CNB-001, a pleiotropic drug is efficacious in embolized agyrencephalic New Zealand white rabbits and ischemic gyrencephalic cynomolgus monkeys.

abstract：:Our previous studies showed that Insulin-like Growth Factor (IGF)-1 reduced blood brain barrier permeability and decreased infarct volume caused by middle cerebral artery occlusion (MCAo) in middle aged female rats. Similarly, cultures of primary brain microvessel endothelial cells from middle-aged female rats and exp...

journal_title：Experimental neurology

authors： Bake S,Okoreeh A,Khosravian H,Sohrabji F

更新日期：2019-01-01 00:00:00

abstract：:The present study was carried out to investigate whether estrogen modulates the drinking response induced by activation of angiotensinergic neural pathways from the subfornical organ (SFO) to the median preoptic nucleus (MnPO). Microinjection of angiotensin II (ANG II, 10(-10) M, 0.2 microl) into the SFO elicited drin...

journal_title：Experimental neurology

authors： Tanaka J,Miyakubo H,Fujisawa S,Nomura M

更新日期：2003-01-01 00:00:00

abstract：:Abnormal corticostriatal plasticity is a key mechanism of L-DOPA-induced dyskinesia (LID) in Parkinson's disease (PD). Antagonists at glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, such as IEM 1460, reduce induction and expression of dyskinesia in rat and non-human primate models ...

journal_title：Experimental neurology

authors： Kobylecki C,Crossman AR,Ravenscroft P

更新日期：2013-09-01 00:00:00

abstract：:Increased intercellular coupling has been implicated in contributing to the synchronization of discharges characteristic of epileptic foci. Using RNA blot analysis, the level of mRNA for the heart-type gap junction protein, connexin43, is shown to be elevated in samples of temporal lobe neocortex obtained at the time ...

journal_title：Experimental neurology

authors： Naus CC,Bechberger JF,Paul DL

更新日期：1991-02-01 00:00:00

abstract：:We recently reported structural changes in nodes of Ranvier of frog dorsal roots that are associated with activation at 20 or 50 Hz for 15 min. The structural effects co-occur with alterations in the latency, amplitude, and waveform of the compound action potential. The alterations in nodal morphology include formatio...

journal_title：Experimental neurology

authors： Wurtz CC,Ellisman MH

更新日期：1988-07-01 00:00:00

abstract：:Neuropathological studies of human traumatic brain injury (TBI) cases have described amyloid plaques acutely after a single severe TBI, and tau pathology after repeat mild TBI (mTBI). This has helped drive the hypothesis that a single moderate to severe TBI increases the risk of developing late-onset Alzheimer's disea...

journal_title：Experimental neurology

authors： Washington PM,Villapol S,Burns MP

更新日期：2016-01-01 00:00:00

abstract：:In the cerebellum of adult-aging Ts65Dn mice, a murine model of Down syndrome, Purkinje cells undergo degeneration. Searching for the cause of Purkinje cell degeneration, we have studied the ubiquitin-proteasome system (UPS) in the cerebellum of aging Ts65Dn mice. Inhibition of UPS is sufficient to induce neuron degen...

journal_title：Experimental neurology

authors： Necchi D,Lomoio S,Scherini E

更新日期：2011-12-01 00:00:00

abstract：:Axons of retinal ganglion cells (RGCs) of adult cats were transected and regenerated by the transplantation of peripheral nerves. Two months after transplantation dendritic arbors of RGCs with regenerated axons (r-RGCs) were visualized with intracellular injections of horseradish peroxidase (HRP). The HRP-filled r-RGC...

journal_title：Experimental neurology

authors： Watanabe M,Fukuda Y

更新日期：1997-01-01 00:00:00

abstract：:Angiopoietin-1 (Ang-1) and its naturally occurring antagonist angiopoietin-2 (Ang-2) are novel ligands that regulate tyrosine phosphorylation of the Tie2/Tek receptor on endothelial cells. Proper regulation of Tie2/Tek is absolutely required for normal vascular development, seemingly by regulating vascular remodeling ...

journal_title：Experimental neurology

authors： Zagzag D,Hooper A,Friedlander DR,Chan W,Holash J,Wiegand SJ,Yancopoulos GD,Grumet M

更新日期：1999-10-01 00:00:00

abstract：:Four lectins (Abrus precatorius (APA), Maackia amurensis (MAA), Momordica charantia (MCA) and Sambucus nigra (SNA)) have been used to identify glycohistochemically the microglial cells (MGC) activation in autoptic brain samples from Alzheimer's disease (AD) subjects. Three of these lectins (APA, MAA and MCA) have util...

