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A spinal cord pathway connecting primary afferents to the segmental sympathetic outflow system.

Abstract：

:The sympathetic innervation of lumbar dorsal root ganglia (DRGs) and the possible presence of spinal cord circuits connecting primary sensory afferents to the sympathetic outflow to DRGs were investigated. We used simultaneous tracing of the sympathetic input to and sensory output from DRGs. Adult male rats received unilateral microinjections of the Bartha strain of pseudorabies virus into four lumbar DRGs. At 24 h post-inoculation, productive infection was detected in both DRG neurons and sympathetic postganglionic neurons. Infection of spinal cord neurons was first observed in sympathetic preganglionic neurons of the intermediolateral column. Subsequently, the infection spread to the contralateral intermediolateral column, the area around the central canal and the superficial dorsal horn layers. To investigate the relationship between infected spinal cord neurons and primary afferents from the corresponding DRGs, we injected pseudorabies virus for retrograde tracing together with cholera toxin B for anterograde tracing. We found that infected LIV/LV and LX neurons were in close apposition to cholera toxin B labeled afferents. Importantly, immunohistochemical detection of bassoon, a pre-synaptic zone protein, identified such contacts as synapses. Together, this suggests synaptic contacts between primary sensory afferents and neurons regulating sympathetic outflow to corresponding DRGs.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Hofstetter CP,Card JP,Olson L

doi

10.1016/j.expneurol.2005.01.028

keywords:

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

128-38

issue

1

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(05)00039-7

journal_volume

194

pub_type

杂志文章

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