Interaction between serotonergic and noradrenergic axons during axonal regeneration.

abstract：:Human immunodeficiency virus (HIV) patients treated with nucleoside reverse transcriptase inhibitors (NRTIs), have been known to develop neuropathic pain. While there has been a major shift away from some neurotoxic NRTIs in current antiretroviral therapy, a large number of HIV patients alive today have previously rec...

journal_title：Experimental neurology

authors： Iida T,Yi H,Liu S,Huang W,Kanda H,Lubarsky DA,Hao S

更新日期：2016-07-01 00:00:00

abstract：:Zebrafish is an excellent model to study central nervous system (CNS) axonal degeneration and regeneration since we can observe these processes in vivo and in real time in transparent larvae. Previous studies have shown that Mauthner cell (M-cell) axon regenerates poorly after mechanical spinal cord injury. Inconsiste...

journal_title：Experimental neurology

authors： Hu BB,Chen M,Huang RC,Huang YB,Xu Y,Yin W,Li L,Hu B

更新日期：2018-02-01 00:00:00

abstract：:The sciatic nerve of the rat is a commonly used model for studies on nerve injury, regeneration, and recovery of function. To interpret the changes that occur in a neuron population subsequent to peripheral nerve injury, and to compare different repair procedures, it is essential to have a complete and accurate unders...

journal_title：Experimental neurology

authors： Swett JE,Wikholm RP,Blanks RH,Swett AL,Conley LC

更新日期：1986-07-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for motoneurons (MNs), and is considered a potential agent for the treatment of amyotrophic lateral sclerosis (ALS) and other MN diseases. The effectiveness of GDNF may depend significantly upon its route of delivery to MNs. In this study w...

journal_title：Experimental neurology

authors： Li W,Brakefield D,Pan Y,Hunter D,Myckatyn TM,Parsadanian A

更新日期：2007-02-01 00:00:00

abstract：:The EEG of 20 Wistar rats inbred for audiogenic seizures was recorded during 40 daily auditory stimuli 90 s long. The first stimuli provoked wild running, with no cortical EEG abnormality, and then a tonic phase with a characteristic EEG of a brief flat trace 2 to 3 s long followed by low-amplitude regular activity, 1...

journal_title：Experimental neurology

authors： Marescaux C,Vergnes M,Kiesmann M,Depaulis A,Micheletti G,Warter JM

更新日期：1987-07-01 00:00:00

abstract：:The precise role of hypothalamic norepinephrine (NE) in the control of vasopressin (AVP) release has remained unclear, due to reports of both inhibitory and excitatory effects of NE and only a few studies with direct hypothalamic manipulations. The present study utilized a chronically implanted swivel brain cannula to...

journal_title：Experimental neurology

authors： Leibowitz SF,Eidelman D,Suh JS,Diaz S,Sladek CD

更新日期：1990-12-01 00:00:00

abstract：:Dopaminergic loss is known to be one of the major hallmarks of Parkinson disease (PD). In addition to its function as a neurotransmitter, dopamine plays significant roles in developmental and adult neurogenesis. Both dopaminergic deafferentation and stimulation modulate proliferation in the subventricular zone (SVZ)/o...

journal_title：Experimental neurology

authors： Winner B,Geyer M,Couillard-Despres S,Aigner R,Bogdahn U,Aigner L,Kuhn G,Winkler J

更新日期：2006-01-01 00:00:00

abstract：:Intracranial collaterals provide residual blood flow to penumbral tissue in acute ischemic stroke and contribute to infarct size variability in humans. In the present study, hemodynamic monitoring of the borderzone territory between the leptomeningeal branches of middle cerebral artery and anterior cerebral artery was...

journal_title：Experimental neurology

authors： Riva M,Pappadà GB,Papadakis M,Cuccione E,Carone D,Menendez VR,Sganzerla EP,Beretta S

更新日期：2012-02-01 00:00:00

abstract：:In human diabetes, degenerative and functional disorders of the central nervous system, including depression, are common findings. Defective dentate gyrus (DG) neurogenesis is associated with affective-related disorders and depression. We previously demonstrated reduced DG neurogenesis in a pharmacological type 1 diab...

journal_title：Experimental neurology

authors： Beauquis J,Saravia F,Coulaud J,Roig P,Dardenne M,Homo-Delarche F,De Nicola A

更新日期：2008-04-01 00:00:00

abstract：:Parkinson's Disease (PD) is the most common neurodegenerative movement disorder. Autosomal-recessive mutations in the mitochondrial protein kinase PINK1 (PTEN-induced kinase 1) account for 1-2% of the hereditary early-onset cases. To study the mechanisms underlying disease development, we generated Pink1-deficient mic...