journal_title：Experimental neurology

authors： Zambenedetti P,Giordano R,Zatta P

更新日期：1998-09-01 00:00:00

abstract：:Destruction of the entorhinal cortex (EC) triggers a number of cellular and molecular responses in the denervated hippocampus and dentate gyrus. The signals that trigger these changes are not known but could include physiological events that occur during the production of the injury or during the early postlesion peri...

journal_title：Experimental neurology

authors： Kelley MS,Steward O

更新日期：1996-05-01 00:00:00

abstract：:Repeatedly it was reported that a short ischemic episode may ameliorate biochemical and morphological impairment upon succeeding severe ischemia. We investigated whether the pattern of respiratory enzyme activity (RA), adenine nucleotides, and membrane potential in hippocampal slices following low-dose in vivo (20 mg/...

journal_title：Experimental neurology

authors： Riepe MW,Niemi WN,Megow D,Ludolph AC,Carpenter DO

更新日期：1996-03-01 00:00:00

abstract：:The roles of inflammation and degeneration as well as of gray matter abnormalities in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are controversial. We analyzed the pathological manifestations in two EAE models, the chronic oligodendrocyte glycoprotein (MOG)-induced ver...

journal_title：Experimental neurology

authors： Aharoni R,Sasson E,Blumenfeld-Katzir T,Eilam R,Sela M,Assaf Y,Arnon R

更新日期：2013-02-01 00:00:00

abstract：:Assessing the efficacy of human stem cell transplantation in rodent models is complicated by the significant immune rejection that occurs. Two recent reports have shown conflicting results using neonatal tolerance to xenografts in rats. Here we extend this approach to mice and assess whether neonatal tolerance can pre...

journal_title：Experimental neurology

authors： Mattis VB,Wakeman DR,Tom C,Dodiya HB,Yeung SY,Tran AH,Bernau K,Ornelas L,Sahabian A,Reidling J,Sareen D,Thompson LM,Kordower JH,Svendsen CN

更新日期：2014-04-01 00:00:00

abstract：:We compared mitochondrial respiratory chain function, mitochondrial DNA (mtDNA) integrity, and oxidative stress levels in muscle, myoblasts, fibroblasts and cybrids, from 12 amyotrophic lateral sclerosis (ALS) patients with 28 control samples. Mitochondrial respiratory chain enzyme activities were normal in muscle, my...

journal_title：Experimental neurology

authors： Bradley LJ,Taanman JW,Kallis C,Orrell RW

更新日期：2009-07-01 00:00:00

abstract：:Embryonic substantia nigra grafts partially reinnervate the dopamine-denervated corpus striatum when implanted adjacent to that structure. This reinnervation is generally limited to a small portion of the denervated striatum and does not completely compensate for the behavioral effects of a 6-hydroxydopamine lesion of...

journal_title：Experimental neurology

authors： de Beaurepaire R,Freed WJ

更新日期：1987-02-01 00:00:00

abstract：:Anterograde transneuronal degeneration is caused by the loss of afferent input to the nerve cells and may occur in a number of neuronal systems. Transection of the adult spinal cord, causing anterograde transneuronal degeneration in ventral horn neurons, distal to the lesion, has been reported by some authors, while o...

journal_title：Experimental neurology

authors： Bjugn R,Nyengaard JR,Rosland JH

更新日期：1997-11-01 00:00:00

abstract：:Locally generating new proteins in subcellular regions provide means to spatially and temporally modify protein content in polarized cells. Recent years have seen resurgence of the concept that axonal processes of neurons can locally synthesize proteins. Experiments from a number of groups have now shown that axonal p...

journal_title：Experimental neurology

authors： Yoo S,van Niekerk EA,Merianda TT,Twiss JL

更新日期：2010-05-01 00:00:00

abstract：:Peripheral nerve regeneration was studied across a tubulated 10-mm gap in the rat sciatic nerve using histomorphometry and electrophysiological measurements of A-fiber, B-fiber, and C-fiber peaks of the evoked action potentials. Tubes fabricated from large-pore collagen (max. pore diameter, 22 nm), small-pore collagen...

journal_title：Experimental neurology

authors： Chamberlain LJ,Yannas IV,Hsu HP,Strichartz G,Spector M

更新日期：1998-12-01 00:00:00

abstract：:Globoid cell leukodystrophy (GLD, Krabbe Disease) is a lysosomal storage disease, resulting from the genetic deficiency of galactosylceramidase (GALC). This disease is marked by accumulation of the cytotoxic lipid psychosine (Psy). Psychosine is known to induce oxidative stress in cultured cells, and this stress can b...

