Respiratory outcomes after mid-cervical transplantation of embryonic medullary cells in rats with cervical spinal cord injury.

abstract：:A neurochemical target at which cannabinoids interact to have global effects on behavior is brain noradrenergic circuitry. Acute and repeated administration of a cannabinoid receptor synthetic agonist is capable of increasing multiple indices of noradrenergic activity. This includes cannabinoid-induced 1) increases in...

journal_title：Experimental neurology

authors： Reyes BAS,Carvalho AF,Szot P,Kalamarides DJ,Wang Q,Kirby LG,Van Bockstaele EJ

更新日期：2017-06-01 00:00:00

abstract：:We previously reported that 1 month following unilateral loss (>95%) of striatal dopamine, there is an increase in striatal glutamate function as measured by in vivo microdialysis and quantitative immuno-gold electron microscopy, Neuroscience 88, 1-16). The goal of this study was to determine the effect of bilateral l...

journal_title：Experimental neurology

authors： Robinson S,Freeman P,Moore C,Touchon JC,Krentz L,Meshul CK

更新日期：2003-03-01 00:00:00

abstract：:The anticonvulsant long-term efficacy of diazepam was studied in amygdala-kindled rats. The drug was administered three times daily at doses of 5 mg/kg i.p. for 2 weeks in fully kindled animals. The severity of the kindled seizures was markedly reduced throughout the period of treatment, while tolerance developed to t...

journal_title：Experimental neurology

authors： Löscher W,Schwark WS

更新日期：1985-11-01 00:00:00

abstract：:Epidermal growth factor responsive (EGFr) neural progenitor (NP) cells have been shown to be a potential alternative tissue source for neural transplantation and for developmental study. We have shown that nonpassaged EGFr NP cells can self-renew for 2 years in neurospheres and can robustly differentiate into glia and...

journal_title：Experimental neurology

authors： Zhou FC,Kelley MR,Chiang YH,Young P

更新日期：2000-07-01 00:00:00

abstract：:To determine whether or not brain damage is likely to occur in the repeated apneic episodes experienced by some alcoholics during intoxicated sleep, rats were anesthetized with alcohol and subjected to repeated episodes to asphyxia. Each episode lasted 90 s, arterial PO2 was less than 50 mm Hg for 60 s, and 30 episode...

journal_title：Experimental neurology

authors： Cragg B,Phillips S

更新日期：1984-04-01 00:00:00

abstract：:When adrenal medullary cells are cultured in vitro, tyrosine hydroxylase (TH) mRNA, preproenkephalin (PPEnk) mRNA, and methionine enkephalin (Mek) immunoreactivity was markedly increased compared with intact adrenal medullary cells in situ, suggesting an increased biosynthesis of catecholamines and enkephalin-containi...

journal_title：Experimental neurology

authors： Wang XT,Unnerstall JR,Ibuki T,Wang H,Pappas GD

更新日期：2000-01-01 00:00:00

abstract：:Ischemic stroke is a devastating brain injury and an important cause of neurologic disability worldwide and across the lifespan. Despite the physical, social, and economic burdens of this disease there is only a single approved medicine for the treatment of acute stroke, and its use is unfortunately limited to the sma...

journal_title：Experimental neurology

authors： Felling RJ,Song H

更新日期：2015-06-01 00:00:00

abstract：:Exposing rat dorsal root ganglion (DRG) neurons to dibutyryl cAMP (db-cAMP) enables central branches to regenerate in the spinal cord by nullifying the ability of CNS myelin to inhibit elongation. A conditioning lesion (CL) promotes similar regeneration of central branches in the spinal cord by increasing neuronal cAM...

journal_title：Experimental neurology

authors： Han PJ,Shukla S,Subramanian PS,Hoffman PN

更新日期：2004-10-01 00:00:00

abstract：:Apolipoprotein E (apoE) is known to bind to at least five receptors, including the low-density lipoprotein (LDL) receptor-related protein (LRP), very low density LDL receptor (VLDL-R), LDL-R, apoE receptor 2 (apoER2), and megalin/gp330. In this context, the main objective of the present study was to better understand ...

journal_title：Experimental neurology

authors： Veinbergs I,Van Uden E,Mallory M,Alford M,McGiffert C,DeTeresa R,Orlando R,Masliah E

更新日期：2001-07-01 00:00:00

abstract：:Interest in beta activity in the basal ganglia has mushroomed since it was first identified in the subthalamic nucleus of patients with Parkinson's disease in Jonathan Dostrovsky's landmark paper (Levy et al., 2000). Here we consider a less explored phenomenon; namely gamma frequency synchronisation of neurons in the ...

