Cortical slow wave activity correlates with striatal synaptic strength in normal but not in Parkinsonian rats.

abstract：:Stroke causes CNS injury associated with strong fast microglial activation as part of the inflammatory response. In rat models of stroke, sulphonylurea receptor blockade with glibenclamide reduced cerebral edema and infarct volume. We postulated that glibenclamide administered during the early stages of stroke might f...

journal_title：Experimental neurology

authors： Ortega FJ,Gimeno-Bayon J,Espinosa-Parrilla JF,Carrasco JL,Batlle M,Pugliese M,Mahy N,Rodríguez MJ

更新日期：2012-05-01 00:00:00

abstract：:We have treated spinal cord injured rats with demyelination plus Schwann cell transplantation and assessed neurite outgrowth in a quantifiable model of axonal regeneration. Axonal injuries of differing severity were induced in the dorsal funiculus of adult rats using a micromanipulator-controlled Scouten knife. Demyel...

journal_title：Experimental neurology

authors： Keirstead HS,Morgan SV,Wilby MJ,Fawcett JW

更新日期：1999-09-01 00:00:00

abstract：:Neuropathological studies of human traumatic brain injury (TBI) cases have described amyloid plaques acutely after a single severe TBI, and tau pathology after repeat mild TBI (mTBI). This has helped drive the hypothesis that a single moderate to severe TBI increases the risk of developing late-onset Alzheimer's disea...

journal_title：Experimental neurology

authors： Washington PM,Villapol S,Burns MP

更新日期：2016-01-01 00:00:00

abstract：:For most individuals, the respiratory control system produces a remarkably stable and coordinated motor output-recognizable as a breath-from birth until death. Very little is understood regarding the processes by which the respiratory control system maintains network stability in the presence of changing physiological...

journal_title：Experimental neurology

authors： Braegelmann KM,Streeter KA,Fields DP,Baker TL

更新日期：2017-01-01 00:00:00

abstract：:Neural stem cell (NSC) transplantation provides a new approach for the repair of damage to the central nervous system (CNS), including that resulting from cerebral infarction and spinal cord injury (SCI). In the past, there were no reputable means of converting non-neural somatic cells into neural cells. This status w...

journal_title：Experimental neurology

authors： Matsui T,Akamatsu W,Nakamura M,Okano H

更新日期：2014-10-01 00:00:00

abstract：:Grafts of embryonic ventral mesencephalic tissue placed in the striatum of 6-hydroxydopamine-lesioned rats survive, and make and receive connections to and from the host brain. The dopaminergic neurons of the graft can grow processes into the host brain, and thereby alleviate many of the behavioral deficits of this fo...

journal_title：Experimental neurology

authors： Barker RA,Dunnett SB,Faissner A,Fawcett JW

更新日期：1996-09-01 00:00:00

abstract：:The gastrointestinal tract of vertebrates is a heterogeneous organ system innervated to varying degrees by a local enteric neural network as well as extrinsic parasympathetic and sympathetic neural circuits located along the brainstem and spinal axis. This diverse organ system serves to regulate the secretory and prop...

journal_title：Experimental neurology

authors： Holmes GM,Blanke EN

更新日期：2019-10-01 00:00:00

abstract：:GABAergic dysfunction is implicated in hippocampal deficits of the Ts65Dn mouse model of Down syndrome (DS). Since Ts65Dn mice overexpress G-protein coupled inward-rectifying potassium (GIRK2) containing channels, we sought to evaluate whether increased GABAergic function disrupts the functioning of hippocampal circui...

journal_title：Experimental neurology

authors： Best TK,Cramer NP,Chakrabarti L,Haydar TF,Galdzicki Z

更新日期：2012-02-01 00:00:00

abstract：:Mammals adopt a limited number of postures during their day-to-day activities. These stereotyped skeletal configurations are functionally adequate and limit the number of degrees of freedom to be controlled by the central nervous system. The temporal pattern of emergence of these configurations in altricial mammals is...

journal_title：Experimental neurology

authors： Lelard T,Jamon M,Gasc JP,Vidal PP

更新日期：2006-11-01 00:00:00

abstract：:We have previously demonstrated an opioid link in nucleus accumbens (NAc) that mediates antinociception produced by a novel ascending pain modulation pathway. For example, noxious stimulation induces heterosegmental antinociception that is mediated by both mu- and delta-opioid receptors in NAc. However, spinal intrath...

