Neonatal immune-tolerance in mice does not prevent xenograft rejection.

abstract：:Previous work utilizing the 2-deoxyglucose (2-DG) technique demonstrated that denervation, both direct (enucleation) or indirect (retinal receptor destruction, leaving ganglion cells intact), resulted in a depression followed by an increase in glucose metabolism in the superior colliculus (SC) of the mature hooded rat...

journal_title：Experimental neurology

authors： Thurlow GA,Cooper RM

更新日期：1989-06-01 00:00:00

abstract：:Cats were kindled in the amygdala. After completion of kindling, their EEG was monitored almost continuously by a computer system which allowed the detection of spontaneous seizures and the quantification of interictal spikes. The relationships between seizures triggered by stimulation, spontaneous seizures, and inter...

journal_title：Experimental neurology

authors： Gotman J

更新日期：1984-05-01 00:00:00

abstract：:The ectopic discharges observed in uninjured dorsal root ganglion (DRG) neurons following various lesions of spinal nerves have been attributed to functional alterations of voltage-gated sodium channels (VGSCs). Such mechanisms may be important for the development of neuropathic pain. However, the pathophysiology unde...

journal_title：Experimental neurology

authors： Chen X,Pang RP,Shen KF,Zimmermann M,Xin WJ,Li YY,Liu XG

更新日期：2011-02-01 00:00:00

abstract：:The effects of a very low oral dose of Al on spatial learning and neurogenesis were evaluated in a transgenic mouse (Tg 2576) model of Alzheimer disease. At 5 months of age, wild and Tg 2576 mice received a diet supplemented with Al lactate at 0 and 1 mg/g of diet for 120 days. The experimental groups (n=7-8) were: co...

journal_title：Experimental neurology

authors： Ribes D,Colomina MT,Vicens P,Domingo JL

更新日期：2008-12-01 00:00:00

abstract：:Status epilepticus (SE) is an acute event, characterized by repeated or continuous seizures, which alters neuronal properties of the brain and can promote the epileptic disorder. Experimental observations indicate that SE becomes progressively less responsive to anti-epileptic drugs, suggesting changes in the underlyi...

journal_title：Experimental neurology

authors： Karunakaran S,Grasse DW,Moxon KA

更新日期：2012-04-01 00:00:00

abstract：:Hypernatremic dehydration was induced in rabbits during a 3- to 5-day period resulting in mean plasma sodium concentrations of 187 meq/liter. The animals were then rehydrated during a 4-h period by intravenous administration of a 2.5% glucose or fructose solution. The water content of four regions of brain sample show...

journal_title：Experimental neurology

authors： Hogan GR,Pickering LK,Dodge PR,Shepard JB,Master S

更新日期：1985-02-01 00:00:00

abstract：:Inflammation plays a central role in the development of numerous disorders of the central nervous system (CNS) such as multiple sclerosis (MS). For a long time it was assumed that recruitment of macrophages into the CNS and breakdown of the blood-brain barrier (BBB) are closely linked. In the present study we challeng...

journal_title：Experimental neurology

authors： Ladewig G,Jestaedt L,Misselwitz B,Solymosi L,Toyka K,Bendszus M,Stoll G

更新日期：2009-11-01 00:00:00

abstract：:We provide evidence for apoptosis in Alzheimer's disease using the in situ labeling technique TUNEL (terminal transferase-mediated dUTP-biotin nick end labeling). The technique specifically detects apoptotic cells by utilizing terminal transferase to incorporate biotinylated nucleotides into the fragmented DNA of apop...

journal_title：Experimental neurology

authors： Smale G,Nichols NR,Brady DR,Finch CE,Horton WE Jr

更新日期：1995-06-01 00:00:00

abstract：:Kindling is traditionally viewed as a chronic, focal epilepsy model which consistently induces complex partial seizures from limbic structures in animals. This study revealed that primary or exceedingly rapid secondary generalized seizures could also be kindled when stimulation was applied to the lateral geniculate nu...

journal_title：Experimental neurology

authors： Shouse MN,Ryan W

更新日期：1984-10-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder associated with selective loss of the dopaminergic neurons in the substantia nigra. We have previously shown that tetrahydrobiopterin (BH4), the obligatory cofactor for dopamine synthesis, exerts selective toxicity on dopamine-producing cells. In the present study we...

