Abstract：
:Golgi and computer morphometric analysis of neuronal dendrites was done on four cases, one each of Tay-Sachs disease, infantile type 2 sialidosis, Hurler's syndrome, and Sanfilippo's syndrome. There were large meganeurites on pyramidal neurons in Tay-Sachs disease, and small ones in Hurler's and Sanfilippo's syndromes. All the meganeurites in these three diseases were predominantly distal to the soma in layer 3, but close to it in layer 5. These findings may be accounted for by different rates of ganglioside accumulation and cortical neuronal morphogenesis. Computer morphometric analysis revealed atrophic or less developed layer 5 dendritic length and branching in Tay-Sachs disease, sialidosis, and Hurler's syndrome compared with tissues from control patients. These dendritic changes may be secondary to ganglioside accumulation or due to abnormal surface membrane production during dendritic development. This study contributes to an understanding of how enzyme deficiency is translated into abnormal cell structure and, presumably, function.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Takashima S,Becker LE,Chan FW,Augustin Rdoi
10.1016/0014-4886(85)90078-0subject
Has Abstractpub_date
1985-06-01 00:00:00pages
652-72issue
3eissn
0014-4886issn
1090-2430journal_volume
88pub_type
杂志文章abstract：:Focal infarction (stroke) of the lateral cerebral cortex of rats (including the sensorimotor cortex) produces deficits in sensorimotor function of the contralateral limbs that recover partially over time. In previous studies, we found that the intracisternal injection of basic fibroblast growth factor (bFGF), a potent...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7101
更新日期：1999-07-01 00:00:00
abstract：:Twenty-eight-day-old (juvenile) rats were kindled with hourly stimulations to partial or fully kindled status. Adult rats were stimulated with hourly or daily stimulations. Alterations in [3H]dihydroalprenolol binding were determined 3 weeks after the last stimulation. We found that partially kindled, hourly stimulate...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90006-9
更新日期：1987-01-01 00:00:00
abstract：:Neuregulins have been shown to play an important role in the development of the central nervous system, but their function in adult tissues is still unclear. We investigated the expression of the neuregulin receptors erbB3 and erbB4 in the adult rat brain by in situ hybridization histochemistry. Areas with considerabl...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7163
更新日期：1999-10-01 00:00:00
abstract：:The influence that the amygdala may exert on the development of hippocampal kindling was investigated using three different approaches: (i) after uni- or bilateral amygdalectomy by thermocoagulation, (ii) after prestimulation of the amygdala until the appearance of masticatory movements, and (iii) after increasing the...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90416-8
更新日期：1983-11-01 00:00:00
abstract：:The effects of D-Ala2-Met5-enkephalinamide (DAME) upon the hissing component of hypothalamically elicited affective defense behavior in the cat were examined in this study. Microinjections of DAME placed into the nucleus accumbens significantly suppressed this response in a dose and time dependent manner. This dose de...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90008-3
更新日期：1989-04-01 00:00:00
abstract：:Spinal cord injury results in cell loss, disruption of neural circuitry and chronic functional impairment. Several different cell types generate progeny in response to injury, which participate in scar formation and remyelination. Work over the last few years has identified neural stem cells and delineated the stem ce...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2013.01.026
更新日期：2014-10-01 00:00:00
abstract：:The kindling phenomenon, i.e., the progressive development of focal and secondarily generalized seizures upon repeated electrical stimulation of a limbic brain region, occurs in various species, but with marked differences in kindling rate between species and also within the same species. In rats, differences in kindl...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6948
更新日期：1998-12-01 00:00:00
abstract：:The present study attempts to determine whether the neurotoxicity of p-chloroamphetamine (PCA) is dependent on a releasable pool of serotonin (5-HT). Rats treated with PCA alone or with reserpine and PCA exhibit a profound loss of 5-HT innervation in cerebral cortex after a 2-week survival period. However, depletion o...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90071-x
