Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach.

abstract：:Hyperreflexia develops after spinal cord injury (SCI) in the human and in the spinal cord transected animal, and can be measured by the loss of low frequency-dependent depression of the H-reflex. Previous studies demonstrated normalization of low frequency-dependent depression of the H-reflex using passive exercise wh...

journal_title：Experimental neurology

authors： Yates CC,Charlesworth A,Reese NB,Skinner RD,Garcia-Rill E

更新日期：2008-10-01 00:00:00

abstract：:The dependence of movement on visual information was compared for healthy individuals and Stage II-III patients with Parkinson's disease (PD). A time delay (0-1400 ms) was introduced into a visually guided motor tracking task which required the subject to maintain constant index finger position relative to a stationar...

journal_title：Experimental neurology

authors： Beuter A,Milton JG,Labrie C,Glass L,Gauthier S

更新日期：1990-11-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder associated with selective loss of the dopaminergic neurons in the substantia nigra. We have previously shown that tetrahydrobiopterin (BH4), the obligatory cofactor for dopamine synthesis, exerts selective toxicity on dopamine-producing cells. In the present study we...

journal_title：Experimental neurology

authors： Choi HJ,Kim SW,Lee SY,Moon YW,Hwang O

更新日期：2003-06-01 00:00:00

abstract：:Infant rats were subjected to pentylenetetrazol-induced convulsions on alternate days from 5 to 13 days of age. At 17 days of age, their susceptibility to the convulsant effects of hyperthermia was examined. It was found that previous pentylenetetrazol-induced convulsions caused a significant facilitation in the devel...

journal_title：Experimental neurology

authors： McCaughran JA Jr,Manetto C

更新日期：1983-01-01 00:00:00

abstract：:Multiple cellular and molecular interactions are required for the differentiation and development of central neurons. For example, neural activity may modulate trophic function. In the developing cerebellum, establishment of functional excitatory synaptic connections coincides with the expression of NGF and its recept...

journal_title：Experimental neurology

authors： Cohen-Cory S,Elliott RC,Dreyfus CF,Black IB

更新日期：1993-02-01 00:00:00

abstract：:The effects of D-Ala2-Met5-enkephalinamide (DAME) upon the hissing component of hypothalamically elicited affective defense behavior in the cat were examined in this study. Microinjections of DAME placed into the nucleus accumbens significantly suppressed this response in a dose and time dependent manner. This dose de...

journal_title：Experimental neurology

authors： Brutus M,Zuabi S,Siegel A

更新日期：1989-04-01 00:00:00

abstract：:We have recently shown that tanycytes present in the median eminence (ME) constitute a preferential support for the regeneration of lesioned neurohypophysial oxytocinergic and vasopressinergic axons. However, although tanycytes are particularly abundant in the ME, they are also present along the third ventricle wall. ...

journal_title：Experimental neurology

authors： Chauvet N,Prieto M,Alonso G

更新日期：1998-05-01 00:00:00

abstract：:The regional cerebral blood flow of 27 young (mean age 24 years) schizophrenic patients was measured using the intravenous 133Xe method. The results were compared with those obtained from a group of age- and sex-matched control subjects. The main findings of the study were as follows: (a) the gray matter mean values o...

journal_title：Experimental neurology

authors： Dousse M,Mamo H,Ponsin JC,Tran Dinh Y

更新日期：1988-04-01 00:00:00

abstract：:The anticonvulsant long-term efficacy of diazepam was studied in amygdala-kindled rats. The drug was administered three times daily at doses of 5 mg/kg i.p. for 2 weeks in fully kindled animals. The severity of the kindled seizures was markedly reduced throughout the period of treatment, while tolerance developed to t...

journal_title：Experimental neurology

authors： Löscher W,Schwark WS

更新日期：1985-11-01 00:00:00

abstract：:Twenty-eight-day-old (juvenile) rats were kindled with hourly stimulations to partial or fully kindled status. Adult rats were stimulated with hourly or daily stimulations. Alterations in [3H]dihydroalprenolol binding were determined 3 weeks after the last stimulation. We found that partially kindled, hourly stimulate...

journal_title：Experimental neurology

authors： Michelson HB,Buterbaugh GG

更新日期：1987-01-01 00:00:00

abstract：:Triggering receptor expressed on myeloid cells-2 (TREM2) was a newly identified receptor expressed on microglia. Several observations support the hypothesis that TREM2 variation may confer susceptibility to Parkinson's disease (PD). Therefore, in this paper, we explored the role of TREM2 in the 1-methyl-4-phenyl-1,2,3...

