A low chronic ethanol exposure induces morphological changes in the adolescent rat brain that are not fully recovered even after a long abstinence: an immunohistochemical study.

abstract：:The effects of a very low oral dose of Al on spatial learning and neurogenesis were evaluated in a transgenic mouse (Tg 2576) model of Alzheimer disease. At 5 months of age, wild and Tg 2576 mice received a diet supplemented with Al lactate at 0 and 1 mg/g of diet for 120 days. The experimental groups (n=7-8) were: co...

journal_title：Experimental neurology

authors： Ribes D,Colomina MT,Vicens P,Domingo JL

更新日期：2008-12-01 00:00:00

abstract：:Decreased brain insulin signaling has been found recently in Alzheimer's disease (AD). Intranasal administration of insulin, which delivers the drug directly into the brain, improves memory and cognition in both animal studies and small clinical trials. However, the underlying mechanisms are unknown. Here, we treated ...

journal_title：Experimental neurology

authors： Chen Y,Zhao Y,Dai CL,Liang Z,Run X,Iqbal K,Liu F,Gong CX

更新日期：2014-11-01 00:00:00

abstract：:Exogenous myelin- or axolemma-enriched fractions were assessed for the ability to inhibit biochemical and morphological expressions of reactive gliosis in rat optic nerve. Elvax pellets containing exogenous myelin, axolemma, whole-brain homogenate, liver, or red cell extracts or no homogenate were inserted into a dura...

journal_title：Experimental neurology

authors： Politis MJ

更新日期：1988-05-01 00:00:00

abstract：:We examined the pharmacological basis for the suppression of the masseteric (jaw-closer) reflex which occurs during the behavioral state of active sleep. Accordingly, the masseteric reflex was recorded in intact, unanesthetized, normally respiring cats during naturally occurring states of wakefulness and active sleep....

journal_title：Experimental neurology

authors： Soja PJ,Finch DM,Chase MH

更新日期：1987-04-01 00:00:00

abstract：:Extrinsic factors appear to contribute to the lack of regeneration in the injured adult spinal cord. It is likely that these extrinsic factors include a group of putative growth inhibitory molecules known as chondroitin sulfate proteoglycans (CSPGs). The aims of this study were to determine: (1) the consequences of sp...

journal_title：Experimental neurology

authors： Lemons ML,Howland DR,Anderson DK

更新日期：1999-11-01 00:00:00

abstract：:The development of the spinal cord represents one of the most complex structure developments of the central nervous system (CNS) as it has to unfold along the longitudinal axis and within segmental cues. There it has to cope with on the one hand connection to the periphery (skeletal muscle, dermomyotome, smooth muscle...

journal_title：Experimental neurology

authors： Wiese S,Faissner A

更新日期：2015-12-01 00:00:00

abstract：:The behavioral effects of augmenting dopamine D1 receptor expression in the brain were investigated in mice incorporating additional copies of the mouse D1 receptor gene. Two transgenic lines showed increases in brain D1 receptor binding sites, which were greatest in extrastriatal regions. The full D1 agonist SKF 8129...

journal_title：Experimental neurology

authors： Dracheva S,Xu M,Kelley KA,Haroutunian V,Holstein GR,Haun S,Silverstein JH,Sealfon SC

更新日期：1999-05-01 00:00:00

abstract：:Global cerebral ischemia depletes brain tissue NAD+, an essential cofactor for mitochondrial and cellular metabolism, leading to bioenergetics failure and cell death. The post-ischemic NAD+ levels can be replenished by the administration of nicotinamide mononucleotide (NMN), which serves as a precursor for NAD+ synthe...

journal_title：Experimental neurology

authors： Klimova N,Fearnow A,Long A,Kristian T

更新日期：2020-03-01 00:00:00

abstract：:Thyroid hormones and spermidine, a motor neuron trophic polyamine (PA), have been shown to enhance peripheral motor nerve regeneration; however, the mechanism by which these treatment modalities exert their effect is unknown. Similarities in treatment outcome suggest that these molecules may be working via a common me...

journal_title：Experimental neurology

authors： Oble DA,Burton L,Maxwell K,Hassard T,Nathaniel EJ

更新日期：2004-09-01 00:00:00

abstract：:The olfactory bulb is the target of neural progenitor cells that are generated in the subventricular zone of the lateral ventricle in the adult brain. This permanent neurogenesis is likely influenced by olfactory input to the bulb since previous studies have shown that cell proliferation and/or apoptotic death are sti...

journal_title：Experimental neurology

authors： Veyrac A,Didier A,Colpaert F,Jourdan F,Marien M

更新日期：2005-08-01 00:00:00

abstract：:Here, we describe a bilateral cervical contusion model for mice. Adult female mice received graded bilateral contusion injuries at cervical level 5 (C5) using a commercially available impactor (the IH device). Three separate experiments were carried out to define conditions that produce impairments in forelimb functio...

