Abstract：
:Implantable silicon microelectrode array technology is a useful technique for obtaining high-density, high-spatial resolution sampling of neuronal activity within the brain and holds promise for a wide range of neuroprosthetic applications. One of the limitations of the current technology is inconsistent performance in long-term applications. Although the brain tissue response is believed to be a major cause of performance degradation, the precise mechanisms that lead to failure of recordings are unknown. We observed persistent ED1 immunoreactivity around implanted silicon microelectrode arrays implanted in adult rat cortex that was accompanied by a significant reduction in nerve fiber density and nerve cell bodies in the tissue immediately surrounding the implanted silicon microelectrode arrays. Persistent ED1 up-regulation and neuronal loss was not observed in microelectrode stab controls indicating that the phenotype did not result from the initial mechanical trauma of electrode implantation, but was associated with the foreign body response. In addition, we found that explanted electrodes were covered with ED1/MAC-1 immunoreactive cells and that the cells released MCP-1 and TNF-alpha under serum-free conditions in vitro. Our findings suggest a potential new mechanism for chronic recording failure that involves neuronal cell loss, which we speculate is caused by chronic inflammation at the microelectrode brain tissue interface.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Biran R,Martin DC,Tresco PAdoi
10.1016/j.expneurol.2005.04.020keywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
115-26issue
1eissn
0014-4886issn
1090-2430pii
S0014-4886(05)00145-7journal_volume
195pub_type
杂志文章abstract：:Activation of N-methyl-d-aspartate (NMDA) receptors in the spinal dorsal horn has been shown to be essential for the initiation of central sensitization and the hyperexcitability of dorsal horn neurons in chronic pain. However, whether the spinal NR2B-containing NMDA (NMDA-2B) receptors are involved still remains larg...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.10.018
更新日期：2009-02-01 00:00:00
abstract：:Human recombinant activated factor-VII (rFVIIa) has been used successfully in the treatment of spontaneous intracerebral hemorrhage. In addition, there is increasing interest in its use to treat uncontrolled bleeding of other origins, including trauma. The aim of this study was to evaluate the safety and potential eff...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2007.12.019
更新日期：2008-04-01 00:00:00
abstract：:The purpose of this study was to assess the respiratory and tonic activity of the abdominal muscles and the postinspiratory activity of the diaphragm (stage 1 expiration) in rats during sleep while they breathed air, hypercapnic, and hypoxic gas mixtures. ECoG and neck EMG recordings enabled the differentiation to be ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90064-7
更新日期：1988-07-01 00:00:00
abstract：:These studies have examined the extent to which intrastriatal grafts of embryonic mesencephalic neurons induce recovery of normal discharge patterns in striatal neurons of rats after a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal dopamine (DA) pathway. Lesioned rats were tested for rotational beha...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.0070
更新日期：1996-04-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective motor neuron degeneration in the motor cortex, brainstem and spinal cord. It is generally accepted that ALS is caused by death of motor neurons, however the exact temporal cascade of degenerative processes is not yet complete...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2017.03.018
更新日期：2017-07-01 00:00:00
abstract：:Sleep and behavioral monitoring of young mice is necessary for understating the progress of symptoms in congenital and acquired diseases associated with sleep and movement disorders. In the current study, we have developed a non-invasive sleep monitoring system that identifies wake and sleep patterns of newborn mice u...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2014.08.004
更新日期：2014-11-01 00:00:00
abstract：:In this study we evaluate the expression of all members of the class 3 semaphorins and their receptor components following complete transection and contusion lesions of the adult rat spinal cord. Following both types of lesions the expression of all class 3 semaphorins is induced in fibroblast in the neural scar. The ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2002.7884
更新日期：2002-05-01 00:00:00
