Alterations in beta-adrenergic receptor binding in partially and fully amygdala-kindled juvenile and adult rats.

abstract：:Death-associated protein kinase 1 (DAPK1) is a key protein that mediates neuronal death in ischemic stroke. Although the substrates of DAPK1 and molecular signal in stroke have been gradually discovered, the modulation of DAPK1 itself is still unclear. Here we first reveal that Caytaxin, a brain-specific member of BCL...

journal_title：Experimental neurology

authors： Wang S,Chen K,Yu J,Wang X,Li Q,Lv F,Shen H,Pei L

更新日期：2020-07-01 00:00:00

abstract：:The present experiments focused on the morphological interaction between serotonergic (5-HT) and noradrenergic (NA) axons during regeneration following partial axonal denervation in the cerebral cortex in adult rats. The denervation paradigm used employed two neurotoxins, one for 5-HT and one for NA axons, infused tog...

journal_title：Experimental neurology

authors： Liu Y,Ishida Y,Shinoda K,Nakamura S

更新日期：2003-11-01 00:00:00

abstract：:Infection with human immunodeficiency virus-1 (HIV-1) is associated with dysfunctions of the central nervous system (CNS). HIV-1 induces its effects on the CNS by a variety of mechanisms, including by shedding the neurotoxic viral proteins such as gp120 and Tat. Both HIV-1 and gp120 have been shown to cross the blood-...

journal_title：Experimental neurology

authors： Banks WA,Robinson SM,Nath A

更新日期：2005-05-01 00:00:00

abstract：:Huntington's disease (HD) is an inherited progressive neurodegenerative disorder characterized by progressive movement, psychiatric and cognitive disturbances. Previous studies have indicated that HD pathogenesis may be mediated in part by loss of brain derived neurotrophic factor (BDNF). Antidepressants selectively b...

journal_title：Experimental neurology

authors： Peng Q,Masuda N,Jiang M,Li Q,Zhao M,Ross CA,Duan W

更新日期：2008-03-01 00:00:00

abstract：:We studied electrophysiological and morphological properties of the Aalpha- and Abeta-fibers in the regenerating sciatic nerve to establish whether these fiber types regenerate in numerical proportion and whether and how the electrophysiological properties of these fiber types are adjusted during regeneration. Compoun...

journal_title：Experimental neurology

authors： Vleggeert-Lankamp CL,van den Berg RJ,Feirabend HK,Lakke EA,Malessy MJ,Thomeer RT

更新日期：2004-06-01 00:00:00

abstract：:The present study attempts to determine whether the neurotoxicity of p-chloroamphetamine (PCA) is dependent on a releasable pool of serotonin (5-HT). Rats treated with PCA alone or with reserpine and PCA exhibit a profound loss of 5-HT innervation in cerebral cortex after a 2-week survival period. However, depletion o...

journal_title：Experimental neurology

authors： Berger UV,Grzanna R,Molliver ME

更新日期：1989-02-01 00:00:00

abstract：:Exposing rat dorsal root ganglion (DRG) neurons to dibutyryl cAMP (db-cAMP) enables central branches to regenerate in the spinal cord by nullifying the ability of CNS myelin to inhibit elongation. A conditioning lesion (CL) promotes similar regeneration of central branches in the spinal cord by increasing neuronal cAM...

journal_title：Experimental neurology

authors： Han PJ,Shukla S,Subramanian PS,Hoffman PN

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Novel strategies to improve hand function after stroke are needed. Electromyography-triggered functional neuromuscular stimulation (EMG-FNMS) and repetitive transcranial magnetic stimulation (rTMS) are promising techniques to facilitate recovery of sensory-motor hand dysfunction after stroke. OBJECTIVE:To i...

journal_title：Experimental neurology

authors： Theilig S,Podubecka J,Bösl K,Wiederer R,Nowak DA

更新日期：2011-07-01 00:00:00

abstract：:Traumatic brain injury (TBI) affects millions of individuals every year. Many of these injuries lead to lasting effects, particularly impairments in domains broadly classified as executive functions, such as impulse control and decision-making. While these impairments have been historically associated with frontal bra...

journal_title：Experimental neurology

authors： Ozga-Hess JE,Whirtley C,O'Hearn C,Pechacek K,Vonder Haar C

更新日期：2020-05-01 00:00:00

abstract：:Numerous epidemiological studies have shown an association between pesticide exposure and an increased risk of developing Parkinson's disease (PD). Here, we provide evidence that the insecticide dieldrin causes specific oxidative damage in the nigrostriatal dopamine (DA) system. We report that exposure of mice to low ...

journal_title：Experimental neurology

authors： Hatcher JM,Richardson JR,Guillot TS,McCormack AL,Di Monte DA,Jones DP,Pennell KD,Miller GW

