Abstract:
:The anatomical distribution and the content of dendrite bundles were studied in the spinal cord of adult rats. We injected retrogradely transported Cholera Toxin subunit B into muscles in order to label motoneurons and their dendrites. Twenty-one muscles in the trunk and in extremities were selected which are involved in a variety of motor tasks. Reconstructions were made from consecutive sections and the organization of dendrites was studied. In addition, the distributions of fiber types in the muscles were estimated on the basis of ATPase and succinic dehydrogenase-stained sections. Dendrite bundles are confined to pools of muscles which have postural tasks. Two different types can be distinguished. In the first type, longitudinal dendrite bundles extend over the length of the pool and also transversal bundles occur. Such pools innervate the axial musculature, and the soleus and flexor carpi ulnaris muscles in the extremities. These muscles contain relatively high percentages of slow twitch type I muscle fibers. In the second type, the occurrence of bundles is confined to a few zones within the pool. Such pools innervate muscles which are involved in postural tasks but in addition they also subserve other movement tasks. Distinct regions within these muscles are characterized by high percentages of type I muscle fibers.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Gramsbergen A,Ijkema-Paassen J,Westerga J,Geisler HCdoi
10.1006/exnr.1996.0004subject
Has Abstractpub_date
1996-01-01 00:00:00pages
34-42issue
1eissn
0014-4886issn
1090-2430pii
S0014-4886(96)90004-7journal_volume
137pub_type
杂志文章abstract::The binding of agonists and antagonists to beta-adrenergic receptors in brain tissue obtained postmortem in nonalcoholic controls and matched intoxicated and sober alcoholics was measured to assess the state of the receptors and their coupling to adenylate cyclase. Binding of antagonist, iodocyanopindolol, to cerebral...
journal_title:Experimental neurology
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doi:10.1016/0014-4886(89)90131-3
更新日期:1989-09-01 00:00:00
abstract::After spinal cord injury (SCI), apoptosis of neurons and oligodendrocytes is associated with axonal degeneration and loss of neurological function. Recent data have suggested a potential role for FAS death receptor-mediated apoptosis in the pathophysiology of SCI. In this study, we examined the effect of FAS deficienc...
journal_title:Experimental neurology
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abstract::Neuroimaging genetic studies that associate genetic and epigenetic variation with neural activity or structure provide an opportunity to link genes to psychiatric disorders, often before psychopathology is discernable in behavior. Here we review neuroimaging genetics studies with participants who have Posttraumatic St...
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2000.7555
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abstract::A significant proportion of neurologic patients suffer electroencephalographic (EEG) seizures in the acute phase following traumatic or ischemic brain injury, including many without overt behavioral manifestations. Although such nonconvulsive seizures may exacerbate neuropathological processes, they have received limi...
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abstract::Cyclic nucleotides are thought to act as second messengers of neurotransmission inside central neurons, and cyclic guanosine monophosphate (cGMP) has been postulated to act as a messenger for muscarinic, cholinergic transmission. Nonetheless, the action of cGMP has not yet been established in identified cortical neuro...
journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1986-03-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(91)90070-s
更新日期:1991-05-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1987-08-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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abstract::The threshold current required for the excitation of visual cortex neurons in the vicinity (approximately 1 mm) of an intracortical stimulating electrode was measured as a function of the stimulus pulse duration in the anesthetized cat. For cortical neurons with latencies of activation from 0.4 to 3.4 ms and for stimu...
journal_title:Experimental neurology
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doi:10.1016/0014-4886(83)90270-4
更新日期:1983-08-01 00:00:00
abstract::In the cerebellum of adult-aging Ts65Dn mice, a murine model of Down syndrome, Purkinje cells undergo degeneration. Searching for the cause of Purkinje cell degeneration, we have studied the ubiquitin-proteasome system (UPS) in the cerebellum of aging Ts65Dn mice. Inhibition of UPS is sufficient to induce neuron degen...
journal_title:Experimental neurology
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abstract::Our previous studies showed that Insulin-like Growth Factor (IGF)-1 reduced blood brain barrier permeability and decreased infarct volume caused by middle cerebral artery occlusion (MCAo) in middle aged female rats. Similarly, cultures of primary brain microvessel endothelial cells from middle-aged female rats and exp...
