Abstract:
:Adult mammalian retinal ganglion cells (RGCs) can regenerate through peripheral nerve (PN) grafts and innervate central nervous system (CNS) targets. Previous studies have demonstrated a basic level of differentiation of such projections. To further assess the specificity and functionality of regenerated CNS connections we have developed a new model in which RGCs are directed through a PN graft into the dorsolateral geniculate body (LGBd) while preserving the visual cortex and radiations. We also describe by light microscopy that regenerating RGC axons which enter the LGBd differentiate and form subtypes of RGC terminals reminiscent of those seen in the normal LGBd. Thus the adult CNS contains cues that permit phenotypic differentiation of terminal types during regeneration.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Carter DA,Jhaveri Sdoi
10.1006/exnr.1997.6495subject
Has Abstractpub_date
1997-08-01 00:00:00pages
315-22issue
2eissn
0014-4886issn
1090-2430pii
S0014-4886(97)96495-5journal_volume
146pub_type
杂志文章abstract::A cerebrospinal fluid (CSF) to brain exchange has been postulated for lipid-soluble and small molecular substances and has led to nearly 100 attempts per year to produce central effects via intrathecal injections. With few exceptions, however, modern neurological practice has avoided this approach because of its demon...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(84)90192-4
更新日期:1984-11-01 00:00:00
abstract::The focus of this study is the expression of Toll-like receptor-3 (TLR-3), a receptor for double-stranded RNA, in human brains affected by Alzheimer's disease (AD) pathology. Toll-like receptors are a family of pattern recognition molecules primarily involved in host defenses to microbial pathogens, but roles in neuro...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2018.07.016
更新日期:2018-11-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) support axon regeneration across artificial nerve bridges but their differentiative capacity and ability to promote nerve regeneration remains unclear. In this study, MSCs isolated from bone marrow of Sprague-Dawley rats were characterized by plastic adherence and pluripotency towards mes...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2011.01.013
更新日期:2011-04-01 00:00:00
abstract::Periodic changes in ovarian steroid levels during fertility cycles affect learning both in humans and in rats in parallel with electrophysiological and morphological fluctuations in selective neuronal populations. In particular, during the estrous cycle of the female rat, hippocampal CA1 region undergoes cyclic modifi...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7186
更新日期:1999-10-01 00:00:00
abstract::Many neurological and psychiatric disorders exhibit gender disparities, and sex differences in the brain likely explain some of these effects. Recent work in rodents points to a role for epigenetics in the development or maintenance of neural sex differences, although genome-wide studies have so far been lacking. Here...
journal_title:Experimental neurology
pub_type: 杂志文章,评审
doi:10.1016/j.expneurol.2014.08.006
更新日期:2015-06-01 00:00:00
abstract::Locally generating new proteins in subcellular regions provide means to spatially and temporally modify protein content in polarized cells. Recent years have seen resurgence of the concept that axonal processes of neurons can locally synthesize proteins. Experiments from a number of groups have now shown that axonal p...
