Alterations in beta-adrenergic receptor binding in partially and fully amygdala-kindled juvenile and adult rats.


:Twenty-eight-day-old (juvenile) rats were kindled with hourly stimulations to partial or fully kindled status. Adult rats were stimulated with hourly or daily stimulations. Alterations in [3H]dihydroalprenolol binding were determined 3 weeks after the last stimulation. We found that partially kindled, hourly stimulated juvenile rats showed a significant increase in the dissociation constant (Kd), with no change in maximal binding values. Fully kindled juvenile rats showed no change in Kd or Bmax. Partially kindled, hourly stimulated adult rats showed a significant decrease in Kd, with no change in Bmax. There was no change in Kd or Bmax values in fully kindled, hourly stimulated adult rats. Fully kindled, daily stimulated adult rats showed a decrease in maximal binding, with no change in Kd values. These findings indicate that kindling-induced beta-adrenergic receptor alterations were influenced by the age of the animal and the kindling parameters used, as well as the extent to which the animals were kindled.


Exp Neurol


Experimental neurology


Michelson HB,Buterbaugh GG




Has Abstract


1987-01-01 00:00:00














  • Presynaptic Caytaxin prevents apoptosis via deactivating DAPK1 in the acute phase of cerebral ischemic stroke.

    abstract::Death-associated protein kinase 1 (DAPK1) is a key protein that mediates neuronal death in ischemic stroke. Although the substrates of DAPK1 and molecular signal in stroke have been gradually discovered, the modulation of DAPK1 itself is still unclear. Here we first reveal that Caytaxin, a brain-specific member of BCL...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Wang S,Chen K,Yu J,Wang X,Li Q,Lv F,Shen H,Pei L

    更新日期:2020-07-01 00:00:00

  • Interaction between serotonergic and noradrenergic axons during axonal regeneration.

    abstract::The present experiments focused on the morphological interaction between serotonergic (5-HT) and noradrenergic (NA) axons during regeneration following partial axonal denervation in the cerebral cortex in adult rats. The denervation paradigm used employed two neurotoxins, one for 5-HT and one for NA axons, infused tog...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Liu Y,Ishida Y,Shinoda K,Nakamura S

    更新日期:2003-11-01 00:00:00

  • Permeability of the blood-brain barrier to HIV-1 Tat.

    abstract::Infection with human immunodeficiency virus-1 (HIV-1) is associated with dysfunctions of the central nervous system (CNS). HIV-1 induces its effects on the CNS by a variety of mechanisms, including by shedding the neurotoxic viral proteins such as gp120 and Tat. Both HIV-1 and gp120 have been shown to cross the blood-...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Banks WA,Robinson SM,Nath A

    更新日期:2005-05-01 00:00:00

  • The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model.

    abstract::Huntington's disease (HD) is an inherited progressive neurodegenerative disorder characterized by progressive movement, psychiatric and cognitive disturbances. Previous studies have indicated that HD pathogenesis may be mediated in part by loss of brain derived neurotrophic factor (BDNF). Antidepressants selectively b...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Peng Q,Masuda N,Jiang M,Li Q,Zhao M,Ross CA,Duan W

    更新日期:2008-03-01 00:00:00

  • Electrophysiology and morphometry of the Aalpha- and Abeta-fiber populations in the normal and regenerating rat sciatic nerve.

    abstract::We studied electrophysiological and morphological properties of the Aalpha- and Abeta-fibers in the regenerating sciatic nerve to establish whether these fiber types regenerate in numerical proportion and whether and how the electrophysiological properties of these fiber types are adjusted during regeneration. Compoun...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Vleggeert-Lankamp CL,van den Berg RJ,Feirabend HK,Lakke EA,Malessy MJ,Thomeer RT

    更新日期:2004-06-01 00:00:00

  • Depletion of serotonin using p-chlorophenylalanine (PCPA) and reserpine protects against the neurotoxic effects of p-chloroamphetamine (PCA) in the brain.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Berger UV,Grzanna R,Molliver ME

    更新日期:1989-02-01 00:00:00

  • Cyclic AMP elevates tubulin expression without increasing intrinsic axon growth capacity.