abstract：:Angiotensin II type 1 receptor (AT1R) blocker (ARB) has been reported to modify hypertensive cerebrovascular changes; however, it is not clear whether its protective effects are independent of blood pressure. The aim of this study was to clarify the role of AT1R-mediated signals in cerebral circulation by the chronic ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2007.11.028
更新日期：2008-04-01 00:00:00
abstract：:Caspases are cysteine proteases involved in apoptotic cell death, and pharmacological caspase inhibition has been demonstrated to prevent neuronal cell death in certain experimental paradigms. In this study, the role of caspase-1 and -3 in the death of dopaminergic neurons derived from the E14 rat ventral mesencephalo...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7749
更新日期：2001-09-01 00:00:00
abstract：:Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for motoneurons (MNs), and is considered a potential agent for the treatment of amyotrophic lateral sclerosis (ALS) and other MN diseases. The effectiveness of GDNF may depend significantly upon its route of delivery to MNs. In this study w...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.08.028
更新日期：2007-02-01 00:00:00
abstract：:Assessing the efficacy of human stem cell transplantation in rodent models is complicated by the significant immune rejection that occurs. Two recent reports have shown conflicting results using neonatal tolerance to xenografts in rats. Here we extend this approach to mice and assess whether neonatal tolerance can pre...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2014.01.007
更新日期：2014-04-01 00:00:00
abstract：:The presence of the alpha2macroglobulin receptor/low density lipoprotein receptor-related protein (alpha2Mr/LRP) and its ligands alpha2macroglobulin (alpha2M), apoliprotein E, and plasminogen activators was detected in senile plaques of Alzheimer's disease (AD). To explore a possible role of alpha2M in neurodegenerati...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6978
更新日期：1999-02-01 00:00:00
abstract：:The cortical reorganization after spinal cord injury (SCI) involves a series of physiological changes that drive the expansion of the intact cortical area to the deafferented cortical area. These changes have always been studied under a stimulus-response paradigm, which demonstrates that the deafferented cortex become...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2019.113035
更新日期：2019-12-01 00:00:00
abstract：:Stimulation of peripheral nerves activates corresponding regions in sensorimotor cortex. We have applied functional magnetic resonance imaging (fMRI) techniques to monitor activated brain regions by means of measuring changes of blood oxygenation level-dependent contrast during electric stimulation of the forepaw, hin...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7524
更新日期：2000-12-01 00:00:00
abstract：:For the past 15 years, patients with Parkinson's disease have participated in clinical trials evaluating the efficacy of intrastriatal dopamine transplants. Principally, two donor tissues have been employed, the chromaffin cells of the adrenal medulla and fetal ventral mesencephalon. The clinical response following ea...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1006/exnr.1996.6386
更新日期：1997-03-01 00:00:00
abstract：:Stress is a common environmental factor associated with depressive illness and the amygdala is thought to be integral for this association. For example, repeated stress impairs amygdalar neuroplasticity in rodents and these defects parallel amygdalar deficits in depressive illness patients. Because the excitatory neur...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.12.005
更新日期：2013-03-01 00:00:00
abstract：:The study investigates if alpha-lipoic acid is neuroprotective against chemotherapy induced neurotoxicity, if mitochondrial damage plays a critical role in toxic neurodegenerative cascade, and if neuroprotective effects of alpha-lipoic acid depend on mitochondria protection. We used an in vitro model of chemotherapy i...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.08.013
更新日期：2008-12-01 00:00:00
abstract：:Adult cats were subjected to subarachnoid hemorrhage by three repeated intracisternal injections of autogenous nonheparinized blood (2 ml/injection) at weekly intervals. Histological studies (light and electron microscope) were made of the basilar artery and the middle cerebral arteries of all animals. In the subarach...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(86)90103-2
更新日期：1986-11-01 00:00:00
abstract：:We have studied the functional involvement of J1-160 and J1-180 in the interaction between oligodendrocytes and neurons, astrocytes, or L cells in short- and long-term adhesion assays using monoclonal antibodies directed against topographically distinct epitopes on the molecules. Whereas antibodies to mouse liver memb...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(05)80012-3
