Progesterone and allopregnanolone exacerbate hypoxic-ischemic brain injury in immature rats.

abstract：:Systemic administration of the amphetamine derivative p-chloroamphetamine (PCA) causes degeneration of 5-HT axon terminals in rat brain. The present study was designed to determine whether PCA induces neurotoxic effects by a direct action on 5-HT axon terminals. PCA was administered by microinjection directly into the...

journal_title：Experimental neurology

authors： Berger UV,Molliver ME,Grzanna R

更新日期：1990-09-01 00:00:00

abstract：:Subcortical deafferentation of the rat hippocampus has been suggested to offer a model for developing limbic epilepsy. In the present study, the long-term effect of fimbria-fornix lesioning on the density and distribution of hippocampal N-methyl-D-aspartate (NMDA)-sensitive L-[3H]glutamate binding was studied using qu...

journal_title：Experimental neurology

authors： Lahtinen H,Korhonen E,Castrén E,Miettinen R,Ylinen A,Riekkinen PJ Sr

更新日期：1993-06-01 00:00:00

abstract：:The control of gene expression by miRNAs has been widely investigated in different species and cell types. Following a probabilistic rather than a deterministic regimen, the action of these short nucleotide sequences on specific genes depends on intracellular concentration, which in turn reflects the balance between b...

journal_title：Experimental neurology

authors： Kinjo ER,Higa GS,de Sousa E,Casado OA,Damico MV,Britto LR,Kihara AH

更新日期：2013-10-01 00:00:00

abstract：:We have used retrograde labeling with horseradish peroxidase (HRP) and a wheat germ agglutinin conjugate of HRP (WGA:HRP) to investigate the projections of the nucleus postglomerulosus (nPg) both in normal goldfish and in animals which had undergone retinal removal. In normal animals, our evidence indicates that nPg p...

journal_title：Experimental neurology

authors： Levine RL,Dethier S

更新日期：1988-11-01 00:00:00

abstract：:Intracranial collaterals provide residual blood flow to penumbral tissue in acute ischemic stroke and contribute to infarct size variability in humans. In the present study, hemodynamic monitoring of the borderzone territory between the leptomeningeal branches of middle cerebral artery and anterior cerebral artery was...

journal_title：Experimental neurology

authors： Riva M,Pappadà GB,Papadakis M,Cuccione E,Carone D,Menendez VR,Sganzerla EP,Beretta S

更新日期：2012-02-01 00:00:00

abstract：:Astrocytes react to CNS injury by building a dense wall of filamentous processes around the lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective tissue elements that contribute to fibrosis. Oligodendrocyte precursor cells proliferate within the lesion and entrap dystrophic axon ...

journal_title：Experimental neurology

authors： Cregg JM,DePaul MA,Filous AR,Lang BT,Tran A,Silver J

更新日期：2014-03-01 00:00:00

abstract：:Using an approach that combines gene therapy with aromatic l-amino acid decarboxylase (AADC) gene and a pro-drug (l-dopa), dopamine, the neurotransmitter involved in Parkinson's disease, can be synthesized and regulated. Striatal neurons infected with the AADC gene by an adeno-associated viral vector can convert perip...

journal_title：Experimental neurology

authors： Bankiewicz KS,Eberling JL,Kohutnicka M,Jagust W,Pivirotto P,Bringas J,Cunningham J,Budinger TF,Harvey-White J

更新日期：2000-07-01 00:00:00

abstract：:Monosialoganglioside GM1 prevents excitatory amino acid (EAA)-related neuronal death in cultured central nervous system (CNS) neurons and reduces the severity of acute brain damage in different experimental models of cerebral ischemia. Using a model of brain damage induced by intracerebroventricular administration of ...

journal_title：Experimental neurology

authors： Lipartiti M,Lazzaro A,Zanoni R,Mazzari S,Toffano G,Leon A

更新日期：1991-09-01 00:00:00

abstract：:Adult mammalian retinal ganglion cells (RGCs) can regenerate through peripheral nerve (PN) grafts and innervate central nervous system (CNS) targets. Previous studies have demonstrated a basic level of differentiation of such projections. To further assess the specificity and functionality of regenerated CNS connectio...

journal_title：Experimental neurology

authors： Carter DA,Jhaveri S

更新日期：1997-08-01 00:00:00

abstract：:Dopamine (DA) affects GABA neuronal function in the striatum and together these neurotransmitters play a large role in locomotor function. We recently reported that unilateral striatal administration of GDNF, a growth factor that has neurotrophic effects on DA neurons and enhances DA release, bilaterally increased str...

