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Chronic administration of quinolinic acid in the rat striatum causes spatial learning deficits in a radial arm water maze task.

Abstract：

:Chronic intrastriatal administration of quinolinic acid (QA) in the rat produces a pattern of neurodegeneration similar to that seen in Huntington's disease (HD). Although these changes have been related to transient motor abnormalities, the effects of chronic QA administration on cognitive abilities have not been assessed. The present study investigated whether the striatal deterioration observed during chronic QA administration produces cognitive impairments in this animal model of HD by testing the effects of chronic administration of QA on spatial learning ability of rats in a radial arm water maze (RAWM) task. Rats were given bilateral implantation of a chronic dialysis probe apparatus which delivered either vehicle or QA (20 mM) into the striatum. Beginning 1 day after implantation, the rats were tested daily for 3 weeks in the RAWM. Nocturnal activity levels were also assessed at 1-, 3-, 5-, 7-, 14-, and 21-days following probe implantation. Results of behavioral testing indicated that chronic exposure to QA causes spatial learning deficits in the RAWM task with only a transient increase in activity levels. Collectively, these results suggest that chronic striatal exposure to QA mimics some aspects of the cognitive deficits observed in HD.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Shear DA,Dong J,Haik-Creguer KL,Bazzett TJ,Albin RL,Dunbar GL

doi

10.1006/exnr.1998.6767

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

305-11

issue

2

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(98)96767-X

journal_volume

150

pub_type

杂志文章

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