Autoradiographic distribution of bombesin/gastrin-releasing peptide receptors in fetal cortex transplants.

abstract：:The threshold current required for the excitation of visual cortex neurons in the vicinity (approximately 1 mm) of an intracortical stimulating electrode was measured as a function of the stimulus pulse duration in the anesthetized cat. For cortical neurons with latencies of activation from 0.4 to 3.4 ms and for stimu...

journal_title：Experimental neurology

authors： Ronner SF,Lee BG

更新日期：1983-08-01 00:00:00

abstract：:Eph tyrosine kinase receptors and their ligands, the ephrins, play a key role in the establishment of retinotectal topography during development. Tectal up-regulation of ephrin-A2 in goldfish, coincident with the reestablishment of a retinotectal map, suggests a similar role during optic nerve regeneration. Here we re...

journal_title：Experimental neurology

authors： King CE,Wallace A,Rodger J,Bartlett C,Beazley LD,Dunlop SA

更新日期：2003-10-01 00:00:00

abstract：:Oxaliplatin (OXA) is the common and extremely potent anti-advanced colorectal cancer chemotherapeutic. Accumulating evidence reveals that OXA evokes mechanical and cold hypersensitivity. However, the mechanism underlying these bothersome and dose-limiting adverse effects is poorly understood. It is well known that cyc...

journal_title：Experimental neurology

authors： Jiang SP,Zhang ZD,Kang LM,Wang QH,Zhang L,Chen HP

更新日期：2016-01-01 00:00:00

abstract：:The postischemic time course of amyloid protein precursor (APP), beta-amyloid protein (beta-AP), and apolipoprotein E (APO-E) immunoreactivity were examined in comparison to neuronal necrosis in the selectively vulnerable hippocampal CA1 region of gerbils subjected to 10 min of bilateral carotid occlusion-induced fore...

journal_title：Experimental neurology

authors： Hall ED,Oostveen JA,Dunn E,Carter DB

更新日期：1995-09-01 00:00:00

abstract：:Forebrain-bisected cats underwent kindling at primary and secondary amygdala sites. The behavioral effect of amygdala kindling was then examined according to the extent of the surgical lesion in the forebrain commissures. Bisection of the corpus callosum with or without lesion of the hippocampal commissure modified bo...

journal_title：Experimental neurology

authors： Fukuda H,Wada JA,Riche D,Naquet R

更新日期：1987-10-01 00:00:00

abstract：:Neonatal hypoxia-ischemia (HI) is the most common cause of brain injury in neonates, which leads to high neonatal mortality and severe neurological morbidity in later life (Vannucci, 2000; Volpe, 2001). Yet the molecular mechanisms of neuronal death and brain damage induced by neonatal HI remain largely elusive. Herei...

journal_title：Experimental neurology

authors： Ma Q,Zhang L

更新日期：2018-06-01 00:00:00

abstract：:The inferior colliculus was selected as a brain stem site for study of neural grafting and identification of calcium binding proteins. Unilateral ablation sites of eight midbrain inferior colliculus in adult Long-Evans rats were implanted with E17-18 caudal tectum. After 2 to 9 months animals were sacrificed and secti...

journal_title：Experimental neurology

authors： Coleman JR,McDonald AJ,Pinek B,Zrull MC

更新日期：1992-01-01 00:00:00

abstract：:Idiopathic inflammatory myopathies (IIMs), comprising of polymyositis, dermatomyositis, and inclusion-body myositis, are characterized by muscle weakness and various types of inflammatory changes in muscle cells. They also show non-inflammatory changes, including perifascicular atrophy, mitochondrial changes, and amyl...

journal_title：Experimental neurology

authors： Nozaki K,Das A,Ray SK,Banik NL

更新日期：2010-10-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) in dorsal root ganglia (DRGs) are known to be upregulated and to contribute to the mechanisms of neuropathic pain following peripheral nerve injury. Moreover, transcription factor c-Jun regulates the expressions of both VIP and NPY in cultured DRG neurons. T...

journal_title：Experimental neurology

authors： Son SJ,Lee KM,Jeon SM,Park ES,Park KM,Cho HJ

更新日期：2007-03-01 00:00:00

abstract：:Hyperbaric oxygen preconditioning (HBO-PC) has been demonstrated to attenuate hemorrhagic transformation (HT) after middle cerebral artery occlusion (MCAO) in hyperglycemic rats. However, the mechanisms remain to be illustrated. Recently, HBO-PC has been shown to activate peroxisome proliferator-activated receptor-gam...