journal_title：Experimental neurology

authors： Hawkins-Salsbury JA,Qin EY,Reddy AS,Vogler CA,Sands MS

更新日期：2012-10-01 00:00:00

abstract：:In 3-, 9-, 24-, and 30-month-old male rats (Fischer 344), the nuclear perimeter and the density and diameter of nuclear pore complexes in the granule cells of the dentate fascia were studied. Whereas the nuclear perimeter and the diameter of nuclear pore complexes did not change as a function of age, there was a signi...

journal_title：Experimental neurology

authors： Fifková E,Tonks M,Cullen-Dockstader K

更新日期：1987-03-01 00:00:00

abstract：:SCI is followed by dramatic upregulation of chondroitin sulfate proteoglycans (CSPGs) which limit axonal regeneration, oligodendrocyte replacement and remyelination. The recent discovery of the specific CSPGs signaling receptor protein tyrosine phosphatase sigma (RPTPσ) provided an opportunity to refine the therapeuti...

journal_title：Experimental neurology

authors： Rink S,Arnold D,Wöhler A,Bendella H,Meyer C,Manthou M,Papamitsou T,Sarikcioglu L,Angelov DN

更新日期：2018-11-01 00:00:00

abstract：:Overexpression of nerve growth factor (NGF) using adenoviruses (Adts) after spinal cord injury induces extensive regeneration and sprouting of calcitonin-gene-related peptide immunoreactive (CGRP-IR) fibers, whereas overexpression of cell adhesion molecules (CAMs) has no effect on the normal distribution of these fibe...

journal_title：Experimental neurology

authors： Chaudhry N,de Silva U,Smith GM

更新日期：2006-11-01 00:00:00

abstract：:Neural stem cell (NSC) transplantation provides a new approach for the repair of damage to the central nervous system (CNS), including that resulting from cerebral infarction and spinal cord injury (SCI). In the past, there were no reputable means of converting non-neural somatic cells into neural cells. This status w...

journal_title：Experimental neurology

authors： Matsui T,Akamatsu W,Nakamura M,Okano H

更新日期：2014-10-01 00:00:00

abstract：:Graft-induced dyskinesia has emerged as a problematic side effect after transplantation of fetal dopamine cells into the striatum of patients with Parkinson's disease. These adverse effects of dystonic and choreatiform hyperkinesias that persisted even after withdrawal of L-DOPA medication are not yet fully understood...

journal_title：Experimental neurology

authors： García J,Carlsson T,Döbrössy M,Nikkhah G,Winkler C

更新日期：2011-12-01 00:00:00

abstract：:Paired-pulse potentiation was studied in the CA1 region of rats exposed prenatally to alcohol. Pregnant rats were fed a liquid diet containing 35% ethanol-derived calories on days 3 to 21 of gestation. Control animals were fed liquid diets without ethanol. When the pups of both groups were 40 to 60 days old, hippocamp...

journal_title：Experimental neurology

authors： Hablitz JJ

更新日期：1986-08-01 00:00:00

abstract：:The expression of vasoactive intestinal peptide (VIP) and gastrin-releasing peptide (GRP) in the suprachiasmatic nucleus (SCN) changes depending on light. VIP mRNA increases and GRP mRNA decreases in the light phase, while they do not show change without light. In the present study we investigated the involvement of s...

journal_title：Experimental neurology

authors： Hayashi S,Ueda M,Amaya F,Matusda T,Tamada Y,Ibata Y,Tanaka M

更新日期：2001-10-01 00:00:00

abstract：:In what ways do passive touch and active touch require particular properties of cortical physiology? Because it is not easy to make predictions "bottom up" from neurophysiology and anatomy to behavior, there have been surprises in studying behavioral deficits following selective ablations of SI versus SII. For example...

journal_title：Experimental neurology

authors： Glassman RB

更新日期：1994-01-01 00:00:00

abstract：:Chondroitin sulfate proteoglycans (CSPGs), extracellular matrix molecules that increase dramatically following a variety of CNS injuries or diseases, have long been known for their potent capacity to curtail cell migrations as well as axon regeneration and sprouting. The inhibition can be conferred through binding to ...

journal_title：Experimental neurology

authors： Tran AP,Warren PM,Silver J

更新日期：2020-06-01 00:00:00

abstract：:Alzheimer's disease is associated with an age-related accumulation of Abeta and inflammation. The inflammatory mediator, TNFalpha activates a signaling cascade involving NFkappaB translocation to the nucleus and a beneficial or detrimental transcriptional response, depending on the age of the neurons and the type of s...

journal_title：Experimental neurology

authors： Patel JR,Brewer GJ

更新日期：2008-09-01 00:00:00