Pioglitazone activates paraoxonase-2 in the brain: A novel neuroprotective mechanism.


:Paraoxonase-2 regulates reactive oxygen species production in mitochondria. Stimulating its expression has therapeutic potential for diseases where oxidative stress plays a significant role in the pathology. Evidence suggests that the anti-diabetic drug pioglitazone may provide neuroprotection in Parkinson's disease, Alzheimer's disease, brain trauma and ischemia, but the biochemical pathway(s) responsible has not been fully elucidated. Here we report that pioglitazone (10 mg/kg/day) for 5 days significantly increased paraoxonase-2 expression in mouse striatum. Thus, this result highlights paraoxonase-2 as a target for neuroprotective strategies and identifies pioglitazone as a tool to study the role of paraoxonase-2 in brain.


Exp Neurol


Experimental neurology


Blackburn JK,Curry DW,Thomsen AN,Roth RH,Elsworth JD




Has Abstract


2020-05-01 00:00:00












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    journal_title:Experimental neurology

    pub_type: 杂志文章,评审


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    更新日期:2017-01-01 00:00:00