    abstract::Exposing rat dorsal root ganglion (DRG) neurons to dibutyryl cAMP (db-cAMP) enables central branches to regenerate in the spinal cord by nullifying the ability of CNS myelin to inhibit elongation. A conditioning lesion (CL) promotes similar regeneration of central branches in the spinal cord by increasing neuronal cAM...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Han PJ,Shukla S,Subramanian PS,Hoffman PN

    更新日期:2004-10-01 00:00:00

  • Functional neuromuscular stimulation to improve severe hand dysfunction after stroke: does inhibitory rTMS enhance therapeutic efficiency?

    abstract:BACKGROUND:Novel strategies to improve hand function after stroke are needed. Electromyography-triggered functional neuromuscular stimulation (EMG-FNMS) and repetitive transcranial magnetic stimulation (rTMS) are promising techniques to facilitate recovery of sensory-motor hand dysfunction after stroke. OBJECTIVE:To i...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Theilig S,Podubecka J,Bösl K,Wiederer R,Nowak DA

    更新日期:2011-07-01 00:00:00

  • Unilateral parietal brain injury increases risk-taking on a rat gambling task.

    abstract::Traumatic brain injury (TBI) affects millions of individuals every year. Many of these injuries lead to lasting effects, particularly impairments in domains broadly classified as executive functions, such as impulse control and decision-making. While these impairments have been historically associated with frontal bra...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Ozga-Hess JE,Whirtley C,O'Hearn C,Pechacek K,Vonder Haar C

    更新日期:2020-05-01 00:00:00

  • Dieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine system.

    abstract::Numerous epidemiological studies have shown an association between pesticide exposure and an increased risk of developing Parkinson's disease (PD). Here, we provide evidence that the insecticide dieldrin causes specific oxidative damage in the nigrostriatal dopamine (DA) system. We report that exposure of mice to low ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Hatcher JM,Richardson JR,Guillot TS,McCormack AL,Di Monte DA,Jones DP,Pennell KD,Miller GW

    更新日期:2007-04-01 00:00:00

  • Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions.

    abstract::We previously showed that overexpressing the 70-kDa inducible heat shock protein in primary astrocyte cultures and in a rodent stroke model using viral vectors resulted in protection from ischemia and ischemia-like injury. However, viral transfection could potentially provoke a stress response itself; therefore, we ex...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Lee JE,Yenari MA,Sun GH,Xu L,Emond MR,Cheng D,Steinberg GK,Giffard RG

    更新日期:2001-07-01 00:00:00

  • Partial recovery after treatment of chronic paraplegia in rat.

    abstract::While acute spinal cord injury has been the object of intensive research, chronic spinal cord injury has received less attention although most clinical cases of spinal cord injury become chronic. We attempted to surgically "repair" chronic and acute spinal cord injury in a complete transection rat model using a multip...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Fraidakis MJ,Spenger C,Olson L

    更新日期:2004-07-01 00:00:00

  • Adenosine and propentofylline inhibit the proliferation of cultured microglial cells.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Si QS,Nakamura Y,Schubert P,Rudolphi K,Kataoka K

    更新日期:1996-02-01 00:00:00

  • Moderate posttraumatic hypothermia decreases early calpain-mediated proteolysis and concomitant cytoskeletal compromise in traumatic axonal injury.

    abstract::Traumatic brain injury (TBI) in animals and man generates widespread axonal injury characterized by focal axolemmal permeability changes, induction of calpain-mediated proteolysis, and neurofilament side-arm modification associated with neurofilament compaction (NFC) evolving to axonal disconnection. Recent observatio...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Büki A,Koizumi H,Povlishock JT

    更新日期:1999-09-01 00:00:00

  • Allosteric modulation of NMDA receptors alters neurotransmission in the striatum of a mouse model of Parkinson's disease.

    abstract::The GluN2 subunits that compose N-methyl-d-aspartate receptors (NMDARs) are attractive drug targets for therapeutic intervention in several diseases, in particular Parkinson's disease (PD). The precise roles and possible dysfunctions of NMDARs attributed to specific GluN2 subunits are however unresolved. Through the u...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Feng ZJ,Zhang X,Chergui K

