Abstract:
:Paraoxonase-2 regulates reactive oxygen species production in mitochondria. Stimulating its expression has therapeutic potential for diseases where oxidative stress plays a significant role in the pathology. Evidence suggests that the anti-diabetic drug pioglitazone may provide neuroprotection in Parkinson's disease, Alzheimer's disease, brain trauma and ischemia, but the biochemical pathway(s) responsible has not been fully elucidated. Here we report that pioglitazone (10 mg/kg/day) for 5 days significantly increased paraoxonase-2 expression in mouse striatum. Thus, this result highlights paraoxonase-2 as a target for neuroprotective strategies and identifies pioglitazone as a tool to study the role of paraoxonase-2 in brain.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Blackburn JK,Curry DW,Thomsen AN,Roth RH,Elsworth JDdoi
10.1016/j.expneurol.2020.113234subject
Has Abstractpub_date
2020-05-01 00:00:00pages
113234eissn
0014-4886issn
1090-2430pii
S0014-4886(20)30065-0journal_volume
327pub_type
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