Neuropeptides and morphological changes in cisplatin-induced dorsal root ganglion neuronopathy.


:Dorsal root ganglia (DRG) neuronopathy was induced in rats by chronic treatment (2 mg/kg twice a week for nine injections) with the antineoplastic drug cisplatin. Morphological alterations and changes in peptide [calcitonin gene-related peptide (CGRP), substance P, galanin (Gal), and somatostatin] concentration were studied in the DRG, the spinal cord, and the sciatic nerve. Peptide concentration was increased in DRG neurons, with CGRP and Gal showing the highest increase. Conversely, in the sciatic nerve there was a general decrease in peptide content. In DRG a reduction in the nuclear, cytoplasmic, and nucleolar areas of primary sensory neurons was evident and was accompanied by clear-cut aspects of nucleolar structural damage. In peripheral nerves only extensive morphometric determinations could evidence a reduction in nerve conduction velocities and impairment in pain detection and coordination. Some of the nerve fibers presented axonal and adaxonal accumulations, suggesting the presence of an axonopathy. These results confirm that DRG cells are the primary target of cisplatin-induced neurotoxicity. Milder alterations can be detected in peripheral nerves. The increase in peptide concentration in DRG is probably due to cisplatin-related damage to the axonal transport system rather than to an increased synthesis.


Exp Neurol


Experimental neurology


Barajon I,Bersani M,Quartu M,Del Fiacco M,Cavaletti G,Holst JJ,Tredici G




Has Abstract


1996-03-01 00:00:00














  • The effects of passive exercise therapy initiated prior to or after the development of hyperreflexia following spinal transection.

    abstract::Hyperreflexia develops after spinal cord injury (SCI) in the human and in the spinal cord transected animal, and can be measured by the loss of low frequency-dependent depression of the H-reflex. Previous studies demonstrated normalization of low frequency-dependent depression of the H-reflex using passive exercise wh...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Yates CC,Charlesworth A,Reese NB,Skinner RD,Garcia-Rill E

    更新日期:2008-10-01 00:00:00

  • Performance of movement in hemiparkinsonian rats influences the modifications induced by dopamine agonists in striatal efferent dynorphinergic neurons.

    abstract::A previous study of our group demonstrated that movement performance induced by dopamine agonist drugs in hemiparkinsonian rats unilaterally lesioned with 6-hydroxydopamine (6-OHDA), governs the occurrence of a sensitized motor response to a subsequent dopaminergic challenge (priming model). In the present study, we e...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Frau L,Morelli M,Simola N

    更新日期:2013-09-01 00:00:00

  • Impaired axonal transport and altered axolemmal permeability occur in distinct populations of damaged axons following traumatic brain injury.

    abstract::Traumatic axonal injury (TAI) evolves within minutes to hours following traumatic brain injury (TBI). Previous studies have identified axolemmal disruption and impaired axonal transport (AxT) as key mechanisms in the evolution of TAI. While initially hypothesized that axolemmal disruption culminates in impaired AxT, p...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Stone JR,Okonkwo DO,Dialo AO,Rubin DG,Mutlu LK,Povlishock JT,Helm GA

    更新日期:2004-11-01 00:00:00

  • Combinatorial influences of paclitaxel and strain on axonal transport.

    abstract::Paclitaxel is an effective chemotherapeutic agent that, despite its common use, often causes peripheral sensory neuropathy. In neurons, paclitaxel binds to and stabilizes microtubules, and through unknown mechanisms, bundles microtubules and disrupts their organization. Because microtubules serve as tracks on which a ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Bober BG,Gutierrez E,Plaxe S,Groisman A,Shah SB

    更新日期:2015-09-01 00:00:00

  • Epigenetic mechanisms of neuroplasticity and the implications for stroke recovery.

    abstract::Ischemic stroke is a devastating brain injury and an important cause of neurologic disability worldwide and across the lifespan. Despite the physical, social, and economic burdens of this disease there is only a single approved medicine for the treatment of acute stroke, and its use is unfortunately limited to the sma...

    journal_title:Experimental neurology

    pub_type: 杂志文章,评审


    authors: Felling RJ,Song H

    更新日期:2015-06-01 00:00:00

  • The L-amino acid carrier inhibitor 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (BCH) reduces L-dopa-elicited responses in dopaminergic neurons of the substantia nigra pars compacta.

    abstract::It is not yet clear how L-dopa, that is the most effective drug for the treatment of Parkinson's disease, enters into the dopaminergic neurons to be transformed into dopamine. It is suggested that L-dopa is mainly transported into cells by a group of L-amino acid carriers named "System L". Since these carriers are sel...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Sebastianelli L,Ledonne A,Marrone MC,Bernardi G,Mercuri NB

    更新日期:2008-07-01 00:00:00

  • Unity of costal and crural diaphragmatic activity in respiration.