    更新日期:2014-05-01 00:00:00

  • Melatonin protects primary cultures of cerebellar granule neurons from kainate but not from N-methyl-D-aspartate excitotoxicity.

    abstract::the antiexcitotoxic efficacy of melatonin, a putative endogenous hydroxyl radical scavenger, was studied in primary cultures of rat cerebellar granule neurons. Excitotoxicity was induced in 7- to 9-day-old cultures by an exposure to glutamate (15 min in the absence of magnesium) or to glutamate receptor agonists, kain...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Giusti P,Gusella M,Lipartiti M,Milani D,Zhu W,Vicini S,Manev H

    更新日期:1995-01-01 00:00:00

  • Dexamethasone enhances NT-3 expression in rat hippocampus after traumatic brain injury.

    abstract::The cellular events in traumatic brain injury (TBI) are complicated, and the factors mediating neurotrophins to protect and repair the injured brain cells are only beginning to be identified. This study examined the effect of dexamethasone (DEX) on neurotrophin-3 (NT-3) expression following TBI. Levels of NT-3 mRNA an...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Yang JT,Lee TH,Weng HH,Chang CN,Chen WC,Cheng WC,Wu JH

    更新日期:2005-04-01 00:00:00

  • Ciliary neurotrophic factor is expressed in the magnocellular neurosecretory system of the rat in vivo: evidence for injury- and activity-induced upregulation.

    abstract::Although ciliary neurotrophic factor (CNTF) has been shown to promote the survival of magnocellular neurons when applied exogenously to explants of the paraventricular and supraoptic nuclei (SON) in vitro, little is known regarding its expression or regulation in the adult magnocellular neurosecretory system (MNS) fol...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Watt JA,Bone S,Pressler M,Cranston HJ,Paden CM

    更新日期:2006-01-01 00:00:00

  • Periaqueductal gray inhibition of trigeminal subnucleus caudalis unitary responses evoked by dentine and nonnoxious facial stimulation.

    abstract::The possible pain inhibitory effects of periaqueductal gray (PAG) stimulation were investigated in cats anesthetized with Nembutal and immobilized with Flaxedil. Unitary responses evoked by electrical stimulation of the upper canine dentine and by cutaneous facial noxious and nonnoxious stimuli were recorded extracell...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Figueiras R,Buño W Jr,García-Austt E,Delgado JM

    更新日期:1983-07-01 00:00:00

  • Involvement of apoptosis and calcium mobilization in tetrahydrobiopterin-induced dopaminergic cell death.

    abstract::Parkinson's disease is a neurodegenerative disorder associated with selective loss of the dopaminergic neurons in the substantia nigra. We have previously shown that tetrahydrobiopterin (BH4), the obligatory cofactor for dopamine synthesis, exerts selective toxicity on dopamine-producing cells. In the present study we...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Choi HJ,Kim SW,Lee SY,Moon YW,Hwang O

    更新日期:2003-06-01 00:00:00

  • NMDA receptor overstimulation triggers a prolonged wave of immediate early gene expression: relationship to excitotoxicity.

    abstract::Exposure of the rodent striatum to quinolinic acid (QA, N-methyl-D-aspartate receptor agonist) induces immediate early gene (IEG; c-fos, c-jun, jun-B, zif/268) expression that may extend 12-24 h after injection. In order to determine the specificity of the prolonged IEG response to the QA injection, the temporal patte...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Shan Y,Carlock LR,Walker PD

    更新日期:1997-04-01 00:00:00

  • A comparison of thyroxine- and polyamine-mediated enhancement of rat facial nerve regeneration.

    abstract::Thyroid hormones and spermidine, a motor neuron trophic polyamine (PA), have been shown to enhance peripheral motor nerve regeneration; however, the mechanism by which these treatment modalities exert their effect is unknown. Similarities in treatment outcome suggest that these molecules may be working via a common me...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Oble DA,Burton L,Maxwell K,Hassard T,Nathaniel EJ

    更新日期:2004-09-01 00:00:00

  • Transplantation of clonal neural precursor cells derived from adult human brain establishes functional peripheral myelin in the rat spinal cord.

