Abstract：
:Male white mice were exposed to electroshock and then injected intravenously with 5-[3H]uridine immediately after the shock. After 5, 30, or 60 min or 6, 12, or 24 h, the mice were killed, microautoradiographs were prepared, and grains were counted in the cortex, hippocampus, and basal ganglia. The results of the grain counts were compared with grain counts in the cortex, hippocampus, and basal ganglia of mice exposed to anoxia for 25 s and then treated in the same manner as the first groups. After electroshock the grain count decreased to 25% of that in control animals in the hippocampus and to 50% in the cortex but was normal in the basal ganglia. The counts returned to normal values within 6 h in the hippocampus, and within 1 h in the cortex. After anoxia, the grain counts were normal in the cortex and hippocampus but increased in the basal ganglia. The distribution of cells with a high or low grain count in vertical and horizontal columns of the cortex in control and convulsion animals was analyzed. There were random variations from column to column in both control and convulsion animals. In some anatomic layers there were significantly different grain counts, indicating differences in functional activity.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Pakkenberg H,Pakkenberg B,Fog Rdoi
10.1016/0014-4886(85)90269-9subject
Has Abstractpub_date
1985-07-01 00:00:00pages
115-22issue
1eissn
0014-4886issn
1090-2430pii
0014-4886(85)90269-9journal_volume
89pub_type
杂志文章abstract：:By combining neurochemical measurement of norepinephrine (NE) with double-label immunocytochemistry for tyrosine hydroxylase-positive (TH+) noradrenergic nerves and specific lymphoid markers, we have examined the developmental compartmentation of noradrenergic nerves in the rat spleen. TH+ nerve fibers were present in...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90048-4
更新日期：1989-03-01 00:00:00
abstract：:Four lectins (Abrus precatorius (APA), Maackia amurensis (MAA), Momordica charantia (MCA) and Sambucus nigra (SNA)) have been used to identify glycohistochemically the microglial cells (MGC) activation in autoptic brain samples from Alzheimer's disease (AD) subjects. Three of these lectins (APA, MAA and MCA) have util...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6862
更新日期：1998-09-01 00:00:00
abstract：:Muscular dystrophies (MDs) consist of a genetically heterogeneous group of disorders, recessive or dominant, characterized by progressive skeletal muscle weakening. To date, no effective treatment is available. Experimental strategies pursuing muscle regeneration through the transplantation of stem cell preparations h...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2009.08.002
更新日期：2009-11-01 00:00:00
abstract：:Infection with human immunodeficiency virus-1 (HIV-1) is associated with dysfunctions of the central nervous system (CNS). HIV-1 induces its effects on the CNS by a variety of mechanisms, including by shedding the neurotoxic viral proteins such as gp120 and Tat. Both HIV-1 and gp120 have been shown to cross the blood-...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.11.019
更新日期：2005-05-01 00:00:00
abstract：:the antiexcitotoxic efficacy of melatonin, a putative endogenous hydroxyl radical scavenger, was studied in primary cultures of rat cerebellar granule neurons. Excitotoxicity was induced in 7- to 9-day-old cultures by an exposure to glutamate (15 min in the absence of magnesium) or to glutamate receptor agonists, kain...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(95)90005-5
更新日期：1995-01-01 00:00:00
abstract：:GABAergic dysfunction is implicated in hippocampal deficits of the Ts65Dn mouse model of Down syndrome (DS). Since Ts65Dn mice overexpress G-protein coupled inward-rectifying potassium (GIRK2) containing channels, we sought to evaluate whether increased GABAergic function disrupts the functioning of hippocampal circui...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.11.033
更新日期：2012-02-01 00:00:00
abstract：:We have studied the functional involvement of J1-160 and J1-180 in the interaction between oligodendrocytes and neurons, astrocytes, or L cells in short- and long-term adhesion assays using monoclonal antibodies directed against topographically distinct epitopes on the molecules. Whereas antibodies to mouse liver memb...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(05)80012-3
更新日期：1990-07-01 00:00:00
abstract：:Chronic intrastriatal administration of quinolinic acid (QA) in the rat produces a pattern of neurodegeneration similar to that seen in Huntington's disease (HD). Although these changes have been related to transient motor abnormalities, the effects of chronic QA administration on cognitive abilities have not been ass...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6767
更新日期：1998-04-01 00:00:00
abstract：:Deep brain stimulation (DBS) of the subthalamic nucleus (STN) can be a highly effective treatment for Parkinson's disease (PD). However, therapeutic efficacy is limited by difficulties in consistently and correctly targeting this nucleus. Increasing evidence suggests that there is abnormal synchronization of beta freq...
