Abstract：
:Caloric restriction (CR) is a daily reduction of total caloric intake without a decrease in micronutrients or disproportionate reduction of any one dietary component. CR can increase lifespan reliably in a wide range of species and appears to counteract some aspects of the aging process throughout the body. The effects on the brain are less clear, but moderate CR seems to attenuate age-related cognitive decline. Thus, we determined the effects of age and CR on key synaptic proteins in the CA3 region of the hippocampus and whether these changes were correlated with differences in behavior on a hippocampal-dependent learning and memory task. We observed an overall, age-related decline in the NR1, N2A and N2B subunits of the N-methyl-d-aspartate (NMDA)-type and the GluR1 and GluR2 subunits of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA)-type ionotropic glutamate receptors. Interestingly, we found that CR initially lowers the glutamate receptor subunit levels as compared to young AL animals, and then stabilizes the levels across lifespan. Synaptophysin, a presynaptic vesicle protein, showed a similar pattern. We also found that both CR and ad libitum (AL) fed animals exhibited age-related cognitive decline on the Morris water maze task. However, AL animals declined between young and middle age, and between middle age and old, whereas CR rats only declined between young and middle age. Thus, the decrease in key synaptic proteins in CA3 and cognitive decline occurring across lifespan are stabilized by CR. This age-related decrease and CR-induced stabilization are likely to affect CA3 synaptic plasticity and, as a result, hippocampal function.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Adams MM,Shi L,Linville MC,Forbes ME,Long AB,Bennett C,Newton IG,Carter CS,Sonntag WE,Riddle DR,Brunso-Bechtold JKdoi
10.1016/j.expneurol.2008.01.016subject
Has Abstractpub_date
2008-05-01 00:00:00pages
141-9issue
1eissn
0014-4886issn
1090-2430pii
S0014-4886(08)00033-2journal_volume
211pub_type
杂志文章abstract：:The precise role of hypothalamic norepinephrine (NE) in the control of vasopressin (AVP) release has remained unclear, due to reports of both inhibitory and excitatory effects of NE and only a few studies with direct hypothalamic manipulations. The present study utilized a chronically implanted swivel brain cannula to...
journal_title：Experimental neurology
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pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章,评审
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更新日期：2004-08-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1006/exnr.1999.7016
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pub_type： 杂志文章
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pub_type： 评论,杂志文章
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