Abstract:
:delta-Aminolevulinic acid (ALA), a toxic precursor of porphyrin, when injected i.v. failed to enter most brain structures, such as the cortex, thalamus, midbrain, and others, as determined by the autoradiographic technique. However, the choroid plexus, median eminence, and a narrow strip of the periventricular zone, which usually lack a barrier function, were labeled in these experiments. These results indicate that the blood-brain barrier is virtually impermeable for ALA, although the amino acid may enter the cerebrospinal fluid via fenestrated capillaries of the circumventricular organs and tanycytes of the median eminence.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Terr L,Weiner LPdoi
10.1016/0014-4886(83)90234-0subject
Has Abstractpub_date
1983-02-01 00:00:00pages
564-8issue
2eissn
0014-4886issn
1090-2430pii
0014-4886(83)90234-0journal_volume
79pub_type
杂志文章abstract::The anticonvulsant long-term efficacy of diazepam was studied in amygdala-kindled rats. The drug was administered three times daily at doses of 5 mg/kg i.p. for 2 weeks in fully kindled animals. The severity of the kindled seizures was markedly reduced throughout the period of treatment, while tolerance developed to t...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(85)90026-3
更新日期:1985-11-01 00:00:00
abstract::The role of microglia and their contribution to the development and maintenance of pain states has emerged as an attractive field of study. Sensitization of central nociceptors and interneurons is thought to be responsible for the symptoms of chronic neuropathic pain states. Microglia interact with these neurons at th...
journal_title:Experimental neurology
pub_type: 杂志文章,评审
doi:10.1016/j.expneurol.2011.12.021
更新日期:2012-04-01 00:00:00
abstract::We provide evidence for apoptosis in Alzheimer's disease using the in situ labeling technique TUNEL (terminal transferase-mediated dUTP-biotin nick end labeling). The technique specifically detects apoptotic cells by utilizing terminal transferase to incorporate biotinylated nucleotides into the fragmented DNA of apop...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1995.1025
更新日期:1995-06-01 00:00:00
abstract::Nitrosative stress contributes to nerve conduction slowing, thermal hypoalgesia, and impaired nitrergic innervation in animal models of Type 1 diabetes. The role for reactive nitrogen species in Type 2 diabetes-associated neuropathy remains unexplored. This study evaluated the role for nitrosative stress in functional...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2007.03.019
更新日期:2007-06-01 00:00:00
abstract::Increased intercellular coupling has been implicated in contributing to the synchronization of discharges characteristic of epileptic foci. Using RNA blot analysis, the level of mRNA for the heart-type gap junction protein, connexin43, is shown to be elevated in samples of temporal lobe neocortex obtained at the time ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(91)90007-y
更新日期:1991-02-01 00:00:00
abstract::We have previously shown that the expression of voltage-operated Ca(++) channels (VOCCs) is highly regulated in the oligodendroglial lineage and is essential for proper oligodendrocyte progenitor cell (OPC) migration. Here we assessed the role of VOCCs, in particular the L-type, in oligodendrocyte maturation. We used ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2014.12.012
更新日期:2015-03-01 00:00:00
abstract::Stress and glucocorticoids exacerbate pain via undefined mechanisms. Macrophage migration inhibitory factor (MIF) is a constitutively expressed protein that is secreted to maintain immune function when glucocorticoids are elevated by trauma or stress. Here we show that MIF is essential for the development of neuropath...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2012.04.018
更新日期:2012-08-01 00:00:00
abstract::Pluripotent neural stem cells (NSCs) have been used as replacement cells in a variety of neurological disease models. Among the many different NSCs that have been used to date, most robust results have been obtained with the immortalized neural stem cell line (C17.2) isolated from postnatal cerebellum. However, it is ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2004.07.011
更新日期:2005-08-01 00:00:00
abstract::Damage to the medial frontal cortex in rats results in a learning deficit on a reinforced alternation task. The rate of recovery from this deficit was accelerated by transplantation of either adult or embryonic frontal cortex, provided that a delay was introduced between injury and transplantation. The rates of recove...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(86)90241-4