journal_title：Experimental neurology

authors： Jenkinson N,Kühn AA,Brown P

更新日期：2013-07-01 00:00:00

abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) has neuroprotective effects against ischemia, even when given by intravenous (iv) administration 24 h after stroke. Transport of PACAP across the blood-brain barrier (BBB) by peptide transport system (PTS)-6 underlies its effectiveness after iv administration....

journal_title：Experimental neurology

authors： Nonaka N,Shioda S,Banks WA

更新日期：2005-01-01 00:00:00

abstract：:Diffuse and neuritic plaques are sites of accumulation of beta-amyloid peptides (A beta) in the brains of Alzheimer's disease (AD) patients. Although amyloid fibrils are formed from A beta, the contribution of other plaque-associated proteins and peptides to the pathogenesis of AD amyloidosis is unknown. To pursue thi...

journal_title：Experimental neurology

authors： Schmidt ML,DiDario AG,Otvos L Jr,Hoshi N,Kant JA,Lee VM,Trojanowski JQ

更新日期：1994-12-01 00:00:00

abstract：:Mice genetically deficient in growth hormone were compared with normal littermates for evidence of altered neuronal development. In the lit/lit motor cortex, area 6 of Caviness, cell number, stratification of neurons, and the proportionate layer widths were identical to those of the controls (lit/+). Examined by the G...

journal_title：Experimental neurology

authors： Noguchi T,Sugisaki T

更新日期：1985-07-01 00:00:00

abstract：:Excessive synchronization of basal ganglia neuronal activity at ~20 Hz is characteristic of patients with untreated Parkinson's disease (PD). Correlative evidence suggests that this activity may contribute to bradykinesia. Attempts to demonstrate causality through stimulation imposed synchronization at 20 Hz in the re...

journal_title：Experimental neurology

authors： Chen CC,Lin WY,Chan HL,Hsu YT,Tu PH,Lee ST,Chiou SM,Tsai CH,Lu CS,Brown P

更新日期：2011-09-01 00:00:00

abstract：:Urethane-induced cortical slow wave activity (SWA) spreads into the basal ganglia in dopamine (DA)-depleted rat models of Parkinson's disease (PD). During physiological sleep, SWA is powerfully expressed at the beginning of night and progressively reduced during sleep-time reflecting the sleep need. However, its under...

journal_title：Experimental neurology

authors： Galati S,Song W,Orban G,Luft AR,Kaelin-Lang A

更新日期：2018-03-01 00:00:00

abstract：:Locally generating new proteins in subcellular regions provide means to spatially and temporally modify protein content in polarized cells. Recent years have seen resurgence of the concept that axonal processes of neurons can locally synthesize proteins. Experiments from a number of groups have now shown that axonal p...

journal_title：Experimental neurology

authors： Yoo S,van Niekerk EA,Merianda TT,Twiss JL

更新日期：2010-05-01 00:00:00

abstract：:The inferior colliculus was selected as a brain stem site for study of neural grafting and identification of calcium binding proteins. Unilateral ablation sites of eight midbrain inferior colliculus in adult Long-Evans rats were implanted with E17-18 caudal tectum. After 2 to 9 months animals were sacrificed and secti...

journal_title：Experimental neurology

authors： Coleman JR,McDonald AJ,Pinek B,Zrull MC

更新日期：1992-01-01 00:00:00

abstract：:This study reevaluated the possibility of using predegenerated nerves as donor nerve allografts for nerve repair and compared the results of functional recovery to those obtained after standard, fresh nerve allograft repair. Twenty donor rats underwent a ligature/ section of the left sciatic nerve 4 weeks before nerve...

journal_title：Experimental neurology

authors： Dubuisson AS,Foidart-Dessalle M,Reznik M,Grosdent JC,Stevenaert A

更新日期：1997-11-01 00:00:00

abstract：:The effects of prenatal exposure to carbon monoxide (CO), a major component of cigarette smoke, was studied alone or in combination with postnatal hyperthermia, on the structural and neurochemical development of the postnatal brain at 1 and 8 weeks. Pregnant guinea pigs (n = 11) were exposed to 200 p.p.m CO for 10 h/d...

journal_title：Experimental neurology

authors： Tolcos M,Mallard C,McGregor H,Walker D,Rees S

更新日期：2000-04-01 00:00:00

abstract：:The role of central noradrenergic neurons in kindled seizures was assessed by comparison of alpha 2- and beta-adrenoceptor binding in the cerebral cortex from kindled and control rats. To minimize handling, which may modify kindling-induced changes in binding, the kindling protocol involved stimulation of the amygdala...

