Abstract:
:Previous work utilizing the 2-deoxyglucose (2-DG) technique demonstrated that denervation, both direct (enucleation) or indirect (retinal receptor destruction, leaving ganglion cells intact), resulted in a depression followed by an increase in glucose metabolism in the superior colliculus (SC) of the mature hooded rat. Both enucleation and receptor loss result in (1) cessation of ganglion cell activity and (2) disruption of connections between visual system neurons. To examine the relative importance of these two factors to the metabolic depression-"recovery" sequence, retinal ganglion cells were silenced without denervation for periods ranging from 24 h to 2 months by means of repeated intraocular tetrodotoxin (TTX) injections. SC metabolic activity fell to levels comparable to those seen after enucleation or receptor damage, but no recovery was detected. A more sensitive within-animal comparison was carried out to detect any small shifts in metabolic activity which might have occurred during retinal blockade; after 1 or 2 months of monocular TTX treatment, either binocular enucleation or binocular TTX injections were performed 24 h before 2-DG, depriving both sides of the SC of retinal input. Metabolic activity was slightly higher in the SC that had received no retinal input for 1 or 2 months, indicating that physiological changes had occurred within the SC during the afferent blockade. A second group of rats was allowed to recover from the effects of long-term TTX for from 1 to 12 days and binocularly exposed to visual stimuli during 2-DG uptake to determine whether damage had resulted from the TTX injections and to assess the time course of the effects of retinal blockade on SC functional activity.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Thurlow GA,Cooper RMdoi
10.1016/0014-4886(89)90040-xsubject
Has Abstractpub_date
1989-06-01 00:00:00pages
272-8issue
3eissn
0014-4886issn
1090-2430journal_volume
104pub_type
杂志文章abstract::Studies of the effects of lesions of the parietal cortex suggest that this region plays a critical role in visuomotor guidance, whereas experiments on the effects of disconnecting this region from visual input have been inconsistent in supporting this hypothesis. In the present experiment, monkeys with a unilateral oc...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(83)90161-9
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2017.03.019
更新日期:2017-07-01 00:00:00
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更新日期:1984-05-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1998-02-01 00:00:00
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doi:10.1016/0014-4886(84)90014-1
更新日期:1984-04-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
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更新日期:1997-01-01 00:00:00
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1994.1058
更新日期:1994-04-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(85)90215-8
更新日期:1985-02-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:2000-12-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1991-07-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(95)90005-5
更新日期:1995-01-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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