journal_title：Experimental neurology

authors： Glasl L,Kloos K,Giesert F,Roethig A,Di Benedetto B,Kühn R,Zhang J,Hafen U,Zerle J,Hofmann A,de Angelis MH,Winklhofer KF,Hölter SM,Vogt Weisenhorn DM,Wurst W

更新日期：2012-05-01 00:00:00

abstract：:Tuberoinfundibular peptide of 39 residues (TIP39) synthesizing neurons at the caudal border of the thalamus and in the lateral pons project to areas rich in its receptor, the parathyroid hormone 2 receptor (PTH2R). These areas include many involved in processing nociceptive information. Here we examined the potential ...

journal_title：Experimental neurology

authors： Dimitrov EL,Petrus E,Usdin TB

更新日期：2010-11-01 00:00:00

abstract：:Massive increases in extracellular dopamine have been reported in the ischemic rodent striatum, implicating this neurotransmitter in toxic events. We have examined whether dopamine receptor antagonists are protective against hypoxic insult, using brain slices containing the rostral striatum obtained from adult male C5...

journal_title：Experimental neurology

authors： Davis S,Brotchie J,Davies I

更新日期：2002-07-01 00:00:00

abstract：:Estrogen has been suggested to be pro-epileptic by reducing GABA synthesis, resulting in increased spine density and a decreased threshold for seizures in the hippocampus, which, once they occur, are characterized by a dramatic spine loss in the affected brain areas. As considerable amounts of estradiol are synthesize...

journal_title：Experimental neurology

authors： Zhou L,Lehan N,Wehrenberg U,Disteldorf E,von Lossow R,Mares U,Jarry H,Rune GM

更新日期：2007-01-01 00:00:00

abstract：:Apnea of prematurity (AoP) is associated with severe and repeated episodes of arterial oxygen desaturation (intermittent hypoxia - IH), which in turn increases the number of apneas. So far, there is no data addressing whether IH leads to sex-specific respiratory consequences, neither if drugs targeting AoP are more ef...

journal_title：Experimental neurology

authors： Laouafa S,Iturri P,Arias-Reyes C,Marcouiller F,Gonzales M,Joseph V,Bairam A,Soliz J

更新日期：2019-10-01 00:00:00

abstract：:Development of outcome measures to assess ongoing nerve regeneration in the living animal that can be translated to human can provide extremely useful tools for monitoring the effects of therapeutic interventions to promote nerve regeneration. Diffusion tensor imaging (DTI), a magnetic resonance based technique, provi...

journal_title：Experimental neurology

authors： Lehmann HC,Zhang J,Mori S,Sheikh KA

更新日期：2010-05-01 00:00:00

abstract：:Chronic nerve compression (CNC) injuries induce a robust Schwann cell proliferation in a distinct spatial and temporal pattern, which is accompanied by an increase in the number of small un-myelinated axons in the area of the injury. These findings suggest that this local proliferation of Schwann cells may induce loca...

journal_title：Experimental neurology

authors： Gupta R,Rummler LS,Palispis W,Truong L,Chao T,Rowshan K,Mozaffar T,Steward O

更新日期：2006-08-01 00:00:00

abstract：:No current therapy for Parkinson disease has been shown to slow or reverse the progressive course of the disease. As a departure from traditional treatments, gene therapy approaches provide a new hope for realizing this long-sought goal; but before they can be widely employed for use in patients, they must first be su...

journal_title：Experimental neurology

authors： Lewis TB,Standaert DG

更新日期：2008-01-01 00:00:00

abstract：:Genetically dystrophic chicks (line 413) were administered 0.3 mg/kg dexamethasone (DEX), a corticosteroid, from 2 to 28 days ex ovo. Diluent-injected dystrophic and normal (line 412) chicks served as controls. The effects of DEX on muscle function were evaluated weekly by the exhaustion score (ES) method. Proton magn...

journal_title：Experimental neurology

authors： Misra LK,Entrikin RK

更新日期：1988-11-01 00:00:00

abstract：:Axons of retinal ganglion cells (RGCs) of adult cats were transected and regenerated by the transplantation of peripheral nerves. Two months after transplantation dendritic arbors of RGCs with regenerated axons (r-RGCs) were visualized with intracellular injections of horseradish peroxidase (HRP). The HRP-filled r-RGC...

journal_title：Experimental neurology

authors： Watanabe M,Fukuda Y

更新日期：1997-01-01 00:00:00

abstract：:At the age of 31 days, Long-Evans female rats received electrolytic lesions either of the medial fimbria (N = 24), of the dorsal subcallosal fornix (N = 24), or of both structures (N = 24). Ten rats were used as sham-operated controls. Ten days later, half the rats of each lesion group received intrahippocampal grafts...