journal_title：Experimental neurology

authors： Bian H,Hu Q,Liang X,Chen D,Li B,Tang J,Zhang JH

更新日期：2015-03-01 00:00:00

abstract：:Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, in which the myelin sheath has been considered to be the primary target for many years. However, an increasing number of reports have focused on neurodegenerative aspects of the disease pathogenesis. Recent studies i...

journal_title：Experimental neurology

authors： Herz J,Zipp F,Siffrin V

更新日期：2010-09-01 00:00:00

abstract：:Chronic dopamine depletion produces neurochemical changes within the striatum as well as enhanced behavioral and metabolic responses to dopamine agonists. Changes in striatal neuropeptides have been consistently described, including increased expression of preproenkephalin mRNA and decreased expression of preprotachyk...

journal_title：Experimental neurology

authors： Harrison MB,Kumar S,Hubbard CA,Trugman JM

更新日期：2001-02-01 00:00:00

abstract：:Adult cats were subjected to subarachnoid hemorrhage by three repeated intracisternal injections of autogenous nonheparinized blood (2 ml/injection) at weekly intervals. Histological studies (light and electron microscope) were made of the basilar artery and the middle cerebral arteries of all animals. In the subarach...

journal_title：Experimental neurology

authors： Clower BR,Kapp JP,Moore NA,Smith RR,Haining JL

更新日期：1986-11-01 00:00:00

abstract：:Triggering receptor expressed on myeloid cells-2 (TREM2) was a newly identified receptor expressed on microglia. Several observations support the hypothesis that TREM2 variation may confer susceptibility to Parkinson's disease (PD). Therefore, in this paper, we explored the role of TREM2 in the 1-methyl-4-phenyl-1,2,3...

journal_title：Experimental neurology

authors： Ren M,Guo Y,Wei X,Yan S,Qin Y,Zhang X,Jiang F,Lou H

更新日期：2018-04-01 00:00:00

abstract：:Cross-species transplantation of dopamine-releasing cell lines protected against immune rejection by a semi-permeable synthetic membrane may provide a source of neurotransmitters for the treatment of Parkinson's disease. Experiments were carried out to assess whether polymer-encapsulated PC12 cells, a catecholaminergi...

journal_title：Experimental neurology

authors： Aebischer P,Tresco PA,Winn SR,Greene LA,Jaeger CB

更新日期：1991-03-01 00:00:00

abstract：:Uncertainties from the literature concerning the role of apolipoprotein E (apoE) in central cholinergic function prompted us to investigate what effect apoE may have on transmission at the neuromuscular junction. Both spontaneous and evoked release were measured in isolated extensor digitorum longus (edl) and soleus m...

journal_title：Experimental neurology

authors： Everett AW,Ernst EJ

更新日期：2004-02-01 00:00:00

abstract：:The effects of neonatal 6-hydroxydopamine (6-OHDA) treatment on the projection of locus coeruleus (LC) neurons to the dorsal part of the lateral geniculate nucleus (dLGN) were examined using histofluorescence and electrophysiological methods. Histofluorescence studies confirmed the previous results of Gustafson and Mo...

journal_title：Experimental neurology

authors： Aoki F,Nakamura S

更新日期：1991-06-01 00:00:00

abstract：:One approach to repair of transected nerves is to attempt extrinsic guidance of axons across the gaps. We inserted the proximal and distal stumps of severed mouse sciatic nerves into opposite ends of biodegradable polyester tubes. The nerves and ensheathing tubes were examined after postoperative survival times of as ...

journal_title：Experimental neurology

authors： Henry EW,Chiu TH,Nyilas E,Brushart TM,Dikkes P,Sidman RL

更新日期：1985-12-01 00:00:00

abstract：:Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, are inflammatory demyelinating diseases of the central nervous system. The inflammatory attacks lead to glial dysfunction and death, axonal damage, and neurological deficits. Numerous studies in rat suggest that extrace...

journal_title：Experimental neurology

authors： Brand-Schieber E,Werner P

更新日期：2004-09-01 00:00:00

abstract：:Convection-enhanced delivery (CED) distributes macromolecules in the brain in a homogeneous, targeted fashion in clinically useful volumes. However, the binding of growth factors to heparin-binding sites in the extracellular matrix may limit the volume of distribution (V(d)). To overcome this limitation, we examined t...

journal_title：Experimental neurology

authors： Hamilton JF,Morrison PF,Chen MY,Harvey-White J,Pernaute RS,Phillips H,Oldfield E,Bankiewicz KS

更新日期：2001-03-01 00:00:00

abstract：:Huntington's disease (HD) is a hereditary, progressive and ultimately fatal neurodegenerative disorder. Excitotoxicity and reduced availability of neurotrophic factors (NTFs) likely play roles in HD pathogenesis. Recently we developed a protocol that induces adult human bone marrow derived mesenchymal stem cells (MSCs...