更新日期：2007-04-01 00:00:00

abstract：:We previously showed that overexpressing the 70-kDa inducible heat shock protein in primary astrocyte cultures and in a rodent stroke model using viral vectors resulted in protection from ischemia and ischemia-like injury. However, viral transfection could potentially provoke a stress response itself; therefore, we ex...

journal_title：Experimental neurology

authors： Lee JE,Yenari MA,Sun GH,Xu L,Emond MR,Cheng D,Steinberg GK,Giffard RG

更新日期：2001-07-01 00:00:00

abstract：:While acute spinal cord injury has been the object of intensive research, chronic spinal cord injury has received less attention although most clinical cases of spinal cord injury become chronic. We attempted to surgically "repair" chronic and acute spinal cord injury in a complete transection rat model using a multip...

journal_title：Experimental neurology

authors： Fraidakis MJ,Spenger C,Olson L

更新日期：2004-07-01 00:00:00

abstract：:Propentofylline is a xanthine derivative that has been known to protec t neurons against ischemia-induced damage. To assess its neuroprotective mechanisms, we examined the effect of propentofylline on microglial proliferation that is thought to play an important role in neuronal damage. We determined the proliferation...

journal_title：Experimental neurology

authors： Si QS,Nakamura Y,Schubert P,Rudolphi K,Kataoka K

更新日期：1996-02-01 00:00:00

abstract：:Traumatic brain injury (TBI) in animals and man generates widespread axonal injury characterized by focal axolemmal permeability changes, induction of calpain-mediated proteolysis, and neurofilament side-arm modification associated with neurofilament compaction (NFC) evolving to axonal disconnection. Recent observatio...

journal_title：Experimental neurology

authors： Büki A,Koizumi H,Povlishock JT

更新日期：1999-09-01 00:00:00

abstract：:The GluN2 subunits that compose N-methyl-d-aspartate receptors (NMDARs) are attractive drug targets for therapeutic intervention in several diseases, in particular Parkinson's disease (PD). The precise roles and possible dysfunctions of NMDARs attributed to specific GluN2 subunits are however unresolved. Through the u...

journal_title：Experimental neurology

authors： Feng ZJ,Zhang X,Chergui K

更新日期：2014-05-01 00:00:00

abstract：:the antiexcitotoxic efficacy of melatonin, a putative endogenous hydroxyl radical scavenger, was studied in primary cultures of rat cerebellar granule neurons. Excitotoxicity was induced in 7- to 9-day-old cultures by an exposure to glutamate (15 min in the absence of magnesium) or to glutamate receptor agonists, kain...

journal_title：Experimental neurology

authors： Giusti P,Gusella M,Lipartiti M,Milani D,Zhu W,Vicini S,Manev H

更新日期：1995-01-01 00:00:00

abstract：:The cellular events in traumatic brain injury (TBI) are complicated, and the factors mediating neurotrophins to protect and repair the injured brain cells are only beginning to be identified. This study examined the effect of dexamethasone (DEX) on neurotrophin-3 (NT-3) expression following TBI. Levels of NT-3 mRNA an...

journal_title：Experimental neurology

authors： Yang JT,Lee TH,Weng HH,Chang CN,Chen WC,Cheng WC,Wu JH

更新日期：2005-04-01 00:00:00

abstract：:Although ciliary neurotrophic factor (CNTF) has been shown to promote the survival of magnocellular neurons when applied exogenously to explants of the paraventricular and supraoptic nuclei (SON) in vitro, little is known regarding its expression or regulation in the adult magnocellular neurosecretory system (MNS) fol...

journal_title：Experimental neurology

authors： Watt JA,Bone S,Pressler M,Cranston HJ,Paden CM

更新日期：2006-01-01 00:00:00

abstract：:The possible pain inhibitory effects of periaqueductal gray (PAG) stimulation were investigated in cats anesthetized with Nembutal and immobilized with Flaxedil. Unitary responses evoked by electrical stimulation of the upper canine dentine and by cutaneous facial noxious and nonnoxious stimuli were recorded extracell...

journal_title：Experimental neurology

authors： Figueiras R,Buño W Jr,García-Austt E,Delgado JM

更新日期：1983-07-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder associated with selective loss of the dopaminergic neurons in the substantia nigra. We have previously shown that tetrahydrobiopterin (BH4), the obligatory cofactor for dopamine synthesis, exerts selective toxicity on dopamine-producing cells. In the present study we...