    abstract::We examined the myelin repair potential of transplanted neural precursor cells derived from the adult human brain from tissue removed during surgery. Sections of removed brain indicated that nestin-positive cells were found predominantly in the subventricular zone around the anterior horns of the lateral ventricle and...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Akiyama Y,Honmou O,Kato T,Uede T,Hashi K,Kocsis JD

    更新日期:2001-01-01 00:00:00

  • Reappearance of embryonic neutral alpha-glucosidase isoenzyme in acid maltase-deficient muscle of Japanese quail.

    abstract::Two neutral alpha-glucosidase isoenzymes were isolated from the muscle of Japanese quails with late-onset acid maltase deficiency. One isoenzyme is predominantly expressed in embryonic muscle and the other in adult muscle. The time of switching from one to the other of these two neutral alpha-glucosidases was the same...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Usuki F,Ishiura S,Higuchi I,Sugita H

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  • Calpain inhibition attenuates intracellular changes in muscle cells in response to extracellular inflammatory stimulation.

    abstract::Idiopathic inflammatory myopathies (IIMs), comprising of polymyositis, dermatomyositis, and inclusion-body myositis, are characterized by muscle weakness and various types of inflammatory changes in muscle cells. They also show non-inflammatory changes, including perifascicular atrophy, mitochondrial changes, and amyl...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Nozaki K,Das A,Ray SK,Banik NL

    更新日期:2010-10-01 00:00:00

  • Optogenetic exploration and modulation of pain processing.

    abstract::Intractable pain is the single most common cause of disability, affecting more than 20% of the population world-wide. There is accordingly a global effort to decipher how changes in nociceptive processing in the peripheral and central nervous systems contribute to the onset and maintenance of chronic pain. The past se...

    journal_title:Experimental neurology

    pub_type: 杂志文章,评审


    authors: Xie YF,Wang J,Bonin RP

    更新日期:2018-08-01 00:00:00

  • Nigral dopamine type-1 receptors are reduced in Huntington's disease: a postmortem autoradiographic study using [3H]SCH 23390 and correlation with [3H]forskolin binding.

    abstract::Intrastriatal injection of excitatory amino acids, particularly quinolinic acid, has been proposed as an animal model of Huntington's disease. Such neurotoxic lesions of caudate-putamen result in marked dopamine type-1 (D1) receptor losses in the injected nuclei as well as in the ipsilateral substantia nigra pars reti...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Filloux F,Wagster MV,Folstein S,Price DL,Hedreen JC,Dawson TM,Wamsley JK

    更新日期:1990-11-01 00:00:00

  • Intraspinal microstimulation for respiratory muscle activation.

    abstract::A complex propriospinal network is synaptically coupled to phrenic and intercostal motoneurons, and this makes it difficult to predict how gray matter intraspinal microstimulation (ISMS) will recruit respiratory motor units. We therefore mapped the cervical and high thoracic gray matter at locations which ISMS activat...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Sunshine MD,Ganji CN,Reier PJ,Fuller DD,Moritz CT

    更新日期:2018-04-01 00:00:00

  • Parallel development of noradrenergic innervation and cellular compartmentation in the rat spleen.

    abstract::By combining neurochemical measurement of norepinephrine (NE) with double-label immunocytochemistry for tyrosine hydroxylase-positive (TH+) noradrenergic nerves and specific lymphoid markers, we have examined the developmental compartmentation of noradrenergic nerves in the rat spleen. TH+ nerve fibers were present in...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Ackerman KD,Felten SY,Dijkstra CD,Livnat S,Felten DL

    更新日期:1989-03-01 00:00:00

  • Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration.

    abstract::Based on their differentiation ability, bone marrow stromal cells (MSCs) are a good source for cell therapy. Using a cynomolgus monkey peripheral nervous system injury model, we examined the safety and efficacy of Schwann cells induced from MSCs as a source for auto-cell transplantation therapy in nerve injury. Serial...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Wakao S,Hayashi T,Kitada M,Kohama M,Matsue D,Teramoto N,Ose T,Itokazu Y,Koshino K,Watabe H,Iida H,Takamoto T,Tabata Y,Dezawa M

    更新日期:2010-06-01 00:00:00