Abstract：
:The Alzheimer's disease-related peptide beta(1-40) amyloid self-associates to form fibrils exhibiting a morphology characteristic of amyloidogenic proteins. The mechanism of this fibrillization process has yet to be fully elucidated. In this study we have immobilized the beta(1-40) amyloid to flat gold surfaces using thiol-based self-assembled monolayers. Atomic force microscopy reveals the presence of spherical units of beta(1-40) amyloid immediately following the initiation of fibrillization. Short fibrillar structures, termed nascent fibrils, which appear to be formed by the association of these units are also present at this time point. At later time points extended, branching networks of fibrils are observed. Some fibrils exhibit a more beaded appearance and greater axial periodicity than others. No nascent fibrils are seen to be present. We believe that these data identify an early fibril structure which could act as an intermediate in beta-amyloid fibrillization. The oligomeric units of which these nascent fibrils are comprised are also determined.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Blackley HK,Patel N,Davies MC,Roberts CJ,Tendler SJ,Wilkinson MJ,Williams PMdoi
10.1006/exnr.1999.7114keywords:
subject
Has Abstractpub_date
1999-08-01 00:00:00pages
437-43issue
2eissn
0014-4886issn
1090-2430pii
S0014-4886(99)97114-5journal_volume
158pub_type
杂志文章abstract：:In previous studies of our group, we have reported differential alterations in opioidergic receptor subtypes densities in infarcted and periinfarcted brain tissue following middle cerebral artery occlusion (MCAO) in mice. Other studies have also described subcortical alterations consecutive to focal cortical ischemia....
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7400
更新日期：2000-08-01 00:00:00
abstract：:The present experiments focused on the morphological interaction between serotonergic (5-HT) and noradrenergic (NA) axons during regeneration following partial axonal denervation in the cerebral cortex in adult rats. The denervation paradigm used employed two neurotoxins, one for 5-HT and one for NA axons, infused tog...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(03)00221-8
更新日期：2003-11-01 00:00:00
abstract：:Activation of the visual system with a moving black and white geometric pattern resulted in dense patches or columns of 2-deoxyglucose label in primate extrastriate visual cortex. The three-dimensional reconstruction of these metabolic columns showed that they were arranged in irregularly shaped slabs which extended i...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90148-1
更新日期：1984-08-01 00:00:00
abstract：:After injury of their axons, damaged neurons shift their metabolic activity into a reparative mode aimed at survival and regeneration or, alternatively, they undergo degeneration and die. Previous reports have shown that at the initial stages of the response to axonal injury, polyamines are essential for neuronal surv...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(86)90307-9
更新日期：1986-06-01 00:00:00
abstract：:It is not yet clear how L-dopa, that is the most effective drug for the treatment of Parkinson's disease, enters into the dopaminergic neurons to be transformed into dopamine. It is suggested that L-dopa is mainly transported into cells by a group of L-amino acid carriers named "System L". Since these carriers are sel...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.04.005
更新日期：2008-07-01 00:00:00
abstract：:Rats were treated with single subcutaneous injections of the irreversible AChE inhibitors, sarin (90 to 100 micrograms/kg) or soman (55 micrograms/kg), and with chronic doses of the reversible carbamate inhibitor, pyridostigmine. In surviving animals with severe behavioral symptoms, we examined the end-plate regions o...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90268-7
更新日期：1985-07-01 00:00:00
abstract：:A transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins. We examined whether excitotoxin resistance characterizes mice with mutant huntingtin transgenes. In a n...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2002.7885
更新日期：2002-05-01 00:00:00
abstract：:Because vitamin D hormone deficiency (VDHdef) can worsen severity and outcome for ischemic stroke, we examined the role of VDH in maintaining blood-brain-barrier (BBB integrity) in a rat model of stroke. In most types of stroke, the BBB is markedly compromised, potentially leading to a cascade of injury processes and ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2018.11.005
更新日期：2019-02-01 00:00:00
