Abstract：
:The central histaminergic system is one of the subcortical aminergic projection systems involved in several regulatory functions. The central dopaminergic and histaminergic systems interact extensively, but little is known about the histaminergic system in diseases affecting the dopaminergic neurons. The distribution of histaminergic fibers in the substantia nigra (SN) in postmortem brain samples from patients suffering from Parkinson's disease (PD) and normal controls was examined with a specific immunohistochemical method. Direct connections between dopaminergic neurones and histaminergic fibers were observed. Histamine in human SN was stored in fibers and varicosities. Sites of histamine formation were examined by l-histidine decarboxylase in situ hybridization. In both normal and PD brains HDC mRNA was found only in posterior hypothalamus and not in SN. The presence of histaminergic innervation of the human substantia nigra pars compacta (SNc) and reticulata (SNr), paranigral nucleus, radix of oculomotor nerve, and parabrachial pigmented nucleus was demonstrated. The density of histaminergic fibers in the middle portion of SNc and SNr was increased in brains with PD. In PD the morphology of histaminergic fibers was also altered; they were thinner than in controls and had enlarged varicosities. An increase of histaminergic innervation may reflect a compensatory event due to deficiency of, e.g., dopamine or a putative fiber growth inhibitory factor. Whether the changes seen in histaminergic fibers in PD are primary or secondary remains to be investigated.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Anichtchik OV,Rinne JO,Kalimo H,Panula Pdoi
10.1006/exnr.2000.7362keywords:
subject
Has Abstractpub_date
2000-05-01 00:00:00pages
20-30issue
1eissn
0014-4886issn
1090-2430pii
S0014-4886(00)97362-Xjournal_volume
163pub_type
杂志文章abstract：:The functional and morphologic consequences of treatment of peripheral nerve lesions with exogenous 3,3',5-triiodo-L-thyronine (T3) are unclear. In this study adult Wistar rats with sciatic nerve crush lesions were treated with 20 micrograms/kg/day of T3. The treated animals gained weight though more slowly than vehic...
journal_title：Experimental neurology
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journal_title：Experimental neurology
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更新日期：1988-07-01 00:00:00
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journal_title：Experimental neurology
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journal_title：Experimental neurology
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更新日期：1989-02-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2005-05-01 00:00:00
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.12.006
更新日期：2007-04-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2014.10.018
更新日期：2015-01-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1986-04-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1987-08-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(90)90042-q
更新日期：1990-12-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2018.07.013
更新日期：2018-11-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.05.018
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1995.1025
更新日期：1995-06-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2010-11-01 00:00:00
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更新日期：2012-02-01 00:00:00
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更新日期：2019-03-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
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更新日期：2006-10-01 00:00:00
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2011-07-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2006-07-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章,评审
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更新日期：2010-07-01 00:00:00