journal_title：Experimental neurology
pub_type： 临床试验,杂志文章
doi：10.1016/j.expneurol.2005.11.019
更新日期：2006-03-01 00:00:00
abstract：:Cortical spreading depression (CSD) is associated with various short- and long-term physiological and neurochemical changes and has been shown to confer an increased susceptibility to accompanying ischemic injury or provide protection against a subsequent experimental ischemia. Nitric oxide is involved in the processe...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7218
更新日期：1999-12-01 00:00:00
abstract：:Myasthenia gravis (MG) with antibodies against the acetylcholine receptor (AChR) is characterized by a chronic, fatigable weakness of voluntary muscles. The production of autoantibodies involves the dysregulation of T cells which provide the environment for the development of autoreactive B cells. The symptoms are cau...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2015.03.010
更新日期：2015-08-01 00:00:00
abstract：:Rats were injected with progressively increasing doses of morphine or meperidine during a period of 3 to 40 days. From this colony of animals individual rats were used at 3- to 4-day intervals for electrophysiologic experiments to analyze the activity of nociceptive neurons in the somesthetic thalamus. After an i.p. i...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90051-7
更新日期：1984-01-01 00:00:00
abstract：:Axons of retinal ganglion cells (RGCs) of adult cats were transected and regenerated by the transplantation of peripheral nerves. Two months after transplantation dendritic arbors of RGCs with regenerated axons (r-RGCs) were visualized with intracellular injections of horseradish peroxidase (HRP). The HRP-filled r-RGC...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.6345
更新日期：1997-01-01 00:00:00
abstract：:Spinal cord injury (SCI) results in chronic pain states in which the underlying mechanism is poorly understood. To begin to explore possible mechanisms, calcitonin gene-related peptide (CGRP), a neuropeptide confined to fine primary afferent terminals in laminae I and II in the dorsal horn of the spinal cord and impli...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6608
更新日期：1997-10-01 00:00:00
abstract：:The major neutral and acidic cerebellar lipids were studied in audiogenic seizure (AGS)-resistant C57BL/6 (B6) and AGS-susceptible DBA/2J (D2) mice. These cerebellar lipids were also studied in the D2.B6- Iasb congenic mice and in the B6D2F1 hybrids that are mostly AGS resistant. Except for the Iasb gene, which inhibi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90206-1
更新日期：1984-06-01 00:00:00
abstract：:Caloric restriction (CR) is a daily reduction of total caloric intake without a decrease in micronutrients or disproportionate reduction of any one dietary component. CR can increase lifespan reliably in a wide range of species and appears to counteract some aspects of the aging process throughout the body. The effect...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.01.016
更新日期：2008-05-01 00:00:00
abstract：:Anterograde transneuronal degeneration is caused by the loss of afferent input to the nerve cells and may occur in a number of neuronal systems. Transection of the adult spinal cord, causing anterograde transneuronal degeneration in ventral horn neurons, distal to the lesion, has been reported by some authors, while o...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：
更新日期：1997-11-01 00:00:00
abstract：:The respiratory central pattern generator must respond to chemosensory cues to maintain oxygen (O2) and carbon dioxide (CO2) homeostasis in the blood and tissues. To do this, sensorial cells located in the periphery and central nervous system monitor the arterial partial pressure of O2 and CO2 and initiate respiratory...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2016.05.036
更新日期：2017-01-01 00:00:00
abstract：:Chemokines are a family of structurally related cytokines that activate and recruit leukocytes into areas of inflammation. The "CC" chemokine, monocyte chemoattractant protein (MCP)-1 may regulate the microglia/monocyte response to acute brain injury. Recent studies have documented increased expression of MCP-1 in div...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7466
更新日期：2000-10-01 00:00:00
