当前位置： SCI文献检索 > EXPERIMENTAL NEUROLOGY期刊下所有文献 > Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice.

Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice.

Abstract：

:Decreased brain insulin signaling has been found recently in Alzheimer's disease (AD). Intranasal administration of insulin, which delivers the drug directly into the brain, improves memory and cognition in both animal studies and small clinical trials. However, the underlying mechanisms are unknown. Here, we treated 9-month-old 3xTg-AD mice, a commonly used mouse model of AD, with daily intranasal administration of insulin for seven days and then studied brain abnormalities of the mice biochemically and immunohistochemically. We found that intranasal insulin restored insulin signaling, increased the levels of synaptic proteins, and reduced Aβ40 level and microglia activation in the brains of 3xTg-AD mice. However, this treatment did not affect the levels of glucose transporters and O-GlcNAcylation or tau phosphorylation. Our findings provide a mechanistic insight into the beneficial effects of intranasal insulin treatment and support continuous clinical trials of intranasal insulin for the treatment of AD.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Chen Y,Zhao Y,Dai CL,Liang Z,Run X,Iqbal K,Liu F,Gong CX

doi

10.1016/j.expneurol.2014.06.004

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

610-9

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(14)00191-5

journal_volume

261

pub_type

杂志文章

相关文献

EXPERIMENTAL NEUROLOGY文献大全
  • Elevated potassium enhances glutamate vulnerability of dopaminergic neurons developing in mesencephalic cell cultures.

    abstract：:This study examines the effects of high K+ concentration on the growth and development of mesencephalic cells and their glutamate vulnerability. Mesencephalic cell cultures obtained from Wistar rat embryos on the 14th gestational day were maintained for 14 days in medium with either normal (4.2 mM) or elevated (24.2 m...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1996.0024

    authors： Andreeva N,Ungethum U,Heldt J,Marschhausen G,Altmann T,Andersson K,Gross J

    更新日期：1996-02-01 00:00:00

  • Cell loss in the cerebellum and hippocampal formation of adult rats after long-term low-protein diet.

    abstract：:Whereas quite a number of previous reports have shown that the developing brain is vulnerable to protein deprivation, the mature CNS is usually considered resistant to this condition. To explore this assumption the present experimental model was built on groups of 2-month-old rats fed with a low-protein diet (8% casei...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(89)90081-2

    authors： Paula-Barbosa MM,Andrade JP,Castedo JL,Azevedo FP,Camões I,Volk B,Tavares MA

    更新日期：1989-02-01 00:00:00

  • Embryonic neurons transplanted to regions of targeted photolytic cell death in adult mouse somatosensory cortex re-form specific callosal projections.

    abstract：:In the neocortex, the effectiveness of potential transplantation therapy for diseases involving neuronal loss may depend upon whether donor neurons can reestablish the precise long-distance projections that form the basis of sensory, motor, and cognitive function. During corticogenesis, the formation of these connecti...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1996.0088

    authors： Hernit-Grant CS,Macklis JD

    更新日期：1996-05-01 00:00:00

  • Roles of the periaqueductal gray in descending facilitatory and inhibitory controls of intramuscular hypertonic saline induced muscle nociception.

    abstract：:Despite the importance of the periaqueductal gray (PAG) in the modulation of nociception and pain, many aspects of the roles of the different columns of the PAG in descending controls: facilitation and inhibition, are not understood. Employing a tonic muscle pain model established by i.m. injection of 5.8% saline into...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2014.04.019

    authors： Lei J,Sun T,Lumb BM,You HJ

    更新日期：2014-07-01 00:00:00

  • Serotonin modulates expression of VIP and GRP mRNA via the 5-HT(1B) receptor in the suprachiasmatic nucleus of the rat.

    abstract：:The expression of vasoactive intestinal peptide (VIP) and gastrin-releasing peptide (GRP) in the suprachiasmatic nucleus (SCN) changes depending on light. VIP mRNA increases and GRP mRNA decreases in the light phase, while they do not show change without light. In the present study we investigated the involvement of s...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2001.7759

    authors： Hayashi S,Ueda M,Amaya F,Matusda T,Tamada Y,Ibata Y,Tanaka M

    更新日期：2001-10-01 00:00:00

  • A reassessment of P2X7 receptor inhibition as a neuroprotective strategy in rat models of contusion injury.

