Pioglitazone activates paraoxonase-2 in the brain: A novel neuroprotective mechanism.

abstract：:The sciatic nerve of the rat is a commonly used model for studies on nerve injury, regeneration, and recovery of function. To interpret the changes that occur in a neuron population subsequent to peripheral nerve injury, and to compare different repair procedures, it is essential to have a complete and accurate unders...

journal_title：Experimental neurology

authors： Swett JE,Wikholm RP,Blanks RH,Swett AL,Conley LC

更新日期：1986-07-01 00:00:00

abstract：:Fibroblast Growth Factors (FGFs) and their receptors (FGFRs) are widely expressed in the mature nervous system and are thought to mediate plasticity and repair. We report the generation of transgenic mice that can be induced to express a dominant-negative FGFR (dnFGFR) in select neuronal populations. We show that a mo...

journal_title：Experimental neurology

authors： Eckenstein FP,McGovern T,Kern D,Deignan J

更新日期：2006-04-01 00:00:00

abstract：:Dementia and parkinsonism are late-onset symptoms associated with repetitive head injury, as documented in multiple contact-sport athletes. Clinical symptomatology is the likely phenotype of chronic degeneration and circuit disruption in the substantia nigra (SN). To investigate the initiating neuropathology, we hypot...

journal_title：Experimental neurology

authors： van Bregt DR,Thomas TC,Hinzman JM,Cao T,Liu M,Bing G,Gerhardt GA,Pauly JR,Lifshitz J

更新日期：2012-03-01 00:00:00

abstract：:Muscle disuse-induced changes in the cholinergic system of sciatic nerve, slow-twitch soleus (SOL), and fast-twitch extensor digitorum longus (EDL) muscles were studied in rats. Rats with hind limbs suspended for 2 to 3 weeks showed marked elevation in the activity of choline acetyltransferase in sciatic nerve (38%), ...

journal_title：Experimental neurology

authors： Gupta RC,Misulis KE,Dettbarn WD

更新日期：1985-09-01 00:00:00

abstract：:Following cholinergic denervation of the hippocampal formation, peripheral sympathetic fibers from the superior cervical ganglion (SCG) sprout into hippocampal tissue. The molecular mechanism controlling this process is unknown, although a role by trophic factors seems likely. In the present study, neonatal SCG were u...

journal_title：Experimental neurology

authors： Conner JM,Varon S

更新日期：1994-11-01 00:00:00

abstract：:Electroconvulsive therapy (ECT) is one of the most effective treatments in cases of severe and treatment resistant major depression. 60-80% of patients respond to ECT, but the procedure is demanding and robust prediction of ECT responses would be of great clinical value. Predictions based on neuroimaging data have rec...

journal_title：Experimental neurology

authors： Gärtner M,Ghisu E,Herrera-Melendez AL,Koslowski M,Aust S,Asbach P,Otte C,Regen F,Heuser I,Borgwardt K,Grimm S,Bajbouj M

更新日期：2021-01-01 00:00:00

abstract：:In the June issue of Experimental Neurology, Nizzardo and colleagues demonstrate that the beta-lactam antibiotic ceftriaxone is neuroprotective in a mouse model of spinal muscular atrophy. Here I review their main findings and the relevance to previous and future work on motor neuron disorders and for developing thera...

journal_title：Experimental neurology

authors： Hedlund E

更新日期：2011-09-01 00:00:00

abstract：:This study examines the effects of high K+ concentration on the growth and development of mesencephalic cells and their glutamate vulnerability. Mesencephalic cell cultures obtained from Wistar rat embryos on the 14th gestational day were maintained for 14 days in medium with either normal (4.2 mM) or elevated (24.2 m...

journal_title：Experimental neurology

authors： Andreeva N,Ungethum U,Heldt J,Marschhausen G,Altmann T,Andersson K,Gross J

更新日期：1996-02-01 00:00:00

abstract：:Massive increases in extracellular dopamine have been reported in the ischemic rodent striatum, implicating this neurotransmitter in toxic events. We have examined whether dopamine receptor antagonists are protective against hypoxic insult, using brain slices containing the rostral striatum obtained from adult male C5...

journal_title：Experimental neurology

authors： Davis S,Brotchie J,Davies I

更新日期：2002-07-01 00:00:00

abstract：:Neuron loss in layer III of the entorhinal cortex (EC) occurs in patients with temporal lobe epilepsy and in several animal models of the disease and may play a role in the development of spontaneously recurring seizures. This damage can be reproduced in rats by a focal microinjection of the indirect excitotoxin amino...