abstract：:Cerebral edema is a clinical problem that frequently follows ischemic infarcts. Sulfonylurea receptor 1 (SUR1) is an inducible protein that can form a heteromultimeric complex with aquaporin 4 (AQP4) that mediate the ion/water transport involved in brain tissue swelling. Transcription of the Abcc8 gene coding for SUR1...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113353
更新日期：2020-08-01 00:00:00
abstract：:The human small heat shock proteins (HSPBs) form a family of molecular chaperones comprising ten members (HSPB1-HSPB10), whose functions span from protein quality control to cytoskeletal dynamics and cell death control. Mutations in HSPBs can lead to human disease and particularly point mutations in HSPB1 and HSPB8 ar...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2016.08.014
更新日期：2016-12-01 00:00:00
abstract：:Therapeutic hypothermia is a potential protective strategy after stroke. The present study evaluated the neurovascular protective potential of pharmacological hypothermia induced by the neurotensin receptor 1 agonist HPI-201 after severe ischemic stroke. Adult C57BL/6 mice were subjected to filament insertion-induced ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2019.113133
更新日期：2020-03-01 00:00:00
abstract：:The effects of D-Ala2-Met5-enkephalinamide (DAME) upon the hissing component of hypothalamically elicited affective defense behavior in the cat were examined in this study. Microinjections of DAME placed into the nucleus accumbens significantly suppressed this response in a dose and time dependent manner. This dose de...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90008-3
更新日期：1989-04-01 00:00:00
abstract：:The anatomical distribution and the content of dendrite bundles were studied in the spinal cord of adult rats. We injected retrogradely transported Cholera Toxin subunit B into muscles in order to label motoneurons and their dendrites. Twenty-one muscles in the trunk and in extremities were selected which are involved...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.0004
更新日期：1996-01-01 00:00:00
abstract：:Peripheral nerve crush injury (PNCI) has been used for many years in adult animals to study central and peripheral changes related to regeneration across the injury site. While these adult animals experience full recovery with no neuronal cell loss following PNCI, it has been noted that the injury in perinatal animals...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7014
更新日期：1999-05-01 00:00:00
abstract：:Dentate gyrus is usually assumed to be resistant to ischemia. However, the mechanisms underlying this functional plasticity are not fully understood. Herein, we aimed at identifying a neuroprotective mechanism in the dentate gyrus of the adult rat after global ischemia. Cyclic AMP response element (CRE)-binding protei...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.06.016
更新日期：2006-12-01 00:00:00
abstract：:Epidermal growth factor responsive (EGFr) neural progenitor (NP) cells have been shown to be a potential alternative tissue source for neural transplantation and for developmental study. We have shown that nonpassaged EGFr NP cells can self-renew for 2 years in neurospheres and can robustly differentiate into glia and...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7425
更新日期：2000-07-01 00:00:00
abstract：:Myelin accelerates action potential conduction velocity and provides essential energy support for axons. Unfortunately, myelin and myelinating cells are often vulnerable to injury or disease, resulting in myelin damage, which in turn can lead to axon dysfunction, overt pathology and neurological impairment. Inflammati...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2016.05.001
更新日期：2016-09-01 00:00:00
abstract：:Both fresh and cryopreserved-thawed human fetal ventral mesencephalon have been used for preclinical research and implantation into the brains of patients with Parkinson's disease. Further characterization and an evaluation of the effects of cryopreservation on immunocytochemical and neurochemical markers of monoamine...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1993.1084
更新日期：1993-06-01 00:00:00
abstract：:Clinical studies have provided evidence that the progression of HIV-1-associated neurocognitive disorders (HAND) involves alterations in dopamine (DA) systems. Drugs of abuse that act on the brain DA system, such as cocaine (Coc), may exacerbate HIV-1 infection and consequent behavioral and neurological manifestations...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.10.008
更新日期：2013-01-01 00:00:00