    abstract::In chronically implanted rats, we examined the respiratory EMG activity of the two parts of the diaphragm, costal and crural, during sleep and wakefulness. Their activity was compared and contrasted with that of the EMG activity of the cricothyroid muscle. Whether in wakefulness, while grooming and drinking, or in non...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Pollard MJ,Megirian D,Sherrey JH

    更新日期:1985-10-01 00:00:00

  • Restitution of functional neural connections in chick embryos assessed in vitro after spinal cord transection in Ovo.

    abstract::Functional neural reconnection is not common after spinal cord transection in the CNS of adult higher vertebrates but has been demonstrated in embryonic avian and neonatal mammalian CNS. Chick brainstem spinal cord preparations from nontransected controls and embryos transected at the cervical level on embryonic days ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Sholomenko GN,Delaney KR

    更新日期:1998-12-01 00:00:00

  • Repin-induced neurotoxicity in rodents.

    abstract::Russian knapweed is a perennial weed found in many parts of the world, including southern California. Chronic ingestion of this plant by horses has been reported to cause equine nigropallidal encephalomalacia (ENE), which is associated with a movement disorder simulating Parkinson's disease (PD). Repin, a principal in...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Robles M,Choi BH,Han B,Santa Cruz K,Kim RC

    更新日期:1998-07-01 00:00:00

  • Spinal Cord Transection-No Loss of Distal Ventral Horn Neurons

    abstract::Anterograde transneuronal degeneration is caused by the loss of afferent input to the nerve cells and may occur in a number of neuronal systems. Transection of the adult spinal cord, causing anterograde transneuronal degeneration in ventral horn neurons, distal to the lesion, has been reported by some authors, while o...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Bjugn R,Nyengaard JR,Rosland JH

    更新日期:1997-11-01 00:00:00

  • Selective loss of NGF-sensitive neurons following experimental colitis.

    abstract::Nerve growth factor (NGF) enhances neuronal survival during injury to the mature central and peripheral nervous systems, but its potential as a neuroprotective factor in the enteric nervous system (ENS) has not been examined. We used the trinitrobenzene sulfonic acid (TNBS)-induced model of colitis to examine if NGF-s...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Lin A,Lourenssen S,Stanzel RD,Blennerhassett MG

    更新日期:2005-02-01 00:00:00

  • Endolymphatic hydrops reduces retrograde labeling of trigeminal innervation to the cochlea.

    abstract::This paper reports that endolymphatic hydrops causes a significant reduction of retrogradely labeled cell bodies of the ipsilateral trigeminal ganglion following application of horseradish peroxidase in the cochlea. We previously showed that the trigeminal ganglion is a source of primary sensory innervation to the coc...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Vass Z,Shore SE,Nuttall AL,Miller JM

    更新日期:1998-06-01 00:00:00

  • Vasomotion in normal and injured spinal cord.

    abstract::Blood flow in the feline thoracic spinal cord was measured, using a laser-Doppler flowmetry. Rhythmic changes in the spinal cord blood flow were repeatedly observed with a frequency of about three to eight cycles per minute, unrelated to the respiratory or cardiac cycles. These changes were unaffected by hypertension ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Mizutani M,Yamamuro T,Shikata J

    更新日期:1988-08-01 00:00:00

  • Transplanted human glial-restricted progenitors can rescue the survival of dysmyelinated mice independent of the production of mature, compact myelin.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Lyczek A,Arnold A,Zhang J,Campanelli JT,Janowski M,Bulte JW,Walczak P

    更新日期:2017-05-01 00:00:00

  • Stimulation of the subthalamic region at 20 Hz slows the development of grip force in Parkinson's disease.

    abstract::Excessive synchronization of basal ganglia neuronal activity at ~20 Hz is characteristic of patients with untreated Parkinson's disease (PD). Correlative evidence suggests that this activity may contribute to bradykinesia. Attempts to demonstrate causality through stimulation imposed synchronization at 20 Hz in the re...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Chen CC,Lin WY,Chan HL,Hsu YT,Tu PH,Lee ST,Chiou SM,Tsai CH,Lu CS,Brown P

    更新日期:2011-09-01 00:00:00

  • Sarcomere length in normal and dystrophic chick muscles.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Ashmore CR,Mechling K,Lee YB

    更新日期:1988-08-01 00:00:00

  • Alterations of striatal glutamate transmission in rotenone-treated mice: MRI/MRS in vivo studies.

    abstract::Animal models treated with agricultural chemicals, such as rotenone, reproduce several degenerative features of human central nervous system (CNS) diseases. Glutamate is the most abundant excitatory amino acid transmitter in the mammalian central nervous system and its transmission is implicated in a variety of brain ...

    journal_title:Experimental neurology

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    authors: Moussa CE,Rusnak M,Hailu A,Sidhu A,Fricke ST

    更新日期:2008-01-01 00:00:00

  • Influence of early life status epilepticus on the developmental expression profile of the GluA2 subunit of AMPA receptors.

