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Kynurenine aminotransferase in the supratentorial dura mater of the rat: effect of stimulation of the trigeminal ganglion.

Abstract：

:Electrical stimulation of the trigeminal ganglion has been widely used as a model of nociception, characterizing migraine. This treatment is known to evoke release of neuropeptides and neurotransmitters from nerve fibers of the dura mater. On the basis of immunocytochemical investigations, we found that under normal conditions, surface membranes of Schwann cells surrounding nerve fibers in the supratentorial dura mater display kynurenine aminotransferase-immunoreaction (KAT-IR); also KAT-IR are the granules of mast cells and the cytoplasms of macrophages (histiocytes). In consequence of stimulation of the trigeminal ganglion, Schwann cells in the dura mater became conspicuously swollen while their KAT-IR decreased considerably; also KAT-IR of mast cells and macrophages decreased significantly. At the same time, nitric oxide synthase (NOS)-IR of nerve fibers in the dura mater increased, suggesting release of nitric oxide (NO), this is known to be involved in NMDA receptor activation leading to vasodilation followed by neurogenic inflammation. Because kynurenic acid (KYNA) is an antagonist of NMDA receptors, we hypothesize that KYNA and its synthesizing enzyme, KAT, may play a role in the prevention of migraine attacks.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Knyihár-Csillik E,Chadaide Z,Okuno E,Krisztin-Péva B,Toldi J,Varga C,Molnár A,Csillik B,Vécsei L

doi

10.1016/j.expneurol.2003.12.001

keywords:

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

242-7

issue

2

eissn

0014-4886

issn

1090-2430

pii

S0014488603005934

journal_volume

186

pub_type

杂志文章

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