Functional recovery following direct or graft repair of nerve gaps in the rat.

abstract：:Bombesin/gastrin-releasing peptide (BB/GRP) receptors were characterized in fetal cortex transplants in the rat. Using in vitro autoradiography techniques, the density of (125I-Tyr4)BB grains was low 2 weeks after transplantation but increased 4 weeks after cortex transplantation into the adult rat fourth ventricle. D...

journal_title：Experimental neurology

authors： Moody TW,Getz R,Rosenstein JM

更新日期：1996-11-01 00:00:00

abstract：:Reactive synaptogenesis and terminal proliferation are known to occur in the dentate gyrus of the rat hippocampus following removal of specific afferents. In the present study we have examined the relation of synaptophysin immunoreactivity to the immunohistochemical staining pattern of GAP-43, a putative marker of neu...

journal_title：Experimental neurology

authors： Masliah E,Fagan AM,Terry RD,DeTeresa R,Mallory M,Gage FH

更新日期：1991-08-01 00:00:00

abstract：:Repeatedly it was reported that a short ischemic episode may ameliorate biochemical and morphological impairment upon succeeding severe ischemia. We investigated whether the pattern of respiratory enzyme activity (RA), adenine nucleotides, and membrane potential in hippocampal slices following low-dose in vivo (20 mg/...

journal_title：Experimental neurology

authors： Riepe MW,Niemi WN,Megow D,Ludolph AC,Carpenter DO

更新日期：1996-03-01 00:00:00

abstract：:The expression of vasoactive intestinal peptide (VIP) and gastrin-releasing peptide (GRP) in the suprachiasmatic nucleus (SCN) changes depending on light. VIP mRNA increases and GRP mRNA decreases in the light phase, while they do not show change without light. In the present study we investigated the involvement of s...

journal_title：Experimental neurology

authors： Hayashi S,Ueda M,Amaya F,Matusda T,Tamada Y,Ibata Y,Tanaka M

更新日期：2001-10-01 00:00:00

abstract：:We previously reported that 1 month following unilateral loss (>95%) of striatal dopamine, there is an increase in striatal glutamate function as measured by in vivo microdialysis and quantitative immuno-gold electron microscopy, Neuroscience 88, 1-16). The goal of this study was to determine the effect of bilateral l...

journal_title：Experimental neurology

authors： Robinson S,Freeman P,Moore C,Touchon JC,Krentz L,Meshul CK

更新日期：2003-03-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is often accompanied by granule cell dispersion (GCD), a migration defect of granule cells in the dentate gyrus. We have previously shown that a decrease in the expression of reelin, an extracellular matrix protein important for neuronal positioning, is associated with the development of G...

journal_title：Experimental neurology

authors： Müller MC,Osswald M,Tinnes S,Häussler U,Jacobi A,Förster E,Frotscher M,Haas CA

更新日期：2009-04-01 00:00:00

abstract：:Chemotherapy-related cognitive deficits are a major neurological problem, but the underlying mechanisms are unclear. The death of neural stem/precursor cell (NSC) by cisplatin has been reported as a potential cause, but this requires high doses of chemotherapeutic agents. Cisplatin is frequently used in modern oncolog...

journal_title：Experimental neurology

authors： Andres AL,Gong X,Di K,Bota DA

更新日期：2014-05-01 00:00:00

abstract：:The accumulation of damage to DNA plays a significant role in the etiology of the aging process. The importance of nutrition in delaying the aging process is well recognized. L-carnitine is a quaternary ammonium compound heterogeneously distributed in the brain. In the present study the effect of L-carnitine on DNA da...

journal_title：Experimental neurology

authors： Juliet PA,Joyee AG,Jayaraman G,Mohankumar MN,Panneerselvam C

更新日期：2005-01-01 00:00:00

abstract：:Grafts of neonatal striatal tissue were placed into the striata of adult rats. When challenged immediately with intrastriatal injections of either kainic or quinolinic acid, excitotoxic damage was prevented. Thirty days later these same graft recipients received another injection of excitotoxin. The intrastriatal graf...

journal_title：Experimental neurology

authors： Tulipan N,Luo SQ,Allen GS,Whetsell WO

更新日期：1988-12-01 00:00:00

abstract：:Following a unilateral fimbria-fornix lesion, the delivery of nerve growth factor (NGF) to the ipsilateral lateral ventricle of the rat can prevent the lesion-induced loss of choline acetyltransferase (ChAT) expression in the ipsilateral medial septum and vertical diagonal band region. In the present study, the abilit...

