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Effects of accumulation of phosphocreatine on utilization and restoration of high-energy phosphates during anoxia and recovery in thin hippocampal slices from the guinea pig.

Abstract：

:Effects of accumulation of phosphocreatine (P-creatine) on utilization and restoration of high-energy phosphates during anoxia and recovery were studied using thin hippocampal slices from the guinea pig. Incubation of slices with creatine (5 to 30 mM) increased the content of tissue P-creatine, in a linear fashion, and these increases depended on the concentration of creatine and the incubation period to as long as 3 h. Concentration of ATP in the slices was not altered. A high concentration of tissue P-creatine (40 to 100 mmol/kg protein) accumulated by incubation with creatine reduced the rate of ATP exhaustion during anoxia whereas P-creatine itself was rapidly decreased. During reoxygenation after anoxia, concentrations of ATP and P-creatine rapidly recovered in slices preincubated with creatine. Concentrations of P-creatine previously exhausted during anoxia increased to 100 mmol/kg protein after 25 min of reoxygenation whereas the concentration was 35 mmol/kg in the control slice. Elevation of the concentration of P-creatine may therefore prolong the survival time of brain tissue during anoxia and facilitate recovery during reoxygenation.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Yoneda K,Arakawa T,Asaoka Y,Fukuoka Y,Kinugasa K,Takimoto K,Okada Y

doi

10.1016/0014-4886(83)90256-x

subject

Has Abstract

pub_date

1983-10-01 00:00:00

pages

215-22

issue

1

eissn

0014-4886

issn

1090-2430

pii

0014-4886(83)90256-X

journal_volume

82

pub_type

杂志文章

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