotein E, and plasminogen activators was detected in senile plaques of Alzheimer's disease (AD). To explore a possible role of alpha2M in neurodegenerati...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1998.6978
更新日期:1999-02-01 00:00:00
abstract::The extent and kinetic profiles of lipid peroxidation induced with Fe2+-ascorbic acid in a homogenate of spinal cord from greyhound dogs were ascertained by measurement of the formation of malondialdehyde (MDA) and chemiluminescence in the presence of four drugs. Changes in MDA and chemiluminescence were correlated as...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(83)90338-2
更新日期:1983-09-01 00:00:00
abstract::Sciatic cryoneurolysis (SCN) is an experimental rat mononeuropathy model that produces neuropathic behavioral sequelae distinct from other neuropathy models. Following SCN, there is limited autotomy peaking in severity and incidence at 7-14 days and delayed but sustained allodynia appearing at about 21 days, with no e...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1995.1028
更新日期:1995-06-01 00:00:00
abstract::In the present study homonymous and heteronymous projections of muscle spindle afferent fibers in the human jaw-closing system were investigated. Stretch reflex responses were elicited with percutaneous displacement stimuli applied to the belly of the anterior superficial divisions of temporalis and masseter muscles. ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(85)90070-6
更新日期:1985-06-01 00:00:00
abstract::Alpha-tyrosinated tubulin is a cytoskeletal protein that is involved in axonal growth and is considered a marker of neuronal plasticity in adult mammals. In adult rats, unilateral ablation of the left facial sensorimotor cortical areas induces degeneration of corticotrigeminal projections and marked denervation of the...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2008.05.010
更新日期:2008-09-01 00:00:00
abstract::The precise role of hypothalamic norepinephrine (NE) in the control of vasopressin (AVP) release has remained unclear, due to reports of both inhibitory and excitatory effects of NE and only a few studies with direct hypothalamic manipulations. The present study utilized a chronically implanted swivel brain cannula to...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(90)90042-q
更新日期:1990-12-01 00:00:00
abstract::In the peripheral nervous system, regeneration of motor and sensory axons into chronically denervated distal nerve segments is impaired compared to regeneration into acutely denervated nerves. In order to find possible causes for this phenomenon we examined the changes in the expression pattern of the glial cell-line-...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2001.7826
更新日期:2002-01-01 00:00:00
abstract::Mechanisms underlying affective and cognitive deficits in Parkinson's disease (PD) remain less studied than motor symptoms. Nucleus accumbens (NAc) is affected in PD and due to its well-known involvement in motivation is an interesting target in this context. Furthermore, PD is frequently asymmetrical, with side-speci...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2020.113221
更新日期:2020-05-01 00:00:00
abstract::Germinal matrix hemorrhage (GMH) is the most common neurological disease of premature newborns. GMH causes neurological sequelae such as cerebral palsy, post-hemorrhagic hydrocephalus, and mental retardation. Despite this, there is no standardized animal model of spontaneous GMH using newborn rats to depict the condit...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2012.04.003
更新日期:2012-07-01 00:00:00
abstract::An electron microscopic investigation of neuromuscular synapses of the tensor fasciae latae muscle in juvenile mice was carried out to determine the relationship between the presynaptic (nerve terminal) and postsynaptic (end-plate plaque) elements during the major phase of postnatal growth. In the first month of life ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90065-3
更新日期:1987-05-01 00:00:00
abstract::Various limbic system structures have been implicated in processing noxious information. One such structure is the anterior cingulate cortex (ACC), a region that is thought to modulate higher order processing of noxious input related to the affective/motivational component of pain. The present experiment examined the ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2004.04.003
更新日期:2004-07-01 00:00:00
abstract::Transplantation of stem cells and immature cells has been reported to ameliorate tissue damage, induce axonal regeneration, and improve locomotion following spinal cord injury. However, unless these cells are pushed down a neuronal lineage, the majority of cells become glia, suggesting that the alterations observed ma...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2004.05.043
更新日期:2004-12-01 00:00:00
abstract::MicroRNA-21 (miR-21) is consistently up-regulated in various neurological disorders, including epilepsy. Here, we show that the biogenesis of miR-21 is altered following pilocarpine-induced status epilepticus (SE) with an increase in precursor miR-21 (pre-miR-21) in rats. We demonstrate that pre-miR-21 has an energeti...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2016.10.003
更新日期:2016-12-01 00:00:00
abstract::Functional regeneration of brainstem-spinal pathways occurs in the developing chick when the spinal cord is severed prior to embryonic day (E) 13. Functional spinal cord regeneration is not observed in animals injured after E13. This developmental transition from a permissive to a restrictive repair period may be due ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2000.7496