abstract：:In the present study, we investigated whether cultured astrocytes derived from adult neural precursor cells (NPCs) obtained from the subventricular zone (SVZ) of wobbler mice display metabolic traits of the wobbler astrocytes in situ and in primary culture. We also utilized NPC-derived astrocytes as a tool to investig...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2010.06.008
更新日期：2010-09-01 00:00:00
abstract：:Scopolamine and naloxone were administered singly and in combination to different groups of rats undergoing electrical kindling of the amygdala. Scopolamine significantly reduced the maximal seizure stage attained during 15 drug sessions and increased the total number of afterdischarges required to kindle a generalize...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90171-3
更新日期：1987-04-01 00:00:00
abstract：:As in Alzheimer's disease, brains of Guam Chamorros with amyotrophic lateral sclerosis (ALS) and Parkinsonism-dementia complex (PDC) contain intraneuronal-paired helical filaments composed of accumulated phosphorylated tau protein. Tau mRNA expression in rat neuronal cultures-normally modulated by glutamate-increases ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6962
更新日期：1999-01-01 00:00:00
abstract：:The accumulation of damage to DNA plays a significant role in the etiology of the aging process. The importance of nutrition in delaying the aging process is well recognized. L-carnitine is a quaternary ammonium compound heterogeneously distributed in the brain. In the present study the effect of L-carnitine on DNA da...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.09.009
更新日期：2005-01-01 00:00:00
abstract：:Some forms of electrographic seizures are generated at the level of the cortical network. Neocortical kindling exhibits a resistance to produce generalized convulsive seizures, and therefore, it was rather difficult to use it to study the cortical epileptogenesis. Here, using supra-threshold cortical kindling, we repo...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.02.010
更新日期：2008-06-01 00:00:00
abstract：:Morphologic alterations of the hippocampal mossy fiber pathway after postnatal lead exposure have been observed in rats. It is hypothesized that lead might perturb zinc pools found in this pathway. To test this hypothesis, rat pups were exposed to lead indirectly by administering 0.2% lead acetate to dams via the drin...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90035-9
更新日期：1984-09-01 00:00:00
abstract：:The psychopathological impact of emotional stress on a specific individual varies markedly: while most escape the development of post-traumatic stress disorder and/or major depression, a select group of individuals demonstrate a vulnerability to succumb to these conditions. The past decade has witnessed an explosion i...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2014.05.012
更新日期：2014-11-01 00:00:00
abstract：:After spinal cord injury (SCI), the majority of individuals develop spasticity, a debilitating condition involving involuntary movements, co-contraction of antagonistic muscles, and hyperreflexia. By acting on GABAergic and Ca2+-dependent signaling, current anti-spastic medications lead to serious side effects, includ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2021.113605
更新日期：2021-01-13 00:00:00
abstract：:Recovery from injury to the central nervous system (CNS) is limited in the mammalian adult. Nonetheless, some degree of spontaneous recovery occurs after partial CNS injury. Compensatory axonal growth from uninjured neurons, termed sprouting, contributes to this naturally occurring recovery process and can be modulate...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2018.07.013
更新日期：2018-11-01 00:00:00
abstract：:To test the hypothesis that prepubertal exposure of LHRH neurons to a source of catecholamines and neuropeptides accelerates the onset of puberty, we examined the effects of autologous adrenal transplantation into the base of the third ventricle of the brain in juvenile female rhesus monkeys at 11-13 months of age. Th...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.0127
更新日期：1996-08-01 00:00:00
abstract：:Potassium and caffeine contractures of isolated small bundles (100 to 200 micron diameter) of muscle fibers isolated from the diaphragm of normal and dystrophic (C57BL/6J dy2J/dy2J) mice were compared. In diaphragms of pathologic mice (3 to 5 months old) the resting potential, the characteristics of the twitch, and so...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90126-2
更新日期：1984-03-01 00:00:00