journal_title：Experimental neurology

authors： Hoffman D,Wahlberg L,Aebischer P

更新日期：1990-10-01 00:00:00

abstract：:Serotonergic neurons were recorded in the nucleus centralis superior (NCS) in freely moving cats and were initially identified on-line by their slow and regular spontaneous activity (mean 2.55 +/- 0.21 spikes/s). Discharge rates of NCS serotonergic neurons were highest during active waking (AW) (mean 2.94 +/- 0.28 spi...

journal_title：Experimental neurology

authors： Rasmussen K,Heym J,Jacobs BL

更新日期：1984-02-01 00:00:00

abstract：:Infection with human immunodeficiency virus-1 (HIV-1) is associated with dysfunctions of the central nervous system (CNS). HIV-1 induces its effects on the CNS by a variety of mechanisms, including by shedding the neurotoxic viral proteins such as gp120 and Tat. Both HIV-1 and gp120 have been shown to cross the blood-...

journal_title：Experimental neurology

authors： Banks WA,Robinson SM,Nath A

更新日期：2005-05-01 00:00:00

abstract：:Sciatic cryoneurolysis (SCN) is an experimental rat mononeuropathy model that produces neuropathic behavioral sequelae distinct from other neuropathy models. Following SCN, there is limited autotomy peaking in severity and incidence at 7-14 days and delayed but sustained allodynia appearing at about 21 days, with no e...

journal_title：Experimental neurology

authors： Wagner R,DeLeo JA,Heckman HM,Myers RR

更新日期：1995-06-01 00:00:00

abstract：:We compared the magnetic cerebral activity of 10 fetal subjects at two different gestational ages. Spontaneous cerebral activity was recorded with a large array magnetometer specially designed to conform to the maternal gravid abdomen during the third trimester of pregnancy. We recorded each fetal subject at least twi...

journal_title：Experimental neurology

authors： Rose DF,Eswaran H

更新日期：2004-11-01 00:00:00

abstract：:Peripheral neuropathy (PN) is a debilitating and dose-limiting side effect of treatment with the chemotherapeutic agent, paclitaxel. Understanding the effects of paclitaxel on sensory neuronal function and the signaling pathways which mediate these paclitaxel-induced changes in function are critical for the developmen...

journal_title：Experimental neurology

authors： Pittman SK,Gracias NG,Vasko MR,Fehrenbacher JC

更新日期：2014-03-01 00:00:00

abstract：:The pathophysiology of the tics that define Gilles de la Tourette syndrome (TS) is not well understood. Local disinhibition within the striatum has been hypothesized to play a pathogenic role. In support of this, experimental disinhibition by local antagonism of GABA-A receptors within the striatum produces tic-like p...

journal_title：Experimental neurology

authors： Pogorelov V,Xu M,Smith HR,Buchanan GF,Pittenger C

更新日期：2015-03-01 00:00:00

abstract：:AMPA receptors (AMPARs) are responsible for fast excitatory neurotransmission, and their prolonged activation can result in the generation and spread of epileptic seizures. At early stages of postnatal development, the majority of AMPARs are permeable to both Na(+) and Ca(2+) ions. This permeability, which increases n...

journal_title：Experimental neurology

authors： Szczurowska E,Ergang P,Kubová H,Druga R,Salaj M,Mareš P

更新日期：2016-09-01 00:00:00

abstract：:Interest in beta activity in the basal ganglia has mushroomed since it was first identified in the subthalamic nucleus of patients with Parkinson's disease in Jonathan Dostrovsky's landmark paper (Levy et al., 2000). Here we consider a less explored phenomenon; namely gamma frequency synchronisation of neurons in the ...

journal_title：Experimental neurology

authors： Jenkinson N,Kühn AA,Brown P

更新日期：2013-07-01 00:00:00

abstract：:We used [2-14C]deoxyglucose as a marker of increased metabolism of the hypoglossal nucleus after transection of its nerve. We studied this metabolism in 3-, 12-, and 24-month-old rats. We found an increase in glucose uptake in the control nucleus of 24-month-old rats which was significant when compared to that of 3-mo...

journal_title：Experimental neurology

authors： Singer PA,Mehler S

更新日期：1990-04-01 00:00:00

abstract：:Transplantation of stem cells and immature cells has been reported to ameliorate tissue damage, induce axonal regeneration, and improve locomotion following spinal cord injury. However, unless these cells are pushed down a neuronal lineage, the majority of cells become glia, suggesting that the alterations observed ma...

journal_title：Experimental neurology

authors： Hill CE,Proschel C,Noble M,Mayer-Proschel M,Gensel JC,Beattie MS,Bresnahan JC

更新日期：2004-12-01 00:00:00

abstract：:Neuropathological studies of human traumatic brain injury (TBI) cases have described amyloid plaques acutely after a single severe TBI, and tau pathology after repeat mild TBI (mTBI). This has helped drive the hypothesis that a single moderate to severe TBI increases the risk of developing late-onset Alzheimer's disea...

