Abstract：
:Breathing is a life-sustaining behavior that in mammals is accomplished by activation of dedicated muscles responsible for inspiratory and expiratory forces acting on the lung and chest wall. Motor control is exerted by specialized pools of motoneurons in the medulla and spinal cord innervated by projections from multiple centers primarily in the brainstem that act in concert to generate both the rhythm and pattern of ventilation. Perturbations that prevent the accomplishment of the full range of motor behaviors by respiratory muscles commonly result in significant morbidity and increased mortality. Recent developments in gene therapy and novel targeting strategies have contributed to deeper understanding of the organization of respiratory motor systems. Gene therapy has received widespread attention and substantial progress has been made in recent years with the advent of improved tools for vector design. Genes can be delivered via a variety of plasmids, synthetic or viral vectors and cell therapies. In recent years, adeno-associated viruses (AAV) have become one of the most commonly used vector systems, primarily because of the extensive characterization conducted to date and the versatility in targeting strategies. Recent studies highlight the power of using AAV to selectively and effectively transduce respiratory motoneurons and muscle fibers with promising therapeutic effects. This brief review summarizes current evidence for the use of gene therapy in respiratory disorders with a primary focus on interventions that address motor control and neuroplasticity, including regeneration, in the respiratory system.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Mantilla CBdoi
10.1016/j.expneurol.2016.09.014subject
Has Abstractpub_date
2017-01-01 00:00:00pages
261-267issue
Pt 2eissn
0014-4886issn
1090-2430pii
S0014-4886(16)30300-4journal_volume
287pub_type
杂志文章,评审abstract：:The role of type IIA receptor protein tyrosine phosphatases (RPTPs), which includes LAR, RPTPσ and RPTPδ, in the nervous system is becoming increasingly recognized. Evidence supports a significant role for these RPTPs during the development of the nervous system as well as after injury, and mutations in RPTPs are asso...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2014.02.007
更新日期：2014-05-01 00:00:00
abstract：:The repair of nerve gap injuries with tubular nerve guides has been used extensively as an in vivo test model in identifying substances which may enhance nerve regeneration. The model has also been used clinical nerve repair. The objective of this study was to compare three different gel matrix-forming materials as po...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6543
更新日期：1997-08-01 00:00:00
abstract：:Axonal injury is present in essentially all clinically significant cases of traumatic brain injury (TBI). While no effective treatment has been identified to date, experimental TBI models have shown promising axonal protection using immunosuppressants FK506 and Cyclosporine-A, with treatment benefits attributed to cal...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2016.06.011
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Intracerebral hemorrhage (ICH) is the common brain diseases in middle-aged and elderly people, with high disability and/or mortality rate, and is a serious public health concern. Both WNK3 kinase and the WNK3/SPAK/NKCC1 signaling pathway play an integral role in maintaining normal cell homeostasis. However, ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113386
更新日期：2020-10-01 00:00:00
abstract：:The members of the tenascin family are involved in a number of developmental processes, mainly by their ability to regulate cell adhesion. We have here studied the distribution of mRNAs for tenascin-X, -C, and -R and the closely related molecule tenascin/J1 in the olfactory system and spinal cord. The olfactory bulb a...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7543
更新日期：2000-12-01 00:00:00
abstract：:The antinociceptive properties of a new synthetic dipeptide (N-hexanoyl-5-hydroxytryptophyl-5-hydroxytryptophan amide, or 5-HTP-DP-hex) were studied in rats by an electrophysiological method. After an i.p. injection of alpha-chloralose and urethane, the animals were prepared for stereotaxic approach to the nucleus ven...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90214-7
更新日期：1987-06-01 00:00:00
abstract：:Parkinson's disease (PD) is associated with complex compensatory changes in the functional and neurochemical anatomy of the basal ganglia resulting from striatal dopamine deficiency. Available evidence suggests that glutamatergic corticostriatal pathway becomes overactive following nigrostriatal dopaminergic denervati...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2003.12.012
