Abstract:
:Physiological/anatomical studies of rat frontal cortex in vitro have distinguished subpopulations of gamma-aminobutyric acid (GABA)-expressing inhibitory interneurons defined by expression of the calcium-binding proteins, parvalbumin (PV) and calbindin (CA). Using a novel 2DG/immunostaining technique to double-label hamster barrel cortex for metabolism and phenotype, we have recently shown that while many GABAergic neurons are heavily 2DG labeled during normal exploratory behavior, a subset of GABAergic cells shows relatively sparse 2DG labeling. For this study we used the 2DG/immunostaining technique to test whether, in awake behaving animals, calcium-binding protein expression in a given cell in barrel cortex (as indicated by immunohistochemistry for PV or CA) was related to the degree of 2DG labeling. We found that most PV+ cells were moderately to heavily 2DG labeled, while most CA+ cells were lightly 2DG labeled. Our data indicate that the PV+ and CA+ cells represent metabolically distinct subpopulations of GABAergic neurons in barrel cortex. This distinction corresponds well with the in vitro physiological and anatomical data from frontal cortex and suggests functional implications for the expression of PV and CA, or other colocalized factors, in normally functioning cortical circuitry.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Maier DL,McCasland JSdoi
10.1006/exnr.1997.6426subject
Has Abstractpub_date
1997-05-01 00:00:00pages
71-80issue
1eissn
0014-4886issn
1090-2430pii
S0014-4886(97)96426-8journal_volume
145pub_type
杂志文章abstract::We have previously demonstrated that octanoic (OA) and decanoic acids (DA) inhibit Na+, K+ ATPase activity in synaptic plasma membranes from rat brain. The objective of the present study was to investigate the in vitro effects of the other metabolites that accumulate in tissues of medium-chain acyl-CoA dehydrogenase (...
journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1998.6893
更新日期:1998-11-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章,评审
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更新日期:2013-08-01 00:00:00
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2002.8004
更新日期:2002-10-01 00:00:00
abstract::Green tea polyphenol is known to act as a buffer, reducing biological responses to oxidative stress. Several effects of polyphenol have been reported, such as protection of tissue from ischemia, antineoplasmic and anti-inflammatory effects, and suppression of arteriosclerosis. In this study, we investigated whether pe...
journal_title:Experimental neurology
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更新日期:2003-12-01 00:00:00
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journal_title:Experimental neurology
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doi:10.1016/j.expneurol.2005.07.009
更新日期:2005-11-01 00:00:00
abstract::In birds, a variety of subtotal thoracic spinal cord lesions were made to determine the spinal cord pathways essential for avian hind limb locomotion (bipedal walking). The various surgical disruptions included: section of the dorsal half of the cord, a hemisection, section of the dorsal cord and ventromedial funiculi...
journal_title:Experimental neurology
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doi:10.1016/0014-4886(87)90148-8
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abstract::Cervical spinal cord injury leads to a disruption of bulbospinal innervation from medullary respiratory centers to phrenic motoneurons. Animal models utilizing cervical hemisection result in inhibition of ipsilateral phrenic nerve activity, leading to paralysis of the hemidiaphragm. We have previously demonstrated a r...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2001.7682
更新日期:2001-06-01 00:00:00
abstract::Major practical constraints on neural grafting in Parkinson's disease are the shortage of human donor tissue and the great loss of dopamine neurons during the grafting procedure. The vast majority of implanted embryonic dopamine neurons are believed to die within a few days of transplantation surgery, at least in part...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2000.7406
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abstract::In the present study homonymous and heteronymous projections of muscle spindle afferent fibers in the human jaw-closing system were investigated. Stretch reflex responses were elicited with percutaneous displacement stimuli applied to the belly of the anterior superficial divisions of temporalis and masseter muscles. ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(85)90070-6
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(92)90016-j
更新日期:1992-10-01 00:00:00
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1994.1058
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1993.1005
更新日期:1993-01-01 00:00:00
abstract::Axons of the CNS do normally not regenerate after injury, in contrast to axons of the PNS. This is due to a different microenvironment at the site of the lesion as well as a particular intrinsic program of axonal regrowth. Although transplantation of peripheral nerve tissue bridges is perhaps the most successful appro...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7204
更新日期:1999-11-01 00:00:00
abstract::A variety of growth factors are being explored as therapeutic agents relevant to the axonal and oligodendroglial deficits that occur as a result of demyelinating lesions such as are evident in Multiple Sclerosis (MS). This review focuses on five such proteins that are present in the lesion site and impact oligodendroc...
journal_title:Experimental neurology
pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
abstract::Trophic factors are expressed by neurons throughout several areas of the CNS. We studied the mRNA expression of a member of the neurotrophin family, brain-derived neurotrophic factor (BDNF), and of the two receptor transcripts, full-length trkB and truncated trkB in single intraocular cortex cerebri grafts and in doub...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1994.1092
更新日期:1994-06-01 00:00:00
abstract::The effect of corporal hypothermia on regional blood flow in peripheral nerve is unknown. We compared blood flow in resting sciatic nerves of anesthetized, normothermic rats with that of rats whose rectal temperatures had been acutely lowered to 28 to 30 degrees C. Peripheral nerve regional blood flow in normothermic ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90098-7
更新日期:1987-08-01 00:00:00
abstract::The present study was carried out to determine if augmentation of phrenic nerve activity during the crossed phrenic phenomenon temporally coincides with the morphological changes in the phrenic nucleus that we have observed in previous studies. This investigation consisted of two experiments in spinal cord hemisected ...
journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1991-02-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(88)90048-9
更新日期:1988-09-01 00:00:00
abstract::Human recombinant activated factor-VII (rFVIIa) has been used successfully in the treatment of spontaneous intracerebral hemorrhage. In addition, there is increasing interest in its use to treat uncontrolled bleeding of other origins, including trauma. The aim of this study was to evaluate the safety and potential eff...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2007.12.019
更新日期:2008-04-01 00:00:00