journal_title：Experimental neurology

authors： Salvatore MF,Gerhardt GA,Dayton RD,Klein RL,Stanford JA

更新日期：2009-09-01 00:00:00

abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by chorea, psychiatric disturbances, and dementia. It is caused by a polyglutamine repeat expansion in the huntingtin protein. The striatum is a major site of neuronal loss in HD, but the mechanisms underlying the neurodegenerative pro...

journal_title：Experimental neurology

authors： Duan W,Guo Z,Mattson MP

更新日期：2000-09-01 00:00:00

abstract：:Previous studies have suggested that defective high-affinity glutamate uptake, due mainly to a major loss of the astroglial-specific GLT-1 glutamate transporter, underlies the selective motoneuron degeneration observed in sporadic ALS (24, 28). If a defect in glutamate transport underlies the pathogenesis of sporadic ...

journal_title：Experimental neurology

authors： Medina L,Figueredo-Cardenas G,Rothstein JD,Reiner A

更新日期：1996-12-01 00:00:00

abstract：:Accumulating evidence shows alterations in the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) in ALS patients and in animal models of disease, mainly by endothelial cell (EC) damage. Repair of the altered barrier in the CNS by replacement of ECs via cell transplantation may be a new therapeutic approac...

journal_title：Experimental neurology

authors： Garbuzova-Davis S,Haller E,Navarro S,Besong TE,Boccio KJ,Hailu S,Khatib M,Sanberg PR,Appel SH,Borlongan CV

更新日期：2018-12-01 00:00:00

abstract：:The central histaminergic system is one of the subcortical aminergic projection systems involved in several regulatory functions. The central dopaminergic and histaminergic systems interact extensively, but little is known about the histaminergic system in diseases affecting the dopaminergic neurons. The distribution ...

journal_title：Experimental neurology

authors： Anichtchik OV,Rinne JO,Kalimo H,Panula P

更新日期：2000-05-01 00:00:00

abstract：:Destruction of the entorhinal cortex (EC) triggers a number of cellular and molecular responses in the denervated hippocampus and dentate gyrus. The signals that trigger these changes are not known but could include physiological events that occur during the production of the injury or during the early postlesion peri...

journal_title：Experimental neurology

authors： Kelley MS,Steward O

更新日期：1996-05-01 00:00:00

abstract：:Modifications of the visual evoked potential during generalized epilepsy were investigated in feline generalized penicillin epilepsy. Visual evoked potentials and their intracortical profiles were averaged during intraburst periods and during the wave of the spike and wave complex to a fixed latency from the preceding...

journal_title：Experimental neurology

authors： Pellegrini A,Zanotto L,Ermani M,Chemello R,Testa G

更新日期：1986-12-01 00:00:00

abstract：:Traumatic brain injury (TBI) causes persistent neurologic deficits. Current therapies, predominantly focused upon cortical and hippocampal cellular survival, have limited benefit on cognitive outcomes. Striatal damage is associated with deficits in executive function, learning, and memory. Dopamine and cAMP regulated ...

journal_title：Experimental neurology

authors： Bales JW,Yan HQ,Ma X,Li Y,Samarasinghe R,Dixon CE

更新日期：2011-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by cognitive decline and deposition of beta-amyloid (Abeta) plaques in cortex and hippocampus. A transgenic mouse AD model (Tg2576) that overexpresses a mutant form of human Abeta precursor protein exhibits age-related cognitive deficits, Abeta plaque deposition, and oxidative...

journal_title：Experimental neurology

authors： Stackman RW,Eckenstein F,Frei B,Kulhanek D,Nowlin J,Quinn JF

更新日期：2003-11-01 00:00:00

abstract：:Pericytes are a major component of cerebrovasculature playing a key role in maintaining cerebrovascular homeostasis. These cells have also been suggested to regulate brain metabolism of amyloid-β (Aβ), disturbances of which are believed to contribute to the pathogenesis of Alzheimer's disease (AD). To examine the effe...

journal_title：Experimental neurology

authors： Tachibana M,Yamazaki Y,Liu CC,Bu G,Kanekiyo T

更新日期：2018-02-01 00:00:00

abstract：:Five subjects matched the force of a sustained isometric contraction with a contraction of the contralateral muscle. Estimates of the sustained constant forces increased with time despite the direction to disregard the increased effort associated with the fatiguing contraction. These instructions did not produce a not...

journal_title：Experimental neurology

authors： Jones LA

更新日期：1983-08-01 00:00:00

abstract：:Given the prevalence and societal impact of autism spectrum disorders (ASD), there is an urgent need to develop innovative preventative strategies and treatments to reduce the alarming number of cases and improve core symptoms for afflicted individuals. Translational efforts between clinical and preclinical research a...