journal_title：Experimental neurology

authors： Choi HJ,Kim SW,Lee SY,Moon YW,Hwang O

更新日期：2003-06-01 00:00:00

abstract：:Spectral analysis is a mathematical method which contains and generalizes frequency analysis. The form of spectral analysis most applicable to EEG is tutorially presented, using both algebraic formulae and four simplified illustrative examples. The examples are each converted into an autocorrelogram and auto-spectrogr...

journal_title：Experimental neurology

authors： Walter DO

更新日期：1963-08-01 00:00:00

abstract：:In 18 urethane-anesthetized ovariectomized female rats, 54 neurons in and around the hypothalamic ventromedial nucleus were transynaptically activated by electrical stimulation of the mesencephalic central gray matter. Ventromedial nucleus afferents from either the dorsal longitudinal fascicle (N = 10) or the medial f...

journal_title：Experimental neurology

authors： Akaishi T,Jiang ZY,Sakuma Y

更新日期：1988-02-01 00:00:00

abstract：:Death-associated protein kinase 1 (DAPK1) is a key protein that mediates neuronal death in ischemic stroke. Although the substrates of DAPK1 and molecular signal in stroke have been gradually discovered, the modulation of DAPK1 itself is still unclear. Here we first reveal that Caytaxin, a brain-specific member of BCL...

journal_title：Experimental neurology

authors： Wang S,Chen K,Yu J,Wang X,Li Q,Lv F,Shen H,Pei L

更新日期：2020-07-01 00:00:00

abstract：:An important issue in stem cell biology relates to mechanisms of cellular plasticity. Specifically, could any observed multipotency of, e.g., adult stem cells arise from true transdifferentiation or as a result of cell-cell fusion? We studied this issue using a culture paradigm of astrocyte monolayers and multipotent ...

journal_title：Experimental neurology

authors： Chen KA,Laywell ED,Marshall G,Walton N,Zheng T,Steindler DA

更新日期：2006-03-01 00:00:00

abstract：:The psychopathological impact of emotional stress on a specific individual varies markedly: while most escape the development of post-traumatic stress disorder and/or major depression, a select group of individuals demonstrate a vulnerability to succumb to these conditions. The past decade has witnessed an explosion i...

journal_title：Experimental neurology

authors： Krishnan V

更新日期：2014-11-01 00:00:00

abstract：:Because vitamin D hormone deficiency (VDHdef) can worsen severity and outcome for ischemic stroke, we examined the role of VDH in maintaining blood-brain-barrier (BBB integrity) in a rat model of stroke. In most types of stroke, the BBB is markedly compromised, potentially leading to a cascade of injury processes and ...

journal_title：Experimental neurology

authors： Sayeed I,Turan N,Stein DG,Wali B

更新日期：2019-02-01 00:00:00

abstract：:Most neurons in the dorsal neostriatum die 1 day after 30 min of cerebral ischemia. Dopamine may play a role in the pathogenesis of neuronal injury in neostriatum following ischemia. It has been shown that the number of surviving neurons in the right neostriatum dramatically increased following ischemia after lesions ...

journal_title：Experimental neurology

authors： Xu ZC,Chwang W,Li X,Chen X,He P

更新日期：1999-07-01 00:00:00

abstract：:The amount of myelination in vivo and in vitro depends on the number of oligodendrocyte progenitors, their differentiation, and on the neuron function. It has been shown that continuous administration of FGF2, a mitotic and neuroprotective factor, allows oligodendrocyte progenitors to proliferate, but prevents them fr...

journal_title：Experimental neurology

authors： Magy L,Keita M,Richard L,Piaser M,Vallat JM

更新日期：2003-05-01 00:00:00

abstract：:Periodic changes in ovarian steroid levels during fertility cycles affect learning both in humans and in rats in parallel with electrophysiological and morphological fluctuations in selective neuronal populations. In particular, during the estrous cycle of the female rat, hippocampal CA1 region undergoes cyclic modifi...

journal_title：Experimental neurology

authors： Crispino M,Stone DJ,Wei M,Anderson CP,Tocco G,Finch CE,Baudry M

更新日期：1999-10-01 00:00:00

abstract：:A prospective, multicenter, randomized trial did not demonstrate improved outcomes in severe traumatic brain injured patients treated with mild hypothermia [Clifton, G.L., Miller, E.R., Choi, S.C., Levin, H.S., McCauley, S., Smith, K.R., Jr., Muizelaar, J.P., Wagner, F.C., Jr., Marion, D.W., Luerssen, T.G., Chesnut, R...