journal_title：Experimental neurology

authors： Choi HJ,Kim SW,Lee SY,Moon YW,Hwang O

更新日期：2003-06-01 00:00:00

abstract：:Exposure of the rodent striatum to quinolinic acid (QA, N-methyl-D-aspartate receptor agonist) induces immediate early gene (IEG; c-fos, c-jun, jun-B, zif/268) expression that may extend 12-24 h after injection. In order to determine the specificity of the prolonged IEG response to the QA injection, the temporal patte...

journal_title：Experimental neurology

authors： Shan Y,Carlock LR,Walker PD

更新日期：1997-04-01 00:00:00

abstract：:Thyroid hormones and spermidine, a motor neuron trophic polyamine (PA), have been shown to enhance peripheral motor nerve regeneration; however, the mechanism by which these treatment modalities exert their effect is unknown. Similarities in treatment outcome suggest that these molecules may be working via a common me...

journal_title：Experimental neurology

authors： Oble DA,Burton L,Maxwell K,Hassard T,Nathaniel EJ

更新日期：2004-09-01 00:00:00

abstract：:We examined the myelin repair potential of transplanted neural precursor cells derived from the adult human brain from tissue removed during surgery. Sections of removed brain indicated that nestin-positive cells were found predominantly in the subventricular zone around the anterior horns of the lateral ventricle and...

journal_title：Experimental neurology

authors： Akiyama Y,Honmou O,Kato T,Uede T,Hashi K,Kocsis JD

更新日期：2001-01-01 00:00:00

abstract：:Two neutral alpha-glucosidase isoenzymes were isolated from the muscle of Japanese quails with late-onset acid maltase deficiency. One isoenzyme is predominantly expressed in embryonic muscle and the other in adult muscle. The time of switching from one to the other of these two neutral alpha-glucosidases was the same...

journal_title：Experimental neurology

authors： Usuki F,Ishiura S,Higuchi I,Sugita H

更新日期：1988-05-01 00:00:00

abstract：:Idiopathic inflammatory myopathies (IIMs), comprising of polymyositis, dermatomyositis, and inclusion-body myositis, are characterized by muscle weakness and various types of inflammatory changes in muscle cells. They also show non-inflammatory changes, including perifascicular atrophy, mitochondrial changes, and amyl...

journal_title：Experimental neurology

authors： Nozaki K,Das A,Ray SK,Banik NL

更新日期：2010-10-01 00:00:00

abstract：:Intractable pain is the single most common cause of disability, affecting more than 20% of the population world-wide. There is accordingly a global effort to decipher how changes in nociceptive processing in the peripheral and central nervous systems contribute to the onset and maintenance of chronic pain. The past se...

journal_title：Experimental neurology

authors： Xie YF,Wang J,Bonin RP

更新日期：2018-08-01 00:00:00

abstract：:Intrastriatal injection of excitatory amino acids, particularly quinolinic acid, has been proposed as an animal model of Huntington's disease. Such neurotoxic lesions of caudate-putamen result in marked dopamine type-1 (D1) receptor losses in the injected nuclei as well as in the ipsilateral substantia nigra pars reti...

journal_title：Experimental neurology

authors： Filloux F,Wagster MV,Folstein S,Price DL,Hedreen JC,Dawson TM,Wamsley JK

更新日期：1990-11-01 00:00:00

abstract：:A complex propriospinal network is synaptically coupled to phrenic and intercostal motoneurons, and this makes it difficult to predict how gray matter intraspinal microstimulation (ISMS) will recruit respiratory motor units. We therefore mapped the cervical and high thoracic gray matter at locations which ISMS activat...

journal_title：Experimental neurology

authors： Sunshine MD,Ganji CN,Reier PJ,Fuller DD,Moritz CT

更新日期：2018-04-01 00:00:00

abstract：:By combining neurochemical measurement of norepinephrine (NE) with double-label immunocytochemistry for tyrosine hydroxylase-positive (TH+) noradrenergic nerves and specific lymphoid markers, we have examined the developmental compartmentation of noradrenergic nerves in the rat spleen. TH+ nerve fibers were present in...

journal_title：Experimental neurology

authors： Ackerman KD,Felten SY,Dijkstra CD,Livnat S,Felten DL

更新日期：1989-03-01 00:00:00

abstract：:Based on their differentiation ability, bone marrow stromal cells (MSCs) are a good source for cell therapy. Using a cynomolgus monkey peripheral nervous system injury model, we examined the safety and efficacy of Schwann cells induced from MSCs as a source for auto-cell transplantation therapy in nerve injury. Serial...

journal_title：Experimental neurology

authors： Wakao S,Hayashi T,Kitada M,Kohama M,Matsue D,Teramoto N,Ose T,Itokazu Y,Koshino K,Watabe H,Iida H,Takamoto T,Tabata Y,Dezawa M

更新日期：2010-06-01 00:00:00