journal_title：Experimental neurology

authors： Sadan O,Shemesh N,Barzilay R,Dadon-Nahum M,Blumenfeld-Katzir T,Assaf Y,Yeshurun M,Djaldetti R,Cohen Y,Melamed E,Offen D

更新日期：2012-04-01 00:00:00

abstract：:Numerous epidemiological studies have shown an association between pesticide exposure and an increased risk of developing Parkinson's disease (PD). Here, we provide evidence that the insecticide dieldrin causes specific oxidative damage in the nigrostriatal dopamine (DA) system. We report that exposure of mice to low ...

journal_title：Experimental neurology

authors： Hatcher JM,Richardson JR,Guillot TS,McCormack AL,Di Monte DA,Jones DP,Pennell KD,Miller GW

更新日期：2007-04-01 00:00:00

abstract：:The present study attempts to determine whether the neurotoxicity of p-chloroamphetamine (PCA) is dependent on a releasable pool of serotonin (5-HT). Rats treated with PCA alone or with reserpine and PCA exhibit a profound loss of 5-HT innervation in cerebral cortex after a 2-week survival period. However, depletion o...

journal_title：Experimental neurology

authors： Berger UV,Grzanna R,Molliver ME

更新日期：1989-02-01 00:00:00

abstract：:This study was performed to investigate the physicological properties of histaminergic neurons in intraocular hypothalamic transplants. Pieces of posterolateral hypothalamus containing the tuberomammillary nucleus were dissected from Embryonic Day 17 rat fetuses and transplanted into the anterior chamber of the eye of...

journal_title：Experimental neurology

authors： Bergman H,Prell GD,Lupica CR,Granholm AC

更新日期：1995-11-01 00:00:00

abstract：:Granule cell (GC) neurogenesis increases following seizures, and some newborn GCs develop in abnormal locations within the hilus. These ectopic GCs (EGCs) display robust spontaneous and evoked excitatory activity. However, the pattern of afferent input they receive has not been fully defined. This study used electron ...

journal_title：Experimental neurology

authors： Pierce JP,Melton J,Punsoni M,McCloskey DP,Scharfman HE

更新日期：2005-12-01 00:00:00

abstract：:Organotypic cultures of the brain provide a unique opportunity to directly examine the regional vulnerability of specific brain regions like the hippocampus. Two well-characterized models of oxidative stress were used to examine the regional vulnerability of the hippocampus. Endogenous oxidative stress was induced by ...

journal_title：Experimental neurology

authors： Vornov JJ,Park J,Thomas AG

更新日期：1998-01-01 00:00:00

abstract：:Neuronal activity in the locus ceruleus of awake, behaving stump-tailed monkeys increased consistently and vigorously after presentation of mildly aversive and threatening stimuli. These preliminary data increase the range of stimuli reported to elicit locus ceruleus activity in awake monkeys to include nonpainful thr...

journal_title：Experimental neurology

authors： Grant SJ,Redmond DE Jr

更新日期：1984-06-01 00:00:00

abstract：:The aim of this study was to elucidate whether oligodendrocytes die in fiber tracts that are spared by a spinal cord injury but are in close vicinity of inflammatory cells. Adult rat spinal cords were studied histologically 1 day to 2 weeks after a contusion lesion that left the ventral white matter largely intact. Ma...

journal_title：Experimental neurology

authors： Frei E,Klusman I,Schnell L,Schwab ME

更新日期：2000-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by cognitive decline and deposition of beta-amyloid (Abeta) plaques in cortex and hippocampus. A transgenic mouse AD model (Tg2576) that overexpresses a mutant form of human Abeta precursor protein exhibits age-related cognitive deficits, Abeta plaque deposition, and oxidative...

journal_title：Experimental neurology

authors： Stackman RW,Eckenstein F,Frei B,Kulhanek D,Nowlin J,Quinn JF

更新日期：2003-11-01 00:00:00

abstract：:Human recombinant activated factor-VII (rFVIIa) has been used successfully in the treatment of spontaneous intracerebral hemorrhage. In addition, there is increasing interest in its use to treat uncontrolled bleeding of other origins, including trauma. The aim of this study was to evaluate the safety and potential eff...

journal_title：Experimental neurology

authors： Zhang J,Groff RF 4th,Chen XH,Browne KD,Huang J,Schwartz ED,Meaney DF,Johnson VE,Stein SC,Rojkjaer R,Smith DH

更新日期：2008-04-01 00:00:00