journal_title:Experimental neurology
pub_type: 杂志文章,评审
doi:10.1016/j.expneurol.2009.08.011
更新日期:2010-05-01 00:00:00
abstract::Recovery from injury to the central nervous system (CNS) is limited in the mammalian adult. Nonetheless, some degree of spontaneous recovery occurs after partial CNS injury. Compensatory axonal growth from uninjured neurons, termed sprouting, contributes to this naturally occurring recovery process and can be modulate...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2018.07.013
更新日期:2018-11-01 00:00:00
abstract::In monkeys, unilateral intracarotid infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces a useful model of hemiparkinsonism. To evaluate MPTP-induced neurochemical changes in vivo, brain microdialysis was employed to measure extracellular levels of dopamine and its metabolites in the neostriatum of...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(90)90029-r
更新日期:1990-11-01 00:00:00
abstract::In the peripheral nervous system, regeneration of motor and sensory axons into chronically denervated distal nerve segments is impaired compared to regeneration into acutely denervated nerves. In order to find possible causes for this phenomenon we examined the changes in the expression pattern of the glial cell-line-...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2001.7826
更新日期:2002-01-01 00:00:00
abstract::The abundance and solubility of Abeta peptides are critical determinants of amyloidosis in Alzheimer's disease (AD). Hence, we compared levels of total soluble, insoluble, and total Abeta1-40 and Abeta1-42 in AD brains with those in age-matched normal and pathologic aging brains using a sandwich enzyme-linked immunoso...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7085
更新日期:1999-08-01 00:00:00
abstract::To test the hypothesis that prepubertal exposure of LHRH neurons to a source of catecholamines and neuropeptides accelerates the onset of puberty, we examined the effects of autologous adrenal transplantation into the base of the third ventricle of the brain in juvenile female rhesus monkeys at 11-13 months of age. Th...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0127
更新日期:1996-08-01 00:00:00
abstract::Previous work utilizing the 2-deoxyglucose (2-DG) technique demonstrated that denervation, both direct (enucleation) or indirect (retinal receptor destruction, leaving ganglion cells intact), resulted in a depression followed by an increase in glucose metabolism in the superior colliculus (SC) of the mature hooded rat...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(89)90040-x
更新日期:1989-06-01 00:00:00
abstract::The activity of 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNPase), as a marker for myelinogenesis, was measured in different parts of the nervous system of dilute-lethal mutant mice (d1/d1). The activity in terms of micromoles of 2'-AMP formed per milligram of protein of homogenate per minute was found to be exceed...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(83)90396-5
更新日期:1983-01-01 00:00:00
abstract::Overt behavioral symptoms of Parkinson's disease (PD) do not occur until over 80% of the striatal dopamine content has been lost. Diagnosis of the disorder relies on identifying clinical symptoms including akinesia, resting tremor, and rigidity. In retrospect, behavioral deficits are observed several years prior to di...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2002.8021
更新日期:2002-11-01 00:00:00
abstract::We have studied the functional involvement of J1-160 and J1-180 in the interaction between oligodendrocytes and neurons, astrocytes, or L cells in short- and long-term adhesion assays using monoclonal antibodies directed against topographically distinct epitopes on the molecules. Whereas antibodies to mouse liver memb...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/s0014-4886(05)80012-3
更新日期:1990-07-01 00:00:00
abstract::Cross-species transplantation of dopamine-releasing cell lines protected against immune rejection by a semi-permeable synthetic membrane may provide a source of neurotransmitters for the treatment of Parkinson's disease. Experiments were carried out to assess whether polymer-encapsulated PC12 cells, a catecholaminergi...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(91)90093-r
更新日期:1991-03-01 00:00:00
abstract::Little is known about the morphological effects of alcoholism on the developing adolescent brain and its consequences into adulthood. We studied here the relationship between two neurotransmitter systems (the serotoninergic and nitrergic) and the astrocytic and neuronal cytoskeleton immediately and long after drinking...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2006.03.001
更新日期:2006-08-01 00:00:00
abstract::After spinal cord injury (SCI), apoptosis of neurons and oligodendrocytes is associated with axonal degeneration and loss of neurological function. Recent data have suggested a potential role for FAS death receptor-mediated apoptosis in the pathophysiology of SCI. In this study, we examined the effect of FAS deficienc...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2005.08.020
更新日期:2005-12-01 00:00:00
abstract::Blood flow in the feline thoracic spinal cord was measured, using a laser-Doppler flowmetry. Rhythmic changes in the spinal cord blood flow were repeatedly observed with a frequency of about three to eight cycles per minute, unrelated to the respiratory or cardiac cycles. These changes were unaffected by hypertension ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(88)90009-x
更新日期:1988-08-01 00:00:00
abstract::Mice genetically deficient in growth hormone were compared with normal littermates for evidence of altered neuronal development. In the lit/lit motor cortex, area 6 of Caviness, cell number, stratification of neurons, and the proportionate layer widths were identical to those of the controls (lit/+). Examined by the G...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(85)90284-5
更新日期:1985-07-01 00:00:00
abstract::Alzheimer's disease (AD) is characterized by cognitive decline and deposition of beta-amyloid (Abeta) plaques in cortex and hippocampus. A transgenic mouse AD model (Tg2576) that overexpresses a mutant form of human Abeta precursor protein exhibits age-related cognitive deficits, Abeta plaque deposition, and oxidative...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/s0014-4886(03)00399-6
更新日期:2003-11-01 00:00:00
abstract::The effects of intranigral iron injection on dopamine (DA) release and content in the caudate putamen (CPu) and their relationship to DA-related behavioral response were investigated in rats. Different concentrations of FeCl(3) (10, 20, and 40 microg) and saline were injected separately into the left substantia nigra....