journal_title：Experimental neurology

authors： Aguilar RM,Steward O

更新日期：2010-01-01 00:00:00

abstract：:Four lectins (Abrus precatorius (APA), Maackia amurensis (MAA), Momordica charantia (MCA) and Sambucus nigra (SNA)) have been used to identify glycohistochemically the microglial cells (MGC) activation in autoptic brain samples from Alzheimer's disease (AD) subjects. Three of these lectins (APA, MAA and MCA) have util...

journal_title：Experimental neurology

authors： Zambenedetti P,Giordano R,Zatta P

更新日期：1998-09-01 00:00:00

abstract：:Dopaminergic projections to the caudate putamen (CPu) involve fibers in the nigrostriatal pathway from the ipsilateral substantia nigra-pars compacta. Post-synaptic receptor populations on cells receiving this information are composed of both D1 and D2 dopamine receptor subtypes. In the present study, unilateral lesio...

journal_title：Experimental neurology

authors： Narang N,Hunt ME,Pundt LL,Alburges ME,Wamsley JK

更新日期：1993-05-01 00:00:00

abstract：:Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix (ECM) molecules that are widely expressed throughout the developing and adult CNS. In vitro studies demonstrate their potential to restrict neurite outgrowth, and it is believed that CSPGs also inhibit axonal regeneration after CNS injury in vivo. Prev...

journal_title：Experimental neurology

authors： Jones LL,Margolis RU,Tuszynski MH

更新日期：2003-08-01 00:00:00

abstract：:Modifications of the visual evoked potential during generalized epilepsy were investigated in feline generalized penicillin epilepsy. Visual evoked potentials and their intracortical profiles were averaged during intraburst periods and during the wave of the spike and wave complex to a fixed latency from the preceding...

journal_title：Experimental neurology

authors： Pellegrini A,Zanotto L,Ermani M,Chemello R,Testa G

更新日期：1986-12-01 00:00:00

abstract：:In this study we evaluate the expression of all members of the class 3 semaphorins and their receptor components following complete transection and contusion lesions of the adult rat spinal cord. Following both types of lesions the expression of all class 3 semaphorins is induced in fibroblast in the neural scar. The ...

journal_title：Experimental neurology

authors： De Winter F,Oudega M,Lankhorst AJ,Hamers FP,Blits B,Ruitenberg MJ,Pasterkamp RJ,Gispen WH,Verhaagen J

更新日期：2002-05-01 00:00:00

abstract：:The cascade of events leading to post-traumatic epilepsy (PTE) after traumatic brain injury (TBI) remains unclear. Altered inhibition in the hippocampal formation and dentate gyrus is a hallmark of several neurological disorders, including TBI and PTE. Inhibitory synaptic signaling in the hippocampus is predominately ...

journal_title：Experimental neurology

authors： Butler CR,Boychuk JA,Smith BN

更新日期：2016-06-01 00:00:00

abstract：:We have treated spinal cord injured rats with demyelination plus Schwann cell transplantation and assessed neurite outgrowth in a quantifiable model of axonal regeneration. Axonal injuries of differing severity were induced in the dorsal funiculus of adult rats using a micromanipulator-controlled Scouten knife. Demyel...

journal_title：Experimental neurology

authors： Keirstead HS,Morgan SV,Wilby MJ,Fawcett JW

更新日期：1999-09-01 00:00:00

abstract：:We have previously shown that the expression of voltage-operated Ca(++) channels (VOCCs) is highly regulated in the oligodendroglial lineage and is essential for proper oligodendrocyte progenitor cell (OPC) migration. Here we assessed the role of VOCCs, in particular the L-type, in oligodendrocyte maturation. We used ...

journal_title：Experimental neurology

authors： Cheli VT,Santiago González DA,Spreuer V,Paez PM

更新日期：2015-03-01 00:00:00

abstract：:Dravet syndrome is a severe, early-onset epileptic encephalopathy frequently resulting from de novo mutations of SCN1A. Mice with heterozygous deletion of Scn1a (Scn1a+/-) model many features of Dravet syndrome, including spontaneous seizures and premature lethality. Scn1a+/- mice exhibit variable phenotype penetrance...

journal_title：Experimental neurology

authors： Hawkins NA,Calhoun JD,Huffman AM,Kearney JA

更新日期：2019-01-01 00:00:00

abstract：:Children who are born preterm are at risk for encephalopathy of prematurity, a leading cause of cerebral palsy, cognitive delay and behavioral disorders. Current interventions are limited and none have been shown to reverse cognitive and behavioral impairments, a primary determinant of poor quality of life for these c...

