Effect of L-carnitine on nucleic acid status of aged rat brain.

abstract：RATIONALE:Neurofibromatosis type 1 (NF1) is associated with higher rates of epilepsy compared to the general population. Some NF1 patients with epilepsy do not have intracranial lesions, suggesting the genetic mutation itself may contribute to higher rates of epilepsy in these patients. We have recently demonstrated in...

journal_title：Experimental neurology

authors： Sabetghadam A,Wu C,Liu J,Zhang L,Reid AY

更新日期：2020-09-01 00:00:00

abstract：:Neglect is a clinical syndrome characterized by an inability to orient, report, or respond to novel or meaningful stimuli presented to one side of the body or in one hemispace. Neglect in humans and monkeys most often results from damage to one of several interconnected cortical areas, including limbic cortex. In rats...

journal_title：Experimental neurology

authors： King V,Corwin JV,Reep RL

更新日期：1989-09-01 00:00:00

abstract：:This study characterizes the impact of increasing-intensity treadmill exercise (iTR) on noradrenergic (NE) and serotonergic (5HT) modulation of neuropathic pain. Following sciatic nerve transection and repair (SNTR) rats developed significant mechanical and thermal hyperalgesia that was partially prevented by iTR perf...

journal_title：Experimental neurology

authors： Lopez-Alvarez VM,Puigdomenech M,Navarro X,Cobianchi S

更新日期：2018-01-01 00:00:00

abstract：:The transformation of a cut axonal end into a growth cone (GC), after axotomy, is a critical event in the cascade leading to regeneration. In an earlier series of studies we analyzed the cellular cascades that transform a cut axonal end into a competent GC. We found that axotomy of cultured Aplysia neurons leads to a ...

journal_title：Experimental neurology

authors： Kamber D,Erez H,Spira ME

更新日期：2009-09-01 00:00:00

abstract：:Cervical spinal cord injury leads to a disruption of bulbospinal innervation from medullary respiratory centers to phrenic motoneurons. Animal models utilizing cervical hemisection result in inhibition of ipsilateral phrenic nerve activity, leading to paralysis of the hemidiaphragm. We have previously demonstrated a r...

journal_title：Experimental neurology

authors： Basura GJ,Zhou SY,Walker PD,Goshgarian HG

更新日期：2001-06-01 00:00:00

abstract：:Peripheral nerve injury can result in formation of a neuroma, which is often associated with heightened sensitivity to normally innocuous stimuli as well as spontaneous dysesthesia and pain. The onset and persistence of neuropathic pain have been linked to spontaneous ectopic electrogenesis in axons within neuromas, s...

journal_title：Experimental neurology

authors： Persson AK,Gasser A,Black JA,Waxman SG

更新日期：2011-08-01 00:00:00

abstract：:Nerve growth factor (NGF) enhances neuronal survival during injury to the mature central and peripheral nervous systems, but its potential as a neuroprotective factor in the enteric nervous system (ENS) has not been examined. We used the trinitrobenzene sulfonic acid (TNBS)-induced model of colitis to examine if NGF-s...

journal_title：Experimental neurology

authors： Lin A,Lourenssen S,Stanzel RD,Blennerhassett MG

更新日期：2005-02-01 00:00:00

abstract：:The pathogenic factors leading to selective degeneration of motoneurons in ALS are not yet understood. However, altered functionality of voltage-dependent Na(+) channels may play a role since cortical hyperexcitability was described in ALS patients and riluzole, the only drug approved to treat ALS, seems to decrease g...

journal_title：Experimental neurology

authors： DiFebo F,Curti D,Botti F,Biella G,Bigini P,Mennini T,Toselli M

更新日期：2012-08-01 00:00:00

abstract：:The effects of intranigral iron injection on dopamine (DA) release and content in the caudate putamen (CPu) and their relationship to DA-related behavioral response were investigated in rats. Different concentrations of FeCl(3) (10, 20, and 40 microg) and saline were injected separately into the left substantia nigra....

journal_title：Experimental neurology

authors： Junxia X,Hong J,Wenfang C,Ming Q

更新日期：2003-08-01 00:00:00

abstract：:We have analyzed a mouse model of Charcot-Marie-Tooth disease 2E (CMT2E) harboring a heterozygous p.Asn98Ser (p.N98S) Nefl mutation, whose human counterpart results in a severe, early-onset neuropathy. Behavioral, electrophysiological, and pathological analyses were done on separate cohorts of NeflN98S/+ mutant mice a...