更新日期:2000-11-01 00:00:00
abstract::Phenytoin is known to reduce neural overactivity (pseudomyotonia) affecting the hind limb musculature in C57B1/6J dystrophic (dy2J/dy2J) mice. This study reports a change in the metabolic profile of superficial gastrocnemius muscle fibers from dy2J/dy2J animals after chronic phenytoin treatment. The superficial gastro...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(84)90011-6
更新日期:1984-04-01 00:00:00
abstract::Peripheral nerve grafts (PNG) into the rat spinal cord support axon regeneration after acute or chronic injury, with synaptic reconnection across the lesion site and some level of behavioral recovery. Here, we grafted a peripheral nerve into the injured spinal cord of cats as a preclinical treatment approach to promot...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2010.06.011
更新日期:2010-09-01 00:00:00
abstract::Because vitamin D hormone deficiency (VDHdef) can worsen severity and outcome for ischemic stroke, we examined the role of VDH in maintaining blood-brain-barrier (BBB integrity) in a rat model of stroke. In most types of stroke, the BBB is markedly compromised, potentially leading to a cascade of injury processes and ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2018.11.005
更新日期:2019-02-01 00:00:00
abstract::The hph-1 mice have defective tetrahydrobiopterin biosynthesis and share many neurochemical similarities with l-dopa-responsive dystonia (DRD) in humans. In both, there are deficiencies in GTP cyclohydrolase I and low brain levels of dopamine (DA). Striatal tyrosine hydroxylase (TH) levels are decreased while the numb...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2004.08.022
更新日期:2004-12-01 00:00:00
abstract::Rats were treated with single subcutaneous injections of the irreversible AChE inhibitors, sarin (90 to 100 micrograms/kg) or soman (55 micrograms/kg), and with chronic doses of the reversible carbamate inhibitor, pyridostigmine. In surviving animals with severe behavioral symptoms, we examined the end-plate regions o...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(85)90268-7
更新日期:1985-07-01 00:00:00
abstract::We have treated spinal cord injured rats with demyelination plus Schwann cell transplantation and assessed neurite outgrowth in a quantifiable model of axonal regeneration. Axonal injuries of differing severity were induced in the dorsal funiculus of adult rats using a micromanipulator-controlled Scouten knife. Demyel...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7100
更新日期:1999-09-01 00:00:00
abstract::Hyperbaric oxygen preconditioning (HBO-PC) has been demonstrated to attenuate hemorrhagic transformation (HT) after middle cerebral artery occlusion (MCAO) in hyperglycemic rats. However, the mechanisms remain to be illustrated. Recently, HBO-PC has been shown to activate peroxisome proliferator-activated receptor-gam...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2014.12.016
更新日期:2015-03-01 00:00:00
abstract::The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which produces Parkinsonism, is mediated by its metabolite 1-methyl-4-phenylpyridinium ion (MPP+). When injected into the striatum MPP+ is accumulated by dopaminergic nerve terminals and is then retrogradely transported to the substantia nigra compacta...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1997.6416
更新日期:1997-03-01 00:00:00
abstract::The neural substrate underlying the aversive effects induced by ethanol abstinence is still unclear. One candidate for such effects is the dorsal periaqueductal gray (dPAG), a core structure of the brain aversion system. The main aim of this study is to examine the role of the dPAG as a possible locus of the aversive ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2006.02.004
更新日期:2006-07-01 00:00:00
abstract::After spinal cord injury (SCI), the majority of individuals develop spasticity, a debilitating condition involving involuntary movements, co-contraction of antagonistic muscles, and hyperreflexia. By acting on GABAergic and Ca2+-dependent signaling, current anti-spastic medications lead to serious side effects, includ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2021.113605
更新日期:2021-01-13 00:00:00
abstract::The tibial functional index has been employed to assess functional recovery in rats following nerve repair by direct coaptation under tension or by grafting. Recovery after direct repair of small to moderate gap sizes was better than that after grafting. ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(91)90162-6
更新日期:1991-12-01 00:00:00
abstract::The olfactory bulb is the target of neural progenitor cells that are generated in the subventricular zone of the lateral ventricle in the adult brain. This permanent neurogenesis is likely influenced by olfactory input to the bulb since previous studies have shown that cell proliferation and/or apoptotic death are sti...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2005.03.004
更新日期:2005-08-01 00:00:00
abstract::Previous work utilizing the 2-deoxyglucose (2-DG) technique demonstrated that denervation, both direct (enucleation) or indirect (retinal receptor destruction, leaving ganglion cells intact), resulted in a depression followed by an increase in glucose metabolism in the superior colliculus (SC) of the mature hooded rat...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(89)90040-x
更新日期:1989-06-01 00:00:00