Transient up-regulation of retinal EphA3 and EphA5, but not ephrin-A2, coincides with re-establishment of a topographic map during optic nerve regeneration in goldfish.

Abstract:

:Eph tyrosine kinase receptors and their ligands, the ephrins, play a key role in the establishment of retinotectal topography during development. Tectal up-regulation of ephrin-A2 in goldfish, coincident with the reestablishment of a retinotectal map, suggests a similar role during optic nerve regeneration. Here we report a complementary study of EphA3, EphA5 and ephrin-A2 expression in the retina. EphA3 and EphA5 are transiently up-regulated as ascending naso-temporal gradients, whereas ephrin-A2 remains uniform. The expression profiles differ from those in developing chick and mouse, suggesting that different combinations of retinal Eph receptors and ligands can generate topographic guidance information.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

King CE,Wallace A,Rodger J,Bartlett C,Beazley LD,Dunlop SA

doi

10.1016/s0014-4886(03)00211-5

keywords:

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

593-9

issue

2

eissn

0014-4886

issn

1090-2430

pii

S0014488603002115

journal_volume

183

pub_type

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