journal_title：Experimental neurology

authors： Lancaster E,Li J,Hanania T,Liem R,Scheideler MA,Scherer SS

更新日期：2018-10-01 00:00:00

abstract：:After optic nerve transection beta cells of cat retinal ganglion cells (RGCs) suffer from rapid cell death from 3 to 7 days, whereas alpha cells gradual cell death until 14 days. Here we report electrophysiological properties of Y- (morphological alpha) and X- (morphological beta) cells at 5 and 14 days after axotomy ...

journal_title：Experimental neurology

authors： Takao M,Miyoshi T,Watanabe M,Fukuda Y

更新日期：2002-09-01 00:00:00

abstract：:Adrenergic-stimulated phosphatidylinositol (PI) hydrolysis was measured in cortical slices obtained from adult rats following electroconvulsive seizures (ECS). One group of animals received ECS daily for 15 days and a second group received a single ECS. Rats were then sacrificed at intervals of 15 min, 60 min, 4 h, an...

journal_title：Experimental neurology

authors： Dubeau F,Sherwin AL

更新日期：1989-08-01 00:00:00

abstract：:Studies of the effects of lesions of the parietal cortex suggest that this region plays a critical role in visuomotor guidance, whereas experiments on the effects of disconnecting this region from visual input have been inconsistent in supporting this hypothesis. In the present experiment, monkeys with a unilateral oc...

journal_title：Experimental neurology

authors： Jason GW

更新日期：1983-07-01 00:00:00

abstract：:When adrenal medullary cells are cultured in vitro, tyrosine hydroxylase (TH) mRNA, preproenkephalin (PPEnk) mRNA, and methionine enkephalin (Mek) immunoreactivity was markedly increased compared with intact adrenal medullary cells in situ, suggesting an increased biosynthesis of catecholamines and enkephalin-containi...

journal_title：Experimental neurology

authors： Wang XT,Unnerstall JR,Ibuki T,Wang H,Pappas GD

更新日期：2000-01-01 00:00:00

abstract：:The tibial functional index has been employed to assess functional recovery in rats following nerve repair by direct coaptation under tension or by grafting. Recovery after direct repair of small to moderate gap sizes was better than that after grafting. ...

journal_title：Experimental neurology

authors： Wong AY,Scott JJ

更新日期：1991-12-01 00:00:00

abstract：:Sleep and behavioral monitoring of young mice is necessary for understating the progress of symptoms in congenital and acquired diseases associated with sleep and movement disorders. In the current study, we have developed a non-invasive sleep monitoring system that identifies wake and sleep patterns of newborn mice u...

journal_title：Experimental neurology

authors： Sato M,Sagawa Y,Hirai N,Sato S,Okuro M,Kumar S,Kanbayashi T,Shimizu T,Sakai N,Nishino S

更新日期：2014-11-01 00:00:00

abstract：:Functional relations between hippocampal lamellae, the modular units arranged in parallel in the hippocampal formation, were studied in the guinea pig in experiments of evoked field potential analysis. Perforant path volleys, synaptically elicited by stimulation of the dorsal hippocampal commissure, were used to activ...

journal_title：Experimental neurology

authors： Bartesaghi R,Gessi T,Sperti L

更新日期：1983-12-01 00:00:00

abstract：:The cortical reorganization after spinal cord injury (SCI) involves a series of physiological changes that drive the expansion of the intact cortical area to the deafferented cortical area. These changes have always been studied under a stimulus-response paradigm, which demonstrates that the deafferented cortex become...

journal_title：Experimental neurology

authors： Fernández-López E,Alonso-Calviño E,Humanes-Valera D,Foffani G,Aguilar J

更新日期：2019-12-01 00:00:00

abstract：:Respiratory motor output after cervical spinal cord injury (cSCI) is profoundly influenced by spinal serotonin. We hypothesized that intraspinal transplantation of embryonic midline brainstem (MB) cells rich in serotonergic raphé neurons would improve respiratory outcomes after cSCI. One week after hemisection of the ...

journal_title：Experimental neurology

authors： Dougherty BJ,Gonzalez-Rothi EJ,Lee KZ,Ross HH,Reier PJ,Fuller DD

更新日期：2016-04-01 00:00:00

abstract：:Estrogens and N-methyl-D-aspartate (NMDA) receptors regulate multiple aspects of morphological and functional plasticity in young animals. For example, estrogens increase spine density in the hippocampus, and NMDA antagonists block these effects. Few studies have examined the effects of age, postovariectomy interval, ...