journal_title：Experimental neurology

authors： Washington PM,Villapol S,Burns MP

更新日期：2016-01-01 00:00:00

abstract：:Cervical injuries are the most common form of SCI. In this study, we used a neuromodulatory approach to promote skilled movement recovery and repair of the corticospinal tract (CST) after a moderately severe C4 midline contusion in adult rats. We used bilateral epidural intermittent theta burst (iTBS) electrical stimu...

journal_title：Experimental neurology

authors： Zareen N,Shinozaki M,Ryan D,Alexander H,Amer A,Truong DQ,Khadka N,Sarkar A,Naeem S,Bikson M,Martin JH

更新日期：2017-11-01 00:00:00

abstract：:Paired-pulse potentiation was studied in the CA1 region of rats exposed prenatally to alcohol. Pregnant rats were fed a liquid diet containing 35% ethanol-derived calories on days 3 to 21 of gestation. Control animals were fed liquid diets without ethanol. When the pups of both groups were 40 to 60 days old, hippocamp...

journal_title：Experimental neurology

authors： Hablitz JJ

更新日期：1986-08-01 00:00:00

abstract：:At the age of 31 days, Long-Evans female rats received electrolytic lesions either of the medial fimbria (N = 24), of the dorsal subcallosal fornix (N = 24), or of both structures (N = 24). Ten rats were used as sham-operated controls. Ten days later, half the rats of each lesion group received intrahippocampal grafts...

journal_title：Experimental neurology

authors： Cassel JC,Kelche C,Will BE

更新日期：1987-09-01 00:00:00

abstract：:This work investigated the extent to which constituent proportions of fast- and slow-twitch muscle units determine whole muscle contractile properties. We employed several self- and cross-reinnervation models using synergistic homogeneous and heterogeneous muscles. By comparing the present data with previously publish...

journal_title：Experimental neurology

authors： Foehring RC,Sypert GW,Munson JB

更新日期：1988-09-01 00:00:00

abstract：:Volume-regulated anion channels (VRACs) are critically involved in regulating cell volume, and leucine-rich repeat-containing protein 8A (LRRC8A, SWELL1) is an obligatory subunit of VRACs. Cell swelling occurs early after brain ischemia, but it is unclear whether neuronal LRRC8a contributes to ischemia-induced glutama...

journal_title：Experimental neurology

authors： Zhou JJ,Luo Y,Chen SR,Shao JY,Sah R,Pan HL

更新日期：2020-10-01 00:00:00

abstract：:Synemin (Syn) is an intermediate filament (IF) protein. To gain insight into a morphogenetic role of Syn, we have studied its expression patterns in the developing human retina and lens and compared it with those of other IF proteins. In addition, we have tested Syn expression in fetuses (23 and 28 weeks) affected by ...

journal_title：Experimental neurology

authors： Tawk M,Titeux M,Fallet C,Li Z,Daumas-Duport C,Cavalcante LA,Paulin D,Moura-Neto V

更新日期：2003-10-01 00:00:00

abstract：:The Fmr1 knockout (KO) mouse is characterized by an increased audiogenic seizure (AGS) susceptibility and is considered a good animal model for epilepsy and seizures in the human fragile-X (FRAX) syndrome. Here, we tested the hypothesis that the reintroduction of the FMR1 gene is able to revert the AGS susceptibility ...

journal_title：Experimental neurology

authors： Musumeci SA,Calabrese G,Bonaccorso CM,D'Antoni S,Brouwer JR,Bakker CE,Elia M,Ferri R,Nelson DL,Oostra BA,Catania MV

更新日期：2007-01-01 00:00:00

abstract：:Activation of the visual system with a moving black and white geometric pattern resulted in dense patches or columns of 2-deoxyglucose label in primate extrastriate visual cortex. The three-dimensional reconstruction of these metabolic columns showed that they were arranged in irregularly shaped slabs which extended i...

journal_title：Experimental neurology

authors： Herdman SJ,Hand CL,Hand PJ

更新日期：1984-08-01 00:00:00

abstract：:Many reports indicate that GM1 ganglioside is effective in reducing CNS ischemic injury in animal models. These models employ invasive surgery to induce ischemic damage in otherwise healthy animals. The purpose of this study was to determine if the beneficial effects of GM1 could be generalized to Spontaneously Hypert...

journal_title：Experimental neurology

authors： Hernandez NE,MacDonall JS,Stier CT Jr,Belmonte A,Fernandez R,Karpiak SE

更新日期：1994-03-01 00:00:00