journal_title：Experimental neurology

authors： Gear RW,Levine JD

更新日期：2011-06-01 00:00:00

abstract：:The regional cerebral blood flow of 27 young (mean age 24 years) schizophrenic patients was measured using the intravenous 133Xe method. The results were compared with those obtained from a group of age- and sex-matched control subjects. The main findings of the study were as follows: (a) the gray matter mean values o...

journal_title：Experimental neurology

authors： Dousse M,Mamo H,Ponsin JC,Tran Dinh Y

更新日期：1988-04-01 00:00:00

abstract：:The effects of prenatal exposure to carbon monoxide (CO), a major component of cigarette smoke, was studied alone or in combination with postnatal hyperthermia, on the structural and neurochemical development of the postnatal brain at 1 and 8 weeks. Pregnant guinea pigs (n = 11) were exposed to 200 p.p.m CO for 10 h/d...

journal_title：Experimental neurology

authors： Tolcos M,Mallard C,McGregor H,Walker D,Rees S

更新日期：2000-04-01 00:00:00

abstract：:Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by a progressive and extensive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and their terminals in the striatum, which results in debilitating movement disorders. This devastating disease affects over 1 m...

journal_title：Experimental neurology

authors： Glavaski-Joksimovic A,Bohn MC

更新日期：2013-09-01 00:00:00

abstract：:The longitudinal distributions of both phrenic and medial gastrocnemius motoneurons were quantitatively studied in the cat spinal cord. Both populations of motoneurons were retrogradely labeled by applying horseradish peroxidase (HRP) to the cut central ends of the appropriate peripheral nerves. The longitudinal posit...

journal_title：Experimental neurology

authors： Berger AJ,Cameron WE,Averill DB,Kramis RC,Binder MD

更新日期：1984-12-01 00:00:00

abstract：:Functional relations between hippocampal lamellae, the modular units arranged in parallel in the hippocampal formation, were studied in the guinea pig in experiments of evoked field potential analysis. Perforant path volleys, synaptically elicited by stimulation of the dorsal hippocampal commissure, were used to activ...

journal_title：Experimental neurology

authors： Bartesaghi R,Gessi T,Sperti L

更新日期：1983-12-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal peptide (VIP), and their receptors have been localized within the hippocampus but their physiological function on synaptic transmission is still unclear. We investigated the effects of PACAP and VIP on evoked excitatory postsynaptic curr...

journal_title：Experimental neurology

authors： Ciranna L,Cavallaro S

更新日期：2003-12-01 00:00:00

abstract：:Synaptic reorganization of mossy fibers following kainic acid (KA) administration has been reported to contribute to the formation of recurrent excitatory circuits, resulting in an epileptogenic state. It is unclear, however, whether KA-induced mossy fiber sprouting results from neuronal cell loss or the seizure activ...

journal_title：Experimental neurology

authors： Schauwecker PE,Ramirez JJ,Steward O

更新日期：2000-01-01 00:00:00

abstract：:These experiments were completed as part of an NIH "Facilities of Research Excellence in Spinal Cord Injury" contract to support independent replication of published studies that could be considered for eventual clinical testing. Recent studies have reported that selective inhibition of the P2X7 receptor improves both...

journal_title：Experimental neurology

authors： Marcillo A,Frydel B,Bramlett HM,Dietrich WD

更新日期：2012-02-01 00:00:00

abstract：:Dopamine (DA) release and metabolism within the substantia nigra (SN) were studied in normal rats, rats with unilateral 6-hydroxydopamine (6-OHDA) lesions, and 6-OHDA-lesioned rats treated with glial cells line-derived neurotrophic factor (GDNF). Animals with > 99% DA depletions, as determined by apomorphine-induced c...

journal_title：Experimental neurology

authors： Hoffman AF,van Horne CG,Eken S,Hoffer BJ,Gerhardt GA

更新日期：1997-09-01 00:00:00

abstract：:A single fourth lumbar dorsal rootlet was transected at the entry point into the spinal cord. The nerve fibres were labelled with biotin dextran injected into the rootlet. An endogenous matrix containing olfactory-ensheathing cells (OECs) labelled with green fluorescent protein was applied to the opposing cut surfaces...

