Abstract：
:Peripheral nerve crush injury (PNCI) has been used for many years in adult animals to study central and peripheral changes related to regeneration across the injury site. While these adult animals experience full recovery with no neuronal cell loss following PNCI, it has been noted that the injury in perinatal animals is followed by retrograde neuronal cell death. The present study determines, in mice of different postnatal ages, the degree to which motor neurons are vulnerable to PNCI induced cell death and examines the rate of neuronal loss. Animals of 4 days of age and younger were found to be significantly more vulnerable to motor neuron cell death following PNCI. There also was a proportional relationship between age at injury and final motor neuronal survival and an inverse relationship between age at injury and rate of neuronal cell death following injury. In addition a proportional relationship was observed between the expression level of acidic fibroblast growth factor within motor neurons and the resistance to PNCI induced neuronal death. It was also found that PNCI in an environment that contained higher levels of FGFs (either in mice treated with acidic FGF or in transgenic mice that overexpress basic FGF) significantly decreases neuronal cell death following early postnatal injury.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Kuzis K,Coffin JD,Eckenstein FPdoi
10.1006/exnr.1999.7014keywords:
subject
Has Abstractpub_date
1999-05-01 00:00:00pages
77-87issue
1eissn
0014-4886issn
1090-2430pii
S0014-4886(99)97014-0journal_volume
157pub_type
杂志文章abstract：:The development of reliable biological markers of nigrostriatal degeneration has important implications from both experimental and clinical viewpoints, since such biomarkers could be used for diagnostic and monitoring purposes in models of parkinsonism as well as in Parkinson's disease patients. In this study, levels ...
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