journal_title：Experimental neurology

authors： Bauman MD,Schumann CM

更新日期：2018-01-01 00:00:00

abstract：:Wistar rats (n = 58) were injected subcutaneously during the lactation period with fluoxetine (5, 10, 20 or 40 mg/kg/day) and cortical spreading depression (SD) was recorded immediately after weaning (25-30 days of life). An additional group (10 mg/kg; n = 8) was SD-recorded at 60-70 days. As compared to the saline-in...

journal_title：Experimental neurology

authors： dos Santos AA,Pinheiro PC,de Lima DS,Ozias MG,de Oliveira MB,Guimarães NX,Guedes RC

更新日期：2006-08-01 00:00:00

abstract：:Rats were treated with single subcutaneous injections of the irreversible AChE inhibitors, sarin (90 to 100 micrograms/kg) or soman (55 micrograms/kg), and with chronic doses of the reversible carbamate inhibitor, pyridostigmine. In surviving animals with severe behavioral symptoms, we examined the end-plate regions o...

journal_title：Experimental neurology

authors： Meshul CK,Boyne AF,Deshpande SS,Albuquerque EX

更新日期：1985-07-01 00:00:00

abstract：:The extracellular signal-regulated kinase 1 and 2 (ERK) pathway, regulated by phosphorylation on specific amino acids, is emerging as an important signaling cascade in neurones, transducing sensory input into cellular responses. In the mammalian nervous system, the ERK pathway has been found to mediate plasticity even...

journal_title：Experimental neurology

authors： Cruz CD,McMahon SB,Cruz F

更新日期：2006-07-01 00:00:00

abstract：:We investigated the role of the NO/cGMP system in the vasodilatory response to hypercapnia after cortical spreading depression (CSD) in barbiturate anesthetized rats in vivo. Regional cerebral blood flow (rCBF) was measured by laser Doppler flowmetry (LDF). Hypercapnia (arterial pCO2 50-60 mm Hg) increased rCBF by 2.8...

journal_title：Experimental neurology

authors： Scheckenbach KE,Dreier JP,Dirnagl U,Lindauer U

更新日期：2006-12-01 00:00:00

abstract：:Effects of accumulation of phosphocreatine (P-creatine) on utilization and restoration of high-energy phosphates during anoxia and recovery were studied using thin hippocampal slices from the guinea pig. Incubation of slices with creatine (5 to 30 mM) increased the content of tissue P-creatine, in a linear fashion, an...

journal_title：Experimental neurology

authors： Yoneda K,Arakawa T,Asaoka Y,Fukuoka Y,Kinugasa K,Takimoto K,Okada Y

更新日期：1983-10-01 00:00:00

abstract：:Eph tyrosine kinase receptors and their ligands, the ephrins, play a key role in the establishment of retinotectal topography during development. Tectal up-regulation of ephrin-A2 in goldfish, coincident with the reestablishment of a retinotectal map, suggests a similar role during optic nerve regeneration. Here we re...

journal_title：Experimental neurology

authors： King CE,Wallace A,Rodger J,Bartlett C,Beazley LD,Dunlop SA

更新日期：2003-10-01 00:00:00

abstract：:Blood brain barrier (BBB) hyperpermeability and brain edema contribute to increased seizure susceptibility and brain injury in status epilepticus (SE). The endothelial glycocalyx is the coating on luminal side of the endothelium and can be considered as the first barrier of BBB. Currently, little is known about the ef...

journal_title：Experimental neurology

authors： Li X,Zhu J,Liu K,Hu Y,Huang K,Pan S

更新日期：2020-08-01 00:00:00

abstract：:Parkinson's Disease (PD) and Extrapyramidal Syndrome (EPS) are movement disorders that result from degeneration of the dopaminergic input to the striatum and chronic inhibition of striatal dopamine D(2) receptors by antipsychotics, respectively. Adenosine A(2A) receptors are selectively localized in the basal ganglia,...

journal_title：Experimental neurology

authors： Hodgson RA,Bedard PJ,Varty GB,Kazdoba TM,Di Paolo T,Grzelak ME,Pond AJ,Hadjtahar A,Belanger N,Gregoire L,Dare A,Neustadt BR,Stamford AW,Hunter JC

更新日期：2010-10-01 00:00:00

abstract：:Huntington's disease is an autosomal dominant neurogenetic disorder leading to striatal atrophy, characterized by involuntary movements. Voluntary movements also deteriorate, but the neurophysiological mechanisms are less understood. We investigated voluntary movement execution and its neural correlates by means of mo...

journal_title：Experimental neurology

authors： Beste C,Konrad C,Saft C,Ukas T,Andrich J,Pfleiderer B,Hausmann M,Falkenstein M

更新日期：2009-03-01 00:00:00