abstract：:Bone marrow stromal cells (BMSC) have been shown to generate neural cells under experimental conditions in vitro and following transplantation into animal models of stroke and traumatic CNS injury. Hastened recovery from the neurological deficit has not correlated with structural repair of the lesion in the stroke mod...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2003.09.003
更新日期：2004-01-01 00:00:00
abstract：:Myelin accelerates action potential conduction velocity and provides essential energy support for axons. Unfortunately, myelin and myelinating cells are often vulnerable to injury or disease, resulting in myelin damage, which in turn can lead to axon dysfunction, overt pathology and neurological impairment. Inflammati...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2016.05.001
更新日期：2016-09-01 00:00:00
abstract：:Mutations of the PINK1 gene are a cause of autosomal recessive Parkinson's disease (PD). PINK1 encodes a mitochondrial kinase of unknown function which is widely expressed in both neuronal and non-neuronal cells. We have studied fibroblast cultures from four family members harbouring the homozygous p.Q456X mutation in...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2009.05.027
更新日期：2009-09-01 00:00:00
abstract：:Apnea of prematurity (AoP) is associated with severe and repeated episodes of arterial oxygen desaturation (intermittent hypoxia - IH), which in turn increases the number of apneas. So far, there is no data addressing whether IH leads to sex-specific respiratory consequences, neither if drugs targeting AoP are more ef...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2019.112985
更新日期：2019-10-01 00:00:00
abstract：:The increasing demand on diagnostic assays that are sensitive and specific for pathogenic antibodies, and the interest in identifying new antigens, prompted the development of cell-based assays for the detection of autoantibodies in myasthenia gravis and other autoimmune disorders. Cell-based assays were initially use...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2015.01.011
更新日期：2015-08-01 00:00:00
abstract：:Proximal axotomy in adult animals results in delayed death of motor neurons. Features characteristic of both necrosis and apoptosis have been described in motor neurons of the spinal cord following proximal avulsion of the ventral roots. We have previously demonstrated that a genomic herpes simplex virus (HSV)-based v...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7597
更新日期：2001-04-01 00:00:00
abstract：:Calcium-independent nitric oxide synthase (NOS) activity has been reported in ischemic brains and usually attributed to the inducible isoform, iNOS. Because calcium-independent mechanisms have recently been shown to regulate the constitutive calcium-dependent NOS, we proposed to confirm the presence of iNOS activity i...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.05.001
更新日期：2005-09-01 00:00:00
abstract：:Cortical stimulation (CS) as a means to modulate regional activity and excitability in cortex is emerging as a promising approach for facilitating rehabilitative interventions after brain damage, including stroke. In this study, we investigated whether CS-induced functional improvements are linked with synaptic plasti...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.01.031
更新日期：2008-07-01 00:00:00
abstract：:In birds, a variety of subtotal thoracic spinal cord lesions were made to determine the spinal cord pathways essential for avian hind limb locomotion (bipedal walking). The various surgical disruptions included: section of the dorsal half of the cord, a hemisection, section of the dorsal cord and ventromedial funiculi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90148-8
更新日期：1987-02-01 00:00:00
abstract：:Neuronal activity in the locus ceruleus of awake, behaving stump-tailed monkeys increased consistently and vigorously after presentation of mildly aversive and threatening stimuli. These preliminary data increase the range of stimuli reported to elicit locus ceruleus activity in awake monkeys to include nonpainful thr...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90217-6
更新日期：1984-06-01 00:00:00
abstract：:CNS damage often results in demyelination of spared axons due to oligodendroglial cell death and dysfunction near the injury site. Although new oligodendroglia are generated following CNS injury and disease, the process of remyelination is typically incomplete resulting in long-term functional deficits. Chondroitin su...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2013.04.003
更新日期：2013-09-01 00:00:00