更新日期：1989-02-01 00:00:00
abstract：:The astrocyte-endothelial cell interaction is crucial for normal brain homeostasis and blood-brain barrier (BBB) disruption in pathological conditions. However, the mechanism by which astrocytes control BBB integrity, especially after traumatic brain injury (TBI), remains unclear. Here, we present evidence that astroc...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2019.113044
更新日期：2019-12-01 00:00:00
abstract：:Uncertainties from the literature concerning the role of apolipoprotein E (apoE) in central cholinergic function prompted us to investigate what effect apoE may have on transmission at the neuromuscular junction. Both spontaneous and evoked release were measured in isolated extensor digitorum longus (edl) and soleus m...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2003.10.006
更新日期：2004-02-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs) support axon regeneration across artificial nerve bridges but their differentiative capacity and ability to promote nerve regeneration remains unclear. In this study, MSCs isolated from bone marrow of Sprague-Dawley rats were characterized by plastic adherence and pluripotency towards mes...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.01.013
更新日期：2011-04-01 00:00:00
abstract：:In the previous paper it was demonstrated that striatal dopamine (DA) D1 and D2 receptor subtypes and muscarinic M1 and M2 receptor subtypes show differing responses to lesions of the mesostriatal DA system. To examine this differential regulation further rats were given unilateral injections of 6-hydroxydopamine (6-O...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90017-7
更新日期：1991-09-01 00:00:00
abstract：:Extrinsic factors appear to contribute to the lack of regeneration in the injured adult spinal cord. It is likely that these extrinsic factors include a group of putative growth inhibitory molecules known as chondroitin sulfate proteoglycans (CSPGs). The aims of this study were to determine: (1) the consequences of sp...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7184
更新日期：1999-11-01 00:00:00
abstract：:The possible pain inhibitory effects of periaqueductal gray (PAG) stimulation were investigated in cats anesthetized with Nembutal and immobilized with Flaxedil. Unitary responses evoked by electrical stimulation of the upper canine dentine and by cutaneous facial noxious and nonnoxious stimuli were recorded extracell...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90155-3
更新日期：1983-07-01 00:00:00
abstract：:Ca2+ influx through NMDA receptor-gated channels and the subsequent rise in intracellular Ca2+ concentration ([Ca2+]i) have been implicated in cytotoxic processes that lead to irreversible neuronal injury. While many studies have focused on cytosolic Ca2+ homeostasis, much less is known about Ca2+ fluxes in subcellula...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6599
更新日期：1998-01-01 00:00:00
abstract：:Exposing rat dorsal root ganglion (DRG) neurons to dibutyryl cAMP (db-cAMP) enables central branches to regenerate in the spinal cord by nullifying the ability of CNS myelin to inhibit elongation. A conditioning lesion (CL) promotes similar regeneration of central branches in the spinal cord by increasing neuronal cAM...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.03.010
更新日期：2004-10-01 00:00:00
abstract：:We used [2-14C]deoxyglucose as a marker of increased metabolism of the hypoglossal nucleus after transection of its nerve. We studied this metabolism in 3-, 12-, and 24-month-old rats. We found an increase in glucose uptake in the control nucleus of 24-month-old rats which was significant when compared to that of 3-mo...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(90)90012-h
更新日期：1990-04-01 00:00:00
abstract：:Nerve growth factor (NGF) enhances neuronal survival during injury to the mature central and peripheral nervous systems, but its potential as a neuroprotective factor in the enteric nervous system (ENS) has not been examined. We used the trinitrobenzene sulfonic acid (TNBS)-induced model of colitis to examine if NGF-s...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.10.003
更新日期：2005-02-01 00:00:00
abstract：:In the cerebellum of adult-aging Ts65Dn mice, a murine model of Down syndrome, Purkinje cells undergo degeneration. Searching for the cause of Purkinje cell degeneration, we have studied the ubiquitin-proteasome system (UPS) in the cerebellum of aging Ts65Dn mice. Inhibition of UPS is sufficient to induce neuron degen...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.08.009
