Abstract：
:Some forms of electrographic seizures are generated at the level of the cortical network. Neocortical kindling exhibits a resistance to produce generalized convulsive seizures, and therefore, it was rather difficult to use it to study the cortical epileptogenesis. Here, using supra-threshold cortical kindling, we report electrophysiological patterns of field-potential synchronization and intracellular activities in chronically implanted non-anesthetized cats, during different states of vigilance, and during acute seizures elicited by prolonged (20-60 s) electrical stimulation. Acute seizures were easily elicited during transition from slow-wave sleep (SWS) to waking state. The seizures were mainly clonic accompanied with tonic components followed by prolonged postictal depression. Delayed rhythmic outlasting activities (OA) at approximately 1.5 Hz, first time reported here, followed the postictal depression, and lasted up to 2 h. These activities were clear during waking state, slightly reduced during SWS and completely absent during rapid-eye movement sleep. They started focally and following daily stimulations generalized over the entire cortical surface. Extra- and intracellular neuronal recordings during OA displayed spike-doublets, built on the summation of successive excitatory postsynaptic potentials and fast-prepotentials, entailing an increased dendritic excitation. Our results suggest that such rhythmic long-lasting oscillatory activity outlasting seizures are the key factor of epileptogenesis, leading to epilepsy.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Nita DA,Cissé Y,Timofeev Idoi
10.1016/j.expneurol.2008.02.010subject
Has Abstractpub_date
2008-06-01 00:00:00pages
456-68issue
2eissn
0014-4886issn
1090-2430pii
S0014-4886(08)00075-7journal_volume
211pub_type
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journal_title：Experimental neurology
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journal_title：Experimental neurology
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journal_title：Experimental neurology
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journal_title：Experimental neurology
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pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.01.016
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.04.003
更新日期：2004-07-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90140-9
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pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.08.007
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.07.016
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2013-09-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6948
更新日期：1998-12-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.04.031
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abstract：:The development of the spinal cord represents one of the most complex structure developments of the central nervous system (CNS) as it has to unfold along the longitudinal axis and within segmental cues. There it has to cope with on the one hand connection to the periphery (skeletal muscle, dermomyotome, smooth muscle...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
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更新日期：2015-12-01 00:00:00