更新日期:1986-12-01 00:00:00
abstract::The ventrolateral orbital cortex (VLO) is part of an endogenous analgesic system consisting of an ascending pathway from the spinal cord to VLO via the thalamic nucleus submedius (Sm) and a descending pathway to the spinal cord relaying in the periaqueductal gray (PAG). This study examines whether activation of D(1)-l...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2008.09.018
更新日期:2009-01-01 00:00:00
abstract::A comparison of regenerated and normal frog sciatic nerves showed a marked reduction in conduction velocity from 37.5 to 15.2 m/s with little change in the absolute refractory period. Changes in conduction velocity corresponded to a reduced mean axon caliber (4.8 versus 6.6 micron). Regenerated nerves also had markedl...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(85)90141-4
更新日期:1985-01-01 00:00:00
abstract::Mutations of the PINK1 gene are a cause of autosomal recessive Parkinson's disease (PD). PINK1 encodes a mitochondrial kinase of unknown function which is widely expressed in both neuronal and non-neuronal cells. We have studied fibroblast cultures from four family members harbouring the homozygous p.Q456X mutation in...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2009.05.027
更新日期:2009-09-01 00:00:00
abstract::Trophic factors are expressed by neurons throughout several areas of the CNS. We studied the mRNA expression of a member of the neurotrophin family, brain-derived neurotrophic factor (BDNF), and of the two receptor transcripts, full-length trkB and truncated trkB in single intraocular cortex cerebri grafts and in doub...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1994.1092
更新日期:1994-06-01 00:00:00
abstract::Spinal cord injury (SCI) causes motor and sensory deficits that impair functional performance. While more functional recovery occurs with greater white matter sparing (WMS), it is unclear which locomotor features are more vulnerable to SCI than others, if recovery of certain features depends on specific amounts of WMS...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2004.09.016
更新日期:2005-02-01 00:00:00
abstract::The role of interferon-gamma (IFN-gamma) in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) is still controversial. We have studied the function of IFN-gamma and its receptor in the EAE model using two different IFN-gamma receptor knockout (IFN-gamma R(-/-)) mouse types: C57B...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2001.7815
更新日期:2001-12-01 00:00:00
abstract::The Alzheimer's disease-related peptide beta(1-40) amyloid self-associates to form fibrils exhibiting a morphology characteristic of amyloidogenic proteins. The mechanism of this fibrillization process has yet to be fully elucidated. In this study we have immobilized the beta(1-40) amyloid to flat gold surfaces using ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7114
更新日期:1999-08-01 00:00:00
abstract::Children who are born preterm are at risk for encephalopathy of prematurity, a leading cause of cerebral palsy, cognitive delay and behavioral disorders. Current interventions are limited and none have been shown to reverse cognitive and behavioral impairments, a primary determinant of poor quality of life for these c...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2017.12.010
更新日期:2018-04-01 00:00:00
abstract::Previous work utilizing the 2-deoxyglucose (2-DG) technique demonstrated that denervation, both direct (enucleation) or indirect (retinal receptor destruction, leaving ganglion cells intact), resulted in a depression followed by an increase in glucose metabolism in the superior colliculus (SC) of the mature hooded rat...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(89)90040-x
更新日期:1989-06-01 00:00:00
abstract::Although axons lose some of their intrinsic capacity for growth after their developmental period, some axons retain the potential for regrowth after injury. When provided with a growth-promoting substrate such as a peripheral nerve graft (PNG), severed axons regenerate into and through the graft; however, they stop wh...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2012.09.011
更新日期:2013-01-01 00:00:00