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更新日期:2019-01-01 00:00:00
abstract::These studies have examined the extent to which intrastriatal grafts of embryonic mesencephalic neurons induce recovery of normal discharge patterns in striatal neurons of rats after a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal dopamine (DA) pathway. Lesioned rats were tested for rotational beha...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0070
更新日期:1996-04-01 00:00:00
abstract::Morphologic alterations of the hippocampal mossy fiber pathway after postnatal lead exposure have been observed in rats. It is hypothesized that lead might perturb zinc pools found in this pathway. To test this hypothesis, rat pups were exposed to lead indirectly by administering 0.2% lead acetate to dams via the drin...
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pub_type: 杂志文章
doi:10.1016/0014-4886(84)90035-9
更新日期:1984-09-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2017.10.028
更新日期:2018-02-01 00:00:00
abstract::Thalamocortical spike-and-wave discharges characterize the nonconvulsive absence seizures that occur spontaneously in genetic absence epilepsy rats from Strasbourg (GAERS), a selected strain of Wistar rats. GABA is crucial in the generation of absence seizures. The susceptibility to convulsions induced by threshold do...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7302
更新日期:2000-02-01 00:00:00
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journal_title:Experimental neurology
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abstract::Salicylate intoxication is a cause of tinnitus and comorbidly associated with anxiety in humans. In a previous work, we showed that salicylate induces anxiety-like behavior and hippocampal type 2 theta oscillations (theta2) in mice. Here we investigate if the anxiogenic effect of salicylate is dependent on age and pre...
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7186
更新日期:1999-10-01 00:00:00
abstract::Photic entrainment of circadian rhythms in mammals is mediated through a direct retinal projection to the core region of the suprachiasmatic nucleus (SCN), the circadian clock. A proportion of this projection contains the low-affinity p75 neurotrophic receptor (p75NTR). Neonatal monosodium glutamate (MSG) treatment, w...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2002.7969
更新日期:2002-08-01 00:00:00
abstract::Nerve growth factor (NGF) can induce sprouting of axotomized adult rat medial septum cholinergic neurons and promote their regeneration into septohippocampal nerve grafts and hippocampal formation. This study investigated the potential neurotropic (chemotactic/attracting) action of NGF in the adult rat cholinergic sep...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1993.1005
更新日期:1993-01-01 00:00:00
abstract::Immune rejection of transplanted material is a potential complication of organ donation. In response to tissue transplantation, immune rejection has two components: a host defense directed against the grafted tissue and an immune response from the grafted tissue against the host (graft vs host disease). To treat immun...
journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:2003-08-01 00:00:00
abstract::Previously injured dorsal roots were electrically stimulated to determine if regenerating sensory axons can form physiologically active synaptic contacts with neurons within fetal spinal cord tissue transplants. Dorsal rootlets, sectioned at their spinal cord entry zone, were apposed to intraspinal transplants of feta...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0101
更新日期:1996-06-01 00:00:00
abstract::Despite the importance of the periaqueductal gray (PAG) in the modulation of nociception and pain, many aspects of the roles of the different columns of the PAG in descending controls: facilitation and inhibition, are not understood. Employing a tonic muscle pain model established by i.m. injection of 5.8% saline into...
journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2005.08.028
更新日期:2006-01-01 00:00:00
abstract::In the peripheral nervous system, regeneration of motor and sensory axons into chronically denervated distal nerve segments is impaired compared to regeneration into acutely denervated nerves. In order to find possible causes for this phenomenon we examined the changes in the expression pattern of the glial cell-line-...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2001.7826
更新日期:2002-01-01 00:00:00