journal_title：Experimental neurology

authors： Robinson S,Corbett CJ,Winer JL,Chan LAS,Maxwell JR,Anstine CV,Yellowhair TR,Andrews NA,Yang Y,Sillerud LO,Jantzie LL

更新日期：2018-04-01 00:00:00

abstract：:In human diabetes, degenerative and functional disorders of the central nervous system, including depression, are common findings. Defective dentate gyrus (DG) neurogenesis is associated with affective-related disorders and depression. We previously demonstrated reduced DG neurogenesis in a pharmacological type 1 diab...

journal_title：Experimental neurology

authors： Beauquis J,Saravia F,Coulaud J,Roig P,Dardenne M,Homo-Delarche F,De Nicola A

更新日期：2008-04-01 00:00:00

abstract：:Human apolipoprotein E (apoE) is a 34.2kDa glycosylated protein with three isoforms (apoE2, apoE3 and apoE4). Experimental autoimmune neuritis (EAN), an animal model for human Guillain-Barré syndrome, is an immune-mediated experimental disorder of the peripheral nervous system (PNS). Increased susceptibility to EAN in...

journal_title：Experimental neurology

authors： Zhang HL,Mao XJ,Zhang XM,Li HF,Zheng XY,Adem A,Mix E,Zhu J

更新日期：2011-08-01 00:00:00

abstract：:The role of central noradrenergic neurons in kindled seizures was assessed by comparison of alpha 2- and beta-adrenoceptor binding in the cerebral cortex from kindled and control rats. To minimize handling, which may modify kindling-induced changes in binding, the kindling protocol involved stimulation of the amygdala...

journal_title：Experimental neurology

authors： Stanford SC,Jefferys JG

更新日期：1985-10-01 00:00:00

abstract：:Fibroblast and epidermal growth factors (FGF-2 and EGF) are powerful mitogens for neural precursor cells isolated from the developing striatum and grown as neurospheres. However, questions remain as to the exact role of each of these molecules, and how the proteoglycan heparin may modify their behavior. Here, we show ...

journal_title：Experimental neurology

authors： Caldwell MA,Garcion E,terBorg MG,He X,Svendsen CN

更新日期：2004-08-01 00:00:00

abstract：:Serial diffusion tensor imaging scans were collected at baseline and 1 year follow-up to investigate the neurodegenerative profile of white matter (WM) in seven individuals with the Huntington's Disease (HD) gene mutation and seven control subjects matched on age and gender. In the HD subjects, but not controls, a sig...

journal_title：Experimental neurology

authors： Weaver KE,Richards TL,Liang O,Laurino MY,Samii A,Aylward EH

更新日期：2009-04-01 00:00:00

abstract：:Repeatedly it was reported that a short ischemic episode may ameliorate biochemical and morphological impairment upon succeeding severe ischemia. We investigated whether the pattern of respiratory enzyme activity (RA), adenine nucleotides, and membrane potential in hippocampal slices following low-dose in vivo (20 mg/...

journal_title：Experimental neurology

authors： Riepe MW,Niemi WN,Megow D,Ludolph AC,Carpenter DO

更新日期：1996-03-01 00:00:00

abstract：:We administered tetrahydroaminoacridine (THA), a cholinesterase inhibitor, to rats with bilateral nucleus basalis magnocellularis lesions and measured their performance in a spatial learning task. The subjects, 34 male Fischer-344 rats, received bilateral excitotoxic NBM lesions; 10 other rats served as unlesioned con...

journal_title：Experimental neurology

authors： Kwo-On-Yuen PF,Mandel R,Chen AD,Thal LJ

更新日期：1990-06-01 00:00:00

abstract：:The effects of N-methyl-d-aspartate (NMDA) and non-NMDA receptor antagonists were compared on audiogenic seizures in the rats neonatally exposed to propylthiouracil (PTU). The rats treated with 0.02% PTU through mother's milk during days 0-19 after delivery showed a high incidence of audiogenic seizures consisting of ...

journal_title：Experimental neurology

authors： Higashiyama A,Ishida N,Nishimura T,Yasuda S,Kuroda Y,McEwen BS,Kato N

更新日期：1998-09-01 00:00:00

abstract：:the antiexcitotoxic efficacy of melatonin, a putative endogenous hydroxyl radical scavenger, was studied in primary cultures of rat cerebellar granule neurons. Excitotoxicity was induced in 7- to 9-day-old cultures by an exposure to glutamate (15 min in the absence of magnesium) or to glutamate receptor agonists, kain...

journal_title：Experimental neurology

authors： Giusti P,Gusella M,Lipartiti M,Milani D,Zhu W,Vicini S,Manev H

更新日期：1995-01-01 00:00:00