Abstract:
:Following a unilateral fimbria-fornix lesion, the delivery of nerve growth factor (NGF) to the ipsilateral lateral ventricle of the rat can prevent the lesion-induced loss of choline acetyltransferase (ChAT) expression in the ipsilateral medial septum and vertical diagonal band region. In the present study, the ability of polymer rods to deliver NGF and to prevent a decrease in basal forebrain ChAT expression following a fimbria-fornix lesion was assessed. NGF was loaded into an ethylene vinyl acetate copolymer (EVAc) rod, fabricated by a melt-extrusion process. NGF release was established by the ability of the rods to induce neurite extension from PC12 cells and chick E12 dorsal root ganglia. Unilateral aspirative lesions of the fimbria-fornix were performed in adult rats, followed by implantation of a polymer rod into the ipsilateral lateral ventricle. Five animals received EVAc rods containing only the carrier molecule bovine serum albumin (BSA), and six received EVAc rods containing both BSA and NGF. After 2 weeks, ChAT-positive cells were counted in the medial septum and vertical diagonal band regions. Rats with NGF-releasing rods displayed ChAT(+) cell counts ipsilateral to the lesion equal to 88% of those on the contralateral side. In contrast, ChAT(+) cell numbers were 42% in animals with rods releasing BSA only (P less than 0.001). No undue reaction to implanted rods was noted. Following a fimbria-fornix lesion, NGF released from polymer matrices effectively prevents a lesion-induced reduction in ChAT expression in basal forebrain neurons.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Hoffman D,Wahlberg L,Aebischer Pdoi
10.1016/0014-4886(90)90049-xsubject
Has Abstractpub_date
1990-10-01 00:00:00pages
39-44issue
1eissn
0014-4886issn
1090-2430pii
0014-4886(90)90049-Xjournal_volume
110pub_type
杂志文章abstract::We used [2-14C]deoxyglucose as a marker of increased metabolism of the hypoglossal nucleus after transection of its nerve. We studied this metabolism in 3-, 12-, and 24-month-old rats. We found an increase in glucose uptake in the control nucleus of 24-month-old rats which was significant when compared to that of 3-mo...
journal_title:Experimental neurology
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更新日期:1984-12-01 00:00:00
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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更新日期:1985-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1988-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0014-4886(88)90140-9
更新日期:1988-01-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1994-12-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2004.01.032
更新日期:2004-07-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1991-12-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1983-09-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(85)90179-7
更新日期:1985-03-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(85)90226-2
更新日期:1985-02-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1985-04-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7074
更新日期:1999-07-01 00:00:00
abstract::An in vitro study of the nuclear magnetic resonance (NMR) response of protons in normal and pathological human skeletal muscle is presented. Muscle biopsies from 34 patients with various neuromuscular diseases and five normal subjects were studied by proton NMR techniques and the results were compared with those of li...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(83)90159-0
更新日期:1983-07-01 00:00:00