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/s0014-4886(03)00123-7
更新日期:2003-08-01 00:00:00
abstract::The GluN2 subunits that compose N-methyl-d-aspartate receptors (NMDARs) are attractive drug targets for therapeutic intervention in several diseases, in particular Parkinson's disease (PD). The precise roles and possible dysfunctions of NMDARs attributed to specific GluN2 subunits are however unresolved. Through the u...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2014.03.001
更新日期:2014-05-01 00:00:00
abstract::Fibroblast and epidermal growth factors (FGF-2 and EGF) are powerful mitogens for neural precursor cells isolated from the developing striatum and grown as neurospheres. However, questions remain as to the exact role of each of these molecules, and how the proteoglycan heparin may modify their behavior. Here, we show ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2004.05.007
更新日期:2004-08-01 00:00:00
abstract::We examined the myelin repair potential of transplanted neural precursor cells derived from the adult human brain from tissue removed during surgery. Sections of removed brain indicated that nestin-positive cells were found predominantly in the subventricular zone around the anterior horns of the lateral ventricle and...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2000.7539
更新日期:2001-01-01 00:00:00
abstract::Traumatic brain injury (TBI) affects millions of individuals every year. Many of these injuries lead to lasting effects, particularly impairments in domains broadly classified as executive functions, such as impulse control and decision-making. While these impairments have been historically associated with frontal bra...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2020.113217
更新日期:2020-05-01 00:00:00
abstract::Focal infarction (stroke) of the lateral cerebral cortex of rats (including the sensorimotor cortex) produces deficits in sensorimotor function of the contralateral limbs that recover partially over time. In previous studies, we found that the intracisternal injection of basic fibroblast growth factor (bFGF), a potent...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7101
更新日期:1999-07-01 00:00:00
abstract::Muscle disuse-induced changes in the cholinergic system of sciatic nerve, slow-twitch soleus (SOL), and fast-twitch extensor digitorum longus (EDL) muscles were studied in rats. Rats with hind limbs suspended for 2 to 3 weeks showed marked elevation in the activity of choline acetyltransferase in sciatic nerve (38%), ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(85)90012-3
更新日期:1985-09-01 00:00:00
abstract::Mitochondria actively participate in neurotransmission by providing energy (ATP) and maintaining normative concentrations of reactive oxygen species (ROS) in both presynaptic and postsynaptic elements. In human and animal epilepsies, ATP-producing respiratory rates driven by mitochondrial respiratory complex (MRC) I a...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2013.11.005
更新日期:2014-01-01 00:00:00
abstract::Proteoglycans have a number of important functions in the central nervous system. Aggrecan (hyaluronan-binding proteoglycan, CSPG-cs56) is found in the extracellular matrix of cartilage as well as in the developing brain. We compared the postnatal distribution of CSPG-cs56 in Long Evans (LE) and Royal College of Surge...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2012.01.023
更新日期:2012-04-01 00:00:00