abstract::We have previously demonstrated that systemic administration of testosterone propionate (TP) to adult hamsters accelerates the rate of facial nerve regeneration following crush axotomy of the facial nerve at its exit from the stylomastoid foramen. In this study, we utilized flutamide, a potent nonsteroidal antiandroge...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1995.1016
更新日期:1995-06-01 00:00:00
abstract::Huntington's disease (HD) is a hereditary, progressive and ultimately fatal neurodegenerative disorder. Excitotoxicity and reduced availability of neurotrophic factors (NTFs) likely play roles in HD pathogenesis. Recently we developed a protocol that induces adult human bone marrow derived mesenchymal stem cells (MSCs...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2011.12.045
更新日期:2012-04-01 00:00:00
abstract::The contribution of chondroitin sulfate proteoglycan (CSPG) in the suppression of axonal growth in rat spinal cord has been examined by means of an in vitro bioassay in which regenerating neurons are grown on tissue section substrata. Dissociated embryonic chick dorsal root ganglionic neurons were grown on normal and ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1998.6951
更新日期:1998-12-01 00:00:00
abstract::Nerve growth factor (NGF) can induce sprouting of axotomized adult rat medial septum cholinergic neurons and promote their regeneration into septohippocampal nerve grafts and hippocampal formation. This study investigated the potential neurotropic (chemotactic/attracting) action of NGF in the adult rat cholinergic sep...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1993.1005
更新日期:1993-01-01 00:00:00
abstract::In the human embryo, from approximately 6 weeks gestational age (GA), dopaminergic (DA) neurons can be found in the ventral mesencephalon (VM). More specifically, the post-mitotic neurons are located in the ventral part of the tegmentum (VT), whereas no mature DA neurons are found in the neighboring dorsal part. We us...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2005.12.023
更新日期:2006-04-01 00:00:00
abstract::Major practical constraints on neural grafting in Parkinson's disease are the shortage of human donor tissue and the great loss of dopamine neurons during the grafting procedure. The vast majority of implanted embryonic dopamine neurons are believed to die within a few days of transplantation surgery, at least in part...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2000.7406
更新日期:2000-07-01 00:00:00
abstract::Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for nigrostriatal dopaminergic, central cholinergic, and motoneurons. GDNF also prevents the neuronal loss in experimental animal models for Parkinson's disease (PD). We have now investigated the GDNF gene for possible mutations in a group ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1998.6857
更新日期:1998-08-01 00:00:00
abstract::In cats anesthetized with nitrous oxide and halothane, ion-selecting microelectrodes were used to monitor changes in the concentration of potassium [K+]0 and calcium [Ca2+]0 in the extracellular compartment of the cerebral cortex during as long as 4 h of continuous stimulation of the cortical surface. At stimulus char...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(83)90220-0
更新日期:1983-02-01 00:00:00
abstract::To analyze the role of endogenous opioids on epileptogenesis the effect of repeated doses of naloxone alone (NA) (2, 4, and 8 mg/kg every 15 min) or along with intermittent photic stimulation (NPS) (1, 3, and 10 Hz) was tested on acute "Encephale isolé" cats. The electrical activity recordings of sensorimotor cortex (...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(88)90001-5
更新日期:1988-08-01 00:00:00
abstract::Adeno-associated virus (AAV) vectors are derived from a nonpathogenic and defective human parvovirus. Although currently unable to display the integration specificity featured by its wild-type parent, the recombinant AAV (rAAV) system has continued to attract enormous interest primarily due to its unique features such...
journal_title:Experimental neurology
pub_type: 杂志文章,评审
doi:10.1006/exnr.1996.6396
更新日期:1997-03-01 00:00:00
abstract::Five female adult Macaca nemestrina monkeys, given a unilateral intracarotid (ic) infusion of 2.3-3.5 mg of MPTP-HCl, were studied for 6-8 years. Two to 3 days after MPTP, the animals developed hemiparkinsonism characterized by rigidity and flexed posture of the arm contralateral to the side of infusion with episodes ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1998.6845
更新日期:1998-08-01 00:00:00