journal_title：Experimental neurology

authors： Wu HQ,Schwarcz R

更新日期：1998-10-01 00:00:00

abstract：:Ischemic stroke is an acute neurodegenerative disease that is extremely devastating to patients, their families and society. Stroke is inadequately treated even with endovascular procedures and reperfusion therapy. Using an extensive translational screening process, we have developed a pleiotropic cytoprotective agent...

journal_title：Experimental neurology

authors： Lapchak PA,Boitano PD,Bombien R,Cook DJ,Doyan S,Lara JM,Schubert DR

更新日期：2019-03-01 00:00:00

abstract：:Embryonic stem cells (ESCs) promise an unlimited source of defined cells for cell transplantation therapy, while protocols for derivation of homogeneous populations of desirable cell types are yet to be developed and/or refined. Gamma aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervo...

journal_title：Experimental neurology

authors： Chatzi C,Scott RH,Pu J,Lang B,Nakamoto C,McCaig CD,Shen S

更新日期：2009-06-01 00:00:00

abstract：:Previous studies have shown that the herpes simplex virus type 2 protein kinase ICP10 PK activates the Ras/MEK/MAPK pathway in nonneuronal cells. Here we report that ectopically expressed ICP10 PK has anti-apoptotic activity in various paradigms of neuronal cell death. Neuronally differentiated PC12 cells and primary ...

journal_title：Experimental neurology

authors： Perkins D,Yu Y,Bambrick LL,Yarowsky PJ,Aurelian L

更新日期：2002-03-01 00:00:00

abstract：:Axonal injury close to cell bodies of motoneurons induces the death of the vast majority of affected cells. Neurotrophic factors, such as brain derived neurotrophic factor (BDNF) and glial cell derived neurotrophic factor (GDNF), delivered close to the damaged motor pool in a non-regulated manner induce good survival ...

journal_title：Experimental neurology

authors： Pajenda G,Hercher D,Márton G,Pajer K,Feichtinger GA,Maléth J,Redl H,Nógrádi A

更新日期：2014-11-01 00:00:00

abstract：:Microglia were described by Pio del Rio-Hortega (1932) as being the 'third element' distinct from neurons and astrocytes. Decades after this observation, the function and even the very existence of microglia as a distinct cell type were topics of intense debate and conjecture. However, considerable advances have been ...

journal_title：Experimental neurology

authors： Trang T,Beggs S,Salter MW

更新日期：2012-04-01 00:00:00

abstract：:Infants born very preterm are at high risk for neurological deficits including cerebral palsy. In this study we assessed the neuroprotective effects of umbilical cord blood cells (UCBCs) and optimal administration timing in a fetal sheep model of preterm brain injury. 50 million allogeneic UCBCs were intravenously adm...

journal_title：Experimental neurology

authors： Li J,Yawno T,Sutherland A,Loose J,Nitsos I,Bischof R,Castillo-Melendez M,McDonald CA,Wong FY,Jenkin G,Miller SL

更新日期：2016-09-01 00:00:00

abstract：:Rats were given unilateral 6-hydroxydopamine lesions and tested 4 weeks later for rotational behavior elicited by either systemic or intranigral injections of dopamine agonists. Subsequently, transplants of fetal (E14) ventral mesencephalic (VM) or cortical tissue were implanted into the lesioned substantia nigra and ...

journal_title：Experimental neurology

authors： Yurek DM

更新日期：1997-01-01 00:00:00

abstract：:This study was performed to investigate the physicological properties of histaminergic neurons in intraocular hypothalamic transplants. Pieces of posterolateral hypothalamus containing the tuberomammillary nucleus were dissected from Embryonic Day 17 rat fetuses and transplanted into the anterior chamber of the eye of...

journal_title：Experimental neurology

authors： Bergman H,Prell GD,Lupica CR,Granholm AC

更新日期：1995-11-01 00:00:00

abstract：:Deep brain stimulation (DBS) of the subthalamic nucleus (STN) can be a highly effective treatment for Parkinson's disease (PD). However, therapeutic efficacy is limited by difficulties in consistently and correctly targeting this nucleus. Increasing evidence suggests that there is abnormal synchronization of beta freq...

journal_title：Experimental neurology

authors： Chen CC,Pogosyan A,Zrinzo LU,Tisch S,Limousin P,Ashkan K,Yousry T,Hariz MI,Brown P

更新日期：2006-03-01 00:00:00

abstract：:Little is known about the morphological effects of alcoholism on the developing adolescent brain and its consequences into adulthood. We studied here the relationship between two neurotransmitter systems (the serotoninergic and nitrergic) and the astrocytic and neuronal cytoskeleton immediately and long after drinking...