更新日期：2004-05-01 00:00:00
abstract：:With the consideration of the multifactorial etiology of diabetic peripheral neuropathy, an ideal drug or drug combination should target at least several key pathogenetic mechanisms. The flavonoid baicalein (5,6,7-trihydroxyflavone) has been reported to counteract sorbitol accumulation, activation of 12/15-lipoxygenas...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.04.002
更新日期：2011-07-01 00:00:00
abstract：:Mitochondria actively participate in neurotransmission by providing energy (ATP) and maintaining normative concentrations of reactive oxygen species (ROS) in both presynaptic and postsynaptic elements. In human and animal epilepsies, ATP-producing respiratory rates driven by mitochondrial respiratory complex (MRC) I a...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2013.11.005
更新日期：2014-01-01 00:00:00
abstract：:We examined the myelin repair potential of transplanted neural precursor cells derived from the adult human brain from tissue removed during surgery. Sections of removed brain indicated that nestin-positive cells were found predominantly in the subventricular zone around the anterior horns of the lateral ventricle and...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7539
更新日期：2001-01-01 00:00:00
abstract：:Spinal axons in the larval sea lamprey regenerate following a complete spinal transection. It is not known whether regenerating growth cones require contact with cellular elements or whether the basement membrane and collagenous meninx primitiva which surround the spinal cord are sufficient for neurite out-growth. To ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90114-r
更新日期：1991-04-01 00:00:00
abstract：:Traumatic brain injury (TBI) causes persistent neurologic deficits. Current therapies, predominantly focused upon cortical and hippocampal cellular survival, have limited benefit on cognitive outcomes. Striatal damage is associated with deficits in executive function, learning, and memory. Dopamine and cAMP regulated ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.02.013
更新日期：2011-06-01 00:00:00
abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) has neuroprotective effects against ischemia, even when given by intravenous (iv) administration 24 h after stroke. Transport of PACAP across the blood-brain barrier (BBB) by peptide transport system (PTS)-6 underlies its effectiveness after iv administration....
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.09.013
更新日期：2005-01-01 00:00:00
abstract：:Functional neural reconnection is not common after spinal cord transection in the CNS of adult higher vertebrates but has been demonstrated in embryonic avian and neonatal mammalian CNS. Chick brainstem spinal cord preparations from nontransected controls and embryos transected at the cervical level on embryonic days ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6944
更新日期：1998-12-01 00:00:00
abstract：:Typical antipsychotic drugs (APDs) with D2antagonistic properties impede functional outcome after experimental traumatic brain injury (TBI) and reduce the effectiveness of environmental enrichment (EE). Here we test the hypothesis that aripiprazole (ARIP), an atypical APD with partial D2and 5-HT1Areceptor agonist acti...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2019.01.010
更新日期：2019-04-01 00:00:00
abstract：:Activation of the visual system with a moving black and white geometric pattern resulted in dense patches or columns of 2-deoxyglucose label in primate extrastriate visual cortex. The three-dimensional reconstruction of these metabolic columns showed that they were arranged in irregularly shaped slabs which extended i...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90148-1
更新日期：1984-08-01 00:00:00
abstract：:AMPAkines are positive modulators of AMPA receptors, and previous work has shown that these compounds can facilitate synaptic plasticity and improve learning and memory in both animals and humans; thus, their role in the treatment of cognitive impairment is worthy of investigation. In this study, we have utilized an o...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.07.010
更新日期：2008-11-01 00:00:00
abstract：:A graded contusion spinal cord injury (SCI) was created in the adult rat spinal cord using the Infinite Horizons (IH) impactor to study the correlation between injury severity and anatomical, behavioral, and electrophysiological outcomes. Adult Fisher rats were equally divided into five groups and received contusion i...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.08.026
更新日期：2005-02-01 00:00:00
