Effect of ACTH4-10 on nerve fiber regeneration after sciatic nerve crush in rabbits: an electrophysiological and morphological study.

Abstract:

:Crush of sciatic nerve in rabbits supported by morphologic and electrophysiologic data was used to evaluate the effects of ACTH4-10 on nerve fiber regeneration. Treated animals showed a statistically significant higher regeneration rate than did control rabbits. Fiber density and mean diameters of myelinated nerve fibers were measured in semithin nerve sections at 1 and 3 cm distal from the crushed point at three different time points. Nerve fiber density results were higher in ACTH4-10-than in vehicle-treated rabbits. This difference showed an unequivocal trend and attained a statistically significant level in the sections 3 cm distal from the crush. ACTH4-10 seemed therefore to have a beneficial effect on nerve fiber regeneration.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Girlanda P,Muglia U,Vita G,Dattola R,Santoro M,Toscano A,Venuto C,Roberto ML,Baradello A,Romano M

doi

10.1016/0014-4886(88)90162-8

subject

Has Abstract,Author List Incomplete

pub_date

1988-02-01 00:00:00

pages

454-60

issue

2

eissn

0014-4886

issn

1090-2430

journal_volume

99

pub_type

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