    abstract：:These experiments were completed as part of an NIH "Facilities of Research Excellence in Spinal Cord Injury" contract to support independent replication of published studies that could be considered for eventual clinical testing. Recent studies have reported that selective inhibition of the P2X7 receptor improves both...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2011.06.008

    authors： Marcillo A,Frydel B,Bramlett HM,Dietrich WD

    更新日期：2012-02-01 00:00:00

  • Elevated regional sciatic nerve blood flow in hypothermic anesthetized rats.

    abstract：:The effect of corporal hypothermia on regional blood flow in peripheral nerve is unknown. We compared blood flow in resting sciatic nerves of anesthetized, normothermic rats with that of rats whose rectal temperatures had been acutely lowered to 28 to 30 degrees C. Peripheral nerve regional blood flow in normothermic ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(87)90098-7

    authors： Sugimoto H,Monafo WW,Shimazaki S

    更新日期：1987-08-01 00:00:00

  • Gene therapy and respiratory neuroplasticity.

    abstract：:Breathing is a life-sustaining behavior that in mammals is accomplished by activation of dedicated muscles responsible for inspiratory and expiratory forces acting on the lung and chest wall. Motor control is exerted by specialized pools of motoneurons in the medulla and spinal cord innervated by projections from mult...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1016/j.expneurol.2016.09.014

    authors： Mantilla CB

    更新日期：2017-01-01 00:00:00

  • The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.

    abstract：:We examined the effect of glial cell line-derived neurotrophic factor (GDNF) upon nigrostriatal dopaminergic function in response to two-pulse potassium (K(+)) stimulation in rats under in vivo microdialysis conditions. The two-pulse infusion protocol permits us to focus upon the role of this neurotrophin as related t...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2000.7515

    authors： Xu K,Dluzen DE

    更新日期：2000-12-01 00:00:00

  • Effects of pathway and neuronal aging on the specificity of motor axon regeneration.

    abstract：:Youth is a strong predictor of functional recovery after peripheral nerve repair, while adulthood is commonly associated with poor outcome. Identification of the factors responsible for this difference could form the basis for strategies to improve regeneration in adults. Preferential reinnervation of motor pathways b...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2000.7538

    authors： Le TB,Aszmann O,Chen YG,Royall RM,Brushart TM

    更新日期：2001-01-01 00:00:00

  • Inhibition of heterosensory thalamocortical evoked potentials by delta-9-tetrahydrocannabinol.

    abstract：:The effects of delta-9-tetrahydrocannabinol on sensory activity in the thalamic intralaminar nuclei, centralis lateralis and the mesencephalic reticular formation were compared with the effects on cortical association or heterosensory systems in alpha-chloralose-anesthetized cats. The drug depressed the anterior margi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(87)90121-x

    authors： Pontzer NJ,Wilkison DM

    更新日期：1987-09-01 00:00:00

  • Peripheral nerve grafts after cervical spinal cord injury in adult cats.

    abstract：:Peripheral nerve grafts (PNG) into the rat spinal cord support axon regeneration after acute or chronic injury, with synaptic reconnection across the lesion site and some level of behavioral recovery. Here, we grafted a peripheral nerve into the injured spinal cord of cats as a preclinical treatment approach to promot...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2010.06.011

    authors： Côté MP,Hanna A,Lemay MA,Ollivier-Lanvin K,Santi L,Miller K,Monaghan R,Houlé JD

    更新日期：2010-09-01 00:00:00

  • Acetaldehyde promotes rapamycin-dependent activation of p70(S6K) and glucose uptake despite inhibition of Akt and mTOR in dopaminergic SH-SY5Y human neuroblastoma cells.

    abstract：:Alcohol intake is one of the important lifestyle factors for the risk of insulin resistance and type 2 diabetes. Acetaldehyde, the major ethanol metabolite which is far more reactive than ethanol, has been postulated to participate in alcohol-induced tissue injury although its direct impact on insulin signaling is unc...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.08.002

    authors： Fang CX,Yang X,Sreejayan N,Ren J

    更新日期：2007-01-01 00:00:00

  • Escalating dose-multiple binge methamphetamine exposure results in degeneration of the neocortex and limbic system in the rat.

    abstract：:Abuse of stimulant drugs such as methamphetamine (METH) and cocaine has been associated with long-lasting persistent behavioral alterations. Although METH-induced changes in the striatal dopaminergic system might play a role in these effects, the potential underlying neuroanatomical substrate for the chronic cognitive...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2007.05.023

    authors： Kuczenski R,Everall IP,Crews L,Adame A,Grant I,Masliah E

    更新日期：2007-09-01 00:00:00

  • The amygdala and the pedunculopontine tegmental nucleus: interactions controlling active (rapid eye movement) sleep.