journal_title：Experimental neurology

authors： Ren M,Guo Y,Wei X,Yan S,Qin Y,Zhang X,Jiang F,Lou H

更新日期：2018-04-01 00:00:00

abstract：:Stroke is a devastating neurological disease with no satisfactory therapies to preserve long-term neurological function, perhaps due to the sole emphasis on neuronal survival in most preclinical studies. Recent studies have revealed the importance of protecting multiple cell types in the injured brain, such as oligode...

journal_title：Experimental neurology

authors： Zhang W,Wang H,Zhang H,Leak RK,Shi Y,Hu X,Gao Y,Chen J

更新日期：2015-10-01 00:00:00

abstract：:beta-N-methylamino-l-alanine (BMAA) is a non-protein amino acid implicated in the neurodegenerative disease amyotrophic lateral sclerosis/Parkinson-dementia complex (ALS/PDC) on Guam. BMAA has recently been discovered in the brains of Alzheimer's patients in Canada and is produced by various species of cyanobacteria a...

journal_title：Experimental neurology

authors： Liu X,Rush T,Zapata J,Lobner D

更新日期：2009-06-01 00:00:00

abstract：:Although aluminum (Al) contributes to a variety of cognitive dysfunctions and mental diseases, the underlying mechanisms of Al interactions with the nervous system are still unknown. We have studied the action of Al on synaptic transmission and long-term potentiation (LTP) by performing electrophysiological recordings...

journal_title：Experimental neurology

authors： Platt B,Carpenter DO,Büsselberg D,Reymann KG,Riedel G

更新日期：1995-07-01 00:00:00

abstract：:Synaptic reorganization of mossy fibers following kainic acid (KA) administration has been reported to contribute to the formation of recurrent excitatory circuits, resulting in an epileptogenic state. It is unclear, however, whether KA-induced mossy fiber sprouting results from neuronal cell loss or the seizure activ...

journal_title：Experimental neurology

authors： Schauwecker PE,Ramirez JJ,Steward O

更新日期：2000-01-01 00:00:00

abstract：:Alcohol intake is one of the important lifestyle factors for the risk of insulin resistance and type 2 diabetes. Acetaldehyde, the major ethanol metabolite which is far more reactive than ethanol, has been postulated to participate in alcohol-induced tissue injury although its direct impact on insulin signaling is unc...

journal_title：Experimental neurology

authors： Fang CX,Yang X,Sreejayan N,Ren J

更新日期：2007-01-01 00:00:00

abstract：:Some forms of electrographic seizures are generated at the level of the cortical network. Neocortical kindling exhibits a resistance to produce generalized convulsive seizures, and therefore, it was rather difficult to use it to study the cortical epileptogenesis. Here, using supra-threshold cortical kindling, we repo...

journal_title：Experimental neurology

authors： Nita DA,Cissé Y,Timofeev I

更新日期：2008-06-01 00:00:00

abstract：:Adult cats were subjected to subarachnoid hemorrhage by three repeated intracisternal injections of autogenous nonheparinized blood (2 ml/injection) at weekly intervals. Histological studies (light and electron microscope) were made of the basilar artery and the middle cerebral arteries of all animals. In the subarach...

journal_title：Experimental neurology

authors： Clower BR,Kapp JP,Moore NA,Smith RR,Haining JL

更新日期：1986-11-01 00:00:00

abstract：:Blood flow in the feline thoracic spinal cord was measured, using a laser-Doppler flowmetry. Rhythmic changes in the spinal cord blood flow were repeatedly observed with a frequency of about three to eight cycles per minute, unrelated to the respiratory or cardiac cycles. These changes were unaffected by hypertension ...

journal_title：Experimental neurology

authors： Mizutani M,Yamamuro T,Shikata J

更新日期：1988-08-01 00:00:00

abstract：:Lead induces peripheral nerve segmental demyelination in rats. Arsenic and thallium produce a peripheral neuropathy characterized by axonal degeneration in humans. Mercury and thallium appear to damage both the peripheral and the central nervous system. It is not known whether this difference in effect is due to diffe...