journal_title：Experimental neurology

authors： Ma M,Matthews BT,Lampe JW,Meaney DF,Shofer FS,Neumar RW

更新日期：2009-01-01 00:00:00

abstract：:Synthesis of leukemia inhibitory factor (LIF) is increased in lesioned peripheral nerves and it is thought that this may cause increased expression of galanin (GAL) in axotomized dorsal root ganglia (DRG) neurons and also to promote axonal regeneration. We therefore compared effects of LIF and nerve growth factor (NGF...

journal_title：Experimental neurology

authors： Oztürk G,Tonge DA

更新日期：2001-06-01 00:00:00

abstract：:The present study was carried out to determine if augmentation of phrenic nerve activity during the crossed phrenic phenomenon temporally coincides with the morphological changes in the phrenic nucleus that we have observed in previous studies. This investigation consisted of two experiments in spinal cord hemisected ...

journal_title：Experimental neurology

authors： O'Hara TE Jr,Goshgarian HG

更新日期：1991-02-01 00:00:00

abstract：:The hph-1 mice have defective tetrahydrobiopterin biosynthesis and share many neurochemical similarities with l-dopa-responsive dystonia (DRD) in humans. In both, there are deficiencies in GTP cyclohydrolase I and low brain levels of dopamine (DA). Striatal tyrosine hydroxylase (TH) levels are decreased while the numb...

journal_title：Experimental neurology

authors： Zeng BY,Heales SJ,Canevari L,Rose S,Jenner P

更新日期：2004-12-01 00:00:00

abstract：:The present study was carried out to investigate whether estrogen modulates the drinking response induced by activation of angiotensinergic neural pathways from the subfornical organ (SFO) to the median preoptic nucleus (MnPO). Microinjection of angiotensin II (ANG II, 10(-10) M, 0.2 microl) into the SFO elicited drin...

journal_title：Experimental neurology

authors： Tanaka J,Miyakubo H,Fujisawa S,Nomura M

更新日期：2003-01-01 00:00:00

abstract：:Rats were injected with progressively increasing doses of morphine or meperidine during a period of 3 to 40 days. From this colony of animals individual rats were used at 3- to 4-day intervals for electrophysiologic experiments to analyze the activity of nociceptive neurons in the somesthetic thalamus. After an i.p. i...

journal_title：Experimental neurology

authors： Emmers R

更新日期：1984-01-01 00:00:00

abstract：:Muscular dystrophies (MDs) consist of a genetically heterogeneous group of disorders, recessive or dominant, characterized by progressive skeletal muscle weakening. To date, no effective treatment is available. Experimental strategies pursuing muscle regeneration through the transplantation of stem cell preparations h...

journal_title：Experimental neurology

authors： Darabi R,Baik J,Clee M,Kyba M,Tupler R,Perlingeiro RC

更新日期：2009-11-01 00:00:00

abstract：:Zebrafish is an excellent model to study central nervous system (CNS) axonal degeneration and regeneration since we can observe these processes in vivo and in real time in transparent larvae. Previous studies have shown that Mauthner cell (M-cell) axon regenerates poorly after mechanical spinal cord injury. Inconsiste...

journal_title：Experimental neurology

authors： Hu BB,Chen M,Huang RC,Huang YB,Xu Y,Yin W,Li L,Hu B

更新日期：2018-02-01 00:00:00

abstract：:It is controversial whether levodopa (L-DOPA) therapy in the early stages of Parkinson's disease (PD) predisposes to later complications. Partial lesions of the substantia nigra (SN) in rat provide a model of the early stages of PD. We have investigated the potential effects of L-DOPA in early PD by analyzing its infl...

journal_title：Experimental neurology

authors： Cole DG,Growdon JH,DiFiglia M

更新日期：1993-04-01 00:00:00

abstract：:These studies have examined the extent to which intrastriatal grafts of embryonic mesencephalic neurons induce recovery of normal discharge patterns in striatal neurons of rats after a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal dopamine (DA) pathway. Lesioned rats were tested for rotational beha...

journal_title：Experimental neurology

authors： Di Loreto S,Florio T,Capozzo A,Napolitano A,Adorno D,Scarnati E

更新日期：1996-04-01 00:00:00

abstract：:The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyram...

journal_title：Experimental neurology

authors： Immonen T,Alakuijala A,Hytönen M,Sainio K,Poteryaev D,Saarma M,Pasternack M,Sariola H

更新日期：2008-04-01 00:00:00