更新日期：2011-12-01 00:00:00
abstract：:Rats were treated with single subcutaneous injections of the irreversible AChE inhibitors, sarin (90 to 100 micrograms/kg) or soman (55 micrograms/kg), and with chronic doses of the reversible carbamate inhibitor, pyridostigmine. In surviving animals with severe behavioral symptoms, we examined the end-plate regions o...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90268-7
更新日期：1985-07-01 00:00:00
abstract：:Monosialoganglioside GM1 prevents excitatory amino acid (EAA)-related neuronal death in cultured central nervous system (CNS) neurons and reduces the severity of acute brain damage in different experimental models of cerebral ischemia. Using a model of brain damage induced by intracerebroventricular administration of ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90019-9
更新日期：1991-09-01 00:00:00
abstract：:Heme oxygenase-1 is a cellular stress protein expressed in brain and other tissues in response to oxidative challenge and other noxious stimuli. In the present study, immunohistochemistry was used to assess HO-1 expression in various postmortem human brain specimens derived from PD and control subjects. In the substan...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6752
更新日期：1998-03-01 00:00:00
abstract：:The aim of this study was to elucidate whether oligodendrocytes die in fiber tracts that are spared by a spinal cord injury but are in close vicinity of inflammatory cells. Adult rat spinal cords were studied histologically 1 day to 2 weeks after a contusion lesion that left the ventral white matter largely intact. Ma...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7379
更新日期：2000-06-01 00:00:00
abstract：:Transplantation of genetically engineered cells can provide sustained focal delivery of naturally occurring molecules, including neurotransmitters and growth factors. We have engineered immortalized mouse cortical neurons and glia to deliver GABA by driving GAD(65) expression. Engineered cell lines showed GAD(65) mRNA...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7305
更新日期：2000-02-01 00:00:00
abstract：:Salicylate intoxication is a cause of tinnitus and comorbidly associated with anxiety in humans. In a previous work, we showed that salicylate induces anxiety-like behavior and hippocampal type 2 theta oscillations (theta2) in mice. Here we investigate if the anxiogenic effect of salicylate is dependent on age and pre...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113175
更新日期：2020-04-01 00:00:00
abstract：:Both fresh and cryopreserved-thawed human fetal ventral mesencephalon have been used for preclinical research and implantation into the brains of patients with Parkinson's disease. Further characterization and an evaluation of the effects of cryopreservation on immunocytochemical and neurochemical markers of monoamine...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1993.1084
更新日期：1993-06-01 00:00:00
abstract：:Olfactory ensheathing cells (OEC) constitute a specialized population of glia that accompany primary olfactory axons and have been reported to facilitate axonal regeneration after spinal cord injury in vivo. In the present report we describe OEC neurotrophic factor expression and neurotrophic properties of OECs in vit...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(02)00058-4
更新日期：2003-04-01 00:00:00
abstract：:Mitochondria actively participate in neurotransmission by providing energy (ATP) and maintaining normative concentrations of reactive oxygen species (ROS) in both presynaptic and postsynaptic elements. In human and animal epilepsies, ATP-producing respiratory rates driven by mitochondrial respiratory complex (MRC) I a...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2013.11.005
更新日期：2014-01-01 00:00:00
abstract：:Previously injured dorsal roots were electrically stimulated to determine if regenerating sensory axons can form physiologically active synaptic contacts with neurons within fetal spinal cord tissue transplants. Dorsal rootlets, sectioned at their spinal cord entry zone, were apposed to intraspinal transplants of feta...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.0101
更新日期：1996-06-01 00:00:00
abstract：:Falls are a major source of hospitalization, long-term institutionalization, and death in older adults and patients with Parkinson's disease (PD). Limited attentional resources are a major risk factor for falls. In this review, we specify cognitive-behavioral mechanisms that produce falls and map these mechanisms onto...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2014.04.032
更新日期：2014-07-01 00:00:00