journal_title：Experimental neurology

authors： Evrard SG,Duhalde-Vega M,Tagliaferro P,Mirochnic S,Caltana LR,Brusco A

更新日期：2006-08-01 00:00:00

abstract：:The functional and morphologic consequences of treatment of peripheral nerve lesions with exogenous 3,3',5-triiodo-L-thyronine (T3) are unclear. In this study adult Wistar rats with sciatic nerve crush lesions were treated with 20 micrograms/kg/day of T3. The treated animals gained weight though more slowly than vehic...

journal_title：Experimental neurology

authors： Allpress SJ,Pollock M

更新日期：1986-02-01 00:00:00

abstract：:Stress is a common environmental factor associated with depressive illness and the amygdala is thought to be integral for this association. For example, repeated stress impairs amygdalar neuroplasticity in rodents and these defects parallel amygdalar deficits in depressive illness patients. Because the excitatory neur...

journal_title：Experimental neurology

authors： Piroli GG,Reznikov LR,Grillo CA,Hagar JM,Fadel JR,Reagan LP

更新日期：2013-03-01 00:00:00

abstract：:Infusions of an excitant amino acid, N-methyl-D-aspartate (NMDA) into the inferior colliculus (IC) render normal rats susceptible to audiogenic seizures (AGS) and/or spontaneous audiogenic-like seizures without tonic components. The excess excitant amino acid in the IC and the anticonvulsant effects of NMDA antagonist...

journal_title：Experimental neurology

authors： Browning RA,Wang C,Faingold CL

更新日期：1991-05-01 00:00:00

abstract：:The possible pain inhibitory effects of periaqueductal gray (PAG) stimulation were investigated in cats anesthetized with Nembutal and immobilized with Flaxedil. Unitary responses evoked by electrical stimulation of the upper canine dentine and by cutaneous facial noxious and nonnoxious stimuli were recorded extracell...

journal_title：Experimental neurology

authors： Figueiras R,Buño W Jr,García-Austt E,Delgado JM

更新日期：1983-07-01 00:00:00

abstract：:We provide evidence for apoptosis in Alzheimer's disease using the in situ labeling technique TUNEL (terminal transferase-mediated dUTP-biotin nick end labeling). The technique specifically detects apoptotic cells by utilizing terminal transferase to incorporate biotinylated nucleotides into the fragmented DNA of apop...

journal_title：Experimental neurology

authors： Smale G,Nichols NR,Brady DR,Finch CE,Horton WE Jr

更新日期：1995-06-01 00:00:00

abstract：:Human spinal cord injury (SCI) can result in progressive degeneration that may continue for many years and lead to the formation of highly septated cystic cavities. This hallmark feature has been reproduced in experimental models, but neither its pathogenesis nor clinically relevant features have been fully elucidated...

journal_title：Experimental neurology

authors： Radojicic M,Reier PJ,Steward O,Keirstead HS

更新日期：2005-12-01 00:00:00

abstract：:We recently reported structural changes in nodes of Ranvier of frog dorsal roots that are associated with activation at 20 or 50 Hz for 15 min. The structural effects co-occur with alterations in the latency, amplitude, and waveform of the compound action potential. The alterations in nodal morphology include formatio...

journal_title：Experimental neurology

authors： Wurtz CC,Ellisman MH

更新日期：1988-07-01 00:00:00

abstract：:Four lectins (Abrus precatorius (APA), Maackia amurensis (MAA), Momordica charantia (MCA) and Sambucus nigra (SNA)) have been used to identify glycohistochemically the microglial cells (MGC) activation in autoptic brain samples from Alzheimer's disease (AD) subjects. Three of these lectins (APA, MAA and MCA) have util...

journal_title：Experimental neurology

authors： Zambenedetti P,Giordano R,Zatta P

更新日期：1998-09-01 00:00:00

abstract：:Genetically dystrophic chicks (line 413) were administered 0.3 mg/kg dexamethasone (DEX), a corticosteroid, from 2 to 28 days ex ovo. Diluent-injected dystrophic and normal (line 412) chicks served as controls. The effects of DEX on muscle function were evaluated weekly by the exhaustion score (ES) method. Proton magn...

journal_title：Experimental neurology

authors： Misra LK,Entrikin RK

更新日期：1988-11-01 00:00:00

abstract：:The review outlines data consistent with the hypothesis that inspiratory drive transmission that generates fetal breathing movements (FBMs) is essential for the developmental plasticity of phrenic motoneurons (PMNs) and diaphragm musculature prior to birth. A systematic examination during the perinatal period demonstr...

journal_title：Experimental neurology

authors： Greer JJ,Martin-Caraballo M

更新日期：2017-01-01 00:00:00