journal_title：Experimental neurology

authors： Windebank AJ

更新日期：1986-10-01 00:00:00

abstract：:Abuse of stimulant drugs such as methamphetamine (METH) and cocaine has been associated with long-lasting persistent behavioral alterations. Although METH-induced changes in the striatal dopaminergic system might play a role in these effects, the potential underlying neuroanatomical substrate for the chronic cognitive...

journal_title：Experimental neurology

authors： Kuczenski R,Everall IP,Crews L,Adame A,Grant I,Masliah E

更新日期：2007-09-01 00:00:00

abstract：:Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, in which the myelin sheath has been considered to be the primary target for many years. However, an increasing number of reports have focused on neurodegenerative aspects of the disease pathogenesis. Recent studies i...

journal_title：Experimental neurology

authors： Herz J,Zipp F,Siffrin V

更新日期：2010-09-01 00:00:00

abstract：:Sarcoplasmic reticulum (SR) of high purity and functional integrity was isolated from skeletal muscle of normal and ethanol-tolerant rats. Ethanol at low concentrations (0.1 to 0.2 M), added in vitro to isolated SR, resulted in slight inhibition of both calcium loading and calcium-stimulated ATPase rates. Higher conce...

journal_title：Experimental neurology

authors： Mrak RE

更新日期：1983-06-01 00:00:00

abstract：:In the neocortex, the effectiveness of potential transplantation therapy for diseases involving neuronal loss may depend upon whether donor neurons can reestablish the precise long-distance projections that form the basis of sensory, motor, and cognitive function. During corticogenesis, the formation of these connecti...

journal_title：Experimental neurology

authors： Hernit-Grant CS,Macklis JD

更新日期：1996-05-01 00:00:00

abstract：:After spinal cord injury (SCI), the majority of individuals develop spasticity, a debilitating condition involving involuntary movements, co-contraction of antagonistic muscles, and hyperreflexia. By acting on GABAergic and Ca2+-dependent signaling, current anti-spastic medications lead to serious side effects, includ...

journal_title：Experimental neurology

authors： Bilchak JN,Yeakle K,Caron G,Malloy D,Côté MP

更新日期：2021-01-13 00:00:00

abstract：:Nerve injury frequently results in development of chronic, dysesthetic pain and allodynia (painful sensation in response to benign stimulation). Following nerve injury, spinal cord glia become activated and secrete a number of inflammatory cytokines, including interleukin-1 (IL-1), which exists as two genetically dist...

journal_title：Experimental neurology

authors： Skoff AM,Zhao C,Adler JE

更新日期：2009-06-01 00:00:00

abstract：:Neuronal activity in the locus ceruleus of awake, behaving stump-tailed monkeys increased consistently and vigorously after presentation of mildly aversive and threatening stimuli. These preliminary data increase the range of stimuli reported to elicit locus ceruleus activity in awake monkeys to include nonpainful thr...

journal_title：Experimental neurology

authors： Grant SJ,Redmond DE Jr

更新日期：1984-06-01 00:00:00

abstract：:Tuberoinfundibular peptide of 39 residues (TIP39) synthesizing neurons at the caudal border of the thalamus and in the lateral pons project to areas rich in its receptor, the parathyroid hormone 2 receptor (PTH2R). These areas include many involved in processing nociceptive information. Here we examined the potential ...

journal_title：Experimental neurology

authors： Dimitrov EL,Petrus E,Usdin TB

更新日期：2010-11-01 00:00:00

abstract：:Major practical constraints on neural grafting in Parkinson's disease are the shortage of human donor tissue and the great loss of dopamine neurons during the grafting procedure. The vast majority of implanted embryonic dopamine neurons are believed to die within a few days of transplantation surgery, at least in part...

journal_title：Experimental neurology

authors： Hansson O,Castilho RF,Kaminski Schierle GS,Karlsson J,Nicotera P,Leist M,Brundin P

更新日期：2000-07-01 00:00:00

abstract：:A host protein encoded by the gene specifying the scrapie amyloid precursor affects pathogenesis of the transmissible spongiform encephalopathies: Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker's syndrome (GSS), and kuru in man, and scrapie in animals. We found a mutation in this gene of two patients ...

journal_title：Experimental neurology

authors： Goldgaber D,Goldfarb LG,Brown P,Asher DM,Brown WT,Lin S,Teener JW,Feinstone SM,Rubenstein R,Kascsak RJ

更新日期：1989-11-01 00:00:00