    abstract：:There is a consensus that active sleep (AS; i.e., REM sleep) is produced by cholinergic projections from the pedunculopontine tegmental nuclei (PPT) that activate AS-on neurons in the nucleus pontis oralis (NPO) that are components of the AS-Generator. However, there is a growing body of evidence indicating that other...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2012.08.001

    authors： Xi M,Fung SJ,Zhang J,Sampogna S,Chase MH

    更新日期：2012-11-01 00:00:00

  • Recovery of chorda tympani nerve function following injury.

    abstract：:The chorda tympani (CT) nerve carries taste information from the anterior tongue to the brain stem. Injury to the chorda tympani may result in loss or distortion of taste information. This study examined changes occurring in the hamster peripheral taste system during recovery from injury. The hamster chorda tympani ne...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1996.0169

    authors： Cain P,Frank ME,Barry MA

    更新日期：1996-10-01 00:00:00

  • Transendocytosis is impaired in CADASIL-mutant NOTCH3.

    abstract：:Mutations in the human NOTCH3 gene cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), but the pathogenesis of CADASIL has remained unclear. Recently, endocytosis of the Notch ectodermal domain into ligand-expressing cells, called transendocytosis, has come to be...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2011.10.020

    authors： Watanabe-Hosomi A,Watanabe Y,Tanaka M,Nakagawa M,Mizuno T

    更新日期：2012-01-01 00:00:00

  • Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat.

    abstract：:Dementia and parkinsonism are late-onset symptoms associated with repetitive head injury, as documented in multiple contact-sport athletes. Clinical symptomatology is the likely phenotype of chronic degeneration and circuit disruption in the substantia nigra (SN). To investigate the initiating neuropathology, we hypot...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2011.12.003

    authors： van Bregt DR,Thomas TC,Hinzman JM,Cao T,Liu M,Bing G,Gerhardt GA,Pauly JR,Lifshitz J

    更新日期：2012-03-01 00:00:00

  • Effect of methysergide on pudendal inhibition of micturition reflex in cats.

    abstract：:The role of 5-HT2 and opioid receptors in pudendal inhibition of bladder activity induced by intravesical infusion of saline or 0.25% acetic acid (AA) was investigated in anesthetized cats using methysergide (a 5-HT2 receptor antagonist) and naloxone (an opioid receptor antagonist). AA irritated the bladder and signif...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2013.05.006

    authors： Matsuta Y,Schwen Z,Mally AD,Shen B,Wang J,Roppolo JR,de Groat WC,Tai C

    更新日期：2013-09-01 00:00:00

  • Resveratrol reduces cerebral edema through inhibition of de novo SUR1 expression induced after focal ischemia.

    abstract：:Cerebral edema is a clinical problem that frequently follows ischemic infarcts. Sulfonylurea receptor 1 (SUR1) is an inducible protein that can form a heteromultimeric complex with aquaporin 4 (AQP4) that mediate the ion/water transport involved in brain tissue swelling. Transcription of the Abcc8 gene coding for SUR1...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2020.113353

    authors： Alquisiras-Burgos I,Ortiz-Plata A,Franco-Pérez J,Millán A,Aguilera P

    更新日期：2020-08-01 00:00:00

  • Up-regulation of brain-derived neurotrophic factor is regulated by extracellular signal-regulated protein kinase 5 and by nerve growth factor retrograde signaling in colonic afferent neurons in colitis.

    abstract：:Brain-derived neurotrophic factor (BDNF) plays an essential role in sensory neuronal activation in response to visceral inflammation. Here we report that BDNF up-regulation in the primary afferent neurons in the dorsal root ganglia (DRG) in a rat model of colitis is mediated by the activation of endogenous extracellul...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2012.08.007

    authors： Yu SJ,Grider JR,Gulick MA,Xia CM,Shen S,Qiao LY

    更新日期：2012-12-01 00:00:00

  • Functional correlates of central white matter maturation in perinatal period in rabbits.

    abstract：:Anisotropy indices derived from diffusion tensor imaging (DTI) are being increasingly used as biomarkers of central WM structural maturation, myelination and even functional development. Our hypothesis was that the rate of functional changes in central WM tracts directly reflects rate of changes in structural developm...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2014.06.021

    authors： Drobyshevsky A,Jiang R,Derrick M,Luo K,Tan S

    更新日期：2014-11-01 00:00:00

  • Paclitaxel alters the evoked release of calcitonin gene-related peptide from rat sensory neurons in culture.