journal_title：Experimental neurology

authors： Li Y,Carlstedt T,Berthold CH,Raisman G

更新日期：2004-08-01 00:00:00

abstract：:Adult New Zealand Red (NZR) rabbits were used to determine if the techniques developed in the rat to transplant sheets of photoreceptors could be adapted to larger eyes of the rabbit. Adult donor NZR rabbit retina was cut into small strips, oriented, and drawn up in a small and flat polyethylene tube. By transscleral ...

journal_title：Experimental neurology

authors： Schuschereba ST,Silverman MS

更新日期：1992-01-01 00:00:00

abstract：:Mice lacking the gene encoding for substance P and neurokinin A, or the NK-1 receptor, exhibit alterations in behavior to various acute nociceptive stimuli. However, behavioral responses of NK-1 mutant animals have not been well characterized in models of chronic pain. We studied the behavioral responses of NK-1 knock...

journal_title：Experimental neurology

authors： Mansikka H,Sheth RN,DeVries C,Lee H,Winchurch R,Raja SN

更新日期：2000-04-01 00:00:00

abstract：:Hypobaric hypoxia has been implicated with neural degeneration and memory loss. Though there has been considerable knowledge on the role of the p75(NTR) in triggering apoptosis, the occurrence of a similar mechanism in hypoxic stress still remains to be explored. We, in the present study, have tried to explore the rol...

journal_title：Experimental neurology

authors： Hota SK,Barhwal K,Singh SB,Ilavazhagan G

更新日期：2008-07-01 00:00:00

abstract：:Human spinal cord injury (SCI) can result in progressive degeneration that may continue for many years and lead to the formation of highly septated cystic cavities. This hallmark feature has been reproduced in experimental models, but neither its pathogenesis nor clinically relevant features have been fully elucidated...

journal_title：Experimental neurology

authors： Radojicic M,Reier PJ,Steward O,Keirstead HS

更新日期：2005-12-01 00:00:00

abstract：:Cordotomy-denervation interactions were studied on contractile and myofibrillar properties of slow (soleus) and fast (extensor digitorum longus) muscles of the rat. The spinal cord was transected midthoracically in neonatal (2-day-old) animals. Two months after birth, a unilateral transection of the sciatic nerve was ...

journal_title：Experimental neurology

authors： Midrio M,Danieli Betto D,Betto R,Noventa D,Antico F

更新日期：1988-04-01 00:00:00

abstract：:The expression of vasoactive intestinal peptide (VIP) and gastrin-releasing peptide (GRP) in the suprachiasmatic nucleus (SCN) changes depending on light. VIP mRNA increases and GRP mRNA decreases in the light phase, while they do not show change without light. In the present study we investigated the involvement of s...

journal_title：Experimental neurology

authors： Hayashi S,Ueda M,Amaya F,Matusda T,Tamada Y,Ibata Y,Tanaka M

更新日期：2001-10-01 00:00:00

abstract：:Phenytoin is known to reduce neural overactivity (pseudomyotonia) affecting the hind limb musculature in C57B1/6J dystrophic (dy2J/dy2J) mice. This study reports a change in the metabolic profile of superficial gastrocnemius muscle fibers from dy2J/dy2J animals after chronic phenytoin treatment. The superficial gastro...

journal_title：Experimental neurology

authors： Younger LE,Silverman H

更新日期：1984-04-01 00:00:00

abstract：:Spectral analysis is a mathematical method which contains and generalizes frequency analysis. The form of spectral analysis most applicable to EEG is tutorially presented, using both algebraic formulae and four simplified illustrative examples. The examples are each converted into an autocorrelogram and auto-spectrogr...

journal_title：Experimental neurology

authors： Walter DO

更新日期：1963-08-01 00:00:00

abstract：:The increasing demand on diagnostic assays that are sensitive and specific for pathogenic antibodies, and the interest in identifying new antigens, prompted the development of cell-based assays for the detection of autoantibodies in myasthenia gravis and other autoimmune disorders. Cell-based assays were initially use...

journal_title：Experimental neurology

authors： Rodriguez Cruz PM,Huda S,López-Ruiz P,Vincent A

更新日期：2015-08-01 00:00:00

abstract：:Historically, the immune response after spinal cord injury was considered largely detrimental owing to the release of neurotoxic factors. While there is validity to this view, there is much greater heterogeneity of immune cells than was previously realized. Associated with this heterogeneity of immune cell subtypes, t...

journal_title：Experimental neurology

authors： Plemel JR,Wee Yong V,Stirling DP

更新日期：2014-08-01 00:00:00