更新日期：1990-07-01 00:00:00
abstract：:Alpha-tyrosinated tubulin is a cytoskeletal protein that is involved in axonal growth and is considered a marker of neuronal plasticity in adult mammals. In adult rats, unilateral ablation of the left facial sensorimotor cortical areas induces degeneration of corticotrigeminal projections and marked denervation of the...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.05.010
更新日期：2008-09-01 00:00:00
abstract：:An in vivo assay was developed for long-term analyses of Schwann cells at the single cell level. Schwann cells were isolated from sciatic nerves and labeled with the fluorescent gold label Fluoro-Gold. Cells were then transplanted into severed sciatic nerves of young adult rats. Gold-labeled Schwann cells, identified ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90092-q
更新日期：1991-10-01 00:00:00
abstract：:Alzheimer's disease (AD) is the leading cause of dementia and the most common neurodegenerative disorder. AD is mostly a sporadic disorder and its main risk factor is age, but mutations in three genes that promote the accumulation of the amyloid-β (Aβ42) peptide revealed the critical role of amyloid precursor protein ...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2015.05.013
更新日期：2015-12-01 00:00:00
abstract：:After injury of their axons, damaged neurons shift their metabolic activity into a reparative mode aimed at survival and regeneration or, alternatively, they undergo degeneration and die. Previous reports have shown that at the initial stages of the response to axonal injury, polyamines are essential for neuronal surv...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(86)90307-9
更新日期：1986-06-01 00:00:00
abstract：:Systemic administration of kainic acid (12 mg/kg, i.p.), causing the established epileptic syndrome and the associated specific pattern of limbic nerve cell loss, led to substantial time-dependent increases in the brain metabolism of the endogenous excitotoxin, quinolinic acid. These changes preferentially affected bi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90140-9
更新日期：1988-01-01 00:00:00
abstract：:The effects of superior cervical ganglion stimulation and the local application of norepinephrine or its antagonist propranolol were studied in 18 pineal cells. In 61% of the pineal cells, stimulation elicited excitation; the same cells also responded by excitation to norepinephrine ejection. When stimulation and nore...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90149-9
更新日期：1985-12-01 00:00:00
abstract：:Traumatic brain injury (TBI) affects millions of individuals every year. Many of these injuries lead to lasting effects, particularly impairments in domains broadly classified as executive functions, such as impulse control and decision-making. While these impairments have been historically associated with frontal bra...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113217
更新日期：2020-05-01 00:00:00
abstract：:Estrogen has been suggested to be pro-epileptic by reducing GABA synthesis, resulting in increased spine density and a decreased threshold for seizures in the hippocampus, which, once they occur, are characterized by a dramatic spine loss in the affected brain areas. As considerable amounts of estradiol are synthesize...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.07.020
更新日期：2007-01-01 00:00:00
abstract：:This study examines the effects of high K+ concentration on the growth and development of mesencephalic cells and their glutamate vulnerability. Mesencephalic cell cultures obtained from Wistar rat embryos on the 14th gestational day were maintained for 14 days in medium with either normal (4.2 mM) or elevated (24.2 m...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.0024
更新日期：1996-02-01 00:00:00
abstract：:No current therapy for Parkinson disease has been shown to slow or reverse the progressive course of the disease. As a departure from traditional treatments, gene therapy approaches provide a new hope for realizing this long-sought goal; but before they can be widely employed for use in patients, they must first be su...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2007.08.012
更新日期：2008-01-01 00:00:00
abstract：:Interactions between neurotrophic factors and neurotransmitters participate in the formation and maintenance of appropriate connections, as well as in neurodegenerative processes. Here we have measured changes in the developmental expression pattern of BDNF and NT-3 in the striatum, cortex, and substantia nigra induce...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7451
更新日期：2000-09-01 00:00:00