journal_title：Experimental neurology

authors： Cassel JC,Kelche C,Will BE

更新日期：1987-09-01 00:00:00

abstract：:Cortical stimulation (CS) as a means to modulate regional activity and excitability in cortex is emerging as a promising approach for facilitating rehabilitative interventions after brain damage, including stroke. In this study, we investigated whether CS-induced functional improvements are linked with synaptic plasti...

journal_title：Experimental neurology

authors： Adkins DL,Hsu JE,Jones TA

更新日期：2008-07-01 00:00:00

abstract：:The effects of a trigeminal tractotomy on nociceptive reactions induced by electrical stimulation of an inferior incisor were studied in freely moving rats. Behavioral tests were based on the observation of three reactions: jaw opening reflex, face scratching with forepaws, and head rotation toward the stimulated side...

journal_title：Experimental neurology

authors： Dallel R,Clavelou P,Woda A

更新日期：1989-10-01 00:00:00

abstract：:We have treated spinal cord injured rats with demyelination plus Schwann cell transplantation and assessed neurite outgrowth in a quantifiable model of axonal regeneration. Axonal injuries of differing severity were induced in the dorsal funiculus of adult rats using a micromanipulator-controlled Scouten knife. Demyel...

journal_title：Experimental neurology

authors： Keirstead HS,Morgan SV,Wilby MJ,Fawcett JW

更新日期：1999-09-01 00:00:00

abstract：:Extracellular single-unit responses of neurons in the ipsilateral pulvinar-lateral posterior complex were recorded in 10 encéphale isolé cats with stimulating electrodes implanted in the substantia nigra pars reticulata and pars lateralis. Fifteen percent of 101 pulvinar-lateral posterior complex thalamic neurons incr...

journal_title：Experimental neurology

authors： Infante C,Leiva J,Motles E,Saavedra H

更新日期：1988-02-01 00:00:00

abstract：:This study examines the effects of high K+ concentration on the growth and development of mesencephalic cells and their glutamate vulnerability. Mesencephalic cell cultures obtained from Wistar rat embryos on the 14th gestational day were maintained for 14 days in medium with either normal (4.2 mM) or elevated (24.2 m...

journal_title：Experimental neurology

authors： Andreeva N,Ungethum U,Heldt J,Marschhausen G,Altmann T,Andersson K,Gross J

更新日期：1996-02-01 00:00:00

abstract：:The effects of delta-9-tetrahydrocannabinol on sensory activity in the thalamic intralaminar nuclei, centralis lateralis and the mesencephalic reticular formation were compared with the effects on cortical association or heterosensory systems in alpha-chloralose-anesthetized cats. The drug depressed the anterior margi...

journal_title：Experimental neurology

authors： Pontzer NJ,Wilkison DM

更新日期：1987-09-01 00:00:00

abstract：:The chorda tympani (CT) nerve carries taste information from the anterior tongue to the brain stem. Injury to the chorda tympani may result in loss or distortion of taste information. This study examined changes occurring in the hamster peripheral taste system during recovery from injury. The hamster chorda tympani ne...

journal_title：Experimental neurology

authors： Cain P,Frank ME,Barry MA

更新日期：1996-10-01 00:00:00

abstract：:The Alzheimer's disease-related peptide beta(1-40) amyloid self-associates to form fibrils exhibiting a morphology characteristic of amyloidogenic proteins. The mechanism of this fibrillization process has yet to be fully elucidated. In this study we have immobilized the beta(1-40) amyloid to flat gold surfaces using ...

journal_title：Experimental neurology

authors： Blackley HK,Patel N,Davies MC,Roberts CJ,Tendler SJ,Wilkinson MJ,Williams PM

更新日期：1999-08-01 00:00:00

abstract：:Neurons from cerebral neocortex and hippocampus exhibit a striking difference in vulnerability to transient global ischemia. In order to study the contribution of neuronal connections and neuron-glia interactions to this variation in neuronal vulnerability, we used hippocampal and neocortical cultures submitted to var...

journal_title：Experimental neurology

authors： Bernaudin M,Nouvelot A,MacKenzie ET,Petit E

更新日期：1998-03-01 00:00:00

abstract：:Intractable pain is the single most common cause of disability, affecting more than 20% of the population world-wide. There is accordingly a global effort to decipher how changes in nociceptive processing in the peripheral and central nervous systems contribute to the onset and maintenance of chronic pain. The past se...

journal_title：Experimental neurology

authors： Xie YF,Wang J,Bonin RP

更新日期：2018-08-01 00:00:00