journal_title：Experimental neurology

authors： Adams MM,Oung T,Morrison JH,Gore AC

更新日期：2001-08-01 00:00:00

abstract：:Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, are inflammatory demyelinating diseases of the central nervous system. The inflammatory attacks lead to glial dysfunction and death, axonal damage, and neurological deficits. Numerous studies in rat suggest that extrace...

journal_title：Experimental neurology

authors： Brand-Schieber E,Werner P

更新日期：2004-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by cognitive decline and deposition of beta-amyloid (Abeta) plaques in cortex and hippocampus. A transgenic mouse AD model (Tg2576) that overexpresses a mutant form of human Abeta precursor protein exhibits age-related cognitive deficits, Abeta plaque deposition, and oxidative...

journal_title：Experimental neurology

authors： Stackman RW,Eckenstein F,Frei B,Kulhanek D,Nowlin J,Quinn JF

更新日期：2003-11-01 00:00:00

abstract：:Forebrain-bisected cats underwent kindling at primary and secondary amygdala sites. The behavioral effect of amygdala kindling was then examined according to the extent of the surgical lesion in the forebrain commissures. Bisection of the corpus callosum with or without lesion of the hippocampal commissure modified bo...

journal_title：Experimental neurology

authors： Fukuda H,Wada JA,Riche D,Naquet R

更新日期：1987-10-01 00:00:00

abstract：:Microglia were described by Pio del Rio-Hortega (1932) as being the 'third element' distinct from neurons and astrocytes. Decades after this observation, the function and even the very existence of microglia as a distinct cell type were topics of intense debate and conjecture. However, considerable advances have been ...

journal_title：Experimental neurology

authors： Trang T,Beggs S,Salter MW

更新日期：2012-04-01 00:00:00

abstract：:The sympathetic innervation of lumbar dorsal root ganglia (DRGs) and the possible presence of spinal cord circuits connecting primary sensory afferents to the sympathetic outflow to DRGs were investigated. We used simultaneous tracing of the sympathetic input to and sensory output from DRGs. Adult male rats received u...

journal_title：Experimental neurology

authors： Hofstetter CP,Card JP,Olson L

更新日期：2005-07-01 00:00:00

abstract：:Antegrade, target-directed axonal regeneration is the explicit goal of nerve repair. However, aberrant and dysfunctional regrowth is commonly observed as well. At the site of surgical nerve coaptation, axonal sprouts encounter fibrotic connective tissue rich in growth-inhibiting chondroitin sulfate proteoglycan that m...

journal_title：Experimental neurology

authors： Graham JB,Neubauer D,Xue QS,Muir D

更新日期：2007-01-01 00:00:00

abstract：:Increasing evidence indicates that the cytokines, tumor necrosis factor (TNF), interleukin-1, and/or interferon-gamma, may play a crucial role in the pathogenesis of multiple sclerosis. Several reports demonstrated that inhibition of TNF is highly protective in experimental allergic encephalomyelitis (EAE) when sensit...

journal_title：Experimental neurology

authors： Martin D,Near SL,Bendele A,Russell DA

更新日期：1995-02-01 00:00:00

abstract：:We have recently shown that tanycytes present in the median eminence (ME) constitute a preferential support for the regeneration of lesioned neurohypophysial oxytocinergic and vasopressinergic axons. However, although tanycytes are particularly abundant in the ME, they are also present along the third ventricle wall. ...

journal_title：Experimental neurology

authors： Chauvet N,Prieto M,Alonso G

更新日期：1998-05-01 00:00:00

abstract：:Alpha-synuclein (alphaSN) is implicated in Parkinson's disease (PD) and is the major component of Lewy bodies (LBs). Although alphaSN is mainly expressed in neuronal cells and exists as a cytoplasmic protein, it has been found in body fluids including cerebrospinal fluid and blood. This study explored plasma alphaSN a...

journal_title：Experimental neurology

authors： Li QX,Mok SS,Laughton KM,McLean CA,Cappai R,Masters CL,Culvenor JG,Horne MK

更新日期：2007-04-01 00:00:00

abstract：:Neuronal apoptosis is a central pathological process in subarachnoid hemorrhage (SAH)-induced early brain injury. Previous studies indicated that ErbB4 (EGFR family member v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) is essential for normal development and maintenance of the nervous system. In this...

journal_title：Experimental neurology

authors： Yan F,Tan X,Wan W,Dixon BJ,Fan R,Enkhjargal B,Li Q,Zhang J,Chen G,Zhang JH

更新日期：2017-11-01 00:00:00