Pioglitazone activates paraoxonase-2 in the brain: A novel neuroprotective mechanism.

Abstract:

:Paraoxonase-2 regulates reactive oxygen species production in mitochondria. Stimulating its expression has therapeutic potential for diseases where oxidative stress plays a significant role in the pathology. Evidence suggests that the anti-diabetic drug pioglitazone may provide neuroprotection in Parkinson's disease, Alzheimer's disease, brain trauma and ischemia, but the biochemical pathway(s) responsible has not been fully elucidated. Here we report that pioglitazone (10 mg/kg/day) for 5 days significantly increased paraoxonase-2 expression in mouse striatum. Thus, this result highlights paraoxonase-2 as a target for neuroprotective strategies and identifies pioglitazone as a tool to study the role of paraoxonase-2 in brain.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Blackburn JK,Curry DW,Thomsen AN,Roth RH,Elsworth JD

doi

10.1016/j.expneurol.2020.113234

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

113234

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(20)30065-0

journal_volume

327

pub_type

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