journal_title：Experimental neurology

authors： Stanford SC,Jefferys JG

更新日期：1985-10-01 00:00:00

abstract：:The ability of insulin like growth factor 1 (IGF-1) to prevent the pathophysiology associated with amyotrophic lateral sclerosis (ALS) is currently being explored with animal models and in clinical trials with patients. Several studies have reported positive effects of IGF-1 in reducing motor neuron death, delaying th...

journal_title：Experimental neurology

authors： Messi ML,Clark HM,Prevette DM,Oppenheim RW,Delbono O

更新日期：2007-09-01 00:00:00

abstract：:Proteoglycans have a number of important functions in the central nervous system. Aggrecan (hyaluronan-binding proteoglycan, CSPG-cs56) is found in the extracellular matrix of cartilage as well as in the developing brain. We compared the postnatal distribution of CSPG-cs56 in Long Evans (LE) and Royal College of Surge...

journal_title：Experimental neurology

authors： Chen LF,FitzGibbon T,He JR,Yin ZQ

更新日期：2012-04-01 00:00:00

abstract：:Tamoxifen-induced mutagenesis via the so-called CreER(T2) fusion enzyme is a key technology for the inducible gene knockout in the adult murine brain. However, it requires a subchronic transient treatment with high doses of the non-selective estrogen receptor antagonist tamoxifen. It has been shown earlier that acute ...

journal_title：Experimental neurology

authors： Vogt MA,Chourbaji S,Brandwein C,Dormann C,Sprengel R,Gass P

更新日期：2008-05-01 00:00:00

abstract：:Microglia were described by Pio del Rio-Hortega (1932) as being the 'third element' distinct from neurons and astrocytes. Decades after this observation, the function and even the very existence of microglia as a distinct cell type were topics of intense debate and conjecture. However, considerable advances have been ...

journal_title：Experimental neurology

authors： Trang T,Beggs S,Salter MW

更新日期：2012-04-01 00:00:00

abstract：:When antibodies specific to fast-twitch, slow-twitch, and slow-tonic myosins were used to stain the clasp muscle, m. sternoradialis, of Xenopus laevis, three predominant fiber types were identified in both males and females. Three fiber types can also be distinguished by the diameters and conduction velocities of thei...

journal_title：Experimental neurology

authors： Rubinstein NA,Erulkar SD,Schneider GT

更新日期：1983-11-01 00:00:00

abstract：:One of the primary hallmarks of glutamate excitotoxicity is degradation of the neuronal cytoskeleton. Using a tissue culture approach, we have investigated the relationship between excitotoxicity and cytoskeletal degradation within axons, with particular reference to the axon specific neurofilament proteins. Neurofila...

journal_title：Experimental neurology

authors： Chung RS,McCormack GH,King AE,West AK,Vickers JC

更新日期：2005-06-01 00:00:00

abstract：:The ventrolateral orbital cortex (VLO) is part of an endogenous analgesic system consisting of an ascending pathway from the spinal cord to VLO via the thalamic nucleus submedius (Sm) and a descending pathway to the spinal cord relaying in the periaqueductal gray (PAG). This study examines whether activation of D(1)-l...

journal_title：Experimental neurology

authors： Sheng HY,Qu CL,Huo FQ,Du JQ,Tang JS

更新日期：2009-01-01 00:00:00

abstract：:The amount of myelination in vivo and in vitro depends on the number of oligodendrocyte progenitors, their differentiation, and on the neuron function. It has been shown that continuous administration of FGF2, a mitotic and neuroprotective factor, allows oligodendrocyte progenitors to proliferate, but prevents them fr...

journal_title：Experimental neurology

authors： Magy L,Keita M,Richard L,Piaser M,Vallat JM

更新日期：2003-05-01 00:00:00

abstract：:Neuronal populations projecting to a common target may compete for neurotrophic substances. To determine if competition impairs target reinnervation, we examined the effect of capsaicin-induced sensory denervation on sympathetic nerve ingrowth to the sympathectomized rat superior tarsal smooth muscle. In tarsal muscle...

journal_title：Experimental neurology

authors： Fike EA 4th,Simons E,Boswell C,Smith PG

更新日期：1992-10-01 00:00:00

abstract：:Infusions of an excitant amino acid, N-methyl-D-aspartate (NMDA) into the inferior colliculus (IC) render normal rats susceptible to audiogenic seizures (AGS) and/or spontaneous audiogenic-like seizures without tonic components. The excess excitant amino acid in the IC and the anticonvulsant effects of NMDA antagonist...

journal_title：Experimental neurology

authors： Browning RA,Wang C,Faingold CL

更新日期：1991-05-01 00:00:00