    abstract：:Peripheral neuropathy (PN) is a debilitating and dose-limiting side effect of treatment with the chemotherapeutic agent, paclitaxel. Understanding the effects of paclitaxel on sensory neuronal function and the signaling pathways which mediate these paclitaxel-induced changes in function are critical for the developmen...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2013.12.011

    authors： Pittman SK,Gracias NG,Vasko MR,Fehrenbacher JC

    更新日期：2014-03-01 00:00:00

  • An altered histaminergic innervation of the substantia nigra in Parkinson's disease.

    abstract：:The central histaminergic system is one of the subcortical aminergic projection systems involved in several regulatory functions. The central dopaminergic and histaminergic systems interact extensively, but little is known about the histaminergic system in diseases affecting the dopaminergic neurons. The distribution ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2000.7362

    authors： Anichtchik OV,Rinne JO,Kalimo H,Panula P

    更新日期：2000-05-01 00:00:00

  • Ampakine CX516 ameliorates functional deficits in AMPA receptors in a hippocampal slice model of protein accumulation.

    abstract：:AMPAkines are positive modulators of AMPA receptors, and previous work has shown that these compounds can facilitate synaptic plasticity and improve learning and memory in both animals and humans; thus, their role in the treatment of cognitive impairment is worthy of investigation. In this study, we have utilized an o...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2008.07.010

    authors： Kanju PM,Parameshwaran K,Sims C,Bahr BA,Shonesy BC,Suppiramaniam V

    更新日期：2008-11-01 00:00:00

  • Survival of fetal neocortical grafts implanted in brain infarcts of adult rats: the influence of postlesion time and age of donor tissue.

    abstract：:We have previously found that fetal cortex taken from 16- to 18-day-old donors survives grafting to the infarcted cortex 5-7 days after middle cerebral artery occlusion. The present study was undertaken to examine the effect on graft survival of varying the age of the fetal donor tissue and the time between vessel occ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1994.1086

    authors： Grabowski M,Johansson BB,Brundin P

    更新日期：1994-05-01 00:00:00

  • Glutamate induces rapid loss of axonal neurofilament proteins from cortical neurons in vitro.

    abstract：:One of the primary hallmarks of glutamate excitotoxicity is degradation of the neuronal cytoskeleton. Using a tissue culture approach, we have investigated the relationship between excitotoxicity and cytoskeletal degradation within axons, with particular reference to the axon specific neurofilament proteins. Neurofila...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2005.01.005

    authors： Chung RS,McCormack GH,King AE,West AK,Vickers JC

    更新日期：2005-06-01 00:00:00

  • Hereditary peroneal muscular atrophy in the mouse: an experimental model for congenital contractures (arthrogryposis).

    abstract：:A new mutant, peroneal muscular atrophy (pma) mouse in CF#1 strain has an autosomal recessively inherited equinovarus (club foot deformity) of the hind legs because of the absence of the common peroneal nerve branch of the sciatic nerve. We found the peroneal muscles were hypoplastic with histochemical and electron mi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(86)90053-1

    authors： Nonaka I,Kikuchi A,Suzuki T,Esaki K

    更新日期：1986-03-01 00:00:00

  • Functional MRI study of the primary somatosensory cortex in comatose survivors of cardiac arrest.

    abstract：:It is difficult to assess cerebral function in comatose patients. Because earlier functional neuroimaging studies demonstrate associations between cerebral metabolism and levels of consciousness, fMRI in comatose survivors of cardiac arrest could provide further insight into cerebral function during coma. Using fMRI, ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2009.03.011

    authors： Gofton TE,Chouinard PA,Young GB,Bihari F,Nicolle MW,Lee DH,Sharpe MD,Yen YF,Takahashi AM,Mirsattari SM

    更新日期：2009-06-01 00:00:00

  • Spontaneous neuronal activity in fetuses and newborns.

    abstract：:We compared the magnetic cerebral activity of 10 fetal subjects at two different gestational ages. Spontaneous cerebral activity was recorded with a large array magnetometer specially designed to conform to the maternal gravid abdomen during the third trimester of pregnancy. We recorded each fetal subject at least twi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2004.06.026

    authors： Rose DF,Eswaran H

    更新日期：2004-11-01 00:00:00