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    journal_title:Experimental neurology

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    authors: Szczurowska E,Ergang P,Kubová H,Druga R,Salaj M,Mareš P

    更新日期:2016-09-01 00:00:00

  • Distribution of serotonin 2A and 2C receptor mRNA expression in the cervical ventral horn and phrenic motoneurons following spinal cord hemisection.

    abstract::Cervical spinal cord injury leads to a disruption of bulbospinal innervation from medullary respiratory centers to phrenic motoneurons. Animal models utilizing cervical hemisection result in inhibition of ipsilateral phrenic nerve activity, leading to paralysis of the hemidiaphragm. We have previously demonstrated a r...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Basura GJ,Zhou SY,Walker PD,Goshgarian HG

    更新日期:2001-06-01 00:00:00

  • The mode of axonal regeneration of locus coeruleus neurons in the lateral geniculate nucleus following neonatal 6-hydroxydopamine treatment.

    abstract::The effects of neonatal 6-hydroxydopamine (6-OHDA) treatment on the projection of locus coeruleus (LC) neurons to the dorsal part of the lateral geniculate nucleus (dLGN) were examined using histofluorescence and electrophysiological methods. Histofluorescence studies confirmed the previous results of Gustafson and Mo...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Aoki F,Nakamura S

    更新日期:1991-06-01 00:00:00

  • Tianeptine modulates amygdalar glutamate neurochemistry and synaptic proteins in rats subjected to repeated stress.

    abstract::Stress is a common environmental factor associated with depressive illness and the amygdala is thought to be integral for this association. For example, repeated stress impairs amygdalar neuroplasticity in rodents and these defects parallel amygdalar deficits in depressive illness patients. Because the excitatory neur...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Piroli GG,Reznikov LR,Grillo CA,Hagar JM,Fadel JR,Reagan LP

    更新日期:2013-03-01 00:00:00

  • Transendocytosis is impaired in CADASIL-mutant NOTCH3.

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    journal_title:Experimental neurology

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    authors: Watanabe-Hosomi A,Watanabe Y,Tanaka M,Nakagawa M,Mizuno T

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  • Absence of sympathetic sprouting in the rat olfactory bulb after cholinergic denervation.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Gibby WA,Crutcher KA

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  • Vitamin D deficiency increases blood-brain barrier dysfunction after ischemic stroke in male rats.

    abstract::Because vitamin D hormone deficiency (VDHdef) can worsen severity and outcome for ischemic stroke, we examined the role of VDH in maintaining blood-brain-barrier (BBB integrity) in a rat model of stroke. In most types of stroke, the BBB is markedly compromised, potentially leading to a cascade of injury processes and ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Sayeed I,Turan N,Stein DG,Wali B

    更新日期:2019-02-01 00:00:00

  • Mirror-image pain after nerve reconstruction in rats is related to enhanced density of epidermal peptidergic nerve fibers.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Kambiz S,Brakkee EM,Duraku LS,Hovius SE,Ruigrok TJ,Walbeehm ET

    更新日期:2015-05-01 00:00:00

  • Plaque-associated neuronal proteins: a recurrent motif in neuritic amyloid deposits throughout diverse cortical areas of the Alzheimer's disease brain.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Schmidt ML,DiDario AG,Otvos L Jr,Hoshi N,Kant JA,Lee VM,Trojanowski JQ

    更新日期:1994-12-01 00:00:00

  • Retinal cell and photoreceptor transplantation between adult New Zealand red rabbit retinas.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Schuschereba ST,Silverman MS

    更新日期:1992-01-01 00:00:00

  • Transient up-regulation of retinal EphA3 and EphA5, but not ephrin-A2, coincides with re-establishment of a topographic map during optic nerve regeneration in goldfish.

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    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: King CE,Wallace A,Rodger J,Bartlett C,Beazley LD,Dunlop SA

    更新日期:2003-10-01 00:00:00

  • Thalamic kindling: electrical stimulation of the lateral geniculate nucleus produces photosensitive grand mal seizures.

    abstract::Kindling is traditionally viewed as a chronic, focal epilepsy model which consistently induces complex partial seizures from limbic structures in animals. This study revealed that primary or exceedingly rapid secondary generalized seizures could also be kindled when stimulation was applied to the lateral geniculate nu...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Shouse MN,Ryan W

    更新日期:1984-10-01 00:00:00

  • Adult human olfactory neural progenitors cultured in defined medium.

    abstract::Neurosphere-forming cells (NSFCs) derived from primary cultures of adult human olfactory epithelium were established in minimum essential medium (MEM) with Hanks balanced salts and 10% heat-inactivated fetal bovine serum (FBS). A totally defined medium (DM) was employed to examine their proliferation, lineage restrict...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Zhang X,Klueber KM,Guo Z,Lu C,Roisen FJ

    更新日期:2004-04-01 00:00:00