Abstract:
:In this study we evaluate the expression of all members of the class 3 semaphorins and their receptor components following complete transection and contusion lesions of the adult rat spinal cord. Following both types of lesions the expression of all class 3 semaphorins is induced in fibroblast in the neural scar. The distribution of semaphorin-positive fibroblasts differs markedly in scars formed after transection or contusion lesion. In contusion lesions semaphorin expression is restricted to fibroblasts of the meningeal sheet surrounding the lesion, while after transection semaphorin-positive fibroblast penetrate deep into the center of the lesion. Two major descending spinal cord motor pathways, the cortico- and rubrospinal tract, continue to express receptor components for class 3 semaphorins following injury, rendering them potentially sensitive to scar-derived semaphorins. In line with this we observed that most descending spinal cord fibers were not able to penetrate the semaphorin positive portion of the neural scar formed at the lesion site. These results suggest that the full range of secreted semaphorins contributes to the inhibitory nature of the neural scar and thereby may inhibit successful regeneration in the injured spinal cord. Future studies will focus on the neutralization of class 3 semaphorins, in order to reveal whether this creates a more permissive environment for regeneration of injured spinal cord axons.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
De Winter F,Oudega M,Lankhorst AJ,Hamers FP,Blits B,Ruitenberg MJ,Pasterkamp RJ,Gispen WH,Verhaagen Jdoi
10.1006/exnr.2002.7884keywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
61-75issue
1eissn
0014-4886issn
1090-2430pii
S0014488602978842journal_volume
175pub_type
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