Abstract：
:Systemic administration of the amphetamine derivative p-chloroamphetamine (PCA) causes degeneration of 5-HT axon terminals in rat brain. The present study was designed to determine whether PCA induces neurotoxic effects by a direct action on 5-HT axon terminals. PCA was administered by microinjection directly into the cerebral cortex of rats. Continuous intracerebral infusions were made over extended time periods (10 min-48 h) to explore whether the induction of neurotoxicity requires a prolonged exposure of axon terminals to the drug. Two weeks after drug administration, brain sections that passed through the injection site were processed for 5-HT immunohistochemistry. The 5-HT innervation of cerebral cortex in PCA-injected animals was compared with that after intracortical injection of saline or of 5,7-dihydroxytryptamine. The results demonstrate that, in the concentrations used, direct application of PCA into the neocortex does not elicit axonal degeneration, even after a continuous infusion for 2 days. This finding suggests that PCA itself is not directly toxic to 5-HT axons.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Berger UV,Molliver ME,Grzanna Rdoi
10.1016/s0014-4886(05)80015-9subject
Has Abstractpub_date
1990-09-01 00:00:00pages
257-68issue
3eissn
0014-4886issn
1090-2430journal_volume
109pub_type
杂志文章abstract：:Cross-species transplantation of dopamine-releasing cell lines protected against immune rejection by a semi-permeable synthetic membrane may provide a source of neurotransmitters for the treatment of Parkinson's disease. Experiments were carried out to assess whether polymer-encapsulated PC12 cells, a catecholaminergi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90093-r
更新日期：1991-03-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(86)90097-x
更新日期：1986-05-01 00:00:00
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更新日期：2017-06-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1988-02-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2005-02-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1986-12-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2003-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.expneurol.2015.05.005
更新日期：2015-09-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章,评审
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更新日期：2018-08-01 00:00:00
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journal_title：Experimental neurology
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更新日期：2021-01-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90162-6
更新日期：1991-12-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2004.05.008
更新日期：2004-08-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90279-0
更新日期：1983-08-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7539
更新日期：2001-01-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.02.010
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1995-06-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1984-12-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1987-11-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2001-10-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2012-11-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2006-12-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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