abstract：:The roles of activated NF-kappaB subunits in the CNS remain to be discerned. Members of this family of transcription factors are essential to diverse physiological processes and can be activated by pathogens, stress, pharmacological agents, and trauma. We are particularly interested in long-term NF-kappaB activation a...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2002.7967
更新日期：2002-08-01 00:00:00
abstract：:We have used retrograde labeling with horseradish peroxidase (HRP) and a wheat germ agglutinin conjugate of HRP (WGA:HRP) to investigate the projections of the nucleus postglomerulosus (nPg) both in normal goldfish and in animals which had undergone retinal removal. In normal animals, our evidence indicates that nPg p...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90089-1
更新日期：1988-11-01 00:00:00
abstract：:The accumulation of damage to DNA plays a significant role in the etiology of the aging process. The importance of nutrition in delaying the aging process is well recognized. L-carnitine is a quaternary ammonium compound heterogeneously distributed in the brain. In the present study the effect of L-carnitine on DNA da...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.09.009
更新日期：2005-01-01 00:00:00
abstract：:The chorda tympani (CT) nerve carries taste information from the anterior tongue to the brain stem. Injury to the chorda tympani may result in loss or distortion of taste information. This study examined changes occurring in the hamster peripheral taste system during recovery from injury. The hamster chorda tympani ne...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.0169
更新日期：1996-10-01 00:00:00
abstract：:The amount of myelination in vivo and in vitro depends on the number of oligodendrocyte progenitors, their differentiation, and on the neuron function. It has been shown that continuous administration of FGF2, a mitotic and neuroprotective factor, allows oligodendrocyte progenitors to proliferate, but prevents them fr...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(02)00053-5
更新日期：2003-05-01 00:00:00
abstract：:Injections of horseradish peroxidase were made into surgically exposed superior cervical ganglia of Sprague-Dawley rats weighing 250 to 320 g. Anterogradely labeled postganglionic fibers were observed in the nervus conarii, pineal gland, pineal stalk, and the choroid plexus. Terminal fields were identified in lamina i...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90101-4
更新日期：1987-08-01 00:00:00
abstract：:The axonal trajectories of inspiratory bulbospinal neurons were examined after deposition of the anterograde neuronal tracer phaseolus vulgaris leucoagglutinin (PHA-L) into the rostral ventral respiratory group in rats. At the level of the phrenic nucleus, PHA-L-labeled bulbospinal axons crossed the midline of the spi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90061-g
更新日期：1991-01-01 00:00:00
abstract：:Experimental autoimmune neuritis (EAN) is an animal model of the human disease Guillain-Barré syndrome. In this autoimmune inflammatory disease, CD4(+) T cells mediate demyelination in the peripheral nervous system (PNS). Infiltrating macrophages and T cells as well as cytokines like interferon (IFN)-gamma are intimat...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7662
更新日期：2001-06-01 00:00:00
abstract：:We compared mitochondrial respiratory chain function, mitochondrial DNA (mtDNA) integrity, and oxidative stress levels in muscle, myoblasts, fibroblasts and cybrids, from 12 amyotrophic lateral sclerosis (ALS) patients with 28 control samples. Mitochondrial respiratory chain enzyme activities were normal in muscle, my...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2009.04.007
更新日期：2009-07-01 00:00:00
abstract：:Anti-CD40 ligand monoclonal antibody prevents the interaction between CD40 and its T-cell-based ligand, thereby resulting in selective inhibition of T cell costimulation without pan-T-cell suppression. This antibody has found application in several animal models of solid organ transplantation. This study investigated ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2003.10.002
更新日期：2004-03-01 00:00:00
abstract：:Neuronal migration was investigated in rodent cerebellum in vitro and in vivo. Time-lapse video recording showed that cultured neurons migrated on laminin by first extending neurites that formed contacts with other neurons. This was followed by movement of the cell nucleus inside the preformed process. No guidance cue...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(92)90119-b
更新日期：1992-08-01 00:00:00
abstract：:One of the most interesting findings in the field of neurodegeneration in recent years is tfche discovery of a genetic mutation in the C9orf72 gene, the most common mutation found to be causative of sporadic and familial frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) and concomitant FTD-...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2014.06.001
更新日期：2014-12-01 00:00:00
